X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (14) 14
rats (9) 9
male (8) 8
rats, sprague-dawley (8) 8
mice (7) 7
index medicus (6) 6
neurosciences (6) 6
cytokines (5) 5
neuropathic pain (5) 5
astrocytes (4) 4
hyperalgesia (4) 4
hyperalgesia - drug therapy (4) 4
microglial activation (4) 4
neuroimmune activation (4) 4
pain (4) 4
rna, messenger - biosynthesis (4) 4
alzheimers-disease (3) 3
amyloid precursor protein secretases - metabolism (3) 3
anesthesiology (3) 3
chemistry, medicinal (3) 3
chemistry, organic (3) 3
cytokines - genetics (3) 3
dose-response relationship, drug (3) 3
hypersensitivity (3) 3
mice, inbred c57bl (3) 3
mice, transgenic (3) 3
nerve injury (3) 3
pain threshold - drug effects (3) 3
pain threshold - physiology (3) 3
proinflammatory cytokines (3) 3
γ-secretase (3) 3
agriculture (2) 2
allodynia (2) 2
alzheimer disease - drug therapy (2) 2
alzheimer's disease (2) 2
alzheimer’s disease (2) 2
amyloid beta-peptides - metabolism (2) 2
analgesics - pharmacology (2) 2
analgesics - therapeutic use (2) 2
analysis of variance (2) 2
animal husbandry (2) 2
beer (2) 2
behavior, animal (2) 2
behavior, animal - physiology (2) 2
biochemistry (2) 2
care of birds, fishes, insects (2) 2
chemistry (2) 2
chemokines (2) 2
clinical neurology (2) 2
compositions thereof (2) 2
culture media (2) 2
cytokines - biosynthesis (2) 2
cytokines - metabolism (2) 2
disease models, animal (2) 2
enzymology (2) 2
fishing (2) 2
forestry (2) 2
gamma-secretase (2) 2
gene expression - drug effects (2) 2
glia (2) 2
glial activation (2) 2
human necessities (2) 2
humans (2) 2
hunting (2) 2
hygiene (2) 2
hyperalgesia - genetics (2) 2
hyperalgesia - metabolism (2) 2
inflammation - drug therapy (2) 2
inflammation - immunology (2) 2
innate immunity (2) 2
medical or veterinary science (2) 2
metallurgy (2) 2
mice, inbred c3h (2) 2
mice, knockout (2) 2
microbiology (2) 2
microglia (2) 2
microglia - metabolism (2) 2
microorganisms or enzymes (2) 2
model (2) 2
morphine - pharmacology (2) 2
mutation or genetic engineering (2) 2
nerves (2) 2
neuralgia - metabolism (2) 2
neuroglia - drug effects (2) 2
neuroglia - metabolism (2) 2
neuroimmunomodulation - physiology (2) 2
neurology (2) 2
new breeds of animals (2) 2
organic chemistry (2) 2
pain - drug therapy (2) 2
pain measurement (2) 2
peptide fragments - metabolism (2) 2
peptides (2) 2
peripheral-nerve injury (2) 2
persistent pain (2) 2
pharmacology & pharmacy (2) 2
piperidines - chemistry (2) 2
preparations for medical, dental, or toilet purposes (2) 2
propagating, preserving or maintaining microorganisms (2) 2
propentofylline (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 08/2003, Volume 306, Issue 2, pp. 624 - 630
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2005, Volume 102, Issue 16, pp. 5856 - 5861
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 02/2004, Volume 29, Issue 2, pp. 327 - 334
The activation of glial cells and enhanced proinflammatory cytokine expression at the spinal cord has been implicated in the development of morphine tolerance,... 
Tolerance | Morphine | Propentofylline | Cytokines | Glia | Hyperalgesia | NEUROIMMUNE ACTIVATION | MICROGLIAL ACTIVATION | OPIOID ANTINOCICEPTIVE TOLERANCE | GLIAL ACTIVATION | PSYCHIATRY | PATHOLOGICAL PAIN | glia | NEUROSCIENCES | morphine | PERIPHERAL-NERVE INJURY | NEUROPATHIC PAIN | ABNORMAL PAIN | propentofylline | GLUTAMATE TRANSPORTERS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | cytokines | hyperalgesia | tolerance | Neuroprotective Agents - therapeutic use | Glial Fibrillary Acidic Protein - genetics | Morphine Dependence - genetics | Spinal Cord - drug effects | Spinal Cord - metabolism | Drug Tolerance - genetics | Substance Withdrawal Syndrome - drug therapy | Male | Xanthines - therapeutic use | Glial Fibrillary Acidic Protein - metabolism | Behavior, Animal | RNA, Messenger - biosynthesis | Drug Interactions | Inflammation - drug therapy | Reaction Time - drug effects | Reverse Transcriptase Polymerase Chain Reaction - methods | Substance Withdrawal Syndrome - genetics | Macrophage-1 Antigen - metabolism | Morphine Dependence - drug therapy | Cytokines - genetics | Enzyme-Linked Immunosorbent Assay | Morphine - pharmacology | Rats | Substance Withdrawal Syndrome - complications | Inflammation - immunology | Inflammation - etiology | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Animals | Analysis of Variance | Hyperalgesia - drug therapy | Hyperalgesia - genetics | Macrophage-1 Antigen - genetics | Hyperalgesia - etiology | Inflammation - genetics | Pain Measurement
Journal Article
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 7, pp. 2279 - 2282
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 04/2005, Volume 102, Issue 16, p. 5856
astrocytes | behavioral hypersensitivity | microglial activation | nerve injury | neuropathic pain 
Astrocytes | Nerves | Research | Peripheral nerve diseases | Injuries
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2005, Volume 102, Issue 16, p. 5856
  Neuropathic pain remains a prevalent and persistent clinical problem because of our incomplete understanding of its pathogenesis. This study demonstrates for... 
Neurology | Pain | Cytokines | Gene expression | Immune system
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 04/2005, Volume 102, Issue 16, pp. 5856 - 5861
Neuropathic pain remains a prevalent and persistent clinical problem because of our incomplete understanding of its pathogenesis. This study demonstrates for... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2012, Volume 22, Issue 9, pp. 3203 - 3207
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2004, Volume 88, Issue 3, pp. 746 - 758
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 01/2010, Volume 20, Issue 2, pp. 755 - 758
We report herein a novel series of difluoropiperidine acetic acids as modulators of g-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was... 
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 04/2010, Volume 20, Issue 7, pp. 2279 - 2282
The development of a novel series of purines as g-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein.... 
Journal Article