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1. Full Text ABNORMAL METABOLIC NETWORK ACTIVITY IN PARKINSON'S DISEASE WITH GBA VARIANTS
by Schindlbeck, Katharina A and Tang, Chris C and Niethammer, Martin and Eidelberg, David
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 07/2018, Volume 14, Issue 7, pp. P65 - P65
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2. Automated Differential Diagnosis of Early Parkinsonism Using Metabolic Brain Networks: A Validation Study
by Tripathi, Madhavi and Tang, Chris C and Feigin, Andrew and De Lucia, Ivana and Nazem, Amir and Dhawan, Vijay and Eidelberg, David
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2016, Volume 57, Issue 1, pp. 60 - 60
The differentiation of idiopathic Parkinson disease (IPD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), the most common atypical... 
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3. Automated Differential Diagnosis of Early Parkinsonism Using Metabolic Brain Networks: A Validation Study
by Madhavi Tripathi and Chris C Tang and Andrew Feigin and Ivana De Lucia and Amir Nazem and Vijay Dhawan and David Eidelberg
The Journal of Nuclear Medicine, ISSN 0161-5505, 01/2016, Volume 57, Issue 1, p. 60
  The differentiation of idiopathic Parkinson disease (IPD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), the most common... 
Brain | Parkinsons disease | Medical diagnosis | Validation studies
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4. Full Text Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
by Schunkert, Heribert and König, Inke R and Kathiresan, Sekar and Reilly, Muredach P and Assimes, Themistocles L and Holm, Hilma and Preuss, Michael and Stewart, Alexane F. R and Barbalic, Maja and Gieger, Christian and Absher, Devin and Aherrahrou, Zouhair and Allayee, Hooman and Altshuler, David and Anand, Sonia S and Andersen, Karl and Anderson, Jeffrey L and Ardissino, Diego and Ball, Stephen G and Balmforth, Anthony J and Barnes, Timothy A and Becker, Diane M and Becker, Lewis C and Berger, Klaus and Bis, Joshua C and Boekholdt, S. Matthijs and Boerwinkle, Eric and Braund, Peter S and Brown, Morris J and Burnett, Mary Susan and Buysschaert, Ian and Carlquist, John F and Chen, Li and Cichon, Sven and Codd, Veryan and Davies, Robert W and Dedoussis, George and Dehghan, Abbas and Demissie, Serkalem and Devaney, Joseph M and Diemert, Patrick and Do, Ron and Doering, Angela and Eifert, Sana and Mokhtari, Nour Eddine El and Ellis, Stephen G and Elosua, Roberto and Engert, James C and Epstein, Stephen E and de Faire, Ulf and Fischer, Marcus and Folsom, Aaron R and Freyer, Jennifer and Gigante, Bruna and Girelli, Domenico and Gretarsdottir, Solveig and Gudnason, Vilmundur and Gulcher, Jeffrey R and Halperin, Eran and Hammond, Naomi and Hazen, Stanley L and Hofman, Albert and Horne, Benjamin D and Illig, Thomas and Iribarren, Carlos and Jones, Gregory T and Jukema, J. Wouter and Kaiser, Michael A and Kaplan, Lee M and Kastelein, John J. P and Khaw, Kay-Tee and Knowles, Joshua W and Kolovou, Genovefa and Kong, Augustine and Laaksonen, Reijo and Lambrechts, Diether and Leander, Karin and Lettre, Guillaume and Li, Mingyao and Lieb, Wolfgang and Loley, Christina and Lotery, Anew J and Mannucci, Pier M and Maouche, Seraya and Martinelli, Nicola and McKeown, Pascal P and Meisinger, Christa and Meitinger, Thomas and Melander, Olle and Merlini, Pier Angelica and Mooser, Vincent and Morgan, Thomas and Mühleisen, Thomas W and Muhlestein, Joseph B and Münzel, Thomas and Musunuru, Kiran and Nahrstaedt, Janja and Nelson, Christopher P and Nöthen, Markus M and Olivieri, Oliviero and ... and CARDIoGRAM Consortium and Cardiogenics and the CARDIoGRAM Consortium
Nature genetics, ISSN 1061-4036, 2011, Volume 43, Issue 4, pp. 333 - U153
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762... 
HEART-DISEASE | DESIGN | POLYMORPHISMS | METAANALYSIS | MYOCARDIAL-INFARCTION | VARIANTS | CHOLESTEROL | GENETICS | GENETICS & HEREDITY | EXPRESSION | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Genome-Wide Association Study | Coronary Artery Disease - etiology | Gene Frequency | Humans | Middle Aged | Risk Factors | Male | Case-Control Studies | Alleles | Coronary Artery Disease - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Genetic aspects | Disease susceptibility | Research | Single nucleotide polymorphisms | Coronary heart disease | Health aspects | Risk factors | Studies | Genomes | Gene expression | Chromosomes | Meta-analysis
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5. Metabolic resting-state brain networks in health and disease
by Phoebe G Spetsieris and Ji Hyun Ko and Chris C Tang and Amir Nazem and Wataru Sako and Shichun Peng and Yilong Ma and Vijay Dhawan and David Eidelberg
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2015, Volume 112, Issue 8, p. 2563
  The delineation of resting state networks (RSNs) in the human brain relies on the analysis of temporal fluctuations in functional MRI signal, representing a... 
Brain | Nuclear magnetic resonance--NMR | Dopamine | Topography | Metabolism
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6. Full Text Abnormalities in Metabolic Network Activity Precede the Onset of Motor Symptoms in Parkinson's Disease
by Tang, Chris C and Poston, Kathleen L and Dhawan, Vijay and Eidelberg, David
Journal of Neuroscience, ISSN 0270-6474, 01/2010, Volume 30, Issue 3, pp. 1049 - 1056
Imaging studies show that Parkinson's disease (PD) alters the activity of motor- and cognition-related metabolic brain networks. However, it is not known... 
DIAGNOSIS | NEUROSCIENCES | PROGRESSION | MODULATION | SPECT | PERIOD | Dopamine Plasma Membrane Transport Proteins - metabolism | Motor Activity - physiology | Parkinson Disease - pathology | Parkinson Disease - diagnostic imaging | Humans | Middle Aged | Male | Cerebrovascular Circulation | Statistics as Topic | Positron-Emission Tomography - methods | Parkinson Disease - physiopathology | Analysis of Variance | Time Factors | Cognition Disorders - etiology | Brain Mapping | Female | Fluorodeoxyglucose F18 | Metabolic Networks and Pathways - physiology | Aged | Functional Laterality - physiology | Corpus Striatum - diagnostic imaging | Corpus Striatum - pathology | Longitudinal Studies | Protein Binding - physiology
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7. Full Text Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects
by Mure, Hideo and Hirano, Shigeki and Tang, Chris C and Isaias, Ioannis U and Antonini, Angelo and Ma, Yilong and Dhawan, Vijay and Eidelberg, David
NeuroImage, ISSN 1053-8119, 01/2011, Volume 54, Issue 2, pp. 1244 - 1253
The circuit changes that mediate parkinsonian tremor, while likely differing from those underlying akinesia and rigidity, are not precisely known. In this... 
Parkinson's disease | Vim DBS | Tremor | STN DBS | Positron emission tomography | FDG-PET | MOTOR SYMPTOMS | RESTING TREMOR | BASAL GANGLIA | NEUROSCIENCES | NEUROIMAGING | POSITRON-EMISSION-TOMOGRAPHY | SUBTHALAMIC NUCLEUS | THALAMIC-STIMULATION | DEEP BRAIN-STIMULATION | PALLIDAL NEURONAL-ACTIVITY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | MODULATION | Parkinson Disease - therapy | Parkinson Disease - complications | Brain - diagnostic imaging | Parkinson Disease - diagnostic imaging | Humans | Middle Aged | Male | Positron-Emission Tomography | Disease Progression | Deep Brain Stimulation | Female | Fluorodeoxyglucose F18 | Aged | Tremor - therapy | Tremor - etiology | Radiopharmaceuticals | Tremor - diagnostic imaging | Medical imaging | Brain research | Parkinsons disease
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8. Full Text Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis
by Tang, Chris C, MD and Poston, Kathleen L, MD and Eckert, Thomas, MD and Feigin, Andrew, MD and Frucht, Steven, MD and Gudesblatt, Mark, MD and Dhawan, Vijay, PhD and Lesser, Martin, PhD and Vonsattel, Jean-Paul, MD and Fahn, Stanley, MD and Eidelberg, David, MD
Lancet Neurology, The, ISSN 1474-4422, 2010, Volume 9, Issue 2, pp. 149 - 158
Summary Background Idiopathic Parkinson's disease can present with symptoms similar to those of multiple system atrophy or progressive supranuclear palsy. We... 
Neurology | CRITERIA | MULTIPLE SYSTEM ATROPHY | IMPROVE | CLINICAL-DIAGNOSIS | DISEASE | NETWORK ACTIVITY | DEEP-BRAIN-STIMULATION | CLINICAL NEUROLOGY | PROGRESSIVE SUPRANUCLEAR PALSY | ACCURACY | FEATURES | Predictive Value of Tests | Brain - diagnostic imaging | Diagnosis, Differential | Reproducibility of Results | Humans | Middle Aged | Parkinsonian Disorders - diagnosis | Fluorodeoxyglucose F18 - metabolism | Male | Parkinsonian Disorders - classification | Positron-Emission Tomography | Brain - metabolism | Radiopharmaceuticals - metabolism | Psychiatric Status Rating Scales | Sensitivity and Specificity | Parkinsonian Disorders - diagnostic imaging | Brain Mapping | Female | Aged | Retrospective Studies | Pattern Recognition, Automated - methods | Neurosciences | Parkinson's disease | Diagnosis | Universities and colleges | Atrophy | Basal ganglia | Neurodegenerative diseases | Classification | Central nervous system diseases | Clinical trials | Differential diagnosis | Movement disorders | progressive supranuclear palsy
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9. Full Text Large-scale gene-centric analysis identifies novel variants for coronary artery disease
by Butterworth, Adam S and Braund, Peter S and Farrall, Martin and Hardwick, Robert J and Saleheen, Danish and Peden, John F and Soranzo, Nicole and Chambers, John C and Sivapalaratnam, Suthesh and Kleber, Marcus E and Keating, Brendan and Qasim, Atif and Klopp, Norman and Erdmann, Jeanette and Assimes, Themistocles L and Ball, Stephen G and Balmforth, Anthony J and Barnes, Timothy A and Basart, Hanneke and Baumert, Jens and Bezzina, Connie R and Boerwinkle, Eric and Boehm, Bernhard O and Brocheton, Jessy and Bugert, Peter and Cambien, Francois and Clarke, Robert and Codd, Veryan and Collins, Rory and Couper, David and Cupples, L. Aienne and de Jong, Jonas S and Diemert, Patrick and Ejebe, Kenechi and Elbers, Clara C and Elliott, Paul and Fornage, Myriam and Franzosi, Maria-Grazia and Frossard, Philippe and Garner, Stephen and Goel, Anuj and Kastelein, John J. P and Wilde, Arthur A. M and Trip, Mieke D and Dekker, Lukas R and Henriques, José P and Koch, Karel T and de Winter, Robbert J and Boekholdt, S. Matthijs and Maitland-van der Zee, Anke-Hilse and IBC 50K CAD Consortium and The IBC 50K CAD Consortium
PLoS genetics, ISSN 1553-7390, 2011, Volume 7, Issue 9, p. e1002260
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies,... 
LIPOPROTEIN | METAANALYSIS | MYOCARDIAL-INFARCTION | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | RISK | GENOME-WIDE ASSOCIATION | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Risk | Case-Control Studies | Genetic Variation | Alleles | Coronary Artery Disease - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Quantitative trait loci | Genetic aspects | Research | Genetic variation | Coronary heart disease | Risk factors | Heart | Medical research | Health sciences | Biomedical research | Cardiovascular disease | Genomes | Grants
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10. Full Text Automated differential diagnosis of early parkinsonism using metabolic brain networks: A validation study
by Tripathi, Madhavi and Tang, Chris C and Feigin, Andrew and De Lucia, Ivana and Nazem, Amir and Dhawan, Vijay and Eidelberg, David
Journal of Nuclear Medicine, ISSN 0161-5505, 01/2016, Volume 57, Issue 1, pp. 60 - 66
The differentiation of idiopathic Parkinson disease (IPD) from multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), the most common atypical... 
Parkinson disease | Glucose metabolism | Automated classification algorithm | Differential diagnosis | Brain networks | CRITERIA | differential diagnosis | MRI | CLINICAL-DIAGNOSIS | brain networks | SLEEP BEHAVIOR DISORDER | ACCURACY | MULTIPLE SYSTEM ATROPHY | automated classification algorithm | DISEASE | FEATURES IMPROVE | glucose metabolism | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PROGRESSIVE SUPRANUCLEAR PALSY | CORTICOBASAL DEGENERATION | Automation | Brain - diagnostic imaging | Diagnosis, Differential | Parkinson Disease - diagnostic imaging | Prospective Studies | Humans | Middle Aged | Male | Positron-Emission Tomography | Brain - metabolism | Metabolic Networks and Pathways | Multiple System Atrophy - metabolism | Parkinson Disease - diagnosis | Supranuclear Palsy, Progressive - metabolism | Female | Supranuclear Palsy, Progressive - diagnostic imaging | Parkinson Disease - metabolism | Multiple System Atrophy - diagnosis | Supranuclear Palsy, Progressive - diagnosis | Multiple System Atrophy - diagnostic imaging
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11. Full Text Parkinson's disease cognitive network correlates with caudate dopamine
by Niethammer, Martin and Tang, Chris C and Ma, Yilong and Mattis, Paul J and Ko, Ji Hyun and Dhawan, Vijay and Eidelberg, David
NeuroImage, ISSN 1053-8119, 09/2013, Volume 78, pp. 204 - 209
Prior evidence has suggested a link between caudate dopaminergic functioning and cognition in Parkinson's disease (PD). In this dual tracer study we analyzed... 
Caudate | Cognition | Parkinson's disease | Dopamine | DIAGNOSIS | DEMENTIA | ABNORMALITIES | CIRCULAR ANALYSIS | NEUROSCIENCES | NEUROIMAGING | SPECT | IMPAIRMENT | METABOLIC BRAIN NETWORKS | NUCLEUS | DYSFUNCTION | BINDING | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Parkinson Disease - diagnostic imaging | Humans | Middle Aged | Image Interpretation, Computer-Assisted | Male | Positron-Emission Tomography | Caudate Nucleus - metabolism | Tropanes | Caudate Nucleus - diagnostic imaging | Female | Fluorodeoxyglucose F18 | Parkinson Disease - metabolism | Radiopharmaceuticals | Dopamine - analysis | Dopamine - metabolism | Phenols | Diagnostic imaging | Studies | Parkinsons disease | Values | Software | Patients | Dementia | Age
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12. Full Text Metabolic resting-state brain networks in health and disease
by Phoebe G. Spetsieris and Ji Hyun Ko and Chris C. Tang and Amir Nazem and Wataru Sako and Shichun Peng and Yilong Ma and Vijay Dhawan and David Eidelberg
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 8, pp. 2563 - 2568
The delineation of resting state networks (RSNs) in the human brain relies on the analysis of temporal fluctuations in functional MRI signal, representing a... 
Default mode network | Neurodegeneration | PET | Principal component analysis | Resting state networks | resting state networks | MULTIDISCIPLINARY SCIENCES | neurodegeneration | MULTIVARIATE | DEFAULT-MODE NETWORK | default mode network | principal component analysis | MODULATION | PARKINSONS-DISEASE | LEVODOPA | Alzheimer Disease - physiopathology | Disease | Health | Brain - physiopathology | Humans | Middle Aged | Male | Positron-Emission Tomography | Motor Activity | Parkinson Disease - physiopathology | Brain - metabolism | Magnetic Resonance Imaging | Rest | Alzheimer Disease - metabolism | Brain Mapping | Female | Parkinson Disease - metabolism | Nerve Net - physiopathology | Principal Component Analysis | Task Performance and Analysis | Neural circuitry | Brain research | Brain mapping | Physiological aspects | Nervous system | Degeneration | Research | Observations | Biological Sciences
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13. Full Text Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
by Strawbridge, Rona J and Dupuis, Josée and Prokopenko, Inga and Barker, Adam and Ahlqvist, Emma and Rybin, Denis and Petrie, John R and Travers, Mary E and Bouatia-Naji, Nabila and Dimas, Antigone S and Nica, Alexana and Wheeler, Eleanor and Chen, Han and Voight, Benjamin F and Taneera, Jalal and Kanoni, Stavroula and Peden, John F and Turrini, Fabiola and Gustafsson, Stefan and Zabena, Carina and Almgren, Peter and Barker, David J. P and Barnes, Daniel and Dennison, Elaine M and Eriksson, Johan G and Eriksson, Per and Eury, Elodie and Folkersen, Lasse and Fox, Caroline S and Frayling, Timothy M and Goel, Anuj and Gu, Harvest F and Horikoshi, Momoko and Isomaa, Bo and Jackson, Anne U and Jameson, Karen A and Kajantie, Eero and Kerr-Conte, Julie and Kuulasmaa, Teemu and Kuusisto, Johanna and Loos, Ruth J. F and Luan, Jian'an and Makrilakis, Konstantinos and Manning, Alisa K and Martínez-Larrad, María Teresa and Narisu, Narisu and Nastase Mannila, Maria and Boekholdt, S. Matthijs and Kastelein, John J. P and Rosendaal, Frits R and C4D Consortium and DIAGRAM Consortium and GIANT Consortium and CARDIoGRAM Consortium and MuTHER Consortium and the MuTHER Consortium and the CARDIoGRAM Consortium and the C4D Consortium and the DIAGRAM Consortium and the GIANT Consortium and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Diabetes, ISSN 0012-1797, 2011, Volume 60, Issue 10, pp. 2624 - 2634
Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose... 
POPULATION | TCF7L2 | GLUCOSE-HOMEOSTASIS | OBESITY | METAANALYSIS | ENDOCRINOLOGY & METABOLISM | SUSCEPTIBILITY LOCI | RISK | CORONARY HEART-DISEASE | INSULIN SENSITIVITY | BETA-CELL FUNCTION | Proinsulin - blood | Diabetes Mellitus, Type 2 - genetics | Humans | Genotype | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Genetic Variation | Diabetes Mellitus, Type 2 - blood | Fasting - blood | Polymorphism, Single Nucleotide - genetics | Adult | Female | Genome, Human | Type 2 diabetes | Genetic susceptibility | Genetic variation | Physiological aspects | Genetic aspects | Research | Health aspects | Risk factors | Genetics | Medical and Health Sciences | Medicin och hälsovetenskap
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