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1. Full Text Tracheobronchopathia Osteochondroplastica: A Cause of Difficult Tracheal Intubation
by Matsuki, Takanori and Takeda, Yoshito and Kida, Hiroshi and Kumanogoh, Atsushi
Internal Medicine, ISSN 0918-2918, 2018, Volume 57, Issue 6, pp. 909 - 910
difficult tracheal intubation | tracheobronchopathia osteochondroplastica | bronchoscopy | Bronchoscopy | Tracheobronchopathia osteochondroplastica | Difficult tracheal intubation | MEDICINE, GENERAL & INTERNAL | Biocompatibility | Intubation | Pictures in Clinical Medicine
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2. Full Text Synthesis and structure of 1,4,5,8-tetraethynylnaphthalene derivativesThis article is part of the ChemComm 'Aromaticity' web themed issue.Electronic supplementary information (ESI) available: Experimental procedure and characterization data for new compounds, UV-Vis and fluorescence spectra of 4a, overlays of the structures of 4a in crystal and the theoretically optimized structure, packing arrangement of 4a in crystals, Cartesian coordinates for the optimized structure of 4c, 1H and 13C NMR spectra of new compounds. CCDC 881969. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c2cc33740a
by Takeda, Takashi and Tobe, Yoshito
ISSN 1359-7345, 7/2012, Volume 48, Issue 63, pp. 7841 - 7843
1,4,5,8-Tetraethynylnaphthalene derivatives 4a-c were synthesized for the first time. X-ray crystallographic structure analysis of 4a revealed three different... 
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3. Full Text The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation
by Hamaguchi, Masahide and Kojima, Takao and Itoh, Yoshito and Harano, Yuichi and Fujii, Kota and Nakajima, Tomoaki and Kato, Takahiro and Takeda, Noriyuki and Okuda, Junichi and Ida, Kazunori and Kawahito, Yutaka and Yoshikawa, Toshikazu and Okanoue, Takeshi
The American Journal of Gastroenterology, ISSN 0002-9270, 12/2007, Volume 102, Issue 12, pp. 2708 - 2715
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely associated with the metabolic syndrome.AIM: We evaluated the association among the metabolic... 
DIAGNOSIS | GENERAL-POPULATION | JAPAN | SONOGRAPHY | PREVALENCE | HISTOLOGY | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Japan - epidemiology | Metabolic Syndrome - diagnostic imaging | Cross-Sectional Studies | Area Under Curve | Humans | Middle Aged | Logistic Models | Male | Metabolic Syndrome - complications | Fatty Liver - diagnostic imaging | Intra-Abdominal Fat - diagnostic imaging | Biopsy | Adolescent | Ultrasonography | Adult | Female | Aged | Fatty Liver - epidemiology | Metabolic Syndrome - epidemiology | Fatty Liver - etiology | Obesity | Fatty liver
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4. Full Text Diindenopyrenes: Extended 1,6- and 1,8-Pyrenoquinodimethanes with Singlet Diradical Characters
by Hibi, Daijiro and Kitabayashi, Kenichi and Fujita, Kazuya and Takeda, Takashi and Tobe, Yoshito
The Journal of Organic Chemistry, ISSN 0022-3263, 05/2016, Volume 81, Issue 9, pp. 3735 - 3743
Diindenopyrene 4b and its diastereomer, which are extended homologues of 1,6- and 1,8-pyrenoquinodimethanes fused by indene units, respectively, were... 
BIRADICAL CHARACTER | P-QUINODIMETHANES | FUSION MODE | CYCLIZATIONS | PARALLEL TRIPLE BONDS | MOLECULAR-STRUCTURE | KEKULE HYDROCARBON | CHEMISTRY, ORGANIC | CLOSED-SHELL | ALKYNES | SUBSTITUTED QUINODIMETHANS | Chemical reactions | Chemical properties | Ring formation (Chemistry) | Chemical compounds | Analysis
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5. Full Text MicroRNA-155 controls exosome synthesis and promotes gemcitabine resistance in pancreatic ductal adenocarcinoma
by Mikamori, Manabu and Yamada, Daisaku and Eguchi, Hidetoshi and Hasegawa, Shinichiro and Kishimoto, Tomoya and Tomimaru, Yoshito and Asaoka, Tadafumi and Noda, Takehiro and Wada, Hiroshi and Kawamoto, Koichi and Gotoh, Kunihito and Takeda, Yutaka and Tanemura, Masahiro and Mori, Masaki and Doki, Yuichiro
Scientific Reports, ISSN 2045-2322, 02/2017, Volume 7, Issue 1, p. 42339
The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term... 
ADJUVANT CHEMOTHERAPY | SURVIVAL | MIR-155 | CELLS | INTERFERON-ALPHA | THERAPY | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | UP-REGULATION | CANCER | EXPRESSION | Exosomes - drug effects | Exosomes - metabolism | Adenocarcinoma - ultrastructure | Adenocarcinoma - pathology | Prognosis | Microdissection | Apoptosis - drug effects | Humans | Apoptosis - genetics | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | MicroRNAs - metabolism | Antineoplastic Agents - therapeutic use | Carcinoma, Pancreatic Ductal - genetics | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Time Factors | Carcinoma, Pancreatic Ductal - ultrastructure | Adenocarcinoma - genetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - ultrastructure | Pancreatic Neoplasms - genetics | Up-Regulation - genetics | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Cell Line, Tumor | Mice | MicroRNAs - genetics | Deoxycytidine - analogs & derivatives | Adenocarcinoma | Intercellular signalling | Gemcitabine | Secretion | Pancreatic cancer | Chemoresistance | MiRNA | Pancreas | Exosomes | Apoptosis
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6. Full Text The quiescent intracluster medium in the core of the Perseus cluster
by Aharonian, Felix and Akamatsu, Hiroki and Akimoto, Fumie and Allen, Steven W and Anabuki, Naohisa and Angelini, Lorella and Arnaud, Keith and Audard, Marc and Awaki, Hisamitsu and Axelsson, Magnus and Bamba, Aya and Bautz, Marshall and Blandford, Roger and Brenneman, Laura and Brown, Gregory V and Bulbul, Esra and Cackett, Edward and Chernyakova, Maria and Chiao, Meng and Coppi, Paolo and Costantini, Elisa and De Plaa, Jelle and Den Herder, Jan-Willem and Done, Chris and Dotani, Tadayasu and Ebisawa, Ken and Eckart, Megan and Enoto, Teruaki and Ezoe, Yuichiro and Fabian, Andrew C and Ferrigno, Carlo and Foster, Adam and Fujimoto, Ryuichi and Fukazawa, Yasushi and Furuzawa, Akihiro and Galeazzi, Massimiliano and Gallo, Luigi and Gandhi, Poshak and Giustini, Margherita and Goldwurm, Andrea and Gu, Liyi and Guainazzi, Matteo and Haba, Yoshito and Hagino, Kouichi and Hamaguchi, Kenji and Harrus, Ilana and Hatsukade, Isamu and Hayashi, Katsuhiro and Hayashi, Takayuki and Hayashida, Kiyoshi and Hiraga, Junko and Hornschemeier, Ann and Hoshino, Akio and Hughes, John and Iizuka, Ryo and Inoue, Hajime and Inoue, Yoshiyuki and Ishibashi, Kazunori and Ishida, Manabu and Ishikawa, Kumi and Ishisaki, Yoshitaka and Itoh, Masayuki and Iyomoto, Naoko and Kaastra, Jelle and Kallman, Timothy and Kamae, Tuneyoshi and Kara, Erin and Kataoka, Jun and Katsuda, Satoru and Katsuta, Junichiro and Kawaharada, Madoka and Kawai, Nobuyuki and Kelley, Richard and Khangulyan, Dmitry and Kilbourne, Caroline and King, Ashley and Kitaguchi, Takao and Kitamoto, Shunji and Kitayama, Tetsu and Kohmura, Takayoshi and Kokubun, Motohide and Koyama, Shu and Koyama, Katsuji and Kretschmar, Peter and Krimm, Hans and Kubota, Aya and Kunieda, Hideyo and Laurent, Philippe and Lebrun, François and Lee, Shiu-Hang and Leutenegger, Maurice and Limousin, Olivier and Loewenstein, Michael and Long, Knox S and Lumb, David and Madejski, Grzegorz and Maeda, Yoshitomo and Maier, Daniel and Makishima, Kazuo and Markevitch, Maxim and ... and Hitomi Collaboration and SLAC National Accelerator Lab., Menlo Park, CA (United States)
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 117 - 121
Clusters of galaxies are the most massive gravitationally bound objects in the Universe and are still forming. They are thus important probes(1) of... 
NGC 1275 | GALAXY CLUSTERS | TURBULENT VELOCITY | MULTIDISCIPLINARY SCIENCES | LINE | GAS | NGC-1275 | CONSTRAINTS | X-RAY SPECTROSCOPY | XMM-NEWTON | FEEDBACK | Clusters | Observations | Stars | Cosmology | Astrophysics | Velocity | Stars & galaxies | ASTRONOMY AND ASTROPHYSICS | GRQC | ASTRO
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7. Preventive role of tetraspanin CD9 in systemic inflammation of chronic obstructive pulmonary disease
by Takeda, Yoshito and Suzuki, Mayumi and Jin, Yingji and Tachibana, Isao
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 12/2015, Volume 53, Issue 6, pp. 751 - 760
Chronic obstructive pulmonary disease (COPD) is frequently associated with extrapulmonary complications, including cardiovascular disease, diabetes, and... 
Cd9 | Chronic obstructive pulmonary disease | Inflammation | Macrophage | Tetraspanin | METABOLIC SYNDROME | CD81 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE-CELL FUSION | macrophage | MACROPHAGE ACTIVATION | SECONDARY PREVENTION | MICE LACKING | CELL BIOLOGY | IN-VITRO | inflammation | tetraspanin | RESPIRATORY SYSTEM | REDUCING LIPIDS | ANTIINFLAMMATORY THERAPIES | CD9 | CHOLESTEROL-BIOSYNTHESIS | chronic obstructive pulmonary disease | Up-Regulation | Animals | Membrane Microdomains - metabolism | Humans | Tetraspanin-29 - physiology | Pulmonary Disease, Chronic Obstructive - immunology | Macrophage Activation | Cardiovascular disease | Insulin resistance | Health risk assessment | Cholesterol
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8. Full Text Transcriptomics Identify CD9 as a Marker of Murine IL-10-Competent Regulatory B Cells
by Sun, Jianbo and Wang, Jiguang and Pefanis, Evangelos and Chao, Jaime and Rothschild, Gerson and Tachibana, Isao and Chen, Jun Kui and Ivanov, Ivaylo I and Rabadan, Raul and Takeda, Yoshito and Basu, Uttiya
Cell Reports, ISSN 2211-1247, 11/2015, Volume 13, Issue 6, pp. 1110 - 1117
Regulatory B cells (Breg) have immune suppressive functions in various autoimmune/inflammation models and diseases and are found to be enriched in diverse B... 
INFLAMMATORY RESPONSES | AUTOIMMUNITY | IMMUNE-RESPONSES | B10 CELLS | GENE-EXPRESSION | EXOSOMES | TETRASPANIN | MICE | PROTEOMIC ANALYSIS | SUBSET | CELL BIOLOGY | B-Lymphocytes, Regulatory - metabolism | Animals | Interleukin-10 - genetics | Mice, Inbred C57BL | B-Lymphocytes, Regulatory - cytology | Cells, Cultured | Transcriptome | Interleukin-10 - metabolism | Mice | Tetraspanin-29 - metabolism | Tetraspanin-29 - genetics
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9. Full Text Natural gas storage and transportation within gas hydrate of smaller particle: Size dependence of self-preservation phenomenon of natural gas hydrate
by Mimachi, Hiroko and Takeya, Satoshi and Yoneyama, Akio and Hyodo, Kazuyuki and Takeda, Tohoru and Gotoh, Yoshito and Murayama, Tetsuro
Chemical Engineering Science, ISSN 0009-2509, 10/2014, Volume 118, pp. 208 - 213
In this study, the preservation ability of natural gas hydrate (NGH) with different particle size from 0.50 mm to 30 mm was investigated. It is known that... 
Self-preservation | Particle size | Ice film | Clathrate hydrate | Natural gas hydrate | ENGINEERING, CHEMICAL | METHANE CLATHRATE HYDRATE | CH4 HYDRATE | 1 ATM | ICE | ANOMALOUS PRESERVATION | Methane | Methane hydrate | Gas industry | Powders | Storage | Natural gas
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10. Full Text Impact of sarcopenia in patients with advanced non–small cell lung cancer treated with PD-1 inhibitors: A preliminary retrospective study
by Shiroyama, Takayuki and Nagatomo, Izumi and Koyama, Shohei and Hirata, Haruhiko and Nishida, Sumiyuki and Miyake, Kotaro and Fukushima, Kiyoharu and Shirai, Yuya and Mitsui, Yuichi and Takata, So and Masuhiro, Kentaro and Yaga, Moto and Iwahori, Kota and Takeda, Yoshito and Kida, Hiroshi and Kumanogoh, Atsushi
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 2447 - 7
The aim of this study was to investigate the clinical impact of sarcopenia on the efficacy of programmed death (PD)-1 inhibitors. We retrospectively reviewed... 
CHECKPOINT INHIBITORS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | MASS | CLINICAL-IMPLICATIONS | DOUBLE-BLIND | TOXICITY | BODY-COMPOSITION | NIVOLUMAB | PROGNOSTIC VALUE | OBESITY SKELETAL-MUSCLE | Sarcopenia | Vertebrae | Pembrolizumab | PD-1 protein | Computed tomography | Lung cancer | Medical records | Tomography | Psoas muscle | Non-small cell lung carcinoma | Apoptosis
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11. Full Text Tracheobronchopathia Osteochondroplastica: A Cause of Difficult Tracheal Intubation
by Matsuki, Takanori and Takeda, Yoshito and Kida, Hiroshi and Kumanogoh, Atsushi
Internal Medicine, ISSN 0918-2918, 2018
Bronchoscopy | tracheobronchopathia osteochondroplastica | Difficult Tracheal Intubation
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12. Full Text The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila
by Imai, Yuzuru and Kanao, Tomoko and Sawada, Tomoyo and Kobayashi, Yoshito and Moriwaki, Yasuhiro and Ishida, Yosuke and Takeda, Kohsuke and Ichijo, Hidenori and Lu, Bingwei and Takahashi, Ryosuke
PLoS genetics, ISSN 1553-7390, 12/2010, Volume 6, Issue 12, pp. e1001229 - 14
PTEN-induced kinase 1 (PINK1), which is required for mitochondrial homeostasis, is a gene product responsible for early-onset Parkinson's disease (PD). Another... 
INDUCED CELL-DEATH | LIFE-SPAN | OXIDATIVE STRESS | MUTANTS | SIGNALING PATHWAY | UBIQUITIN-PROTEIN LIGASE | GENETICS & HEREDITY | MITOPHAGY | MUTATIONS | RECESSIVE PARKINSONISM | PARKINSONS-DISEASE | Protein Kinases - metabolism | Mitochondria - enzymology | Protein Kinases - genetics | Down-Regulation | Humans | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Parkinson Disease - genetics | Drosophila Proteins - metabolism | Drosophila - enzymology | Animals | Mitochondria - genetics | HEK293 Cells | Protein Binding | Parkinson Disease - metabolism | Drosophila Proteins - genetics | Ubiquitin-Protein Ligases - genetics | Phosphoglycerate Kinase - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Drosophila - genetics | Phosphoglycerate Kinase - metabolism | Parkinson's disease | Drosophila | Genes | Physiological aspects | Genetic aspects | Research | Risk factors | Proteins | Studies | Genotype & phenotype | Mitochondria | Insects | Parkinsons disease | Homeostasis | Kinases | Binding sites | Metabolic disorders
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13. Full Text Epistatic effects between pairs of the growth hormone secretagogue receptor 1a, growth hormone, growth hormone receptor, non‐SMC condensin I complex, subunit G and stearoyl‐CoA desaturase genes on carcass, price‐related and fatty acid composition traits in Japanese Black cattle
by Komatsu, Masanori and Nishino, Kagetomo and Fujimori, Yuki and Haga, Yasutoshi and Iwama, Nagako and Arakawa, Aisaku and Aihara, Yoshito and Takeda, Hisato and Takahashi, Hideaki
Animal Science Journal, ISSN 1344-3941, 02/2018, Volume 89, Issue 2, pp. 273 - 288
Growth hormone secretagogue receptor 1a (GHSR1a), growth hormone (GH), growth hormone receptor (GHR), non‐SMC condensin I complex, subunit G (NCAPG) and... 
NCAPG | carcass and fatty acids traits | epistasis | GHSR1a/GH/GHR | Japanese Black cattle | GHRELIN RECEPTOR | AGRICULTURE, DAIRY & ANIMAL SCIENCE | SECRETAGOGUE RECEPTOR | SEX | HETERODIMERIZATION | BEEF-CATTLE | GHR | CASTRATED MALE | GHSR1a | FEMALE CATTLE | CROSS | 4 AGES | ASSOCIATION | Cattle - metabolism | Multifactorial Inheritance - genetics | Meat - analysis | Fatty Acids - analysis | Commerce | Male | 5' Untranslated Regions - genetics | Epistasis, Genetic - genetics | Meat - economics | Receptors, Ghrelin - genetics | Stearoyl-CoA Desaturase - genetics | Cattle - genetics | Receptors, Somatotropin - genetics | Adipose Tissue - metabolism | Growth Hormone - genetics | Animals | Alleles | Cell Cycle Proteins - genetics | Female | Lipid Metabolism - genetics | Somatotropin | Analysis | Genes | Genetic research | Physiological aspects | Beef cattle | Fatty acids | Genetic polymorphisms | Adipose tissues | Adipose tissue | Epistasis | Stearoyl-CoA desaturase | Desaturase | Condensin | Fatty acid composition | 5' Untranslated Regions | Cattle | Growth hormones | Growth hormone | Physical growth | Polymorphism
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14. Full Text Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis
by Takeda, Yoshito and Tsujino, Kazuyuki and Kijima, Takashi and Kumanogoh, Atsushi
Patient Preference and Adherence, ISSN 1177-889X, 03/2014, Volume 8, pp. 361 - 370
Idiopathic pulmonary fibrosis (IPF) is a devastating chronic fibrotic lung disease. Although the precise cause of the disease is still unknown, recent studies... 
Efficacy | Safety | Pirfenidone | Anti-fibrotic drugs | LUNG FIBROSIS | DIAGNOSIS | SUSCEPTIBILITY | N-ACETYLCYSTEINE | efficacy | FACTOR-ALPHA | AGENT | anti-fibrotic drugs | MEDICINE, GENERAL & INTERNAL | TUMOR-NECROSIS-FACTOR | pirfenidone | END-POINT | safety | VITAL CAPACITY | GENOME-WIDE ASSOCIATION | Drug therapy | Pulmonary fibrosis | Disease | Cytokines | Mortality | Clinical trials | Fibroblasts | Extracellular matrix | Tumor necrosis factor-TNF | Inflammation | Interferon | Growth factors
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15. Full Text Lysosomal protein Lamtor1 controls innate immune responses via nuclear translocation of transcription factor EB
by Hayama, Yoshitomo and Kimura, Tetsuya and Takeda, Yoshito and Nada, Shigeyuki and Koyama, Shohei and Takamatsu, Hyota and Kang, Sujin and Ito, Daisuke and Maeda, Yohei and Nishide, Masayuki and Nojima, Satoshi and Sarashina-Kida, Hana and Hosokawa, Takashi and Kinehara, Yuhei and Kato, Yasuhiro and Nakatani, Takeshi and Nakanishi, Yoshimitsu and Tsuda, Takeshi and Koba, Taro and Okada, Masato and Kumanogoh, Atsushi
Journal of Immunology, ISSN 0022-1767, 06/2018, Volume 200, Issue 11, pp. 3790 - 3800
Amino acid metabolism plays important roles in innate immune cells, including macrophages. Recently, we reported that a lysosomal adaptor protein, Lamtor1,... 
DEFENSE | RECRUITMENT | MTORC1 | ACTIVATION | RAG GTPASES | BIOGENESIS | PATHWAY | INFLAMMATION | TFEB | IMMUNOLOGY | MACROPHAGE POLARIZATION | TOR protein | Translocation | Phosphorylation | Transcription factors | Immune response | Amino acids | Chemoreception | Rapamycin | Inflammation | Metabolism | Macrophages | Autophagy | Nuclear transport | Lipopolysaccharides | Proteins | Bleomycin | Acids | Protease inhibitors | Rodents | Mice | Alveoli | Lysosomal protein | Trachea | Immune system
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