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Current Opinion in Pharmacology, ISSN 1471-4892, 2008, Volume 8, Issue 4, pp. 370 - 374
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 2009, Volume 9, Issue 15, pp. 1436 - 1446
Hsp90 is a molecular chaperone with important roles in regulating the function of several proteins with potential pathogenic activity. Because many of these... 
Purine | Neurodegeneration | Cancer | Heat shock protein 90 | CANCER-CELLS | CHEMISTRY, MEDICINAL | KINASE | neurodegeneration | ATP BINDING | POTENT ANTITUMOR-ACTIVITY | HEAT-SHOCK-PROTEIN-90 INHIBITORS | TUMOR SELECTIVITY | AFFINITY | SHOCK-PROTEIN 90 | purine | IN-VIVO | MOLECULAR CHAPERONE | cancer
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 10/2016, Volume 16, Issue 25, pp. 2753 - 2764
Heat shock proteins (HSPs) present as a double edged sword. While they play an important role in maintaining protein homeostasis in a normal cell, cancer cells... 
HSP90 | N-Terminal | Inhibitor | Chaperone | Cancer | FDG-PET | CO-CHAPERONES | COMPLEX | CHEMISTRY, MEDICINAL | HEAT-SHOCK-PROTEIN-90 | MOLECULAR CHAPERONES | POSTTRANSLATIONAL MODIFICATIONS | INHIBITOR NVP-AUY922 | PHASE-I | BINDING
Journal Article
Molecular Neurodegeneration, ISSN 1750-1326, 2010, Volume 5, Issue 1, pp. 24 - 24
Hsp90 is a molecular chaperone with important roles in regulating pathogenic transformation. In addition to its well-characterized functions in malignancy,... 
HSP90 INHIBITOR | IN-VITRO | MOLECULAR CHAPERONES | GELDANAMYCIN | PHOSPHORYLATED TAU | PROTEASOME-DEPENDENT MANNER | CHAPERONE SUPPRESSION | HUNTINGTONS-DISEASE | NEUROSCIENCES | AGGREGATION | PARKINSONS-DISEASE | Care and treatment | Heat shock proteins | Nervous system | Degeneration | Drug therapy | Health aspects | Alzheimer's disease
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 05/2009, Volume 106, Issue 20, pp. 8368 - 8373
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2011, Volume 7, Issue 11, pp. 818 - 826
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 10/2019, Volume 87, Issue 10, pp. 869 - 877
ABSTRACT Hsp90α and Hsp90β are implicated in a number of cancers and neurodegenerative disorders but the lack of selective pharmacological probes confounds... 
paralog selectivity | Hsp90beta | inhibitor | Hsp90alpha | COMPLEX | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOFORM | CHAPERONE | GRP94 | BIOPHYSICS | SHOCK-PROTEIN 90 | GROWTH | BINDING | Binding | Alanine | Inhibitors | Neurodegenerative diseases | Selectivity | Mutation | ATP | Crystal structure
Journal Article
Journal Article
Journal Article