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Yakugaku Zasshi, ISSN 0031-6903, 11/2015, Volume 135, Issue 11, pp. 1245 - 1253
Journal Article
Organic Letters, ISSN 1523-7060, 07/2014, Volume 16, Issue 14, pp. 3756 - 3759
A highly reactive alkylrhodium complex was formed from Me2Zn and RhCl(PPh3)3 and effectively catalyzed a Csp3–Csp3 homocoupling reaction of benzyl halides. A... 
Benzyl Compounds - chemistry | Molecular Structure | Combinatorial Chemistry Techniques | Catalysis | Hydrocarbons, Halogenated - chemistry | Rhodium - chemistry
Journal Article
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2015, Volume 135, Issue 11, p. 1245
Multi-substituted β-lactam compounds have not only attracted considerable interest as core structures of pharmaceutical compounds such as antibiotics but also... 
Stereoisomerism | Halogenation | beta-Lactams - chemical synthesis | Amino Acids - chemistry | beta-Lactams - chemistry | Alkylation
Journal Article
Journal Article
RSC Advances, ISSN 2046-2069, 2018, Volume 8, Issue 37, pp. 20568 - 20575
We developed a decarboxylative aldol reaction using α,α-difluoro-β-ketocarboxylate salt, carbonyl compounds, and ZnCl2/N,N,N′,N′-tetramethylethylenediamine.... 
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 12/2017, Volume 13, Issue 1, pp. 2690 - 2697
A series of aniline and m-phenylenediamine derivatives with electron-withdrawing 3,3,3-trifluoropropenyl substituents were synthesized as small and chemically... 
Fluorogenic substrate | Small fluorescent molecule | Fluorometry | Dipeptidyl peptidase-4 | CELLS | fluorogenic substrate | fluorometry | DESIGN | VIOLET | dipeptidyl peptidase-4 | IN-VIVO | TUMOR | CHEMISTRY, ORGANIC | small fluorescent molecule | SOLID-STATE | FLUORESCENT-PROBE | Enzymes | Phenylenediamine | Peptidase | Aniline | Hydrogen bonds | Organic compounds
Journal Article
Organic Letters, ISSN 1523-7060, 03/2016, Volume 18, Issue 5, pp. 1128 - 1131
A nickel-catalyzed Negishi coupling of bromodifluoroacetamides with arylzinc reagents has been developed. This reaction allows access to difluoromethylated... 
MEDICINAL CHEMISTRY | ETHYL BROMODIFLUOROACETATE | ARYL BORONIC ACIDS | ALPHA-ARYLATION | FLUORO-BETA-LACTAM | ARENES | CHEMISTRY, ORGANIC | COPPER | FORMING REDUCTIVE ELIMINATION | ARYLBORONIC ACIDS
Journal Article
ISSN 1477-0520, 3/2019, Volume 17, Issue 1, pp. 2818 - 2823
Fluorine-alkoxy group exchange reactions of fluorinated isoxazoline derivatives promoted by Lewis acids to give various 5-alkoxylated 4,4-difluoroisoxazolines... 
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 07/2016, Volume 12, Issue 1, pp. 1608 - 1615
An effective synthesis for syn-beta-lactams was achieved using a Rh-catalyzed reductive Mannich-type reaction. A rhodium-hydride complex (Rh-H) derived from... 
Rhodium-hydride | Reductive Mannich-type reaction | β-lactam | Zinc enolate | Ezetimibe | ALPHA-AMINO | ASYMMETRIC-SYNTHESIS | STAUDINGER REACTION | rhodium-hydride | IMINES | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | zinc enolate | beta-lactam | STEREOSELECTIVE SYNTHESIS | CHOLESTEROL ABSORPTION | reductive Mannich-type reaction | BETA-AMINO ACIDS | ezetimibe | ESTERS | LACTAMS | rhodium–hydride
Journal Article
Organic & Biomolecular Chemistry, ISSN 1477-0520, 01/2019, Volume 17, Issue 10, pp. 2818 - 2823
Fluorine-alkoxy group exchange reactions of fluorinated isoxazoline derivatives promoted by Lewis acids to give various 5-alkoxylated 4,4-difluoroisoxazolines... 
Exchanging | Lewis acid | Acids | Fluorine | Aromatic compounds | Phenols | Fluorination | Chemical synthesis | Substrates | Information systems
Journal Article
by Abe, Toshikazu and Abe, Toshikazu and Ogura, Hiroshi and Ogura, Hiroshi and Shiraishi, Atsushi and Shiraishi, Atsushi and Kushimoto, Shigeki and Kushimoto, Shigeki and Saitoh, Daizoh and Saitoh, Daizoh and Fujishima, Seitaro and Fujishima, Seitaro and Mayumi, Toshihiko and Mayumi, Toshihiko and Shiino, Yasukazu and Shiino, Yasukazu and Nakada, Taka-Aki and Nakada, Taka-Aki and Tarui, Takehiko and Tarui, Takehiko and Hifumi, Toru and Hifumi, Toru and Otomo, Yasuhiro and Otomo, Yasuhiro and Okamoto, Kohji and Okamoto, Kohji and Umemura, Yutaka and Umemura, Yutaka and Kotani, Joji and Kotani, Joji and Sakamoto, Yuichiro and Sakamoto, Yuichiro and Sasaki, Junichi and Sasaki, Junichi and Shiraishi, Shin-Ichiro and Shiraishi, Shin-Ichiro and Takuma, Kiyotsugu and Takuma, Kiyotsugu and Tsuruta, Ryosuke and Tsuruta, Ryosuke and Hagiwara, Akiyoshi and Hagiwara, Akiyoshi and Yamakawa, Kazuma and Yamakawa, Kazuma and Masuno, Tomohiko and Masuno, Tomohiko and Takeyama, Naoshi and Takeyama, Naoshi and Yamashita, Norio and Yamashita, Norio and Ikeda, Hiroto and Ikeda, Hiroto and Ueyama, Masashi and Ueyama, Masashi and Fujimi, Satoshi and Fujimi, Satoshi and Gando, Satoshi and Gando, Satoshi and Tasaki, Osamu and Mizobata, Yasumitsu and Funakoshi, Hiraku and Okuyama, Toshiro and Yamashita, Iwao and Kanai, Toshio and Yamada, Yasuo and Aibiki, Mayuki and Sato, Keiji and Yamashita, Susumu and Yoshida, Kenichi and Kasaoka, Shunji and Kon, Akihide and Rinka, Hiroshi and Kato, Hiroshi and Okudera, Hiroshi and Narimatsu, Eichi and Fujiwara, Toshifumi and Sugita, Manabu and Shichinohe, Yasuo and Nakae, Hajime and Iiduka, Ryouji and Nakamura, Mitsunobu and Murata, Yuji and Sato, Yoshitake and Ishikura, Hiroyasu and Myojo, Yasuhiro and Tsujita, Yasuyuki and Kinoshita, Kosaku and Yamaguchi, Hiroyuki and Sakurai, Toshihiro and Miyatake, Satoru and Saotome, Takao and Yasuda, Susumu and JAAM FORECAST Grp and JAAM FORECAST group and on behalf of JAAM FORECAST group
Critical Care, ISSN 1364-8535, 11/2018, Volume 22, Issue 1, pp. 322 - 12
BackgroundSepsis is a leading cause of death and long-term disability in developed countries. A comprehensive report on the incidence, clinical... 
Sepsis | Elderly | Bundle | Resuscitation | POPULATION | MULTICENTER | INTERNATIONAL CONSENSUS DEFINITIONS | GUIDELINES | CLINICAL-CRITERIA | SEPTIC SHOCK | INFECTION | GOAL-DIRECTED RESUSCITATION | CAMPAIGN | EPIDEMIOLOGY | CRITICAL CARE MEDICINE | Care and treatment | Patient outcomes | Analysis | Prevalence studies (Epidemiology)
Journal Article
Circulation Research, ISSN 0009-7330, 02/2015, Volume 116, Issue 4, pp. 653 - 664
Journal Article
The Journal of organic chemistry, ISSN 0022-3263, 12/2019
A series of aniline-based fluorophores were newly synthesized. To increase their fluorescence quantum yields, it was particularly important to substitute... 
Journal Article
CRITICAL CARE, ISSN 1466-609X, 11/2019, Volume 23, Issue 1, pp. 360 - 11
Background: Time to antibiotic administration is a key element in sepsis care; however, it is difficult to implement sepsis care bundles. Additionally, sepsis... 
Protocols | MULTICENTER | MANAGEMENT | Bundle | PROTOCOL | CARE | Antibiotic | Sepsis | INTERNATIONAL GUIDELINES | IN-HOSPITAL MORTALITY | OUTCOMES | CAMPAIGN | RESUSCITATION | CRITICAL CARE MEDICINE
Journal Article
ISSN 1477-0520, 7/2014, Volume 12, Issue 33, pp. 6484 - 6489
A practical and highly enantioselective Reformatsky reaction of ethyl bromodifluoroacetate with imines using a cheap and commercially available amino alcohol... 
Journal Article
RSC Advances, 2018, Volume 8, Issue 37, pp. 20568 - 20575
We developed a decarboxylative aldol reaction using α,α-difluoro-β-ketocarboxylate salt, carbonyl compounds, and ZnCl2/N,N,N′,N′-tetramethylethylenediamine.... 
Carbonyl compounds | Zinc chlorides | Ketones | Aldehydes | Carbonyls
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 03/2019, Volume 17, Issue 10, pp. 2818 - 2823
Fluorine-alkoxy group exchange reactions of fluorinated isoxazoline derivatives promoted by Lewis acids to give various 5-alkoxylated 4,4-difluoroisoxazolines... 
CHEMISTRY, ORGANIC | TRIFLUORINATION | ARYL | SELECTFLUOR | C-H FLUORINATION | NUCLEAR FLUORINATION
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 07/2015, Volume 13, Issue 33, pp. 8886 - 8892
Journal Article
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