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Bioanalysis, 08/2017, Volume 9, Issue 16, p. 1203
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 6/2015, Volume 32, Issue 6, pp. 2060 - 2071
To investigate whether it is possible to specifically suppress the expression and function of endogenous canine P-glycoprotein (cPgp) in Madin-Darby canine... 
Biochemistry, general | Biomedical Engineering | P-glycoprotein | Biomedicine | breast cancer resistance protein | Pharmacy | Medical Law | zinc finger nucleases | Pharmacology/Toxicology | MDCKII | ABC–transporter | ABC-transporter | CLEAVAGE | BLOOD-BRAIN-BARRIER | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | EFFLUX TRANSPORTERS | MDR1 | QUANTITATIVE ATLAS | ENZYMES | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | EXPRESSION | CANCER RESISTANCE PROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Species Specificity | Humans | Gene Expression Regulation | Genotype | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | DNA Breaks, Double-Stranded | Blotting, Western | Gene Knockdown Techniques | Endodeoxyribonucleases - genetics | Phenotype | Animals | Transfection | ATP-Binding Cassette Transporters - genetics | Biological Transport | Dogs | Endodeoxyribonucleases - metabolism | Madin Darby Canine Kidney Cells | ATP Binding Cassette Transporter, Sub-Family B - metabolism | ATP-Binding Cassette Transporters - metabolism | Proteomics - methods | Neoplasm Proteins - genetics | ATP Binding Cassette Transporter, Sub-Family B - genetics | Drugstores | Nucleases | Zinc finger proteins | DNA binding proteins | Analysis | Enzymes | Chemotherapy | Genomics | Glycoproteins | Breast cancer | Pharmacology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2006, Volume 103, Issue 46, pp. 17408 - 17413
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 14, pp. 4400 - 4418
Journal Article
Journal Article
Journal Article
Cellular Microbiology, ISSN 1462-5814, 03/2013, Volume 15, Issue 3, pp. 458 - 473
Journal Article
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 04/2018, Volume 46, Issue 4, pp. 429 - 439
Mass balance, metabolism, and excretion of ABT-126, an alpha 7 neuronal acetylcholine receptor agonist, were characterized in healthy male subjects (n = 4)... 
SAFETY | ALZHEIMERS-DISEASE | SUBSTRATE | DOUBLE-BLIND | COGNITIVE IMPAIRMENT | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | HUMAN LIVER | INHIBITORS | N-GLUCURONIDATION | EXPOSURE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7486 - 7502
The development of glycine transporter 1 (GlyT1) inhibitors may offer putative treatments for schizophrenia and other disorders associated with hypofunction of... 
CHEMISTRY, MEDICINAL | ANTAGONIST | MICROSOMES | SCHIZOPHRENIA | CANDIDATES | GLYT1 | BINDING | BRAIN | L-687,414 | P-GLYCOPROTEIN | KETAMINE
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2018, Volume 61, Issue 17, pp. 7503 - 7524
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report the synthesis and biological... 
INTERNALIZATION | CHEMISTRY, MEDICINAL | ANTAGONIST | HYDROGENATION | PHARMACOLOGY | SCHIZOPHRENIA | CNS | OPTIMIZATION | D-ASPARTATE RECEPTOR | BRAIN | P-GLYCOPROTEIN
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2006, Volume 49, Issue 15, pp. 4606 - 4615
Journal Article
Bioanalysis, ISSN 1757-6180, 2014, Volume 6, Issue 10, pp. 1295 - 1309
In the recent past, we have seen an increase in the outsourcing of bioanalysis in pharmaceutical companies in support of their drug development pipeline. This... 
electronic laboratory notebook | process optimization | laboratory information management system | automation | outsourcing | MATRIX | CHEMISTRY, ANALYTICAL | PRODUCTIVITY | BIOCHEMICAL RESEARCH METHODS | NOTEBOOKS
Journal Article
Proteome Science, ISSN 1477-5956, 06/2003, Volume 1, Issue 1, pp. 3 - 3
The completion of the human genome sequence has led to a rapid increase in genetic information. The invention of DNA microarrays, which allow for the parallel... 
Journal Article
Journal Article
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