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1. Full Text A metagenome-wide association study of gut microbiota in type 2 diabetes
by Wang, Jun and Qin, Junjie and Li, Yingrui and Cai, Zhiming and Li, Shenghui and Zhu, Jianfeng and Zhang, Fan and Liang, Suisha and Zhang, Wenwei and Guan, Yuanlin and Shen, Dongqian and Peng, Yangqing and Zhang, Dongya and Jie, Zhuye and Wu, Wenxian and Qin, Youwen and Xue, Wenbin and Li, Junhua and Han, Lingchuan and Lu, Donghui and Wu, Peixian and Dai, Yali and Sun, Xiaojuan and Li, Zesong and Tang, Aifa and Zhong, Shilong and Li, Xiaoping and Chen, Weineng and Xu, Ran and Wang, Mingbang and Feng, Qiang and Gong, Meihua and Yu, Jing and Zhang, Yanyan and Zhang, Ming and Hansen, Torben and Sanchez, Gaston and Raes, Jeroen and Falony, Gwen and Okuda, Shujiro and Almeida, Mathieu and Lechatelier, Emmanuelle and Renault, Pierre and Pons, Nicolas and Batto, Jean-Michel and Zhang, Zhaoxi and Chen, Hua and Yang, Ruifu and Zheng, Weimou and Li, Songgang and Yang, Huanming and Ehrlich, S. Dusko and Nielsen, Rasmus and Pedersen, Oluf and Kristiansen, Karsten and Wang, Jian
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7418, pp. 55 - 60
Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine... 
OBESITY | FRAGMENTS | VARIANTS | BACTEREMIA | MULTIDISCIPLINARY SCIENCES | DISEASE | DIVERSITY | INFECTION | MICE | STRESS | China - ethnology | Diabetes Mellitus, Type 2 - classification | Butyrates - metabolism | Sulfates - metabolism | Diabetes Mellitus, Type 2 - microbiology | Humans | Metagenomics - methods | Genetic Markers | Opportunistic Infections - microbiology | Feces - microbiology | Asian Continental Ancestry Group | Metabolic Networks and Pathways - genetics | Metagenome - genetics | Reference Standards | Diabetes Mellitus, Type 2 - physiopathology | Intestines - microbiology | High-Throughput Nucleotide Sequencing | Genetic Linkage - genetics | Genome-Wide Association Study - methods | Diabetes Mellitus, Type 2 - complications | Cohort Studies | Opportunistic Infections - complications | Type 2 diabetes | Research | Microbiota (Symbiotic organisms) | Biological markers | Identification and classification | Testing | Oxidative stress | Microbiology | Taxonomy | Genes | Data processing | Genomes | Studies | Hospitals | Risk assessment | Bacteria | Genetic testing | Diabetes | Methods | Life Sciences
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2. Full Text Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
by Guo, Guangwu and Sun, Xiaojuan and Chen, Chao and Wu, Song and Huang, Peide and Li, Zesong and Dean, Michael and Huang, Yi and Jia, Wenlong and Zhou, Quan and Tang, Aifa and Yang, Zuoquan and Li, Xianxin and Song, Pengfei and Zhao, Xiaokun and Ye, Rui and Zhang, Shiqiang and Lin, Zhao and Qi, Mingfu and Wan, Shengqing and Xie, Liangfu and Fan, Fan and Nickerson, Michael L and Zou, Xiangjun and Hu, Xueda and Xing, Li and Lv, Zhaojie and Mei, Hongbin and Gao, Shengjie and Liang, Chaozhao and Gao, Zhibo and Lu, Jingxiao and Yu, Yuan and Liu, Chunxiao and Li, Lin and Fang, Xiaodong and Jiang, Zhimao and Yang, Jie and Li, Cailing and Zhao, Xin and Chen, Jing and Zhang, Fang and Lai, Yongqi and Lin, Zheguang and Zhou, Fangjian and Chen, Hao and Chan, Hsiao Chang and Tsang, Shirley and Theodorescu, Dan and Li, Yingrui and Zhang, Xiuqing and Wang, Jian and Yang, Huanming and Gui, Yaoting and Wang, Jun and Cai, Zhiming
Nature Genetics, ISSN 1061-4036, 12/2013, Volume 45, Issue 12, pp. 1459 - 1463
Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic... 
ANEUPLOIDY | GENETICS & HEREDITY | MUTATIONS | FUSIONS | FGFR3 | CARCINOMA | VARIANT | Sister Chromatid Exchange - genetics | Genome-Wide Association Study | Gene Frequency | Humans | Sequence Analysis, DNA | Case-Control Studies | Exome - genetics | Urinary Bladder Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | Base Sequence | Polymorphism, Single Nucleotide | Carcinoma, Transitional Cell - genetics | Chromosome Segregation - genetics | Genetic aspects | Research | Gene mutations | Bladder cancer | Identification and classification | Cancer | Survival analysis | Genes | Medical prognosis | Cell division | Genomes | Tumorigenesis | Mutation | Tumors
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3. Full Text Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
by Gui, Yaoting and Guo, Guangwu and Huang, Yi and Hu, Xueda and Tang, Aifa and Gao, Shengjie and Wu, Renhua and Chen, Chao and Li, Xianxin and Zhou, Liang and He, Minghui and Li, Zesong and Sun, Xiaojuan and Jia, Wenlong and Chen, Jinnong and Yang, Shangming and Zhou, Fangjian and Zhao, Xiaokun and Wan, Shengqing and Ye, Rui and Liang, Chaozhao and Liu, Zhisheng and Huang, Peide and Liu, Chunxiao and Jiang, Hui and Wang, Yong and Zheng, Hancheng and Sun, Liang and Liu, Xingwang and Jiang, Zhimao and Feng, Dafei and Chen, Jing and Wu, Song and Zou, Jing and Zhang, Zhongfu and Yang, Ruilin and Zhao, Jun and Xu, Congjie and Yin, Weihua and Guan, Zhichen and Ye, Jiongxian and Zhang, Hong and Li, Jingxiang and Kristiansen, Karsten and Nickerson, Michael L and Theodorescu, Dan and Li, Yingrui and Zhang, Xiuqing and Li, Songgang and Wang, Jian and Yang, Huanming and Wang, Jun and Cai, Zhiming
Nature Genetics, ISSN 1061-4036, 09/2011, Volume 43, Issue 9, pp. 875 - 878
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the... 
PATHWAYS | CANCER | FGFR3 | SOMATIC MUTATIONS | GENETICS & HEREDITY | Urinary Bladder Neoplasms - genetics | Humans | Chromosome Aberrations | Gene Expression Regulation, Neoplastic | Chromatin Assembly and Disassembly - genetics | Mutation | Carcinoma, Transitional Cell - genetics | Adenocarcinoma | Polymerase chain reaction | Usage | Genetic aspects | Research | Gene mutations | Genetics | Genes | Cancer
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4. Full Text Standardized assays for determining the catalytic activity and kinetics of peroxidase-like nanozymes
by Jiang, Bing and Duan, Demin and Gao, Lizeng and Zhou, Mengjie and Fan, Kelong and Tang, Yan and Xi, Juqun and Bi, Yuhai and Tong, Zhou and Gao, George Fu and Xie, Ni and Tang, Aifa and Nie, Guohui and Liang, Minmin and Yan, Xiyun
Nature Protocols, ISSN 1754-2189, 07/2018, Volume 13, Issue 7, pp. 1506 - 1520
Nanozymes are nanomaterials exhibiting intrinsic enzyme-like characteristics that have increasingly attracted attention, owing to their high catalytic... 
COFE2O4 NANOPARTICLES | OXIDE NANOPARTICLES | GLUCOSE | BIOCHEMICAL RESEARCH METHODS | MIMICKING ACTIVITY | HYDROGEN-PEROXIDE | COLORIMETRIC DETECTION | HORSERADISH-PEROXIDASE | MAGNETIC NANOPARTICLES | CARBON NANOTUBES | CO3O4 NANOPARTICLES | Superoxide dismutase | Nanomaterials | Catalytic activity | Superoxide | Assaying | Nanoparticles | Haloperoxidase | Reaction kinetics | Peroxidase | Diagnostic systems | Kinetics | Catalysis | Iron oxides | Nanotechnology | Physicochemical properties
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5. Full Text MicroRNA expression signatures of bladder cancer revealed by deep sequencing
by Han, Yonghua and Chen, Jiahao and Zhao, Xiaokun and Liang, Chaozhao and Wang, Yong and Sun, Liang and Jiang, Zhimao and Zhang, Zhongfu and Yang, Ruilin and Chen, Jing and Li, Zesong and Tang, Aifa and Li, Xianxin and Ye, Jiongxian and Guan, Zhichen and Gui, Yaoting and Cai, Zhiming
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 3, p. e18286
Background: MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They are aberrantly expressed in many types of cancers. In... 
IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | GENES | Reproducibility of Results | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - biosynthesis | MicroRNAs - metabolism | Up-Regulation - genetics | Gene Expression Profiling | Reverse Transcriptase Polymerase Chain Reaction | Down-Regulation - genetics | Urinary Bladder Neoplasms - genetics | MicroRNAs - genetics | High-Throughput Nucleotide Sequencing - methods | Cluster Analysis | MicroRNA | Genes | Genomics | Genetic research | Development and progression | Genomes | Gene expression | Bladder cancer | Reproductive health | Laboratories | Bladder | Antisense | Urology | Ovarian cancer | Gene sequencing | Urinary bladder | Genetics | Urothelial carcinoma | Library collections | MiRNA | Patients | Suppressors | Medicine | Hospitals | Ribonucleic acids | MicroRNAs | Aberration | Cancer | Urothelium | Tumors
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6. Full Text Decreased expression of SRY-box containing gene 30 is related to malignant phenotypes of human bladder cancer and correlates with poor prognosis
by Liu, Yang and Wang, Han and Zhong, Jianhua and Wu, Chenglong and Yang, Gang and Zhong, Yuantang and Zhang, Jinghua and Tang, Aifa
BMC Cancer, ISSN 1471-2407, 06/2018, Volume 18, Issue 1, pp. 642 - 8
In human pulmonary malignancies, the SRY-box containing gene 30 (SOX30) is a known cancer-suppressing gene. Nevertheless, its molecular role and clinical... 
Proliferation | Bladder cancer | Invasion | Therapeutic target | Apoptosis | SOX30 | Tumor Suppressor Proteins - metabolism | Urinary Bladder Neoplasms - mortality | Prognosis | Biomarkers, Tumor - analysis | Humans | Middle Aged | Cell Proliferation - physiology | Kaplan-Meier Estimate | Male | Cell Movement - physiology | Phenotype | Neoplasm Invasiveness - pathology | SOX Transcription Factors - metabolism | Urinary Bladder Neoplasms - pathology | Adult | Female | Aged | Apoptosis - physiology | Immunohistochemistry | RNA | Genes | Genetic aspects | Metastasis | Health aspects
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7. Full Text Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
by Guo, Guangwu and Gui, Yaoting and Gao, Shengjie and Tang, Aifa and Hu, Xueda and Huang, Yi and Jia, Wenlong and Li, Zesong and He, Minghui and Sun, Liang and Song, Pengfei and Sun, Xiaojuan and Zhao, Xiaokun and Yang, Sangming and Liang, Chaozhao and Wan, Shengqing and Zhou, Fangjian and Chen, Chao and Zhu, Jialou and Li, Xianxin and Jian, Minghan and Zhou, Liang and Ye, Rui and Huang, Peide and Chen, Jing and Jiang, Tao and Liu, Xiao and Wang, Yong and Zou, Jing and Jiang, Zhimao and Wu, Renhua and Wu, Song and Fan, Fan and Zhang, Zhongfu and Liu, Lin and Yang, Ruilin and Liu, Xingwang and Wu, Haibo and Yin, Weihua and Zhao, Xia and Liu, Yuchen and Peng, Huanhuan and Jiang, Binghua and Feng, Qingxin and Li, Cailing and Xie, Jun and Lu, Jingxiao and Kristiansen, Karsten and Li, Yingrui and Zhang, Xiuqing and Li, Songgang and Wang, Jian and Yang, Huanming and Cai, Zhiming and Wang, Jun
Nature Genetics, ISSN 1061-4036, 01/2012, Volume 44, Issue 1, pp. 17 - 19
We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of similar to 1,100 genes in 88 additional ccRCCs, from which... 
SOMATIC MUTATIONS | GENETICS & HEREDITY | Ubiquitin | Gene mutations | Physiological aspects | Genetic aspects | Research | Carcinoma, Renal cell | Health aspects | Risk factors | Studies | Pathogenesis | Censuses | Epigenetics | Mutation | Methods | Cancer
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8. Full Text Regulation of dndB gene expression in streptomyces lividans
by Dai, Daofeng and Pu, Tianning and Liang, Jingdan and Wang, Zhijun and Tang, Aifa
Frontiers in Microbiology, ISSN 1664-302X, 10/2018, Volume 9, p. 2387
DNA sulfur modification is a unique modification occurring in the sugar-phosphate backbone of DNA, with a nonbridging oxygen atom substituted with sulfur in a... 
Streptomyces lividans | DNA sulfur modification | Epigenetic regulation | DndB gene | Transcriptional regulation | transcriptional regulation | PHOSPHOROTHIOATION | MICROBIOLOGY | SULFUR | epigenetic regulation | CONFORMATIONS | dndB gene | S-MODIFICATION | RESTRICTION SYSTEM | BACKBONE | DNA MODIFICATION | RNA sequencing | Sulfur compounds | Usage | Streptomyces | Genetic aspects | Research | Gene expression
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9. FGFR 3S249C mutation promotes chemoresistance by activating Akt signaling in bladder cancer cells
by Xie, Xina and Lin, Jiatian and Zhong, Yuantang and Fu, Mianheng and Tang, Aifa
Experimental and therapeutic medicine, ISSN 1792-0981, 08/2019, Volume 18, Issue 2, p. 1226
Fibroblast growth factor receptor 3 (FGFR3) is a high frequency mutant gene in bladder cancer (BCa) and has become a promising therapeutic target due to its... 
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10. Full Text Exosome-like Nanozyme Vesicles for H 2 O 2 -Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma
by Ding, Hui and Cai, Yanjuan and Gao, Lizeng and Liang, Minmin and Miao, Beiping and Wu, Hanwei and Liu, Yang and Xie, Ni and Tang, Aifa and Fan, Kelong and Yan, Xiyun and Nie, Guohui
Nano Letters, ISSN 1530-6984, 01/2019, Volume 19, Issue 1, pp. 203 - 209
Photoacoustic imaging (PAI) is an attractive imaging modality, which is promising for clinical cancer diagnosis due to its advantages on deep tissue... 
graphene quantum dot nanozyme | nasopharyngeal carcinoma | exosome-like vesicle | Photoacoustic imaging | erythrocyte membranes | responsive
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11. Full Text The EDA-containing cellular fibronectin induces epithelial-mesenchymal transition in lung cancer cells through integrin α9β1-mediated activation of PI3-K/AKT and Erk1/2
by Sun, Xiaojuan and Fa, Pingping and Cui, Zhiwen and Xia, Ye and Sun, Liang and Li, Zesong and Tang, Aifa and Gui, Yaoting and Cai, Zhiming
Carcinogenesis, ISSN 0143-3334, 01/2014, Volume 35, Issue 1, pp. 184 - 191
Cellular fibronectin (cFN) is one of the main components of tissue extracellular matrices and is involved in multiple physiologic and pathologic processes such... 
Protein Structure, Tertiary | Fibronectins - pharmacology | Adenocarcinoma - pathology | Humans | Lung Neoplasms - metabolism | Epithelial-Mesenchymal Transition - drug effects | Lung Neoplasms - pathology | Cell Line, Tumor - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Integrins - metabolism | Fibronectins - metabolism | Adenocarcinoma - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Fibronectins - genetics | Mice | Enzyme Activation | Proto-Oncogene Proteins c-akt - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
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12. Full Text Detection of dendritic cells and related cytokines in follicular fluid of patients with polycystic ovary syndrome
by Zhang, Tao and Tian, Fuying and Huo, Ran and Tang, Aifa and Zeng, Yong and Duan, Yong‐Gang
American Journal of Reproductive Immunology, ISSN 1046-7408, 09/2017, Volume 78, Issue 3, p. n/a
Problem The presence of dendritic cells (DCs) and associated cytokines in follicular fluid (FF) from patients with polycystic ovary syndrome (PCOS) remains... 
immune dysfunction | cytokines | dendritic cells | follicular fluid | polycystic ovary syndrome | QUALITY | CLINICAL PREGNANCY | IMMUNOLOGY | INTERLEUKIN-6 | WOMEN | REPRODUCTIVE BIOLOGY | HUMAN PREOVULATORY FOLLICLES | OVULATION | IN-VITRO FERTILIZATION | IVF PATIENTS | SERUM ESTRADIOL LEVELS | EXPRESSION | Cytokines - metabolism | Ovary - immunology | Polycystic Ovary Syndrome - immunology | Dendritic Cells - immunology | Humans | Inflammation Mediators - metabolism | Cellular Microenvironment | Female | Male | Treatment Outcome | Follicular Fluid | Polycystic Ovary Syndrome - diagnosis | Interleukin 6 | Polycystic ovary syndrome | Flow cytometry | Dendritic cells | Cytokines | Tumor necrosis factor | Infertility | Interleukin 10 | Interleukin 23 | Histocompatibility antigen HLA | Follicular fluid | Enzyme-linked immunosorbent assay
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13. Full Text TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis
by Yan, Dehong and Wang, Jinghui and Sun, Honghong and Zamani, Ali and Zhang, Honglin and Chen, Weihong and Tang, Aifa and Ruan, Qingguo and Yang, Xiaolu and Chen, Youhai H and Wan, Xiaochun
The Journal of Experimental Medicine, ISSN 0022-1007, 10/2019, p. jem.20182005
Myeloid-derived suppressor cells (MDSCs) are “polarized” myeloid cells that effectively promote tumorigenesis by inhibiting antitumor immunity. How myeloid... 
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14. Full Text Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma
by Wu, Song and Wu, Song and Wang, Yong and Wang, Yong and Sun, Liang and Sun, Liang and Zhang, Zhiling and Zhang, Zhiling and Jiang, Zhimao and Jiang, Zhimao and Qin, Zike and Qin, Zike and Han, Hui and Han, Hui and Liu, Zhuowei and Liu, Zhuowei and Li, Xianxin and Li, Xianxin and Tang, Aifa and Tang, Aifa and Gui, Yaoting and Gui, Yaoting and Cai, Zhiming and Cai, Zhiming and Zhou, Fangjian and Zhou, Fangjian
BMC Cancer, ISSN 1471-2407, 2011, Volume 11, Issue 1, pp. 413 - 413
Background: The molecular mechanisms involved in the development and progression of clear cell renal cell carcinomas (ccRCCs) are poorly understood. The... 
SURVIVAL | INHIBITION | ONCOLOGY | MARKER | MKP-1 | KINASE | KIDNEY CANCER | Immunohistochemistry | Kidney Neoplasms - genetics | Prognosis | Carcinoma, Renal Cell - pathology | Dual-Specificity Phosphatases - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Kaplan-Meier Estimate | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - mortality | RNA, Messenger - metabolism | Mitogen-Activated Protein Kinase Phosphatases - genetics | Carcinoma, Renal Cell - mortality | Dual-Specificity Phosphatases - genetics | Adult | Female | Kidney Neoplasms - pathology | Aged | Neoplasm Staging | Mitogen-Activated Protein Kinase Phosphatases - metabolism | Polymerase chain reaction | Usage | Care and treatment | Development and progression | Genetic aspects | Carcinoma, Renal cell | Research | Risk factors
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