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Cancer Research, ISSN 0008-5472, 10/2015, Volume 75, Issue 20, pp. 4384 - 4397
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2008, Volume 105, Issue 4, pp. 1285 - 1290
Monoclonal gammopathy of undetermined significance (MGUS) is a common disorder of aging and a precursor lesion to full-blown multiple myeloma (MM). The... 
T lymphocytes | Dendritic cells | K562 cells | DNA damage | Plasma cells | Antibodies | Ligands | Natural killer cells | Mica | Tumors | ERp5 | NKG2D | Tumor immunity | MICA | Plasma cell | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION FACTOR XBP-1 | DELTA T-CELLS | tumor immunity | NKG2D RECEPTOR | PLASMA-CELL DIFFERENTIATION | TUMOR-IMMUNITY | NK CELLS | UNDETERMINED SIGNIFICANCE | MONOCLONAL GAMMOPATHY | plasma cell | EXPRESSION | Bortezomib | Prognosis | Dendritic Cells - immunology | Humans | Histocompatibility Antigens Class I - immunology | Multiple Myeloma - immunology | Antineoplastic Agents - therapeutic use | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Multiple Myeloma - metabolism | Disease Progression | Histocompatibility Antigens Class I - metabolism | Multiple Myeloma - pathology | Isoantibodies - therapeutic use | Cell Line, Tumor | Cross-Priming | Antineoplastic Agents - pharmacology | Histocompatibility Antigens Class I - biosynthesis | Tumor Cells, Cultured | Pyrazines - pharmacology | Dendritic Cells - metabolism | Boronic Acids - pharmacology | Isoantibodies - metabolism | Proteins | Control | Major histocompatibility complex | Multiple myeloma | Physiological aspects | Development and progression | Influence | Genetic aspects | Properties | Immunity | Biological Sciences
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2012, Volume 18, Issue 17, pp. 4669 - 4681
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 238 - 238
Abstract Introduction: Immunoglobulin (Ig) gene rearrangement is a hallmark of early B-cell development. As multiple myeloma is considered a clonal disease... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 485 - 485
Abstract Introduction Molecular mechanisms of multiple myeloma (MM) pathogenesis are unknown, but a role for bone marrow (BM) niche in supporting MM is well... 
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2018, Volume 128, Issue 6, pp. 2487 - 2499
Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive... 
Animal models | Cell survival | Hematology | Immunoregulation | Syngeneic grafts | Blocking antibodies | Multiple myeloma | Melanoma | Homeostasis | Bone marrow transplantation | Lymphocytes T | Genomes | Patients | Immunosuppression | Developmental stages | Lymphocytes | Immunotherapy | Bone marrow | Remission | Lymphomas | Interferon | Cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2006, Volume 103, Issue 51, pp. 19478 - 19483
A critical role for vascular endothelial factor (VEGF) has been demonstrated in multiple myeloma (MM) pathogenesis. Here, we characterized the effect of the... 
Angiogenesis | Cell growth | Receptors | Human umbilical vein endothelial cells | Secretion | Cell lines | Cell adhesion | Endothelial cells | Cells | Tumors | Xenograft mouse model | xenograft mouse model | angiogenesis | MULTIDISCIPLINARY SCIENCES | GROWTH | C-MYC | OVERCOMES DRUG-RESISTANCE | THERAPEUTIC IMPLICATIONS | ANTIANGIOGENESIS | CANCER | MICROARRAY DATA | PROGRESSION | CHEMOTHERAPY | Immunohistochemistry | RNA, Small Interfering - genetics | Immunoprecipitation | Apoptosis - drug effects | Humans | Pyrimidines - metabolism | Multiple Myeloma - drug therapy | Receptors, Vascular Endothelial Growth Factor - metabolism | Microarray Analysis | Gene Expression Regulation, Neoplastic - drug effects | Enzyme-Linked Immunosorbent Assay | Pyrimidines - pharmacology | Multiple Myeloma - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-myc - metabolism | Blotting, Western | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Sulfonamides - metabolism | Cell Line, Tumor | Mice | Neovascularization, Pathologic - metabolism | Proto-Oncogene Proteins c-myc - genetics | Endothelial Cells - drug effects | Development and progression | Dosage and administration | Research | Vascular endothelial growth factor | Patient outcomes | Multiple myeloma | Biological Sciences
Journal Article
British Journal of Haematology, ISSN 0007-1048, 05/2010, Volume 149, Issue 4, pp. 537 - 549
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 5039 - 5039
Abstract Abstract 5039 Smoldering multiple myeloma (SMM) patients are at high risk for progression to active multiple myeloma (MM), making them candidates for... 
Journal Article
Leukemia, ISSN 0887-6924, 01/2019, Volume 33, Issue 1, pp. 171 - 180
Immunomodulatory drugs (IMiDs) including lenalidomide and pomalidomide bind cereblon (CRBN) and activate the CRL4(C)(RBN) ubiquitin ligase to trigger... 
MULTIPLE-MYELOMA | DEXAMETHASONE | ONCOLOGY | HIGH-DOSE THERAPY | COP9 SIGNALOSOME | BONE-MARROW | LENALIDOMIDE | DEGRADATION | THALIDOMIDE | HEMATOLOGY | E3 UBIQUITIN LIGASE | TRANSPLANTATION | Prognosis | Peptide Hydrolases - genetics | Humans | Gene Expression Regulation, Neoplastic | Bortezomib - pharmacology | Ikaros Transcription Factor - genetics | COP9 Signalosome Complex - antagonists & inhibitors | Multiple Myeloma - drug therapy | Ubiquitination | Proteolysis | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Ikaros Transcription Factor - metabolism | Tumor Cells, Cultured | Peptide Hydrolases - metabolism | Enzyme Inhibitors - pharmacology | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | Multiple Myeloma - pathology | CRISPR-Cas Systems | Biomarkers, Tumor - genetics | COP9 Signalosome Complex - genetics | COP9 Signalosome Complex - metabolism | Immunologic Factors - pharmacology | Multiple Myeloma - genetics | Research | Drug resistance | Gene expression | Immunity | Cancer cells | Ubiquitin | CRISPR | Regulators | Transcription factors | Deactivation | Immunomodulation | Toxicity | Multiple myeloma | Cytotoxicity | Genomes | Medical screening | Proteasome inhibitors | Cullin | Degradation | Screening | Sensitivity | Inhibitors | Proteasomes | Sensitivity enhancement | Pretreatment | Ubiquitin-protein ligase
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 24, pp. 6570 - 6582
Purpose: Antibody-drug conjugates (ADC) utilizing noncleavable linker drugs have been approved for clinical use, and several are in development targeting solid... 
TARGET EXPRESSION | BREAST-CANCER TH3RESA | EFFICACY | ONCOLOGY | BRENTUXIMAB VEDOTIN | RESISTANCE | OPEN-LABEL | HODGKIN-LYMPHOMA | TRASTUZUMAB EMTANSINE T-DM1 | CELL MATURATION ANTIGEN | PHYSICIANS CHOICE
Journal Article
Chemical Science, ISSN 2041-6520, 2016, Volume 7, Issue 6, pp. 3556 - 3563
Fundamental insight into excimer formation has been gained by using 9,10-bis[4-(9-carbazolyl)phenyl] anthracene] (Cz(9)PhAn) as a probe. Cz(9)PhAn exhibits a... 
EXTERNAL QUANTUM EFFICIENCY | FLUORESCENCE | SUBSTITUTED ANTHRACENE-DERIVATIVES | ELECTROLUMINESCENT DEVICES | BLUE | MOLECULE | HOST MATERIALS | DIODES | SINGLE-EMITTING-COMPONENT | EMISSION | CHEMISTRY, MULTIDISCIPLINARY | Anthracene | Orbitals | Phenyls | White light | Excimers | Lighting | Fluorescence | Formations
Journal Article