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PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0177140
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 33, pp. 12163 - 12168
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2017, Volume 199, Issue 9, pp. 3116 - 3128
Journal Article
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2013, Volume 43, Issue 12, pp. 3183 - 3196
Phosphatidylinositol‐3‐kinase gamma (PI3Kγ) is a leukocyte‐specific lipid kinase with signaling function downstream of G protein‐coupled receptors to regulate... 
T cells | Cell activation | PI3K gamma | Immune responses | Cell differentiation | T cells | MIGRATION | DOMAIN | Tcells | P85 SUBUNIT | PHOSPHATIDYLINOSITOL 3-KINASE | IMMUNOLOGY | ARTHRITIS | CYTOKINE PRODUCTION | PI3K | PHOSPHOINOSITIDE 3-KINASE GAMMA | IMMUNOLOGICAL SYNAPSE | BINDING | Hypersensitivity, Delayed - pathology | Class Ib Phosphatidylinositol 3-Kinase - genetics | Hypersensitivity, Delayed - immunology | Proto-Oncogene Proteins c-akt - genetics | Autoimmune Diseases - genetics | Membrane Microdomains - immunology | Cell Differentiation - genetics | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Phosphorylation - genetics | T-Lymphocytes, Helper-Inducer - immunology | Phosphorylation - immunology | Autoimmune Diseases - pathology | Autoimmune Diseases - drug therapy | Hypersensitivity, Delayed - genetics | Mitogen-Activated Protein Kinase 3 - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Autoimmune Diseases - immunology | Mice, Transgenic | Enzyme Inhibitors - therapeutic use | Cell Differentiation - immunology | Animals | Proto-Oncogene Proteins c-akt - immunology | Antigens - immunology | Mice | Mice, Inbred BALB C | Class Ib Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Class Ib Phosphatidylinositol 3-Kinase - immunology | Membrane Microdomains - genetics | Cellular Immune Response
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 2019, Volume 14, Issue 4, pp. 644 - 654
Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects the synovial joints and can lead to bone erosion and cartilage damage. One hallmark... 
ANTIBODIES | CYCLIC CITRULLINATED PEPTIDE | RITUXIMAB | REGENERATION | PERFORMANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMERICAN-COLLEGE | ARGININE | PERIPHERAL-BLOOD | IDENTIFICATION | FIBRINOGEN
Journal Article
by Jia, H and Dai, GX and Su, WG and Xiao, K and Weng, JY and Zhang, ZL and Wang, Q and Yuan, TH and Shi, FY and Zhang, Z and Chen, W and Sai, Y and Wang, J and Li, X and Cai, Y and Yu, J and Ren, P and Venable, J and Rao, T and Edwards, JP and Bembenek, SD
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 4936 - 4948
An electronic density model was developed and used to identify a novel pyrrolotriazinone replacement for a quinazolinone, a commonly used moiety to impart... 
P110-DELTA | AUTOIMMUNE | CHEMISTRY, MEDICINAL | PI3K-DELTA | INFLAMMATION | DELTA | KINASE | PI3K-GAMMA | FAMILY
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2004, Volume 153, Issue 1, pp. 108 - 121
FTY720 is a prodrug for FTY-phosphate, an agonist at four of the five known receptors for sphingosine-1-phosphate (S1P). We show that administration of either... 
Lymphopoenia | Gene expression | Relapsing–remitting EAE | FTY720 | Relapsing-remitting EAE | PROTEOLIPID PROTEIN | LYSOPHOSPHOLIPID RECEPTORS | COLONY-STIMULATING FACTOR | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | SPINAL-CORD | IMMUNOLOGY | NEUROSCIENCES | lymphopoenia | CIRCULATING MATURE LYMPHOCYTES | MULTIPLE-SCLEROSIS | SKIN ALLOGRAFT SURVIVAL | IN-VIVO | POSSESSING UNIQUE MECHANISMS | relapsing-remitting EAE | gene expression | Peptide Fragments | Encephalomyelitis, Autoimmune, Experimental - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Immunosuppressive Agents - therapeutic use | Molecular Sequence Data | Antineoplastic Agents - therapeutic use | Interferon-gamma - metabolism | Receptors, G-Protein-Coupled - agonists | Receptors, Lysophospholipid | Nitric Oxide Synthase - genetics | Nitric Oxide Synthase Type II | Lymphopenia - etiology | Dose-Response Relationship, Drug | RNA, Messenger - biosynthesis | Lymphocytes - physiology | Drug Interactions | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Time Factors | Propylene Glycols - therapeutic use | Reverse Transcriptase Polymerase Chain Reaction - methods | Female | Interferon-gamma - genetics | Immunosuppressive Agents - pharmacology | Mitoxantrone - therapeutic use | Disease Models, Animal | Propylene Glycols - pharmacology | Myelin Proteolipid Protein | Gene Expression Regulation - immunology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Encephalomyelitis, Autoimmune, Experimental - blood | Fingolimod Hydrochloride | Mice, Inbred Strains | Myelin Proteins - genetics | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Sphingosine - analogs & derivatives | Animals | Lymphopenia - drug therapy | Lymphocytes - drug effects | Mice | Nitric Oxide Synthase - metabolism | Myelin Proteins - metabolism
Journal Article
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 08/2015, Volume 56, Issue 8, pp. 1492 - 1500
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2013, Volume 43, Issue 12, pp. 3183 - 3196
  Phosphatidylinositol-3-kinase gamma (PI3K[gamma]) is a leukocyte-specific lipid kinase with signaling function downstream of G protein-coupled receptors to... 
T cells | Analysis | G proteins
Journal Article
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 11/2017, Volume 199, Issue 9, pp. 3116 - 3128
CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR) with established roles... 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2009, Volume 52, Issue 9, pp. 3047 - 3062
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2011, Volume 336, Issue 2, pp. 468 - 478
Journal Article
Journal Article