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Frontiers in Cellular Neuroscience, ISSN 1662-5102, 02/2016, Volume 10
Mitochondrial dysfunction is one of the earliest and most prominent features in the brains of Alzheimer’s disease (AD) patients. Recent studies suggest that... 
Alzheimer’s disease | Mitophagosome | Mitochondrial dynamics | Mitochondrial transport | Axonal transport | Mitophagy | Mitochondrial quality control | Brain | Animal models | Disease | Neurons | Pathogenesis | Mammals | Organelles | Autophagy | Proteins | Pathology | Mitochondria | Insects | Quality control | Mutation | Alzheimer's disease | Axonal Transport | mitophagy | mitochondrial transport | mitochondrial dynamics
Journal Article
Journal of Medical Systems, ISSN 0148-5598, 7/2019, Volume 43, Issue 7, pp. 1 - 7
The significance of pattern recognition techniques is widely enhanced in image processing and medical applications. Thus, lesion segmentation method is an... 
Gradient | Medicine & Public Health | Segmentation | Statistics for Life Sciences, Medicine, Health Sciences | Melanoma | Health Informatics | Feature extraction | Model testing | Medical imaging | Shape | Image processing | Noise | Error reduction | Pattern recognition | Object recognition | Skin cancer | Image detection | Image segmentation | Algorithms | Contours | Skin | Image enhancement | Cancer
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 04/2017, Volume 57, Issue 4, pp. 1087 - 1103
Journal Article
European Journal of Drug Metabolism and Pharmacokinetics, ISSN 0378-7966, 12/2016, Volume 41, Issue 6, pp. 733 - 741
Infection and inflammation are known to cause wide variability in disposition of drugs through modulation of drug transporters. However, the effects of... 
Pharmaceutical Sciences/Technology | Medical Biochemistry | Biomedicine | Human Physiology | Pharmacology/Toxicology | Pharmacy | INTESTINAL-ABSORPTION | DIPYRIDAMOLE | PATHOGENESIS | ANION TRANSPORTING POLYPEPTIDE | EFFLUX TRANSPORTER | MACROPHAGES | ENDOTOXIN | PHARMACOLOGY & PHARMACY | METABOLIZING-ENZYMES | EXPRESSION | P-GLYCOPROTEIN | Ciprofloxacin - agonists | Anti-Bacterial Agents - blood | Rats, Wistar | Area Under Curve | Escherichia coli - drug effects | Escherichia coli Infections - blood | Half-Life | Biological Availability | Male | Metabolic Clearance Rate | Fluoroquinolones - pharmacokinetics | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Anti-Bacterial Agents - chemistry | Biotransformation | Dipyridamole - pharmacology | Membrane Transport Modulators - pharmacology | Escherichia coli - growth & development | Dipyridamole - therapeutic use | Escherichia coli Infections - drug therapy | Lipopolysaccharides - toxicity | Ciprofloxacin - therapeutic use | Escherichia coli - immunology | Fluoroquinolones - therapeutic use | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Escherichia coli Infections - metabolism | Ciprofloxacin - blood | Random Allocation | Ciprofloxacin - pharmacokinetics | Drug Synergism | Animals | Fluoroquinolones - agonists | Fluoroquinolones - blood | Anti-Bacterial Agents - pharmacokinetics | Membrane Transport Modulators - therapeutic use | Escherichia coli Infections - immunology | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus
Journal Article
eLife, ISSN 2050-084X, 01/2017, Volume 6
Neurons face unique challenges of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located.... 
Neurodegenerative diseases | Ethanol | Neurons | Phagosomes | Lysosomes | Retrograde transport | Autophagy | Defects | Recruitment | Studies | Proteins | Axons | Clonal deletion | Microscopy | Epoxy resins | Dynein | Axonal transport | Alzheimer's disease | Phagocytosis | Vacuoles
Journal Article
Neuron, ISSN 0896-6273, 05/2017, Volume 94, Issue 3, pp. 595 - 610.e6
Chronic mitochondrial stress is a central problem associated with neurodegenerative diseases. Early removal of defective mitochondria from axons constitutes a... 
axonal mitochondria | physiological stress | mitochondrial transport | ALS | late endosome | syntaphilin | Mitochondrial quality control | PARKIN | TRANSPORT | FUSION | DAMAGED MITOCHONDRIA | TRAFFICKING | NEURODEGENERATION | AMYOTROPHIC-LATERAL-SCLEROSIS | QUALITY-CONTROL | AUTOPHAGY | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Calcium - metabolism | Microtubule-Associated Proteins - metabolism | Vesicular Transport Proteins - metabolism | Humans | Middle Aged | Stress, Physiological | Male | Neurons - cytology | Cerebral Cortex - cytology | Endosomes - metabolism | Microscopy, Immunoelectron | Mitochondrial Degradation - genetics | Aged, 80 and over | Female | Neurons - metabolism | Spinal Cord - cytology | Amyotrophic Lateral Sclerosis - genetics | Axons - metabolism | Rats | Mitochondria - metabolism | Mice, Knockout | Motor Neurons - metabolism | Nerve Tissue Proteins - metabolism | Animals | Carrier Proteins - metabolism | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Aged | Mice | Mutation | Alzheimer Disease - genetics | Ubiquitin-Protein Ligases - genetics | Nervous system diseases | Neurosciences | Neurons | Alzheimer's disease | Stress (Physiology) | Phosphorylation | Motility | Disease | Homeostasis | Nervous system | Sclerosis | Defects | Mitochondria | Anchoring | Stresses | Image resolution | Neurodegenerative diseases | Amyotrophic lateral sclerosis | Electron microscopy | Neurological diseases | Pathology | Axons | Insects | Quality control | Parkin protein | Budding | Phagocytosis | Endosomes | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 3, pp. E307 - E316
After endocytosis, transmembrane cargo reaches endosomes, where it encounters complexes dedicated to opposing functions: recycling and degradation.... 
Hrs | Clathrin | RME-8 | Endosome | SNX-1 | SORTING NEXIN-1 | clathrin | MULTIDISCIPLINARY SCIENCES | CLATHRIN COATS | GOLGI RETRIEVAL | J-DOMAIN PROTEIN | endosome | RETROMER | ENDOCYTIC RECYCLING COMPARTMENT | RECEPTOR-MEDIATED ENDOCYTOSIS | CAENORHABDITIS-ELEGANS | RETROGRADE TRANSPORT | REQUIRES | RNA, Small Interfering - genetics | Sorting Nexins - genetics | Humans | Caenorhabditis elegans Proteins - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | Endosomes - metabolism | Gene Knockdown Techniques | Endosomal Sorting Complexes Required for Transport - antagonists & inhibitors | Proteolysis | Protein Interaction Domains and Motifs | Sorting Nexins - metabolism | Recombinant Proteins - metabolism | Caenorhabditis elegans - metabolism | Animals, Genetically Modified | Caenorhabditis elegans - genetics | Endosomal Sorting Complexes Required for Transport - metabolism | Recombinant Proteins - genetics | Phosphoproteins - genetics | Protein Transport | Animals | Caenorhabditis elegans Proteins - antagonists & inhibitors | Sorting Nexins - antagonists & inhibitors | HeLa Cells | Caenorhabditis elegans Proteins - genetics | Physiological aspects | Caenorhabditis elegans | Endocytosis | Observations | Proteins | Membranes | Kinases | Binding sites | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 2019
Bipolar disorder (BD) is a common mood disorder characterized by recurrent episodes of mania and depression. Both genetic and environmental factors have been... 
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 11/2017, Volume 26, Issue 22, pp. 4352 - 4366
Lysosomal proteolysis is essential for the quality control of intracellular components and the maintenance of cellular homeostasis. Lysosomal alterations have... 
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2017, Volume 292, Issue 5, pp. 1679 - 1690
Journal Article