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Movement Disorders, ISSN 0885-3185, 10/2019, Volume 34, Issue 10, pp. 1434 - 1439
Journal Article
Neuron, ISSN 0896-6273, 05/2019, Volume 102, Issue 4, pp. 899 - 899
Journal Article
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2018, Volume 1049, pp. 1 - 28
Journal Article
Advances in experimental medicine and biology, ISSN 0065-2598, 2018, Volume 1049, p. 1
Huntington's disease (HD) is the most common monogenic neurodegenerative disease and the commonest genetic dementia in the developed world. With autosomal... 
Journal Article
NEURON, ISSN 0896-6273, 05/2019, Volume 102, Issue 4, pp. 899 - 899
Journal Article
Human Brain Mapping, ISSN 1065-9471, 03/2018, Volume 39, Issue 3, pp. 1339 - 1353
Novel methods that stimulate neuroplasticity are increasingly being studied to treat neurological and psychiatric conditions. We sought to determine whether... 
neurodegenerative diseases | real‐time fMRI | neurofeedback training | Huntington's disease | brain training | neuroplasticity | real-time fMRI | TRACK-HD | RESONANCE-IMAGING NEUROFEEDBACK | HUMAN BRAIN | SELF-REGULATION | PREMANIFEST | NEUROSCIENCES | NEUROIMAGING | CONNECTIVITY | CLINICAL-TRIALS | COGNITIVE ASSESSMENT | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | MICROSTRUCTURE | PROGRESSION | Motor Activity - physiology | Humans | Huntington Disease - pathology | Middle Aged | Magnetic Resonance Imaging - methods | Male | Volition - physiology | Neuronal Plasticity - physiology | Cognition - physiology | Adult | Female | Neurofeedback - methods | Huntington Disease - physiopathology | Putaminal Hemorrhage - physiopathology | Organ Size | Motor Cortex - physiopathology | Motor Cortex - pathology | Proof of Concept Study | Gray Matter - diagnostic imaging | Huntington Disease - diagnostic imaging | Motor Cortex - diagnostic imaging | Learning - physiology | Gray Matter - pathology | Putaminal Hemorrhage - diagnostic imaging | Brain Mapping | Aged | Neurofeedback - physiology | Medicine, Experimental | Medical research | Biofeedback training | Nervous system diseases | Magnetic resonance imaging | Huntingtons disease | Neuroimaging | Brain | Cognitive ability | Motor task performance | Substantia grisea | Plasticity (neural) | Plasticity (functional) | Training | Plasticity (behavioral) | Functional anatomy | Feedback | Neurodegeneration | Functional magnetic resonance imaging | Supplementary motor area | Medical imaging | Cortex | Brain mapping | Feasibility studies | Real time | Patients | Putamen | Neurology | Neural networks | Structure-function relationships
Journal Article
Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, 09/2018, Volume 89, Issue Suppl 1, p. A35
Background Despite histological evidence of widespread grey matter atrophy by end-stage Huntington’s disease (HD), the progression of cortical atrophy in HD... 
Atrophy
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, p. 1307
We have previously shown that exon 1 of the huntingtin gene does not always splice to exon 2 resulting in the production of a small polyadenylated mRNA... 
CAG REPEAT | R6/2 | INSTABILITY | MULTIDISCIPLINARY SCIENCES | MUTANT HUNTINGTIN | LENGTH | GENE-EXPRESSION | IN MOUSE MODEL | ANTISENSE OLIGONUCLEOTIDES | BRAIN | TRANSGENIC MICE
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1 - 14
Neurodegenerative diseases, characterised by the progressive and selective neuronal death in the central nervous system, are frequently accompanied by an... 
Huntingtons disease | Phenotypes | Animal models | Immune response | Neurodegenerative diseases | Immunomodulation | Central nervous system | Inflammation | Macrophages | Huntington's disease | Bisphosphonates | Immunosuppressive agents | Clodronic acid | Monocytes | Immune system
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 12
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by the expansion of the CAG repeat in exon 1 of the huntingtin (HTT) gene, which... 
Huntingtons disease | Animal models | Polyglutamine | Immune response | Huntingtin | Cytokines | Neurodegenerative diseases | Trinucleotide repeats | Inflammation | Tumor necrosis factor-α | Huntington's disease | Interleukin 6 | Neurotoxicity | Etanercept | Rodents | Neostriatum | Plasma levels | Trinucleotide repeat diseases | Tumors
Journal Article
Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, 09/2018, Volume 89, Issue Suppl 1, p. A11
Background While the central nervous system is considered to be the primary site of Huntington’s disease pathology, the systemic innate immune system may be a... 
Genotype & phenotype | Cytokines | Immune system
Journal Article
Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, 09/2018, Volume 89, Issue Suppl 1, p. A47
Background The TRACK, PREDICT and IMAGE-HD studies provide rich and varied datasets with which to identify robust imaging and clinical biomarkers of... 
Biomarkers
Journal Article