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PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167934
Background Novel direct-acting antivirals (DAAs) have completely changed the panorama of hepatitis C due to their high efficacy and optimal safety profile.... 
ANGIOGENESIS | EFFICACY | SOFOSBUVIR | CIRRHOSIS | MULTIDISCIPLINARY SCIENCES | C VIRUS-INFECTION | GENE-EXPRESSION | RIBAVIRIN | HEPATITIS-C | LEDIPASVIR | ENDOTHELIAL GROWTH-FACTOR | Hepatitis C - drug therapy | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Vascular Endothelial Growth Factor A - blood | Interleukin-10 - blood | Male | Antiviral Agents - administration & dosage | Epidermal Growth Factor - blood | Hepacivirus - metabolism | Inflammation - blood | Neoplasms | Inflammation - drug therapy | Antiviral Agents - adverse effects | Hepatitis C - blood | Aged, 80 and over | Adult | Female | Aged | Cell Proliferation - drug effects | Antiviral agents | Complications and side effects | Liver cancer | Hepatitis C | Drug therapy | Vascular endothelial growth factor | Health aspects | Risk factors | Therapy | Interleukin | Hepatocellular carcinoma | Infections | Cancer therapies | Hepatitis | Angiogenesis | Biological effects | Cell growth | Epidermal growth factor | Interleukins | Hepatology | Pretreatment | Immune system | Liver diseases | Cytokines | Internal medicine | Inflammation | Tumor necrosis factor-α | Gene expression | Patients | Endothelial cells | Medicine | Hypotheses | Interleukin 10 | Interferon | Hepatitis C virus | Umbilical vein | Viral infections
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, p. e24084
There is growing evidence that mitochondrial dysfunction, and more specifically fatty acid beta-oxidationimpairment, is involved in the pathophysiology of... 
RESPIRATORY-CHAIN | METABOLISM | INSULIN-RESISTANCE | BIOLOGY | CONJUGATED LINOLEIC ACIDS | GENE-EXPRESSION | ATP HOMEOSTASIS | MITOCHONDRIAL DYSFUNCTION | MODEL | LIVER-DISEASE | HUMAN NONALCOHOLIC STEATOHEPATITIS | Gene Expression Regulation, Enzymologic - drug effects | Palmitic Acid - metabolism | Carnitine O-Palmitoyltransferase - genetics | Liver - pathology | Liver - enzymology | Rats, Wistar | 3-Hydroxyacyl CoA Dehydrogenases - metabolism | Male | Methionine - pharmacology | Hepatocytes - metabolism | RNA, Messenger - metabolism | Mitochondrial Membranes - drug effects | Liver - drug effects | Carnitine O-Palmitoyltransferase - metabolism | Oxidation-Reduction - drug effects | Fatty Acids - blood | Fatty Acids - metabolism | Hepatocytes - drug effects | Methionine - deficiency | Malonyl Coenzyme A - pharmacology | RNA, Messenger - genetics | Rats | Enzyme Assays | Methionine - administration & dosage | Mitochondria, Liver - enzymology | Feeding Behavior - drug effects | Mitochondrial Membranes - metabolism | Blood Glucose - drug effects | Mitochondria, Liver - drug effects | Animals | Choline - administration & dosage | Diet | Cell Membrane Permeability - drug effects | Choline - pharmacology | Blood Glucose - metabolism | Acetyl-CoA Carboxylase - metabolism | Enzymes | Choline | Liver | Oxidation-reduction reaction | Fatty acids | Carnitine | Cytochrome | Oxidative stress | Laboratories | Pathogenesis | Carbon dioxide | Lipids | Biochemistry | mRNA | Ketone bodies | Proteins | Liver cancer | Mitochondria | Rodents | Oxidation | Liver diseases | Internal medicine | Methionine | Medicine | Environmental science | Hepatocytes | Insulin resistance | Molecular biology
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2017, Volume 59, Issue 2, pp. 615 - 631
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2017, Volume 108, p. S85
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2017, Volume 108, p. S85
The identification of key regulators in hepatic progenitor cells differentiation is determinant for organ regeneration and may improve stem cell... 
Virus diseases | Transplantation | Liver diseases | Stem cells | Liver
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2016, Volume 96, pp. 323 - 333
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2014, Volume 73, pp. 117 - 126
The accumulation of toxic hydrophobic bile acids in hepatocytes, observed during chronic cholestasis, induces substantial modification in the redox state and... 
Citrate carrier | Peroxisome proliferator-activated receptor coactivator-1α | Lipogenic enzymes | Secondary biliary cirrhosis | Mitochondrial biogenesis | Free radicals | CARDIOLIPIN | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPIDS | PROLIFERATION | coactivator-1 alpha | PEROXIDATION | Peroxisome proliferator-activated receptor | BIOENERGETICS | PROTON LEAK | ENDOCRINOLOGY & METABOLISM | SILYMARIN | EXPRESSION | Fatty Acid Synthase, Type I - biosynthesis | Liver - pathology | Reactive Oxygen Species - metabolism | Rats, Wistar | Male | Hepatocytes - metabolism | DNA, Mitochondrial - genetics | Biological Transport | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Anti-Inflammatory Agents - therapeutic use | Cholestasis - drug therapy | Phospholipids - metabolism | Silymarin - therapeutic use | Oxidation-Reduction | Liver - metabolism | Liver Cirrhosis, Biliary - drug therapy | Rats | Cardiolipins - metabolism | Mitochondria - metabolism | Liver Cirrhosis, Biliary - pathology | Transcription Factors - metabolism | Cholestasis - pathology | Antioxidants - therapeutic use | Animals | Carrier Proteins - metabolism | Acetyl-CoA Carboxylase - biosynthesis | Citric Acid - metabolism | Enzyme Activation | Mitochondrial Turnover - physiology | Lipid Metabolism - physiology | Antioxidants | Enzymes | Membrane lipids | Synthesis | Cardiolipin | Fatty acids | Index Medicus
Journal Article
Nutrition, ISSN 0899-9007, 01/2020, Volume 69, p. 110588
Older patients are frequently subjected to prolonged hospitalization and extended bed rest, with a negative effect on physical activity and caloric intake.... 
Sarcopenia | Hospitalization | Amino acid mixture | Low mobility | Older people | OXIDATIVE STRESS | BED-REST | PROGNOSTIC VALUE | SKELETAL-MUSCLE | NUTRITION & DIETETICS | MUSCLE PROTEIN-SYNTHESIS | RESISTANCE EXERCISE | MASS
Journal Article
Journal Article
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 10/2014, Volume 75 Suppl 1, pp. S16 - S17
Non-alcoholic fatty liver disease (NAFLD) is a chronic hepatic disorder affecting up to 25% of the general population. Several intracellular events leading to... 
Monounsaturated fatty acids | Fatty liver | Saturated fatty acids | Analysis
Journal Article