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Journal of the American Chemical Society, ISSN 0002-7863, 12/2006, Volume 128, Issue 50, pp. 16159 - 16168
In the amyloid fibrils formed from long fragments of the amyloid β-protein (Aβ-protein), the monomers are arranged in parallel and lie perpendicular to the... 
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 08/2015, Volume 119, Issue 33, pp. 10478 - 10487
We have studied the dimer of amyloid beta peptide Aβ of 40 residues by means of all-atom replica exchange molecular dynamics. The Aβ-dimers have been found to... 
Thermodynamics | Peptide Fragments - chemistry | Protein Structure, Secondary | Protein Multimerization | Water - chemistry | Amyloid beta-Peptides - chemistry | Molecular Dynamics Simulation | Index Medicus
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 06/2008, Volume 379, Issue 4, pp. 815 - 829
The initial events in protein aggregation involve fluctuations that populate monomer conformations, which lead to oligomerization and fibril assembly. The... 
amyloid β-protein | free-energy surface | transition disconectivity graphs | Alzheimer's disease | molecular dynamics simulation
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2013, Volume 57, Issue 5, pp. 2231 - 2242
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
RNA-BINDING | MOLECULAR-DYNAMICS | IN-VITRO | INHIBITION | REPLICATION | H5N1 NUCLEOPROTEIN | AMINO-ACIDS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | IDENTIFICATION | OLIGOMERIZATION | MUTATIONAL ANALYSIS | Nucleoproteins - chemistry | Influenza A Virus, H3N2 Subtype - drug effects | Influenza A Virus, H3N2 Subtype - metabolism | Naproxen - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Viral Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | RNA, Viral - antagonists & inhibitors | Antiviral Agents - chemistry | Madin Darby Canine Kidney Cells | RNA, Viral - metabolism | Binding Sites | Influenza A Virus, H1N1 Subtype - metabolism | Orthomyxoviridae Infections - drug therapy | Antiviral Agents - pharmacology | Viral Proteins - chemistry | Viral Proteins - antagonists & inhibitors | Drug Repositioning | Influenza A Virus, H1N1 Subtype - drug effects | Drug Discovery | Molecular Dynamics Simulation | Nucleoproteins - antagonists & inhibitors | Naproxen - chemistry | Point Mutation | Animals | Influenza A Virus, H3N2 Subtype - chemistry | RNA, Viral - chemistry | Nucleoproteins - metabolism | Dogs | Protein Binding | Influenza A Virus, H1N1 Subtype - chemistry | Mice | Molecular Docking Simulation | Orthomyxoviridae Infections - virology | Anti-Inflammatory Agents, Non-Steroidal | Influenza A Virus, H3N2 Subtype | Nucleoproteins | Biochemistry, Molecular Biology | Viral Proteins | Antiviral Agents | Life Sciences | Naproxen | RNA, Viral | Influenza A Virus, H1N1 Subtype | Biomolecules | Orthomyxoviridae Infections
Journal Article
Biophysical Journal, ISSN 0006-3495, 01/2015, Volume 108, Issue 2, pp. 204a - 204a
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 09/2015, Volume 21, Issue 36, pp. 12657 - 12666
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30038
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2003, Volume 125, Issue 50, pp. 15359 - 15365
Aberrant protein oligomerization is an important pathogenetic process in vivo. In Alzheimer's disease (AD), the amyloid β-protein (Aβ) forms neurotoxic... 
Oxidation-Reduction | Methionine - chemistry | Methionine - metabolism | Amyloid - biosynthesis | Amyloid beta-Peptides - metabolism | Amyloid - chemistry | Amyloid beta-Peptides - chemistry
Journal Article
INCAS BULLETIN, ISSN 2066-8201, 06/2012, Volume 4, Issue 2, pp. 99 - 110
  A moving vehicle creates a flow of the surrounding air, continuous and compressible fluid. When the movement is at a constant speed, the air flow is not time... 
vehicles | aerodynamics | aerodynamic drag | non-stationary process
Journal Article
INCAS BULLETIN, ISSN 2066-8201, 03/2012, Volume 4, Issue 1, pp. 93 - 102
  The main consequence of on air flow surrounding a moving train resides in the aerodynamic drag and a certain pressure distribution on the frontal and lateral... 
aerodynamics | locomotives | diesel fuel consumption
Journal Article
UPB Scientific Bulletin, Series D: Mechanical Engineering, ISSN 1454-2358, 2011, Volume 73, Issue 4, pp. 237 - 246
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 31, pp. 12526 - 12531
We report the structure-based design and synthesis of a unique NOS inhibitor, called nanoshutter NS1, with two-photon absorption properties. NS1 targets the... 
Protein isoforms | Human umbilical vein endothelial cells | Imaging | Fluorescence | Oxides | Chromophores | Cell membranes | Catalysis | Endothelial cells | Electrons | Chemical biology | Fluorescence spectroscopy | Inhibition of enzymatic catalysis | Structure-based design and molecular modeling | Two-photon fluorescence imaging | SITE | inhibition of enzymatic catalysis | MULTIDISCIPLINARY SCIENCES | fluorescence spectroscopy | NANOTRIGGER | ENDOTHELIAL NO-SYNTHASE | chemical biology | ELECTRON INJECTION | two-photon fluorescence imaging | DISEASE | OXYGENASE | HEALTH | structure-based design and molecular modeling | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Nitric Oxide - biosynthesis | Nitric Oxide - chemistry | Humans | Human Umbilical Vein Endothelial Cells - chemistry | Isoenzymes - chemistry | NADP - chemistry | Molecular Dynamics Simulation | NADP - pharmacology | Nitric Oxide Synthase Type III - chemistry | NADP - chemical synthesis | Human Umbilical Vein Endothelial Cells - enzymology | Isoenzymes - metabolism | Human Umbilical Vein Endothelial Cells - cytology | NADP - analogs & derivatives | Fluorescent Dyes - pharmacology | Microscopy, Fluorescence, Multiphoton - methods | Nitric Oxide Synthase Type III - metabolism | Nitric oxide | NADP (Coenzyme) | Physiological aspects | Research | Biophysics | Health aspects | Index Medicus | Human Umbilical Vein Endothelial Cells | Isoenzymes | Biochemistry, Molecular Biology | Nitric Oxide Synthase Type III | Nitric Oxide | Life Sciences | NADP | Microscopy, Fluorescence, Multiphoton | Fluorescent Dyes | Biological Sciences
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2018, Volume 61, Issue 16, pp. 7202 - 7217
The nucleoprotein (NP) of influenza A virus (IAV) required for IAV replication is a promising target for new antivirals. We previously identified by in silico... 
RNA-BINDING | COMPLEX | DESIGN | CHEMISTRY, MEDICINAL | PROTEIN | NUCLEOPROTEIN | POLYMERASE | OLIGOMERIZATION | IDENTIFICATION | DISCOVERY | Life Sciences
Journal Article
Journal Article