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PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 8, p. e0134882
.... Herein, we evaluated the effect of selective pharmacological SRPK inhibition by N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamide (SRPIN340) on the viability of lymphoid and myeloid leukemia cell lines... 
Niacinamide - analogs & derivatives | Leukemia - pathology | Apoptosis - drug effects | Humans | Leukemia - metabolism | Antineoplastic Agents - metabolism | Piperidines - pharmacology | Niacinamide - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Molecular Structure | Binding Sites | Leukemia - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Cell Survival - drug effects | Piperidines - chemistry | Niacinamide - metabolism | Jurkat Cells | Piperidines - metabolism | Cells, Cultured | Spectrometry, Fluorescence | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Molecular Dynamics Simulation | K562 Cells | HL-60 Cells | Protein Binding | Molecular Docking Simulation | Protein-Serine-Threonine Kinases - chemistry | HeLa Cells | Niacinamide - pharmacology | Phosphorylation | Leukemia | Emission analysis | Fluorescence | Molecular dynamics | Cytotoxicity | Biosynthesis | mRNA | Drug development | Kinases | Phosphatase | Molecular docking | Ovarian cancer | Proteins | Cell growth | Antitumor agents | Arginine | Site selection | Inhibition | Vascular endothelial growth factor | Dynamic structural analysis | Splicing | Myeloid leukemia | Melanoma | Tryptophan | Pharmacology | Tumor cell lines | Gene expression | Molecular chains | Protein kinase | Splicing factors | Viability | Cancer | Apoptosis
Journal Article
PLoS pathogens, ISSN 1553-7374, 2014, Volume 10, Issue 7, p. e1004261
Journal Article
Molecular psychiatry, ISSN 1476-5578, 2014, Volume 19, Issue 6, pp. 688 - 698
Pharmacologic blockade of monoamine oxidase A (MAOA) or serotonin transporter (5-HTT) has antidepressant and anxiolytic efficacy in adulthood. Yet, genetically... 
anxiety | development | serotonin | aggression | depression | dopamine | BRAIN-SEROTONIN | RHESUS-MONKEYS | PSYCHIATRY | ENVIRONMENT INTERACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFICIENT MICE | NEUROSCIENCES | GENE | SOMATOSENSORY CORTEX | MONOAMINE-OXIDASE-A | TRANSPORTER KNOCKOUT MICE | DORSAL RAPHE NUCLEUS | Aggression - physiology | Dopamine Plasma Membrane Transport Proteins - metabolism | Depression - physiopathology | Male | Brain - growth & development | Mice, 129 Strain | Brain - physiology | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Female | Dopamine - metabolism | Affect - drug effects | 3,4-Dihydroxyphenylacetic Acid - metabolism | Affect - physiology | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Amphetamine - pharmacology | Anxiety - physiopathology | Brain - drug effects | Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Serotonin - metabolism | Central Nervous System Agents - pharmacology | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Aggression - drug effects | Monoamine Oxidase - metabolism | Passive-aggressive personality | Dopamine | Genetic susceptibility | Serotonin | Genetic research | Genetic aspects | Research | Properties | Mouse | Aggression | Development | Depression | Anxiety
Journal Article
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2012, Volume 127, Issue 3, pp. 440 - 450
Journal Article