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Biophysical Journal, ISSN 0006-3495, 02/2018, Volume 114, Issue 3, pp. 24a - 24a
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 11/2018, Volume 430, Issue 23, pp. 4636 - 4649
Eukaryotic cells are known to contain a wide variety of RNA–protein assemblies, collectively referred to as RNP granules. RNP granules form from a combination... 
RNA | phase separation | intrinsically disordered regions | LIQUID PHASE-SEPARATION | PRION-LIKE DOMAINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIZE | ALS | DISORDERED PROTEIN | DROPLETS | TRANSITION | P-BODIES | MUTATIONS | STRESS GRANULES | Proteins
Journal Article
Science, ISSN 0036-8075, 2019, Volume 363, Issue 6431, pp. 1036 - 1037
Transmission of signals from external stimuli into the interior of cells relies on complex signaling pathways that must be efficient and precise—every facet of... 
RECRUITMENT | MULTIDISCIPLINARY SCIENCES | LAT | Bulk density | Membranes | Phosphorylation | Phase transformations | Stochastic processes | Activation | Clustering | Phase transitions | Signal transduction | Signaling | Receptors | Pathways | External stimuli | Dwell time | Effectors | Transduction | Stochasticity
Journal Article
Cell, ISSN 0092-8674, 01/2019, Volume 176, Issue 3, pp. 419 - 434
Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells. This realization has... 
INTRINSICALLY DISORDERED PROTEINS | SEQUENCE DETERMINANTS | RNA | FUS | PHOSPHORYLATION | NUCLEAR IMPORT RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEX COACERVATION | GRANULES | BINDING | DROPLETS | CELL BIOLOGY | Marine biology | Analysis | Cells
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2018, Volume 20, Issue 6, pp. 635 - 637
Phase separation can build assemblies and regulate biological function. Two articles link specific forms of protein and RNA degradation to phase separation.... 
Proteins | Nervous system diseases | MicroRNA | Research | Slicing | Ribonucleic acid--RNA | Metals | Phase separation | MiRNA
Journal Article
Biochemistry, ISSN 0006-2960, 05/2018, Volume 57, Issue 17, pp. 2478 - 2487
Journal Article
The FEBS journal, ISSN 1742-464X, 09/2019
The dysregulation of ubiquitin-mediated proteasomal degradation has emerged as an important mechanism of pathogenesis in several cancers. The Speckle-type POZ... 
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 02/2007, Volume 17, Issue 1, pp. 3 - 14
Journal Article
Neuron, ISSN 0896-6273, 08/2017, Volume 95, Issue 4, pp. 808 - 816.e9
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and... 
low-complexity domain | liquid-liquid phase separation | TDP-43 | T cell-restricted intracellular antigen-1 | stress granules | frontotemporal dementia | amyotrophic lateral sclerosis | membrane-less organelle | frontotemporal lobar degeneration | MULTISYSTEM PROTEINOPATHY | DISTAL MYOPATHY | MESSENGER-RNA | LIQUID DROPLETS | SEQUENCING DATA | HEXANUCLEOTIDE REPEAT | DOMAINS | C9ORF72 | NEUROSCIENCES | FAMILIAL ALS | Humans | Middle Aged | Family Health | Male | Green Fluorescent Proteins - genetics | DNA-Binding Proteins - metabolism | Transfection | Time Factors | Adult | Female | T-Cell Intracellular Antigen-1 | Frontotemporal Dementia - pathology | Frontotemporal Dementia - genetics | Stress, Physiological - physiology | Green Fluorescent Proteins - metabolism | Poly(A)-Binding Proteins - genetics | Amyotrophic Lateral Sclerosis - genetics | Heterogeneous-Nuclear Ribonucleoprotein Group A-B - metabolism | RNA-Binding Protein FUS - metabolism | Mutation - genetics | Heterogeneous Nuclear Ribonucleoprotein A1 | Microscopy, Confocal | Amyotrophic Lateral Sclerosis - pathology | Aged | HeLa Cells | Nervous system diseases | RNA | Analysis | Genetic research | Development and progression | Amyotrophic lateral sclerosis | Genetic aspects | T cells | Binding proteins | Protein binding | Dementia | Disease | Pathogenesis | Genes | Disorders | Lymphocytes T | Phase transitions | Proteins | Consortia | DNA-binding protein | Etiology | Dementia disorders | Age | Deoxyribonucleic acid--DNA | Phase transformations | Neurodegenerative diseases | Metabolism | Ribonucleic acid--RNA | Pathology | Phase separation | Mutation | Frontotemporal dementia | Dismantling | Phase transition | T-cell-restricted intracellular antigen-1
Journal Article