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Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 531 - 531
Journal Article
Perspectives on Science and Christian Faith, ISSN 0892-2675, 03/2018, Volume 70, Issue 1, p. 19
Journal Article
NATURE, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 531 - 531
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 02/2017, Volume 30, Issue 2, pp. 642 - 656
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 04/2015, Volume 28, Issue 4, pp. 797 - 809
Drug toxicity is often caused by electrophilic reactive metabolites that covalently bind to proteins. Consequently, the quantitative strength of a molecules... 
CYTOCHROME-P450 | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | HEPATOCYTES | CHEMISTRY, MEDICINAL | RAT | DRUG DISCOVERY | BIOACTIVATION PATHWAYS | CHEMISTRY, MULTIDISCIPLINARY | NEURAL-NETWORKS | LIVER-INJURY | METABOLISM | BOND-STRENGTH | TOXICOLOGY | Models, Chemical | Glutathione - chemistry | Quantitative Structure-Activity Relationship | Index Medicus
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2016, Volume 48, Issue 10, pp. 1288 - 1295
Methods are needed to reliably prioritize biologically active driver mutations over inactive passengers in high-throughput sequencing cancer data sets. We... 
IMPACT | VARIANTS | GENES | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | MISSENSE MUTATIONS | SOMATIC MUTATIONS | PREDICTION | Stomach Neoplasms - genetics | Algorithms | Neoplasms - genetics | Humans | Models, Genetic | Polymorphism, Single Nucleotide | Mutation | Data Collection - methods | Machine Learning | Datasets | Proteins | Medical research | Software | Genomes | Gene expression | Methods | Cancer | Index Medicus
Journal Article
Briefings in Bioinformatics, ISSN 1467-5463, 7/2011, Volume 12, Issue 4, pp. 327 - 335
Journal Article
Bioinformatics, ISSN 1367-4803, 10/2016, Volume 32, Issue 20, pp. 3183 - 3189
Motivation: Uridine diphosphate glucunosyltransferases (UGTs) metabolize 15% of FDA approved drugs. Lead optimization efforts benefit from knowing how... 
IN-VITRO | RAT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GLUCURONIDATION | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | SITES | DISPOSITION | Pharmaceutical Preparations - metabolism | Drug Interactions | Glucuronosyltransferase - metabolism | Humans | Index Medicus | Original Paper
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 01/2014, Volume 54, Issue 1, pp. 37 - 48
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 03/2007, Volume 47, Issue 2, pp. 302 - 317
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2019, Volume 34, Issue 1, pp. S57 - S57
Journal Article
by Van Voorhis, Wesley C and Adams, John H and Adelfio, Roberto and Ahyong, Vida and Akabas, Myles H and Alano, Pietro and Alday, Aintzane and Alemán Resto, Yesmalie and Alsibaee, Aishah and Alzualde, Ainhoa and Andrews, Katherine T and Avery, Simon V and Avery, Vicky M and Ayong, Lawrence and Baker, Mark and Baker, Stephen and Ben Mamoun, Choukri and Bhatia, Sangeeta and Bickle, Quentin and Bounaadja, Lotfi and Bowling, Tana and Bosch, Jürgen and Boucher, Lauren E and Boyom, Fabrice F and Brea, Jose and Brennan, Marian and Burton, Audrey and Caffrey, Conor R and Camarda, Grazia and Carrasquilla, Manuela and Carter, Dee and Belen Cassera, Maria and Chih-Chien Cheng, Ken and Chindaudomsate, Worathad and Chubb, Anthony and Colon, Beatrice L and Colón-López, Daisy D and Corbett, Yolanda and Crowther, Gregory J and Cowan, Noemi and D’Alessandro, Sarah and Le Dang, Na and Delves, Michael and DeRisi, Joseph L and Du, Alan Y and Duffy, Sandra and Abd El-Salam El-Sayed, Shimaa and Ferdig, Michael T and Fernández Robledo, José A and Fidock, David A and Florent, Isabelle and Fokou, Patrick V. T and Galstian, Ani and Gamo, Francisco Javier and Gokool, Suzanne and Gold, Ben and Golub, Todd and Goldgof, Gregory M and Guha, Rajarshi and Guiguemde, W. Armand and Gural, Nil and Guy, R. Kiplin and Hansen, Michael A. E and Hanson, Kirsten K and Hemphill, Andrew and Hooft van Huijsduijnen, Rob and Horii, Takaaki and Horrocks, Paul and Hughes, Tyler B and Huston, Christopher and Igarashi, Ikuo and Ingram-Sieber, Katrin and Itoe, Maurice A and Jadhav, Ajit and Naranuntarat Jensen, Amornrat and Jensen, Laran T and Jiang, Rays H. Y and Kaiser, Annette and Keiser, Jennifer and Ketas, Thomas and Kicka, Sebastien and Kim, Sunyoung and Kirk, Kiaran and Kumar, Vidya P and Kyle, Dennis E and Lafuente, Maria Jose and Landfear, Scott and Lee, Nathan and Lee, Sukjun and Lehane, Adele M and Li, Fengwu and Little, David and Liu, Liqiong and Llinás, Manuel and Loza, Maria I and Lubar, Aristea and Lucantoni, Leonardo and Lucet, Isabelle and Maes, Louis and Mancama, Dalu and ...
PLoS Pathogens, ISSN 1553-7366, 07/2016, Volume 12, Issue 7, pp. e1005763 - e1005763
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 02/2018, Volume 31, Issue 2, pp. 68 - 80
Cytochromes P450 (CYPs) oxidize alkylated amines commonly found in drugs and other biologically active molecules, cleaving them into an amine and an aldehyde.... 
CHEMISTRY, MEDICINAL | OXIDATIVE METABOLITES | REACTIVITY | TRIFLUOROETHANOL | IFOSFAMIDE | CHEMISTRY, MULTIDISCIPLINARY | PREDICTION | IN-VITRO | INHIBITION | ENZYMES | LIVER | ORAL TERBINAFINE | TOXICOLOGY | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0117898 - e0117898
Journal Article