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Immunity, ISSN 1074-7613, 06/2013, Volume 38, Issue 6, pp. 1154 - 1163
Journal Article
Nature, ISSN 0028-0836, 03/2006, Volume 440, Issue 7081, pp. 237 - 241
Journal Article
Immunity, ISSN 1074-7613, 02/2011, Volume 34, Issue 2, pp. 213 - 223
Type I interferon (IFN) is a common therapy for autoimmune and inflammatory disorders, yet the mechanisms of action are largely unknown. Here we showed that... 
FAMILIAL MEDITERRANEAN FEVER | MULTIPLE-SCLEROSIS | CASPASE-1 | HOST-DEFENSE | INNATE | CRYSTALS | RECOMBINANT INTERLEUKIN-1 | MICE | BACTERIAL-INFECTION | IMMUNOLOGY | RECEPTOR ANTAGONIST | Interleukin-1 - genetics | Inflammasomes - metabolism | STAT1 Transcription Factor - deficiency | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Monocytes - metabolism | Monocytes - immunology | Interleukin-10 - physiology | Interleukin-1 - biosynthesis | Interferon-beta - therapeutic use | Interferon Type I - biosynthesis | STAT3 Transcription Factor - physiology | Candida albicans - physiology | Interferon Type I - physiology | Caspase 1 - physiology | Candidiasis - immunology | Carrier Proteins - physiology | Peritonitis - etiology | STAT1 Transcription Factor - physiology | Poly I-C - pharmacology | Disease Susceptibility | Mice, Inbred C57BL | Peritonitis - immunology | STAT1 Transcription Factor - genetics | Gene Expression Regulation - drug effects | Animals | Candidiasis - etiology | Caspase 1 - genetics | Caspase 1 - deficiency | Interferon Type I - genetics | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Apoptosis Regulatory Proteins - physiology | Cells, Cultured - metabolism | Mice | Interferon Inducers - pharmacology | Multiple Sclerosis - drug therapy | Interferon | Infections | Cytokines | Viral infections | Molecular weight | Immune system | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Neurodegenerative diseases | Secretion | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Immune systems | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2009, Volume 459, Issue 7245, pp. 433 - 436
Fungal infections represent a serious threat, particularly in immunocompromised patients. Interleukin-1 (IL-1 ) is a key pro-inflammatory factor in innate... 
RHEUMATOID-ARTHRITIS | CELLS | ACTIVATION | CANDIDA-ALBICANS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | RECEPTOR | MICE | INHIBITOR | NALP3 INFLAMMASOME | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Monocytes - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Tyrosine Kinases - deficiency | Intracellular Signaling Peptides and Proteins - deficiency | Protein-Tyrosine Kinases - genetics | Candida albicans - physiology | Interleukin-1beta - biosynthesis | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Inflammation - immunology | Candida albicans - immunology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Mice | Nigericin - pharmacology | Enzyme Activation | Protein-Tyrosine Kinases - antagonists & inhibitors | Mycoses | Research | Properties | Phosphotransferases | Cellular control mechanisms | Proteins | Studies | Fungi | E coli | Research & development--R&D | Clinical trials | Pattern recognition | Kinases | Cells | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2009, Volume 460, Issue 7252, pp. 269 - 273
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 48, pp. 17254 - 17259
Inflammasomes are caspase-1-activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b)... 
Dendritic cells | Secretion | Cell death | Anthrax | Peritoneal macrophages | Toxins | Mice | Intoxication | Macrophages | Potassium | pyroptosis | macrophage | interleukin-1beta | dendritic cell | lethal toxin | ANTHRAX LETHAL TOXIN | APOPTOSIS | CYSTEINE PROTEASE | ACTIVATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | INDUCED PROXIMITY MODEL | PROCASPASE-1 | CELL-DEATH | NALP3 INFLAMMASOME | ASC | Inflammasomes - metabolism | Apoptosis - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein | Apoptosis - genetics | Caspase 1 - metabolism | Interleukin-1beta - metabolism | Proteolysis | Apoptosis Regulatory Proteins - genetics | Dendritic Cells - drug effects | Macrophages, Peritoneal - drug effects | Dendritic Cells - metabolism | Cells, Cultured | Mice, Transgenic | Blotting, Western | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Models, Biological | CARD Signaling Adaptor Proteins | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice, Inbred BALB C | Nigericin - pharmacology | Macrophages, Peritoneal - metabolism | Interleukin-18 - metabolism | Microscopy, Fluorescence | Protein research | Research | Enzymes | Pathogens | Rodents | Cells | Apoptosis | Index Medicus | Biological Sciences
Journal Article