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Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e110429
Flavonoids are widely distributed natural products with broad biological activities. Apigenin is a dietary flavonoid that has recently been demonstrated to... 
HNRNP A1 | REPLICATION | INTERACTS | MULTIDISCIPLINARY SCIENCES | Enterovirus A, Human - genetics | Enterovirus Infections - drug therapy | Virus Replication - drug effects | Virus Replication - genetics | Humans | Virion - genetics | Heterogeneous Nuclear Ribonucleoprotein A1 | Virion - drug effects | Enterovirus Infections - virology | RNA, Viral - genetics | Enterovirus A, Human - drug effects | Gene Expression Regulation, Viral | Apigenin - administration & dosage | Internal Ribosome Entry Sites - drug effects | Protein Biosynthesis - drug effects | Protein Biosynthesis - genetics | RNA, Small Interfering | Enterovirus A, Human - pathogenicity | Enterovirus Infections - pathology | RNA, Viral - drug effects | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - genetics | Infection | Proteins | RNA | Health aspects | Isoflavones | Biotechnology | Disease | Laboratories | Viruses | Infections | Medical schools | Antiviral activity | Life sciences | Deoxyribonucleic acid--DNA | RNA viruses | Internal ribosome entry site | Translation | RNA editing | Immunoglobulins | Kaempferol | Ribonucleoproteins | Gene expression | Ribonucleic acid--RNA | DNA viruses | Enteroviruses | Flavonoids | Diet | Natural products | Green fluorescent protein | Reagents | Disruption | Cancer | Pharmaceuticals | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 10/2019, Volume 234, Issue 10, pp. 17392 - 17404
Journal Article
Frontiers in oncology, ISSN 2234-943X, 2019, Volume 9, p. 188
Imatinib (IM) resistance could have significant impact on the survival time of the CML-patients treated with IM. Previous studies have shown that the... 
Usage | Flavonoids | Flavones | Bioflavonoids | Ligands (Biochemistry) | Physiological aspects | Chronic myeloid leukemia | Drug therapy | Drug resistance | Health aspects | Chemokine receptors | β-catenin/P-gp | oroxylin A | Imatinib (IM) | CXCL12/CXCR4 | bone marrow environment
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 10/2019, Volume 234, Issue 10, p. 17392
Microenvironmental hypoxia-mediated drug resistance is responsible for the failure of cancer therapy. To date, the role of the hedgehog pathway in resistance... 
Antimitotic agents | Gliomas | Analysis | Hydroxylases | Drug resistance | Antineoplastic agents
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 10/2019, Volume 234, Issue 10, pp. 17392 - 17404
Journal Article
Journal Article
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2018, Volume 33, Issue 1, pp. 290 - 302
Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new... 
cinnamic acid | multi-target ligand | tacrine hybrid | Cholinesterase inhibitor
Journal Article
Journal Article
Mucosal immunology, ISSN 1933-0219, 09/2019, Volume 12, Issue 5, pp. 1150 - 1163
Emerging evidence suggests that NLRP3 inflammasome was associated with various kinds of immunological diseases including colitis. However, there are few drugs... 
PATHWAY | PLANT FLAVONOIDS | DISEASE | INJURY | MICE | HEALTH | IMMUNOLOGY | UP-REGULATION | EXPRESSION | CANCER | NALP3 INFLAMMASOME | Inflammatory bowel disease | Oxidative stress | Flavonoids | Colon | Rodents | Index Medicus
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 2014, Volume 51, Issue 2, pp. 191 - 200
We designed and synthesized a novel benzenediamine derivate, FC99, that was tested for its ability to protect mice from experimental sepsis. Moreover, we... 
FC-99 | Sepsis | Inflammation | IRAK4 | Macrophage | KINASE-ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | macrophage | CELL BIOLOGY | CYTOKINE PRODUCTION | CECAL LIGATION | inflammation | RESPIRATORY SYSTEM | LIPID-A | CARDIOVASCULAR-DISEASE | GENE-EXPRESSION | FUMIGACLAVINE-C | SIGNALING CASCADES | NF-KAPPA-B | sepsis | INNATE IMMUNITY | Surface Plasmon Resonance | Interleukin-1 Receptor-Associated Kinases - metabolism | Oligonucleotide Array Sequence Analysis | Male | Dose-Response Relationship, Drug | Sepsis - drug therapy | Protein Kinase Inhibitors - chemistry | Time Factors | Interleukin-1 Receptor-Associated Kinases - chemistry | Inflammation Mediators - metabolism | Molecular Structure | Macrophages - immunology | Disease Models, Animal | Cell Line | Sepsis - immunology | Anti-Inflammatory Agents - pharmacology | Gene Expression Regulation | Sepsis - genetics | Macrophages - enzymology | Animals | Anti-Inflammatory Agents - chemistry | Signal Transduction - drug effects | Sepsis - enzymology | Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors | Diamines - chemistry | Diamines - pharmacology | Macrophages - drug effects | Phenylenediamines - pharmacology | Protein Conformation | Mice | Mice, Inbred BALB C | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Phenylenediamines - chemistry | Sepsis - microbiology | Respiratory distress syndrome | Cytokines