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1. Full Text Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function
by Kennedy, Andrew J and Rahn, Elizabeth J and Paulukaitis, Brynna S and Savell, Katherine E and Kordasiewicz, Holly B and Wang, Jing and Lewis, John W and Posey, Jessica and Strange, Sarah K and Guzman-Karlsson, Mikael C and Phillips, Scott E and Decker, Kyle and Motley, S. Timothy and Swayze, Eric E and Ecker, David J and Michael, Todd P and Day, Jeremy J and Sweatt, J. David
Cell reports (Cambridge), ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2666 - 2685
transcription | next-generation sequencing | social interactions | language | schizophrenia | neuroepigenetics | epigenetics | autism | E2-2 | learning and memory | DNA methylation | HDAC inhibitor | Pitt-Hopkins syndrome | autism spectrum disorder | transcription factor 4 | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Memory - drug effects | Transcription, Genetic - drug effects | Autistic Disorder - pathology | Autistic Disorder - physiopathology | Motor Activity - drug effects | Neuronal Plasticity - drug effects | Intellectual Disability - complications | Male | Gene Expression Profiling | Transcription Factor 7-Like 2 Protein - metabolism | Gene Knockdown Techniques | Intellectual Disability - genetics | Neuronal Plasticity - genetics | Long-Term Potentiation - drug effects | Facies | Hyperventilation - physiopathology | Hydroxamic Acids - pharmacology | Disease Models, Animal | Transcription Factor 7-Like 2 Protein - genetics | Hyperventilation - genetics | Hyperventilation - complications | Intellectual Disability - pathology | DNA Methylation - genetics | Intellectual Disability - physiopathology | Hippocampus - metabolism | Animals | Hyperventilation - pathology | Prepulse Inhibition - drug effects | CpG Islands - genetics | Histone Deacetylase Inhibitors - pharmacology | Mice | Histone Deacetylase 2 - metabolism | Autistic Disorder - complications | DNA Methylation - drug effects | Index Medicus
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2. Full Text A modular analysis of microglia gene expression, insights into the aged phenotype
by Cho, Christine E and Damle, Sagar S and Wancewicz, Edward V and Mukhopadhyay, Swagatam and Hart, Christopher E and Mazur, Curt and Swayze, Eric E and Kamme, Fredrik
BMC genomics, ISSN 1471-2164, 02/2019, Volume 20, Issue 1, pp. 164 - 164
Gene modules | Aging | Inflammation | WGCNA | Transcriptome | Microglia | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Cellular Senescence - genetics | Microglia - metabolism | Resveratrol - pharmacology | Signal Transduction | Down-Regulation | Cells, Cultured | Transcriptome - drug effects | Toll-Like Receptor 2 - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Transcription Factors - metabolism | Inflammation - metabolism | Phenotype | Animals | Interferon Type I - pharmacology | Inflammation - genetics | Mice | Interferon-gamma - pharmacology | Physiological aspects | Gene expression | Identification and classification | Brain | Phenotypes | Classification schemes | Disease | Cytokines | Modules | Homeostasis | Genomes | Neurodevelopmental disorders | Genotype & phenotype | Neurodegeneration | Morphology | Classification | Combinatorial analysis | Binding sites
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3. Full Text RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform
by Bennett, C. Frank and Swayze, Eric E
Annual review of pharmacology and toxicology, ISSN 0362-1642, 02/2010, Volume 50, Issue 1, pp. 259 - 293
Antisense oligonucleotides | RNase H | RNA interference | RNA | RNA splicing | Biological and medical sciences | Miscellaneous | Medical sciences | General pharmacology | Pharmacology. Drug treatments | RNA - physiology | Animals | Oligonucleotides, Antisense - pharmacology | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - therapeutic use | Oligonucleotides, Antisense - chemistry | Physiological aspects | Research | Ribonuclease | Oligonucleotides | Index Medicus
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4. Full Text Single-Stranded siRNAs Activate RNAi in Animals
by Lima, Walt F and Prakash, Thazha P and Murray, Heather M and Kinberger, Garth A and Li, Wenyu and Chappell, Alfred E and Li, Cheryl S and Murray, Susan F and Gaus, Hans and Seth, Punit P and Swayze, Eric E and Crooke, Stanley T
Cell (Cambridge), ISSN 0092-8674, 08/2012, Volume 150, Issue 5, pp. 883 - 894
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Argonaute Proteins - genetics | Humans | Liver - metabolism | Cells, Cultured | Molecular Sequence Data | Organophosphonates - metabolism | Lipid Metabolism | Male | Hepatocytes - metabolism | RNA, Small Interfering - chemistry | Animals | RNA Interference | Base Sequence | RNA-Induced Silencing Complex - metabolism | Mice | Mice, Inbred BALB C | HeLa Cells | Vinyl Compounds - metabolism | RNA, Small Interfering - metabolism | Phosphates | Gene expression | Genes | Index Medicus
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5. Full Text Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
by Southwell, Amber L and Southwell, Amber L and Kordasiewicz, Holly B and Langbehn, Douglas and Langbehn, Douglas and Skotte, Niels H and Skotte, Niels H and Parsons, Matthew P and Parsons, Matthew P and Villanueva, Erika B and Villanueva, Erika B and Caron, Nicholas S and Østergaard, Michael E and Ostergaard, Michael E and Anderson, Lisa M and Anderson, Lisa M and Xie, Yuanyun and Cengio, Louisa Dal and Cengio, Louisa Dal and Findlay-Black, Hailey and Doty, Crystal N and Fitsimmons, Bethany and Fitsimmons, Bethany and Swayze, Eric E and Swayze, Eric E and Seth, Punit P and Seth, Punit P and Raymond, Lynn A and Raymond, Lynn A and Frank Bennett, C and Bennett, C. Frank and Hayden, Michael R and Hayden, Michael R
Science translational medicine, ISSN 1946-6234, 10/2018, Volume 10, Issue 461, p. eaar3959
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Neurodegenerative diseases | Huntingtin | Cognitive ability | Antisense oligonucleotides | Limbic system | Single-nucleotide polymorphism | Mutation | Huntington's disease | Mutants | Hereditary diseases | Index Medicus
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6. Full Text LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson’s Disease Mouse Model
by Zhao, Hien Tran and John, Neena and Delic, Vedad and Ikeda-Lee, Karli and Kim, Aneeza and Weihofen, Andreas and Swayze, Eric E and Kordasiewicz, Holly B and West, Andrew B and Volpicelli-Daley, Laura A
Molecular therapy. Nucleic acids, ISSN 2162-2531, 09/2017, Volume 8, pp. 508 - 519
Parkinson's disease | preformed fibrils | LRRK2 | α-synuclein | antisense oligonucleotides | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Tyrosine | Phenotypes | Kidneys | Disease | Neurodegenerative diseases | Neurons | Hydroxylase | Fibrils | Parkinsons disease | Antisense oligonucleotides | Leucine | FDA approval | Tyrosine 3-monooxygenase | Wire | Synuclein | Kinases | Proteins | Mutation | LRRK2 protein | Movement disorders
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7. Full Text Targeting Huntingtin Expression in Patients with Huntington’s Disease
by Tabrizi, Sarah J and Leavitt, Blair R and Landwehrmeyer, G. Bernhard and Wild, Edward J and Saft, Carsten and Barker, Roger A and Blair, Nick F and Craufurd, David and Priller, Josef and Rickards, Hugh and Rosser, Anne and Kordasiewicz, Holly B and Czech, Christian and Swayze, Eric E and Norris, Daniel A and Baumann, Tiffany and Gerlach, Irene and Schobel, Scott A and Paz, Erika and Smith, Anne V and Bennett, C. Frank and Lane, Roger M and Phase 1–2a IONIS-HTTRx Study Site Teams
The New England journal of medicine, ISSN 0028-4793, 06/2019, Volume 380, Issue 24, pp. 2307 - 2316
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Injections, Spinal | Huntingtin Protein - antagonists & inhibitors | Oligonucleotides - therapeutic use | Humans | Middle Aged | Male | Dose-Response Relationship, Drug | Nucleotides - pharmacology | Adult | Female | Huntingtin Protein - cerebrospinal fluid | Oligonucleotides - cerebrospinal fluid | Huntingtin Protein - genetics | Mutation | Nucleotides - chemical synthesis | Huntington Disease - drug therapy | Huntingtons disease | Polyglutamine | Huntingtin | Neurodegenerative diseases | Trinucleotide repeats | Antisense oligonucleotides | Nervous system | mRNA | Cerebrospinal fluid | Proteins | Pharmacokinetics | Drug dosages | Pharmaceuticals | Index Medicus | Abridged Index Medicus
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8. Full Text Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay
by Gaus, Hans J and Gupta, Ruchi and Chappell, Alfred E and Østergaard, Michael E and Swayze, Eric E and Seth, Punit P
Nucleic acids research, ISSN 0305-1048, 02/2019, Volume 47, Issue 3, pp. 1110 - 1122
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Sodium Chloride | Humans | Oligonucleotides, Antisense - chemistry | Oligonucleotides, Antisense - metabolism | Rats | Blood Proteins - metabolism | Carbocyanines | Animals | Protein Binding | Phosphorothioate Oligonucleotides - metabolism | Mice | Fluorescence Polarization | Fluorescent Dyes | Hydrogen-Ion Concentration | Serum Albumin - metabolism | Chemical Biology and Nucleic Acid Chemistry
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9. Full Text Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides
by Østergaard, Michael E and Nichols, Josh and Dwight, Timothy A and Lima, Walt and Jung, Michael E and Swayze, Eric E and Seth, Punit P
Molecular therapy. Nucleic acids, ISSN 2162-2531, 06/2017, Volume 7, Issue C, pp. 20 - 30
SNPs | Huntington’s disease | fluorinated nucleotides | antisense oligonucleotide | allele selectivity | Huntington's disease | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Cell culture | Enzymes | Huntingtin | Antisense oligonucleotides | Ribonuclease H | mRNA | Single-nucleotide polymorphism | Manuscripts | Chemical modification | Alleles | Fibroblasts | Deoxyribonucleic acid--DNA | Ribonuclease H1 | Original
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