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Journal Article
Nature Biotechnology, ISSN 1087-0156, 10/2018, Volume 36, Issue 9, pp. 880 - 898
Protein interaction networks and protein compartmentalization underlie all signaling and regulatory processes in cells. Enzyme-catalyzed proximity labeling... 
REPORTER | TOPOLOGY | PEROXIDASE | CAENORHABDITIS-ELEGANS | PROTEIN | BIOTIN REPRESSOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | KINASE | COMPONENTS | IDENTIFICATION | GENE ONTOLOGY | Proteins | Enzymes | Usage | Physiological aspects | Observations | Affinity labeling | Methods | Organic chemistry | Yeast | Directed evolution | Cell permeability | Toxicity | Cells (biology) | Labelling | Biotin | Labeling | Mutants | Yeasts | Index Medicus
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 01/2020, Volume 11, Issue 1, pp. 359 - 11
Protein ubiquitylation is involved in a plethora of cellular processes. While antibodies directed at ubiquitin remnants (K--GG) have improved the ability to... 
COMPLEX | PROTEIN-DEGRADATION | MULTIDISCIPLINARY SCIENCES | ENRICHMENT | UBIQUITIN SYSTEM | IDENTIFICATION | MASS-SPECTROMETRY | Multiplexing | Ubiquitin | Spectroscopy | Profiling | Ionic mobility | Antibodies | Waveforms | Ions | Mass spectroscopy | Breast cancer | Tissues | Depth profiling | Substrates | Proteins | Proteomics | Measurement methods | Scientific imaging | Mass spectrometry | Ubiquitin-protein ligase
Journal Article
Science, ISSN 0036-8075, 10/2014, Volume 346, Issue 6205, pp. 85 - 89
Cancer genome characterization has revealed driver mutations in genes that govern ubiquitylation; however, the mechanisms by which these alterations promote... 
REPORTS | CELLS | MULTIDISCIPLINARY SCIENCES | ADAPTER | GENES | DEGRADATION | RECEPTOR | MUTATIONS | TUMORIGENESIS | DEK ONCOGENE | LIGASE | Development and progression | Genetic aspects | Gene mutations | Ubiquitin-proteasome system | Identification and classification | Prostate cancer | Tumorigenesis | Mutation | Genomics | Proteomics | Degradation | Proteins | Mutations | Effectors | Prostate | Substrates | Tumors | Cancer
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2014, Volume 55, Issue 2, pp. 332 - 341
Obtaining complete protein inventories for subcellular regions is a challenge that often limits our understanding of cellular function, especially for regions... 
AUTOPHAGOSOMES | COMPLEX | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM UNIPORTER | BIOLOGY | CA2+ UPTAKE | MICU1 | PROTEINS | ENCODED FLUORESCENT REPORTERS | LIVING CELLS | CELL BIOLOGY | Cell Fractionation | Mitochondrial Proteins - metabolism | Humans | HEK293 Cells | Isotope Labeling | Proteome - metabolism | Blotting, Western | Mitochondrial Membranes - metabolism | Proteins | Analysis
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2017, Volume 23, Issue 9, pp. 1046 - 1054
It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses. Cancer genome studies have identified... 
MEDICINE, RESEARCH & EXPERIMENTAL | BROMODOMAIN INHIBITORS | ENDOMETRIAL CARCINOMAS | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | TUMORS | CELL BIOLOGY | BREAST-CANCER | GENOMIC LANDSCAPE | PROSTATE-CANCER | RESISTANCE | MUTATIONS | Immunohistochemistry | Neoplasms, Cystic, Mucinous, and Serous - metabolism | Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Immunoprecipitation | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Epigenesis, Genetic | Humans | Endometrial Neoplasms - metabolism | Drug Resistance, Neoplasm | Immunoblotting | Male | Molecular Targeted Therapy | Carcinoma, Endometrioid - metabolism | Neoplasms, Cystic, Mucinous, and Serous - genetics | Ubiquitination | Prostatic Neoplasms - genetics | Endometrial Neoplasms - genetics | Mass Spectrometry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Chromatography, Liquid | Cullin Proteins - metabolism | Female | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | RNA-Binding Proteins - antagonists & inhibitors | Acetanilides - pharmacology | Carcinoma, Endometrioid - genetics | Carcinosarcoma - metabolism | Adenocarcinoma, Clear Cell - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Mice, Nude | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Carcinosarcoma - genetics | Cell Proliferation - drug effects | Mutation | Adenocarcinoma, Clear Cell - genetics | RNA-Binding Proteins - metabolism | Care and treatment | Gene mutations | Proteolysis | Physiological aspects | Genetic aspects | Research | Cancer | Ubiquitin | Biodegradation | Inhibitor drugs | Endometrial cancer | Genomes | Pharmacology | Substrates | Mutants | Degradation | Proteins | Sensitivity | Missense mutation | Inhibitors | Bet protein | Gene mapping | Prostate cancer | Prostate | Endometrium | Ubiquitin-protein ligase
Journal Article
Nature Methods, ISSN 1548-7091, 12/2017, Volume 14, Issue 12, pp. 1167 - 1170
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 07/2018, Volume 32, Issue 13-14, pp. 929 - 943
While a mutation in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning the function... 
Autoimmunity | SMCR8 | Amyotrophic lateral sclerosis (ALS) | Autophagy | C9ORF72 | Lysosome | ANTIBODIES | autophagy | ALS | IGG | TOXICITY | DEVELOPMENTAL BIOLOGY | AMYOTROPHIC-LATERAL-SCLEROSIS | IDENTIFICATION | amyotrophic lateral sclerosis (ALS) | CELL BIOLOGY | TRANSCRIPTS | C9ORF72 HEXANUCLEOTIDE REPEAT | autoimmunity | EXPANSION | DISEASE | GENETICS & HEREDITY | lysosome | Research Paper
Journal Article