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Nature Cell Biology, ISSN 1465-7392, 10/2015, Volume 17, Issue 10, pp. 1270 - 1281
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL-2 members preserve... 
CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | ACTIVATION | CONFORMATIONAL-CHANGE | MEMBERS | PROAPOPTOTIC BAX | BH3 DOMAINS | PUMA | BH3-ONLY PROTEINS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | bcl-2 Homologous Antagonist-Killer Protein - genetics | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | Cytochromes c - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Embryo, Mammalian - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Mitochondria - genetics | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Fibroblasts - metabolism | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Mice, Inbred C57BL | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Models, Biological | Fibroblasts - cytology | Intestine, Small - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Genotype | Genetic aspects | Properties | Cell death | Cellular control mechanisms | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2013, Volume 123, Issue 7, pp. 3154 - 3165
HGF signals through its cognate receptor, MET, to orchestrate diverse biological processes, including cell proliferation, cell fate specification,... 
TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | CERVICAL-VERTEBRAE | TARGETED DISRUPTION | SCATTER FACTOR | PLASMINOGEN-ACTIVATOR | TYROSINE KINASE | HEPATOCYTE GROWTH-FACTOR | C-MET | BINDING-SITES | PRECURSOR CELLS | Matrix Metalloproteinases, Secreted - metabolism | Proto-Oncogene Proteins c-met - metabolism | Neoplasm Transplantation | Myeloid-Lymphoid Leukemia Protein - metabolism | Epigenesis, Genetic | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Male | Carcinoma, Hepatocellular - secondary | Mice, 129 Strain | Myeloid-Lymphoid Leukemia Protein - chemistry | Liver Neoplasms, Experimental - metabolism | Hepatocyte Growth Factor - physiology | Female | Protein Interaction Domains and Motifs | Proto-Oncogene Protein c-ets-2 - metabolism | Liver Neoplasms, Experimental - pathology | Promoter Regions, Genetic | Signal Transduction | Histone-Lysine N-Methyltransferase | Neoplasm Invasiveness | Mice, Inbred C57BL | Embryo, Mammalian - abnormalities | Hep G2 Cells | Mice, Knockout | Proto-Oncogene Protein c-ets-2 - chemistry | Animals | Myeloid-Lymphoid Leukemia Protein - genetics | Matrix Metalloproteinases, Secreted - genetics | Mice | Protein Processing, Post-Translational | Histones - metabolism | Methylation | Carcinoma, Hepatocellular - metabolism | Genetic aspects | Hepatoma | Research | Health aspects | Hematopoietic growth factors | Cancer | Liver cancer | Rodents | Migration | Kinases | Gene expression | Binding sites | Defects | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7313, pp. 343 - 346
Journal Article
Cell Reports, ISSN 2211-1247, 03/2017, Volume 18, Issue 12, pp. 2893 - 2906
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 12/2017, Volume 21, Issue 10, pp. 2926 - 2939
The BCL-2 family proteins are central regulators of apoptosis. However, cells deficient for BAX and BAK or overexpressing BCL-2 still succumb to oxidative... 
BCL-2 | ferroptosis | glutathione metabolism | necrosis | ROS | apoptosis | programmed necrotic death | oxidative stress | TP63 | redox | CANCER-CELLS | MITOCHONDRIAL APOPTOSIS | STEM-CELLS | ACTIVATION | ONCOGENE | DNA-DAMAGE | BAX | MECHANISMS | P63 | PROGRAM | CELL BIOLOGY | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2013, Volume 19, Issue 12, pp. 3259 - 3267
Journal Article
Journal Article
Journal Article
Cell, ISSN 0092-8674, 02/2018, Volume 172, Issue 4, pp. 825 - 840.e18
Journal Article
Science Signaling, ISSN 1945-0877, 03/2013, Volume 6, Issue 268, pp. ra20 - ra20
The clinical efficacy of tyrosine kinase inhibitors supports the dependence of distinct subsets of cancers on specific driver mutations for survival, a... 
LUNG ADENOCARCINOMAS | HER2 AMPLIFICATION | BREAST-CANCER CELLS | MITOCHONDRIAL APOPTOSIS | DEPENDENT CELL-DEATH | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | KINASE INHIBITORS | BH3 DOMAINS | FOXO TRANSCRIPTION FACTORS | MEMBRANE PERMEABILIZATION | CELL BIOLOGY | Immunohistochemistry | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Humans | Receptor, ErbB-2 - metabolism | Apoptosis - genetics | Immunoblotting | Quinazolines | Oncogenes - physiology | Breast Neoplasms - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Chromatin Immunoprecipitation | Nitrophenols - pharmacology | RNA Interference | Plasmids - genetics | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Oncogenes - genetics | Membrane Proteins - genetics | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Cell Line, Tumor | Signal Transduction - physiology | Mice | Gene Silencing - physiology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article