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Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 6, pp. 864 - 868
Ulcerative colitis (UC) is a refractory disease that causes chronic inflammation or ulceration in the mucosa of the large intestine with multiple relapses.... 
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 04/2012, Volume 129, Issue 3-5, pp. 115 - 128
► Orteronel is a novel, selective, and potent inhibitor of 17,20-lyase. ► Orteronel potently suppressed androgen production in vitro in monkey adrenal cells. ►... 
TAK-700 | Androgen | 17,20-Lyase | Steroid hormone | Prostate cancer | Orteronel | PLUS PREDNISONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTITUMOR-ACTIVITY | CASTRATION | CYP17 BLOCKADE | ANTIANDROGEN | ANDROGEN-RECEPTOR | ENDOCRINOLOGY & METABOLISM | ABIRATERONE ACETATE | P450C17 | RESISTANT PROSTATE-CANCER | EXPRESSION | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Dehydroepiandrosterone - antagonists & inhibitors | Humans | Macaca fascicularis | Male | Naphthalenes - blood | Ketoconazole - pharmacology | Steroids - metabolism | Testosterone - blood | Adrenal Glands - cytology | Adrenal Glands - drug effects | Hydrocortisone - blood | Steroids - blood | Cells, Cultured | Enzyme Inhibitors - pharmacology | Androgen Antagonists - pharmacology | Dehydroepiandrosterone - blood | Imidazoles - pharmacology | Naphthalenes - pharmacology | Orchiectomy | Imidazoles - blood | Animals | Testosterone - antagonists & inhibitors | Cell Line, Tumor | Steroid 17-alpha-Hydroxylase - metabolism | Androgens - metabolism | Hydrocortisone - antagonists & inhibitors | Phosphates | Enzymes | Niacinamide | Pituitary hormones | Albumin | ACTH | Glycoproteins | Monkeys | Glucose | Hormones | Dextrose | Chromatography | Purines | Dehydroepiandrosterone | Androgens | Physiological aspects | Luteinizing hormone | Neurohormones | Hormones, Sex | Steroid hormones
Journal Article
Journal Article
Journal of Pharmaceutical Policy and Practice, ISSN 2052-3211, 07/2016, Volume 10, Issue 1, p. 2
Pharmacists in Japan currently play a key role in patient hospital care. Their responsibilities include filling prescriptions, checking a patient's medication... 
Hospital patients | Medical equipment | Antibiotics | Analysis | Economic aspects | Pharmacists | Pharmaceutical industry | Evidence-based medicine | Physiological apparatus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2011, Volume 19, Issue 21, pp. 6383 - 6399
A novel naphthylmethylimidazole derivative and its related compounds were identified as 17,20-lyase inhibitors. Based on the structure–activity relationship... 
TAK-700 | 17,20-Lyase | Prostate cancer | Orteronel | ENANTIOSELECTIVE REFORMATSKY REACTION | BETA-HYDROXY ESTERS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | ANDROGEN BIOSYNTHESIS | HUMAN 17-ALPHA-HYDROXYLASE-17,20-LYASE CYP17 | STEROIDAL INHIBITORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CYTOCHROME P450(17-ALPHA) | BIOLOGICAL EVALUATION | HUMAN-LIVER-MICROSOMES | 17-ALPHA-HYDROXYLASE-C17,20-LYASE P450 17 | Steroid 17-alpha-Hydroxylase - antagonists & inhibitors | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Crystallography, X-Ray | Male | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Enzyme Inhibitors - chemistry | Inhibitory Concentration 50 | Prostatic Neoplasms - blood | Antineoplastic Agents - pharmacology | Imidazoles - chemical synthesis | Testosterone - blood | Prostatic Neoplasms - drug therapy | Naphthalenes - chemical synthesis | Naphthalenes - chemistry | Magnetic Resonance Spectroscopy | Enzyme Inhibitors - pharmacology | Models, Molecular | Dehydroepiandrosterone - blood | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Haplorhini | Naphthalenes - pharmacology | Animals | Prostatic Neoplasms - enzymology | Care and treatment | Androgens | Dehydroepiandrosterone | Cytochrome P-450 | Electric utilities | Drug therapy | Cancer
Journal Article
Journal of Steroid Biochemistry and Molecular Biology, ISSN 0960-0760, 03/2013, Volume 134, Issue 1, pp. 80 - 91
Journal Article
Journal of Pharmacological and Toxicological Methods, ISSN 1056-8719, 09/2018, Volume 93, pp. 157 - 157
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 2013, Volume 121, Issue suppl, pp. 211 - 211
Journal Article
Journal of Pharmacological Sciences, ISSN 1347-8613, 03/2015, Volume 127, Issue 3, p. 275
Ulcerative colitis (UC) involves chronic inflammation of the large intestine. Several agents are used to treat UC, but adverse side effects are remaining... 
Journal Article
by Tanaka, T and Abe, K and Hayato, Y and Iida, T and Kameda, J and Koshio, Y and Kouzuma, Y and Miura, M and Moriyama, S and Nakahata, M and Nakayama, S and Obayashi, Y and Sekiya, H and Shiozawa, M and Suzuki, Y and Takeda, A and Takenaga, Y and Ueno, K and Ueshima, K and Yamada, S and Yokozawa, T and Ishihara, C and Hazama, S and Kaji, H and Kajita, T and Kaneyuki, K and McLachlan, T and Okumura, K and Shimizu, Y and Tanimoto, N and Dufour, F and Kearns, E and Litos, M and Raaf, J. L and Stone, J. L and Sulak, L. R and Cravens, J. P and Bays, K and Kropp, W. R and Mine, S and Regis, C and Smy, M. B and Sobel, H. W and Ganezer, K. S and Hill, J and Keig, W. E and Jang, J. S and Kim, J. Y and Lim, I. T and Albert, J. B and Scholberg, K and Walter, C. W and Wendell, R and Wongjirad, T and Ishizuka, T and Tasaka, S and Learned, J. G and Matsuno, S and Smith, S and Martens, K and Vagins, M and Watanabe, Y and Hasegawa, T and Ishida, T and Ishii, T and Kobayashi, T and Nakadaira, T and Nakamura, K and Nishikawa, K and Nishino, H and Oyama, Y and Sakashita, K and Sekiguchi, T and Tsukamoto, T and Suzuki, A. T and Takeuchi, Y and Ikeda, M and Minamino, A and Nakaya, T and Labarga, L and Fukuda, Y and Itow, Y and Mitsuka, G and Jung, C. K and McGrew, C and Lopez, G and Yanagisawa, C and Tamura, N and Ishino, H and Kibayashi, A and Sakuda, M and Kuno, Y and Yoshida, M and Kim, S. B and Yang, B. S and Okazawa, H and Choi, Y and Nishijima, K and Yokosawa, Y and Koshiba, M and ... and Super Kamiokande Collaboration
The Astrophysical Journal, ISSN 0004-637X, 12/2011, Volume 742, Issue 2, pp. 78 - jQuery1323901163583='48'
We present the result of an indirect search for high energy neutrinos from Weakly Interacting Massive Particle (WIMP) annihilation in the Sun using... 
neutrinos | SUPERSYMMETRIC DARK-MATTER | ASTRONOMY & ASTROPHYSICS | dark matter | Weakly interacting massive particles | Searching | Categories | Neutrinos | Flux | Sun | Channels | Muons | CROSS SECTIONS | NONLUMINOUS MATTER | ASTROPHYSICS, COSMOLOGY AND ASTRONOMY | SPIN | ANNIHILATION | MUONS | NEUTRINOS | SUN | SCATTERING
Journal Article
Electrochimica Acta, ISSN 0013-4686, 2006, Volume 52, Issue 4, pp. 1632 - 1638
Journal Article
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2002, Volume 124, Issue 24, pp. 6981 - 6990
Journal Article
by Ohfuji, Satoko and Deguchi, Masaaki and Tachibana, Daisuke and Koyama, Masayasu and Takagi, Tetsu and Yoshioka, Takayuki and Urae, Akinori and Ito, Kazuya and Kase, Tetsuo and Maeda, Akiko and Kondo, Kyoko and Fukushima, Wakaba and Hirota, Yoshio and Imai, Shiro and Akagaki, Eiko and Akai, Mariko and Azuma, Yoshitsune and Hamada, Shinichi and Motoyama, Satoru and Chimori, Hiroko and Nakagawa, Shoko and Fukuda, Takehiko and Hagiwara, Masahisa and Okuda, Hideto and Hamanaka, Takuro and Yamamasu, Seiichi and Hirota, Kenji and Oku, Masataka and Hiramatsu, Keizo and Hisamatsu, Masanori and Iijima, Yasushi and Takehara, Mikio and Ikeda, Somei and Inoue, Takeshi and Yamashita, Eriko and Fukuda, Aisaku and Iwata, Itsuko and Nishio, Junko and Tsutsui, Tateki and Yamaji, Kenji and Kamiya, Takao and Kasamatsu, Atsushi and Nakajima, Tatsuya and Kasahara, Kanji and Kasamatsu, Kenjitsu and Ryoichi, Kawabata and Kawabata, Kazume and Kadowaki, Kozo and Nomura, Hiroshi and Kikuchi, Tomoyuki and Suzuki, Ayako and Nagano, Tadayoshi and Komeda, Yoshitsugu and Kondo, Ryousuke and Konishi, Shinjin and Takemura, Hideo and Kasumi, Masako and Masuhiro, Kazuo and Ito, Ryoji and Sakamoto, Yoshiki and Hirai, Kouzo and Yamamoto, Yoshimitsu and Kariya, Yoshitaka and Misaki, Osamu and Miyake, Akira and Osako, Yasuko and Mori, Masao and Naka, Keizo and Tokura, Yasumasa and Yoshimatsu, Jun and Tatsumi, Keiji and Kanda, Takayoshi and Nishikawa, Masahiro and Nishimoto, Sekio and Nishioka, Yoshihiro and Funato, Takao and Nozaki, Kouichi and Ohira, Gengo and Okamura, Yoshiyuki and Oga, Yuzo and Nakamoto, Osamu and Nakata, Shinichi and Nakamura, Tetsuo and Takemura, Masahiko and Sadou, Toshiyuki and Mitsuda, Nobuaki and Fujita, Daisuke and Hisamoto, Koji and Akada, Shinobu and Nonogaki, Takafumi and Horiuchi, Chinami and Shiki, Yasuhiko and Kimura, Tadashi and Kitamura, Koutaro and Ogita, Kazuhide and Matsuo, Shigeki and Ikeda, Yoshihito and Moriyama, Akihiro and Ishikawa, Yukiyoshi and Muso, Hiroshi and ... and Osaka Pregnant Women Influenza S and Osaka Pregnant Women Influenza Study Group
Journal of Infectious Diseases, ISSN 0022-1899, 03/2018, Volume 217, Issue 6, pp. 878 - 886
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 08/2004, Volume 12, Issue 16, pp. 4313 - 4336
A series of 1- and 4-(2-naphthylmethyl)-1H-imidazoles (3 and 4) has been synthesized and evaluated as C -lyase inhibitors. Several 6-methoxynaphthyl... 
Testosterone | Androgen | lyase | 11β-Hydroxylase
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2012, Volume 20, Issue 1, pp. 422 - 434
Journal Article