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Biochemistry-US, ISSN 0006-2960, 03/2013, Volume 50, Issue (49) ; 12, 2011
Pharmacologic chaperoning is a therapeutic strategy being developed to improve the cellular folding and trafficking defects associated with Gaucher disease, a... 
STORAGE | DEFECTS | DESIGN | BASIC BIOLOGICAL SCIENCES | GENE MUTATIONS | CRYSTAL STRUCTURE | 60 APPLIED LIFE SCIENCES | ENZYME ACTIVITY | ENDOPLASMIC RETICULUM | LYSOSOMES | MUTANTS | DISEASES | ENZYMES | GENES | FUNCTIONALS
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2014, Volume 111, Issue 12, p. 4449
  Although much is known about protein folding in buffers, it remains unclear how the cellular protein homeostasis network functions as a system to partition... 
Proteins | Molecules | Protein folding | Fluorescence
Journal Article
Journal Article
Chemical Engineering Communications, ISSN 0098-6445, 11/2013, Volume 200, Issue 11, p. 1503
  Two series of novel azo Schiff bases were synthesized from the condensation reaction of 5-(4-X-phenyl)-azo-salicylaldehyde (X=H, Cl, NO2, CH3) with... 
Temperature | Aldehydes | Condensation | Electrons
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2011, Volume 52, Issue 12, pp. 1339 - 1342
A concise, efficient and simple route to a series of bromoindole building blocks is described. The synthetic routes are highlighted by purification-free... 
Nitrocinnamates | Nitrostyrenes | Indoles | Phosphines | Microwaves | PALLADIUM | ROUTE | PHOSPHINE | 2-NITROSTYRENES | CHEMISTRY, ORGANIC | CONVENIENT | CARBAZOLES | INDOLE ALKALOIDS | REDUCTIVE CYCLIZATION | DERIVATIVES | NITRATION | Solvents | Synthesis (chemistry) | Tetrahedrons | Cleaning | Assembly
Journal Article
中国药理学报:英文版, ISSN 1671-4083, 2016, Volume 37, Issue 2, pp. 228 - 234
Aim: Aberrantly glycosylated IgA1 is a key factor in the pathogenesis of IgA nephropathy (IgAN). In this study we investigated the effects of aggregated IgA1... 
制剂 | 处方 | 药理 | 药学 | extracellular matrix synthesis | FACTOR-BETA | TGF-BETA | trichostatin A | IMMUNOMODULATOR AS101 | antifibrosis | valproic acid | SERUM IGA1 | human renal mesangial cells | TRICHOSTATIN-A | CHEMISTRY, MULTIDISCIPLINARY | FIBROBLAST ACTIVATION | IgA nephropathy | Smad2/3 | OBSTRUCTIVE NEPHROPATHY | Stat3 | INTERSTITIAL FIBROSIS | PHARMACOLOGY & PHARMACY | HDAC
Journal Article
01/2014, ISBN 133953018X
Proteins have to fold into native three-dimensional structures to perform essential biological tasks. In the cell, the quality and concentration of the... 
Biochemistry
Dissertation
Chemical Engineering Communications, ISSN 0098-6445, 11/2013, Volume 200, Issue 11, pp. 1503 - 1512
Two series of novel azo Schiff bases were synthesized from the condensation reaction of 5-(4-X-phenyl)-azo-salicylaldehyde (X˭H, Cl, NO 2 , CH 3 ) with... 
Diazotization | Schiff base | Synthesis | Carbazole | Acylhydrazone | CHAIN | ENGINEERING, CHEMICAL | CONSTANTS | LIGANDS | COMPLEXES | IONS | Schiff bases | Aniline | Chemical engineering | Azo | Infrared radiation | Joining | Derivatives
Journal Article
Fenxi Huaxue, ISSN 0253-3820, 05/2014, Volume 42, Issue 5, pp. 629 - 635
A novel liquid crystal (LC) biosensor was developed for the detection of platelet-derived growth factor BB (PDGF-BB) based on the orientation changes of liquid... 
Alignment | Platelet-derived growth factor | Disrupting | Images | Biosensors | Detection | Liquid crystals | Polarized light
Journal Article
Fenxi Huaxue, ISSN 0253-3820, 05/2014, Volume 42, Issue 5, pp. 629 - 635
A novel liquid crystal (LC) biosensor was developed for the detection of platelet-derived growth factor BB (PDGF-BB) based on the orientation changes of liquid... 
Alignment | Platelet-derived growth factor | Disrupting | Images | Biosensors | Detection | Liquid crystals | Polarized light
Journal Article
Fenxi Huaxue/ Chinese Journal of Analytical Chemistry, ISSN 0253-3820, 2014, Volume 42, Issue 5, pp. 629 - 635
A novel liquid crystal (LC) biosensor was developed for the detection of platelet-derived growth factor BB (PDGF-BB) based on the orientation changes of liquid... 
Self-assembled monolayer | Aptamer | Liquid crystal biosensor | Platelet-derived growth factor BB | CHAIN | CHEMISTRY, ANALYTICAL | COMPLEX | ORIENTATIONS | ASSAYS | IDENTIFICATION
Journal Article
Chemistry & biology, ISSN 1074-5521, 3/2013, Volume 20, Issue 3, pp. 403 - 415
Lysosomal storage diseases (LSDs) are often caused by mutations compromising lysosomal enzyme folding in the endoplasmic reticulum (ER), leading to degradation... 
endoplasmic reticulum associated degradation | lysosomal storage diseases | protein homeostasis
Journal Article
Chemistry & Biology, ISSN 1074-5521, 08/2014, Volume 21, Issue 8, pp. 967 - 976
Gaucher’s disease (GD) is caused by mutations that compromise β-glucocerebrosidase (GCase) folding in the endoplasmic reticulum (ER), leading to excessive... 
Journal Article
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