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rats (48) 48
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rats, wistar (32) 32
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pharmacology & pharmacy (24) 24
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rat (19) 19
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serotonin receptor agonists - pharmacology (12) 12
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receptor, serotonin, 5-ht1a - metabolism (9) 9
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5ht1a (7) 7
agonists (7) 7
arylpiperazines (7) 7
biochemistry & molecular biology (7) 7
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depression (7) 7
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receptor, serotonin, 5-ht1a - drug effects (7) 7
serotonin receptor agonists - chemistry (7) 7
swimming (7) 7
anti-anxiety agents - chemical synthesis (6) 6
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receptor, serotonin, 5-ht2a - metabolism (6) 6
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serotonin antagonists - chemistry (6) 6
serotonin receptor agonists - chemical synthesis (6) 6
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elevated plus-maze (5) 5
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and 5-ht (4) 4
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British Journal of Pharmacology, ISSN 0007-1188, 04/2001, Volume 132, Issue 7, pp. 1423 - 1430
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2004, Volume 47, Issue 3, pp. 342 - 350
Several lines of evidence suggest a crucial involvement of glutamate in the mechanism of action of anxiolytic drugs including the involvement of group I... 
GABA | mGlu5 receptors | Anxiety | MTEP | BZD receptors
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2004, Volume 487, Issue 1-3, pp. 133 - 142
In the present study, we examined effects of the selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitor citalopram, the 5-HT/noradrenaline reuptake... 
Imipramine | Desipramine | Forced swimming test in rats | 5-HT | receptor antagonist | Moclobemide | Citalopram
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2007, Volume 555, Issue 1, pp. 43 - 47
Using the forced swimming test in mice, we examined the effect of the following antidepressants: citalopram, imipramine, desipramine and moclobemide (which are... 
Imipramine | 5-HT 7 receptor antagonist | Desipramine | Forced swimming test in mice | Moclobemide | Citalopram
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 03/2005, Volume 13, Issue 6, pp. 2293 - 2303
Starting with the structure of potent 5-HT ligands, that is, MM77 [1-(2-methoxyphenyl)-4-(4-succinimidobutyl)piperazine, 4] and its constrained version 5... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2009, Volume 44, Issue 11, pp. 4288 - 4296
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 4, pp. 1295 - 1303
The synthesis of 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives with an arylpiperazinylpropyl moiety ( – ) and their in vitro and in... 
Imidazolidine-2,4-diones | Antidepressants | Pre- and postsynaptic 5-HT 1A receptor agonists | Anxiolytics
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 02/2005, Volume 57, Issue 2, pp. 253 - 257
We have examined the effect of lesions of 5‐hydroxytryptamine (5‐HT) neurons, produced by p‐chloroamphetamine (p‐CA; 2 times 10 mg kg−1), and the influence of... 
DIAZEPAM | STIMULATION | INVOLVEMENT | AUTORECEPTORS | NEURONS | PHARMACOLOGY & PHARMACY | SEROTONIN | GUINEA-PIG | RELEASE | ANTAGONISTS | AGONIST | Benzamides - antagonists & inhibitors | Serotonin 5-HT1 Receptor Agonists | Electroshock - adverse effects | Rats, Wistar | Diazepam - pharmacology | Receptor, Serotonin, 5-HT1B - administration & dosage | Serotonin Receptor Agonists - pharmacology | Flumazenil - pharmacology | Diazepam - antagonists & inhibitors | Benzamides - therapeutic use | Oxadiazoles - pharmacology | Conflict (Psychology) | Poland | Water - administration & dosage | Behavior, Animal - drug effects | Benzamides - pharmacology | Neurons - metabolism | Piperazines - antagonists & inhibitors | Anti-Anxiety Agents - therapeutic use | Neurons - drug effects | Disease Models, Animal | Oxadiazoles - antagonists & inhibitors | Pyridines - therapeutic use | Drug Administration Schedule | Neurons - chemistry | p-Chloroamphetamine - adverse effects | Anti-Anxiety Agents - pharmacology | Rats | Piperazines - therapeutic use | Serotonin Antagonists - pharmacology | Piperazines - pharmacology | p-Chloroamphetamine - administration & dosage | Oxadiazoles - therapeutic use | Animals | Serotonin - metabolism | Electroshock - methods | Men | Drinking Behavior - drug effects | Pyridines - pharmacology | Serotonin 5-HT1 Receptor Antagonists
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 02/2005, Volume 57, Issue 2, pp. 253 - 257
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2004, Volume 47, Issue 10, pp. 2659 - 2666
New 1H,3H-pyrimido[2,1-f]purine-2,4-dione derivatives of arylpiperazine (11 − 22) were prepared and evaluated in vitro for their affinity for 5-HT1A, 5-HT2A,... 
CHEMISTRY, MEDICINAL | ANTAGONIST | PROFILE | RAT | ANXIOLYTIC-LIKE | CNS AGENTS | SEROTONIN | MICE | WAY-100635 | TRICYCLIC THEOPHYLLINE DERIVATIVES | ELEVATED PLUS-MAZE
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 04/2007, Volume 15, Issue 8, pp. 2907 - 2919
Novel arylpiperazines with N-acylated amino acids, selected on the basis of a preliminary screening of two libraries previously synthesized on SynPhase... 
Forced swimming test | Long-chain arylpiperazines | Pyrrolidine-2,5-dione | receptor ligands | Four-plate test | receptor agonists | Succinimides | Prolinamides | 5-HT | Solid-phase synthesis | Tail suspension test | tail suspension test | pyrrolidine-2,5-dione | CHEMISTRY, MEDICINAL | succinimides | BIOCHEMISTRY & MOLECULAR BIOLOGY | forced swimming test | CHEMISTRY, ORGANIC | CNS AGENTS | long-chain arylpiperazines | solid-phase synthesis | AGONISTS | 5-HT1A/5-HT2A receptor ligands | 5-HT1A receptor agonists | LOWER-LIP RETRACTION | SEROTONIN 5-HT1A | POTENT | LIGANDS | SYNPHASE LANTERNS | BIOLOGICAL EVALUATION | MICE | four-plate test | DERIVATIVES | prolinamides | Rats, Wistar | Body Temperature - drug effects | Motor Activity - drug effects | Male | Anxiety - drug therapy | Amino Acids - chemical synthesis | Chromatography, Thin Layer | Amino Acids - pharmacology | Serotonin Receptor Agonists - pharmacology | Spectrometry, Mass, Electrospray Ionization | Anti-Anxiety Agents - chemical synthesis | Serotonin Agents - chemical synthesis | Swimming - psychology | Receptors, Dopamine D2 - drug effects | Antidepressive Agents - pharmacology | Receptor, Serotonin, 5-HT2A - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Mice, Inbred C57BL | Anxiety - psychology | Anti-Anxiety Agents - pharmacology | Rats | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Hindlimb Suspension | Piperazines - pharmacology | Receptor, Serotonin, 5-HT1A - drug effects | Animals | Serotonin Agents - pharmacology | Antidepressive Agents - chemical synthesis | Indicators and Reagents | Piperazines - chemical synthesis | Mice | In Vitro Techniques | Receptor, Serotonin, 5-HT2A - metabolism
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 22, pp. 7116 - 7125
New, flexible and rigid 1-( -trifluorophenyl)piperazines with very high affinity and agonistic in vivo activity for 5-HT receptors were synthesized. Flexible... 
5-HT 1A and 5-HT 7 receptor ligands | Anxiolytic- and antidepressant-like activity | 5-HT 1A receptor agonists | Structure–intrinsic activity relationships studies | Arylpiperazines
Journal Article
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