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1. Full Text Swi1 Timeless Prevents Repeat Instability at Fission Yeast Telomeres
by Gadaleta, Mariana C and Das, Mukund M and Tanizawa, Hideki and Chang, Ya-Ting and Noma, Ken-Ichi and Nakamura, Toru M and Noguchi, Eishi
PLoS Genetics, ISSN 1553-7390, 03/2016, Volume 12, Issue 3
  Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication... 
Medical research | Yeast | Genomics | Genomes | Defects | Proteins | Cell cycle | Software | Genetic testing | Charitable foundations | Localization | Chromosomes | Telomerase | Deoxyribonucleic acid--DNA | Cancer | Deoxyribonucleic acid | DNA
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2. Full Text Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
by Minami, Takuma and Tachikawa, Ryo and Matsumoto, Takeshi and Murase, Kimihiko and Tanizawa, Kiminobu and Inouchi, Morito and Handa, Tomohiro and Oga, Toru and Hirai, Toyohiro and Chin, Kazuo
PLoS ONE, ISSN 1932-6203, 09/2019, Volume 14, Issue 9, p. e0222592
The association of obstructive sleep apnea (OSA) with hypothalamic pituitary adrenal (HPA) axis activation has not been fully understood from results of... 
Usage | Sleep apnea syndromes | Diagnosis | Adrenal glands | Multivariate analysis | Health aspects | Volumetric analysis | Menopause | Nervous system | Sleep apnea | Hypothalamus | Hormones | Mental depression | Metabolic syndrome | Sleep disorders | Airway management | Apnea | Computed tomography | Arousal | Physiology | Blood pressure | Adrenal gland | Desaturation | Neuromuscular diseases | Parameters | Hypothalamic-pituitary-adrenal axis | Regression analysis | Stress | Abdomen | Medicine | Studies | Sleep | Pituitary | Hypoxia
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3. Full Text Changes in energy metabolism after continuous positive airway pressure for obstructive sleep apnea
by Tachikawa, Ryo and Ikeda, Kaori and Minami, Takuma and Matsumoto, Takeshi and Hamada, Satoshi and Murase, Kimihiko and Tanizawa, Kiminobu and Inouchi, Morito and Oga, Toru and Akamizu, Takashi and Mishima, Michiaki and Chin, Kazuo
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2016, Volume 194, Issue 6, pp. 729 - 738
Rationale: Disrupted energy homeostasis in obstructive sleep apnea (OSA) may lead to weight gain. Paradoxically, treating OSA with continuous positive airway... 
Energy balance | Appetite-regulating hormones | Body weight | Eating behavior | Basal metabolic rate | VISCERAL FAT | CPAP TREATMENT | appetite-regulating hormones | basal metabolic rate | WEIGHT-LOSS | energy balance | eating behavior | HISTORY QUESTIONNAIRES | body weight | GHRELIN LEVELS | COGNITIVE DIETARY RESTRAINT | JAPANESE ADULTS | RESPIRATORY SYSTEM | PHYSICAL-ACTIVITY | PLASMA LEPTIN | OBESE INDIVIDUALS | CRITICAL CARE MEDICINE | Continuous Positive Airway Pressure | Sleep Apnea, Obstructive - therapy | Humans | Middle Aged | Male | Insulin-Like Growth Factor I - analysis | Polysomnography | Energy Intake | Sleep Apnea, Obstructive - metabolism | Ghrelin - blood | Norepinephrine - blood | Exercise | Leptin - blood | Energy Metabolism | Basal Metabolism | Female | Hydrocortisone - blood
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4. Full Text Impact of Obstructive Sleep Apnea on Abdominal Aortic Diameters
by Tachikawa, Ryo, MD and Hamada, Satoshi, MD and Azuma, Masanori, MD and Toyama, Yoshiro, MD and Murase, Kimihiko, MD and Tanizawa, Kiminobu, MD, PhD and Inouchi, Morito, MD and Handa, Tomohiro, MD, PhD and Oga, Toru, MD, PhD and Mishima, Michiaki, MD, PhD and Chin, Kazuo, MD, PhD
American Journal of Cardiology, The, ISSN 0002-9149, 2014, Volume 114, Issue 4, pp. 618 - 623
Although obesity has been reported to be a potential risk factor for abdominal aortic dilatation, the impact of obstructive sleep apnea (OSA) on the abdominal... 
Cardiovascular | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | HEART HEALTH | CARDIOVASCULAR-DISEASE | ANEURYSM | HYPERTENSION | ASSOCIATION | Aortic Aneurysm, Abdominal - diagnosis | Severity of Illness Index | Sleep Apnea, Obstructive - physiopathology | Prognosis | Cross-Sectional Studies | Follow-Up Studies | Obesity - complications | Humans | Middle Aged | Risk Factors | Male | Obesity - physiopathology | Sleep Apnea, Obstructive - complications | Tomography, X-Ray Computed | Polysomnography | Aorta, Abdominal - diagnostic imaging | Female | Obesity - diagnosis | Retrospective Studies | Sleep Apnea, Obstructive - diagnosis | Aortic Aneurysm, Abdominal - etiology | Analysis | Sleep apnea syndromes | Hypertension | Cardiovascular disease | Sleep apnea | Regression analysis | Cholesterol | Risk factors | Abdomen | Sleep disorders | Body mass index | Mens health | Hypotheses | Diabetes | Drug therapy | Age | Statins
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5. Full Text A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy
by Sanjo, Nobuo and Nose, Yurie and Shishido-Hara, Yukiko and Mizutani, Saneyuki and Sekijima, Yoshiki and Aizawa, Hitoshi and Tanizawa, Toru and Yokota, Takanori
Journal of Neurology, ISSN 0340-5354, 02/2019, Volume 266, Issue 2, pp. 369 - 377
ObjectiveIn the present study, we analyzed the inflammatory profiles of brain tissues obtained from patients with progressive multifocal leukoencephalopathy... 
IRIS | Regulatory plasma cell | CD4:CD8 ratio | JC virus | PML | Progressive multifocal leukoencephalopathy | MEFLOQUINE | CEREBROSPINAL-FLUID | CLINICAL-COURSE | CLINICAL NEUROLOGY | JC VIRUS LOAD | MULTIPLE-SCLEROSIS | DISEASE | CD4(+) | Plasma cells | Research | T cells | Health aspects | Immune system | Immunohistochemistry | Plasma | VP1 protein | Prognosis | PD-1 protein | CD8 antigen | Lymphocytes T | Inflammation | Cerebrospinal fluid | Leukoencephalopathy | CD4 antigen | Biopsy | Autopsy | Medical prognosis | Human immunodeficiency virus--HIV | PD-L1 protein | Surface markers | Brain injury | Movement disorders
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6. Full Text Associations of obstructive sleep apnea with truncal skeletal muscle mass and density
by Matsumoto, Takeshi and Tanizawa, Kiminobu and Tachikawa, Ryo and Murase, Kimihiko and Minami, Takuma and Inouchi, Morito and Handa, Tomohiro and Oga, Toru and Hirai, Toyohiro and Chin, Kazuo
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 6550 - 8
Sarcopenia has been associated with several conditions relevant to obstructive sleep apnea (OSA), such as aging and obesity, but a direct relationship between... 
CANCER-PATIENTS | MULTIDISCIPLINARY SCIENCES | ATTENUATION | SARCOPENIA | QUALITY-OF-LIFE | BODY-COMPOSITION | GENDER-DIFFERENCES | PULMONARY-DISEASE | COMPUTED-TOMOGRAPHY | SEVERITY | ABDOMINAL FAT | Women | Obesity | Adipose tissue | Sleep apnea | Skeletal muscle | Sarcopenia | Body mass index | Sleep disorders | Musculoskeletal system | Sleep | Apnea | Computed tomography | Aging
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7. Full Text HRCT features of interstitial lung disease in dermatomyositis with anti-CADM-140 antibody
by Tanizawa, Kiminobu and Handa, Tomohiro and Nakashima, Ran and Kubo, Takeshi and Hosono, Yuji and Watanabe, Kizuku and Aihara, Kensaku and Oga, Toru and Chin, Kazuo and Nagai, Sonoko and Mimori, Tsuneyo and Mishima, Michiaki
Respiratory Medicine, ISSN 0954-6111, 2011, Volume 105, Issue 9, pp. 1380 - 1387
Summary Background Anti-CADM-140 antibody (anti-CADM-140), also referred to as anti-melanoma differentiation-associated gene 5 (MDA5) antibody, is a... 
Pulmonary/Respiratory | Amyopathic dermatomyositis | Interstitial lung disease | High-resolution computed tomography | Anti-CADM-140 antibody | AUTOANTIBODIES | CARDIAC & CARDIOVASCULAR SYSTEMS | PNEUMONIA | SOCIETY | RESPIRATORY SYSTEM | POLYMYOSITIS-DERMATOMYOSITIS | THIN-SECTION CT | IDIOPATHIC PULMONARY-FIBROSIS | ACUTE EXACERBATION | Prognosis | Humans | Middle Aged | Peptides - immunology | Male | Tomography, X-Ray Computed | Dermatomyositis - diagnostic imaging | Dermatomyositis - complications | Lung Diseases, Interstitial - diagnostic imaging | Lung Diseases, Interstitial - immunology | Autoantibodies - immunology | Dermatomyositis - immunology | Female | Retrospective Studies | Viral antibodies | Medical colleges | Lung diseases | Dermatomyositis | Antibodies | Respiratory agents | Diagnostic imaging | Proteins | Hospitals | Consolidation | Statistical analysis | Disease | Standard deviation | Clinical medicine | Kinases | Personal relationships | Blood
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8. Full Text Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres
by Gadaleta, Mariana C and Das, Mukund M and Tanizawa, Hideki and Chang, Ya-Ting and Noma, Ken-ichi and Nakamura, Toru M and Noguchi, Eishi
PLoS genetics, ISSN 1553-7404, 03/2016, Volume 12, Issue 3, p. e1005943
Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication... 
Genomic Instability | Repetitive Sequences, Nucleic Acid - genetics | Microsatellite Instability | Schizosaccharomyces pombe Proteins - genetics | Humans | DNA-Binding Proteins - genetics | Telomere Homeostasis | Telomere Shortening - genetics | Rad52 DNA Repair and Recombination Protein - genetics | Schizosaccharomyces - genetics | Telomere-Binding Proteins - genetics | Heterochromatin - genetics | Cell Cycle Proteins - genetics | DNA Replication - genetics | Telomere - genetics
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9. Full Text Role of mitochondrial hydrogen peroxide induced by intermittent hypoxia in airway epithelial wound repair in vitro
by Hamada, Satoshi and Sato, Atsuyasu and Hara-Chikuma, Mariko and Satooka, Hiroki and Hasegawa, Koichi and Tanimura, Kazuya and Tanizawa, Kiminobu and Inouchi, Morito and Handa, Tomohiro and Oga, Toru and Muro, Shigeo and Mishima, Michiaki and Chin, Kazuo
Experimental Cell Research, ISSN 0014-4827, 05/2016, Volume 344, Issue 1, pp. 143 - 151
The airway epithelium acts as a frontline barrier against various environmental insults and its repair process after airway injury is critical for the lung... 
Wound repair | Intermittent hypoxia | Reactive oxygen species | Transcription-independent manner | Actin cytoskeleton | RhoA | TRANSFORMATION | OXIDATIVE STRESS | SUPEROXIDE | SLEEP-APNEA | MECHANISMS | CELL BIOLOGY | ONCOLOGY | REDOX REGULATION | RAC | CELL-MIGRATION | RHO GTPASES | Cell Line | Lung - pathology | Actin Cytoskeleton - metabolism | Epithelial Cells - metabolism | Humans | Epithelial Cells - pathology | rhoA GTP-Binding Protein - metabolism | Mitochondria - metabolism | Wound Healing | Cell Adhesion | Hydrogen Peroxide - metabolism | Cell Hypoxia | Focal Adhesions - metabolism | Enzyme Activation | Cell Movement | Medical colleges | Care and treatment | Hydrogen peroxide | Muscle proteins | Wounds and injuries | Oxidases | Actin | Analysis | Superoxide | Signal transduction | Transcription factors | Morphology | Homeostasis | Hypoxia | Respiratory system | Cell adhesion & migration
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10. Changes in habitual sleep duration after continuous positive airway pressure for obstructive sleep apnea
by Tachikawa, Ryo and Minami, Takuma and Matsumoto, Takeshi and Murase, Kimihiko and Tanizawa, Kiminobu and Inouchi, Morito and Oga, Toru and Chin, Kazuo
Annals of the American Thoracic Society, ISSN 2325-6621, 06/2017, Volume 14, Issue 6, pp. 986 - 993
Rationale: Obstructive sleep apnea (OSA) can affect not only sleep quality but also sleep duration. Determining the therapeutic effects of continuous positive... 
Actigraphy | Sleep quality | Phenotype | Sleep time | Sleep habit | phenotype | sleep habit | AMERICAN ACADEMY | POPULATION | AASM | ADULTS | PARAMETERS | MEDICINE | RESPIRATORY SYSTEM | sleep time | actigraphy | UPDATE | VALIDITY | sleep quality | Continuous Positive Airway Pressure | Severity of Illness Index | Sleep Apnea, Obstructive - therapy | Multivariate Analysis | Prospective Studies | Humans | Japan | Middle Aged | Anxiety - psychology | Linear Models | Male | Polysomnography | Psychiatric Status Rating Scales | Time Factors | Depression - psychology | Quality of Life | Sleep Stages - physiology | Female | Surveys and Questionnaires | Aged | Sleep - physiology | Sleep Apnea, Obstructive - psychology
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11. Full Text The prognostic value of HRCT in myositis-associated interstitial lung disease
by Tanizawa, Kiminobu and Handa, Tomohiro and Nakashima, Ran and Kubo, Takeshi and Hosono, Yuji and Aihara, Kensaku and Ikezoe, Kohei and Watanabe, Kizuku and Taguchi, Yoshio and Hatta, Kazuhiro and Oga, Toru and Chin, Kazuo and Nagai, Sonoko and Mimori, Tsuneyo and Mishima, Michiaki
Respiratory Medicine, ISSN 0954-6111, 2013, Volume 107, Issue 5, pp. 745 - 752
Summary Background Polymyositis and dermatomyositis-associated interstitial lung disease (PM/DM-ILD) can have variable courses. We evaluated the prognostic... 
Pulmonary/Respiratory | Anti-aminoacyl-tRNA synthetase antibodies | Polymyositis | Interstitial lung disease | High-resolution computed tomography | Dermatomyositis | Anti-CADM-140 antibody | AMYOPATHIC DERMATOMYOSITIS | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPUTED-TOMOGRAPHY FINDINGS | PNEUMONIA | FEATURES | RESPIRATORY SYSTEM | POLYMYOSITIS-DERMATOMYOSITIS | THIN-SECTION CT | IDIOPATHIC PULMONARY-FIBROSIS | EXPRESSION | ACUTE EXACERBATION | Lung Diseases, Interstitial - etiology | Glucocorticoids - therapeutic use | Prognosis | Autoantibodies - blood | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Peptides - immunology | Tomography, X-Ray Computed - methods | Male | Polymyositis - complications | Treatment Outcome | Myositis - complications | Biomarkers - blood | Dermatomyositis - complications | Myositis - immunology | Lung Diseases, Interstitial - diagnostic imaging | Lung Diseases, Interstitial - immunology | Survival Analysis | Adult | Female | Aged | Retrospective Studies | Medical colleges | Diagnostic imaging | Lung diseases | Disease | Review boards | Mortality | Kinases | Multivariate analysis | Fever | Confidence intervals | Hospitals | Consolidation | Tomography | Carbon monoxide | Scleroderma
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12. Full Text Can the Sarcoidosis Health Questionnaire predict the long-term outcomes in Japanese sarcoidosis patients?
by Tanizawa, Kiminobu and Handa, Tomohiro and Nagai, Sonoko and Oga, Toru and Kubo, Takeshi and Ito, Yutaka and Aihara, Kensaku and Ikezoe, Kohei and Sokai, Akihiko and Nakatsuka, Yoshinari and Hirai, Toyohiro and Chin, Kazuo and Mishima, Michiaki and Izumi, Takateru
Respiratory Medicine, ISSN 0954-6111, 03/2019, Volume 149, pp. 1 - 8
The Sarcoidosis Health Questionnaire (SHQ) is the first sarcoidosis-specific health status questionnaire ever developed. Worse health status, as evaluated by... 
Health-related quality of life | Health status | Questionnaire | Sarcoidosis | Outcomes | CARDIAC & CARDIOVASCULAR SYSTEMS | RESPIRATORY SYSTEM | DISEASE | VALIDATION | QUALITY-OF-LIFE | SF-36 | Medicine, Experimental | Medical research | Health surveys | Heart | Respiratory function | Risk factors | Confidence intervals | Variables | Ultrasonic imaging | Dyspnea | Questionnaires | Electrocardiography | Bioindicators | EKG | Enzymes | Echocardiography | Cytokines | Adjustment | Health | Risk analysis | Patients | Studies | Biopsy | Deterioration | Radiographs | Pulmonary functions | Conditioned stimulus | Biomarkers | Ventricle | Ejection
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13. Full Text Cluster‐randomized trial to improve the quality of diabetes management: The study for the efficacy assessment of the standard diabetes manual (SEAS‐DM)
by Noto, Hiroshi and Tanizawa, Yukio and Aizawa, Toru and Sone, Hirohito and Yoshioka, Narihito and Terauchi, Yasuo and Inagaki, Nobuya and Noda, Mitsuhiko
Journal of Diabetes Investigation, ISSN 2040-1116, 07/2016, Volume 7, Issue 4, pp. 539 - 543
Aims/Introduction ‘The Standard Diabetes Manual’ has been developed by clinical researchers from multiple major institutions in Japan, such as the National... 
Randomized trial | Quality indicator | Disease management | METAANALYSIS | ENDOCRINOLOGY & METABOLISM | DISEASE-MANAGEMENT | CARE | Diabetes Mellitus - therapy | Humans | Middle Aged | Female | Male | Treatment Outcome | Aged | Diabetes Mellitus - diagnosis | Physicians, Primary Care | Program Evaluation | Quality Assurance, Health Care | Corticosteroids | Analysis | Albumin | Hypoglycemic agents | Standards | Diabetes therapy | Quality management | Intervention | Creatinine | Excretion | Retinopathy | Physicians | Research & development--R&D | Diabetes mellitus | Lipids | Management | Patients | Primary care | Clinical outcomes | Studies | Quality | Quality control | Hemoglobin | Blood pressure | Diabetes | Clinical Trial
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14. Full Text The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies
by Tanizawa, Kiminobu and Handa, Tomohiro and Nakashima, Ran and Kubo, Takeshi and Hosono, Yuji and Watanabe, Kizuku and Aihara, Kensaku and Ikezoe, Kohei and Sokai, Akihiko and Nakatsuka, Yoshinari and Taguchi, Yoshio and Hatta, Kazuhiro and Noma, Satoshi and Kobashi, Yoich