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1. Estimation of transmitting power to compensate for rain attenuation for a broadcasting satellite system in the 21-GHz band
by Minematsu, Fumiaki and Tanaka, Shoji and Nakagawa, Hitoshi and Nihon Hōsō Kyōkai. Hōsō Gijutsu Kenkyūjo
2002, NHK laboratories note, Volume no. 482., 14
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2. Full Text PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
by Noriyuki Matsuda and Shigeto Sato and Kahori Shiba and Kei Okatsu and Keiko Saisho and Clement A. Gautier and Yu-shin Sou and Shinji Saiki and Sumihiro Kawajiri and Fumiaki Sato and Mayumi Kimura and Masaaki Komatsu and Nobutaka Hattori and Keiji Tanaka
The Journal of Cell Biology, ISSN 0021-9525, 4/2010, Volume 189, Issue 2, pp. 211 - 221
Parkinson's disease (PD) is a prevalent neuro-degenerative disorder. Recent identification of genes linked to familial forms of PD such as Parkin and PINK1... 
Mitochondria | Report | Ubiquitins | Mitochondrial membranes | HeLa cells | Parkinson disease | Antibodies | Immunoblotting | Genetic mutation | Cytoplasm | Perceptual localization | UBIQUITIN-PROTEIN LIGASE | DISEASE | DEGRADATION | PROTEASOME SYSTEM | MUTATIONS | DYSFUNCTION | AUTOPHAGY | RECESSIVE PARKINSONISM | DROSOPHILA-PINK1 | IMPAIRMENT | CELL BIOLOGY | Protein Kinases - metabolism | Protein Kinases - genetics | Uncoupling Agents - pharmacology | Humans | Fluorescent Dyes - metabolism | Dimethyl Sulfoxide - pharmacology | Mitochondrial Proteins - genetics | Recombinant Fusion Proteins - metabolism | Solvents - pharmacology | Mitochondrial Proteins - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Membrane Potential, Mitochondrial - physiology | Parkinson Disease - metabolism | Fibroblasts - metabolism | Biomarkers - metabolism | Parkinson Disease - pathology | Ubiquitin-Protein Ligases - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Mitochondria - drug effects | Mitochondria - pathology | Mice, Knockout | Animals | Recombinant Fusion Proteins - genetics | Fibroblasts - cytology | Mice | HeLa Cells | Mitochondria - physiology | Ubiquitin-Protein Ligases - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Ubiquitin | Properties | Mitochondrial DNA | Enzymes | Membranes | Cellular biology | Parkinsons disease | Gene expression | Index Medicus
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3. Full Text K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains
by Ohtake, Fumiaki and Tsuchiya, Hikaru and Saeki, Yasushi and Tanaka, Keiji
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2018, Volume 115, Issue 7, pp. E1401 - E1408
Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-linked ubiquitylation is known to regulate... 
proteasome | ITCH | K63-linked ubiquitin chain | NEDD4 family E3 ligase | ubiquitin | OXIDATIVE STRESS | ACTIVATION | MULTIDISCIPLINARY SCIENCES | DISTINCT | THIOREDOXIN-INTERACTING PROTEIN | 26S PROTEASOME | STRUCTURAL BASIS | TXNIP | CARCINOMA | REVEALS | LIGASE | Ubiquitin | Linkages | Chain branching | Chains | Seeding | Cells | Substrates | Proteins | Degradation | Signal transduction | Cell fate | Proteasomes | Transduction | Apoptosis | Quantitative analysis | Index Medicus | Biological Sciences | PNAS Plus
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4. Full Text Palatability and Preference of Gummi Formulations with Various Pharmaceutical Characteristics
by Nakagaki, Fumiaki and Uchida, Shinya and Tanaka, Shimako and Namiki, Noriyuki
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2018, Volume 66, Issue 4, pp. 452 - 457
This study aimed to elucidate the appropriate physical characteristics that are clinically acceptable for gummi formulations. We prepared 11 placebo gummi... 
clinical trial | physical characteristics | gummi formulation | preference | palatability | Clinical trial | Gummi formulation | Palatability | Preference | Physical characteristics | CHEMISTRY, MEDICINAL | DRUGS | PHARMACOLOGY & PHARMACY | CHEWABLE TABLETS | CHEMISTRY, MULTIDISCIPLINARY | Formulations | Penetration | Gelatin | Elasticity | Hardness | Physical properties
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5. Full Text CD13 is a therapeutic target in human liver cancer stem cells
by Haraguchi, Naotsugu and Ishii, Hideshi and Mimori, Koshi and Tanaka, Fumiaki and Ohkuma, Masahisa and Kim, Ho Min and Akita, Hirofumi and Takiuchi, Daisuke and Hatano, Hisanori and Nagano, Hiroaki and Barnard, Graham F and Doki, Yuichiro and Mori, Masaki
Journal of Clinical Investigation, ISSN 0021-9738, 09/2010, Volume 120, Issue 9, pp. 3326 - 3339
Cancer stem cells (CSCs) are generally dormant or slowly cycling tumor cells that have the ability to reconstitute tumors. They are thought to be involved in... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | MAINTENANCE | APOPTOSIS | OXIDATIVE STRESS | HEPATOCELLULAR-CARCINOMA | CD13/AMINOPEPTIDASE-N | RESISTANCE | AMINOPEPTIDASE-N | MICE | ACUTE MYELOID-LEUKEMIA | Fluorouracil - metabolism | Cell Line | Apoptosis - drug effects | Biomarkers, Tumor - analysis | CD13 Antigens - antagonists & inhibitors | Neoplastic Stem Cells - drug effects | Humans | Mice, SCID | CD13 Antigens - metabolism | Antineoplastic Agents - metabolism | Animals | Fluorouracil - administration & dosage | Neoplastic Stem Cells - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Neoplastic Stem Cells - pathology | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Fluorouracil - pharmacology | Mice | Cell Cycle - drug effects | Carcinoma, Hepatocellular - metabolism | Liver cancer | Care and treatment | Chemotherapy | Stem cells | Diagnosis | Properties | Radiotherapy | Methods | Cancer | Index Medicus | Abridged Index Medicus
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6. Full Text Effect of Ti3+ Ions and Conduction Band Electrons on Photocatalytic and Photoelectrochemical Activity of Rutile Titania for Water Oxidation
by Amano, Fumiaki and Nakata, Masashi and Yamamoto, Akira and Tanaka, Tsunehiro
Journal of Physical Chemistry C, ISSN 1932-7447, 03/2016, Volume 120, Issue 12, pp. 6467 - 6474
Although TiO2 is generally considered to be an oxygen deficient n-type compound, the role of oxygen vacancies and Ti3+ ions on its photocatalytic activity is... 
ABSORPTION-SPECTROSCOPY | PARTICLES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | HYDROGENATED TIO2 | QUANTITATIVE-ANALYSIS | SURFACE CHARACTERIZATION | TIO2 NANOWIRE ARRAYS | NANOPARTICLES | OXYGEN VACANCY | REDUCTION | POWDER
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7. Full Text Involvement of Toll-like receptor 2 in the cerebral immune response and behavioral changes caused by latent Toxoplasma infection in mice
by Ihara, Fumiaki and Tanaka, Sachi and Fereig, Ragab M and Nishimura, Maki and Nishikawa, Yoshifumi
PLoS ONE, ISSN 1932-6203, 08/2019, Volume 14, Issue 8, pp. e0220560 - e0220560
Subacute and chronic infections with the intracellular protozoan parasite Toxoplasma gondii are associated with an increased risk of psychiatric diseases like... 
Psychological aspects | Complications and side effects | Immune response | Toxoplasmosis | Central nervous system diseases | Models | Health aspects | TLR2 | Brain | Mental disorders | Funding | Chronic infection | Schizophrenia | Infections | Parasites | Veterinary medicine | Neurogenesis | Freezing | Proteins | Social research | Rodents | Toll-like receptors | Anxiety | Behavior | Trends | Lesions | Drug dosages | Protozoa | Parasitology | Health risks | Latent infection | Inflammation | Gene expression | Immune systems | Studies | Fear | Pathology | Brain research | Cysts | Anxieties | TLR2 protein | Mice | Laboratory animals | Tonic immobility | Index Medicus
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8. Full Text LOTUS as a novel biomarker of multiple sclerosis
by Takahashi, Keita and Tanaka, Fumiaki
Clinical and Experimental Neuroimmunology, ISSN 1759-1961, 02/2019, Volume 10, Issue 1, pp. 27 - 32
Multiple sclerosis ( MS ) is considered to be an autoimmune demyelinating disorder, but recent studies showed that axonal degeneration is also an important... 
axonal degeneration | Nogo receptor‐1 | Nogo | multiple sclerosis | lateral olfactory tract usher substance | Nogo receptor-1 | Multiple sclerosis | Nogo protein | Neurological diseases | Regeneration | Neurodegeneration | Demyelination | Therapeutic applications | Biomarkers | Cerebrospinal fluid
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9. Full Text Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial
by Katsuno, Masahisa, MD and Banno, Haruhiko, MD and Suzuki, Keisuke, MD and Takeuchi, Yu, MD and Kawashima, Motoshi, MD and Yabe, Ichiro, MD and Sasaki, Hidenao, Prof and Aoki, Masashi, MD and Morita, Mitsuya, MD and Nakano, Imaharu, Prof and Kanai, Kazuaki, MD and Ito, Shoichi, MD and Ishikawa, Kinya, MD and Mizusawa, Hidehiro, Prof and Yamamoto, Tomotaka, MD and Tsuji, Shoji, Prof and Hasegawa, Kazuko, MD and Shimohata, Takayoshi, MD and Nishizawa, Masatoyo, Prof and Miyajima, Hiroaki, MD and Kanda, Fumio, Prof and Watanabe, Yasuhiro, MD and Nakashima, Kenji, Prof and Tsujino, Akira, MD and Yamashita, Taro, MD and Uchino, Makoto, Prof and Fujimoto, Yasushi, MD and Tanaka, Fumiaki, MD and Sobue, Gen, Prof and Japan SBMA Interventional Trial TA and Japan SBMA Interventional Trial for TAP-144-SR (JASMITT) study group
Lancet Neurology, The, ISSN 1474-4422, 2010, Volume 9, Issue 9, pp. 875 - 884
Summary Background Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of a polyglutamine tract in the androgen... 
Neurology | ANDROGEN-DEPRIVATION THERAPY | KENNEDY-DISEASE | BONE-MINERAL DENSITY | PROSTATIC-CANCER | METABOLISM | 6-MINUTE WALK TEST | RECEPTOR | RECESSIVE BULBOSPINAL NEURONOPATHY | AMYOTROPHIC-LATERAL-SCLEROSIS | TRANSGENIC MOUSE MODEL | CLINICAL NEUROLOGY | Severity of Illness Index | Double-Blind Method | Humans | Japan | Middle Aged | Male | Treatment Outcome | Muscular Atrophy - drug therapy | Dose-Response Relationship, Drug | Antineoplastic Agents, Hormonal - therapeutic use | Leuprolide - therapeutic use | Statistics, Nonparametric | Adult | Female | Muscular Atrophy, Spinal - drug therapy | Aged | Medical colleges | Medical research | Care and treatment | Neurosciences | Neurons | Clinical trials | Medicine, Experimental | Atrophy, Muscular | Index Medicus | Subpopulations | Barium | swallowing | Hospitals | Polyglutamine | Androgen receptors | Motor neuron disease | spinal and bulbar muscular atrophy | Data processing | Pharynx | Pharmaceuticals
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10. Full Text MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells
by Nishida, Naohiro and Yamashita, Shinya and Mimori, Koshi and Sudo, Tomoya and Tanaka, Fumiaki and Shibata, Kohei and Yamamoto, Hirofumi and Ishii, Hideshi and Doki, Yuichiro and Mori, Masaki
Annals of Surgical Oncology, ISSN 1068-9265, 9/2012, Volume 19, Issue 9, pp. 3065 - 3071
Recent evidence has shown that altered patterns of microRNA (miRNA) expression correlate with various human cancers. We investigated the clinical significance... 
Oncology | Medicine & Public Health | Surgical Oncology | Surgery | BREAST-CANCER | MIGRATION | SURGERY | INVASION | METASTASIS | THERAPY | ONCOLOGY | MIR-B-10 | BIM | CARCINOMAS | TARGETS | EXPRESSION | Multivariate Analysis | Prognosis | Colorectal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | MicroRNAs - metabolism | Fluorouracil - therapeutic use | Transfection | Bcl-2-Like Protein 11 | Colorectal Neoplasms - drug therapy | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | Real-Time Polymerase Chain Reaction | Proto-Oncogene Proteins - metabolism | Gene Expression | Cell Survival | Membrane Proteins - genetics | HCT116 Cells | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Lymphatic Metastasis | Apoptosis Regulatory Proteins - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Analysis of Variance | Aged | MicroRNAs - genetics | Colorectal Neoplasms - pathology | Apoptosis | Index Medicus
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11. Full Text Defined Factors Induce Reprogramming of Gastrointestinal Cancer Cells
by Norikatsu Miyoshi and Hideshi Ishii and Ken-Ichi Nagai and Hiromitsu Hoshino and Koshi Mimori and Fumiaki Tanaka and Hiroaki Nagano and Mitsugu Sekimoto and Yuichiro Doki and Masaki Mori and Takashi Sugimura
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 40 - 45
Although cancer is a disease with genetic and epigenetic origins, the possible effects of reprogramming by defined factors remain to be fully understood. We... 
Neurons | Induced pluripotent stem cells | Epithelial cells | Stem cells | Cell lines | Adipocytes | Pluripotent stem cells | Embryonic stem cells | Cellular differentiation | Cells | Epigenetics | Cancer stem cells | Differentiation | PLURIPOTENT STEM-CELLS | differentiation | pluripotent stem cells | embryonic stem cells | MULTIDISCIPLINARY SCIENCES | NANOG | cancer stem cells | IDENTIFICATION | epigenetics | LINES | Paired Box Transcription Factors - genetics | Neoplastic Stem Cells - cytology | Gastrointestinal Neoplasms - genetics | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | SOXB1 Transcription Factors - metabolism | DNA (Cytosine-5-)-Methyltransferases - metabolism | Octamer Transcription Factor-3 - genetics | Gastrointestinal Neoplasms - pathology | DNA Methylation | Retroviridae - genetics | SOXB1 Transcription Factors - genetics | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Eye Proteins - genetics | Cell Differentiation - physiology | Neoplastic Stem Cells - physiology | Repressor Proteins - metabolism | Gastrointestinal Neoplasms - metabolism | Biomarkers - metabolism | Nanog Homeobox Protein | Pluripotent Stem Cells - cytology | Pluripotent Stem Cells - physiology | Repressor Proteins - genetics | PAX6 Transcription Factor | Mice, SCID | Homeodomain Proteins - genetics | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Eye Proteins - metabolism | Cell Differentiation - drug effects | Octamer Transcription Factor-3 - metabolism | Pluripotent Stem Cells - drug effects | Cell Line, Tumor | Mice, Inbred NOD | Mice | Paired Box Transcription Factors - metabolism | Epigenetic inheritance | Care and treatment | Gastrointestinal cancer | Physiological aspects | Genetic aspects | Research | Proteins | Gene expression | Rodents | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Biological Sciences
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12. Full Text Intestinal CD169 + macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes
by Asano, Kenichi and Takahashi, Naomichi and Ushiki, Mikiko and Monya, Misa and Aihara, Fumiaki and Kuboki, Erika and Moriyama, Shigetaka and Iida, Mayumi and Kitamura, Hiroshi and Qiu, Chun-Hong and Watanabe, Takashi and Tanaka, Masato
Nature Communications, ISSN 2041-1723, 07/2015, Volume 6, Issue 1, pp. 7802 - 7802
Lamina propria (LP) macrophages are constantly exposed to commensal bacteria, and are refractory to those antigens in an interleukin (IL)-10-dependent fashion.... 
CIRCULATING MONOCYTES | ROR-GAMMA-T | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | LAMINA-PROPRIA | HOST-DISEASE | INNATE LYMPHOID-CELLS | LY6C(HI) MONOCYTES | ADULT LIFE | IMMUNE DEFENSE | BOWEL-DISEASE | Dextran Sulfate | Immunity, Mucosal | Colon - immunology | Macrophages - metabolism | Macrophages - secretion | Animals | Mucous Membrane - immunology | Colitis - chemically induced | Sialic Acid Binding Ig-like Lectin 1 - metabolism | Female | Mice | Colitis - immunology | Monocytes - physiology | Chemokine CCL8 - secretion | Index Medicus
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13. Full Text Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network
: VEGF/NRP1/ARHGAP17 signal stimulates filopodia formation of breast cancer
by Kiso, Marina and Tanaka, Sunao and Saji, Shigehira and Toi, Masakazu and Sato, Fumiaki
International Journal of Cancer, ISSN 0020-7136, 12/2018, Volume 143, Issue 11, pp. 2905 - 2918
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14. Full Text The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling
by Ohtake, Fumiaki and Saeki, Yasushi and Ishido, Satoshi and Kanno, Jun and Tanaka, Keiji
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 251 - 266
Polyubiquitin chains of different topologies regulate diverse cellular processes. K48- and K63-linked chains, the two most abundant chain types, regulate... 
NF-κB | CYLD | AQUA | proteomics | Lys63 | inflammation | TRAF6 | HUWE1 | Lys48 | ACTIVATION | COMPLEX | INHIBITION | SPECIFICITY | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYLD USP | DEGRADATION | POLYUBIQUITIN CHAIN | MECHANISMS | LIGASE | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Interleukin-1beta - pharmacology | Deubiquitinating Enzyme CYLD | Humans | Ubiquitin - metabolism | Substrate Specificity | NF-kappa B - metabolism | NF-kappa B - chemistry | Polyubiquitin - genetics | Ubiquitination | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Lysine - metabolism | Protein Interaction Domains and Motifs | Osteoblasts - cytology | TNF Receptor-Associated Factor 6 - genetics | Binding Sites | Polyubiquitin - chemistry | Polyubiquitin - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Tumor Suppressor Proteins - metabolism | Signal Transduction | Osteoblasts - drug effects | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - chemistry | Sequence Alignment | NF-kappa B - genetics | Protein Conformation, beta-Strand | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - chemistry | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Lysine - chemistry | Osteoblasts - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
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15. Full Text Methods to measure ubiquitin chain length and linkage
by Ohtake, Fumiaki and Tsuchiya, Hikaru and Tanaka, Keiji and Saeki, Yasushi
Methods in Enzymology, ISSN 0076-6879, 01/2019, Volume 618, pp. 105 - 133
To understand the biological roles of different ubiquitin chains, it is important to determine the types of ubiquitin linkages, the lengths of the polymers,... 
Ubiquitin | Ubiquitin probe | Mass spectrometry
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