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Molecular and Cellular Endocrinology, ISSN 0303-7207, 2019
Advances in electron cryo-microscopy (cryo-EM) now permit the structure determination of G protein-coupled receptors (GPCRs) coupled to heterotrimeric G... 
Journal Article
Structure, ISSN 0969-2126, 04/2019, Volume 27, Issue 4, pp. 703 - 712.e3
Agonist binding in the extracellular region of the G protein-coupled adenosine A2A receptor increases its affinity to the G proteins in the intracellular... 
molecular dynamics simulations | adenosine receptor | allosteric communication | entropy | G protein-coupled receptors (GPCRs) | ligand mobility
Journal Article
Structure, ISSN 0969-2126, 04/2019, Volume 27, Issue 4, pp. 703 - 712.e3
Lee et al. show that allosteric communication between the agonist binding site and G protein coupling site in GPCRs leads to enhanced agonist affinity. The... 
molecular dynamics simulations | adenosine receptor | allosteric communication | entropy | G protein-coupled receptors (GPCRs) | ligand mobility
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 12/2015, Volume 22, Issue 12, pp. 941 - 942
Journal Article
Structure, ISSN 0969-2126, 04/2019, Volume 27, Issue 4, p. 703
Agonist binding in the extracellular region of the G protein-coupled adenosine A2A receptor increases its affinity to the G proteins in the intracellular... 
Adenosine | Crystals | Molecular dynamics | G proteins | Structure | Molecular biology | Membrane proteins | Protein binding
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 10/2011, Volume 413, Issue 3, pp. 628 - 638
Conformational thermostabilisation of G-protein-coupled receptors is a successful strategy for their structure determination. The thermostable mutants tolerate... 
membrane protein, thermostabilisation | G-protein-coupled receptor
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 05/2019, Volume 488, p. 1
Highlights Advances in electron cryo-microscopy (cryo-EM) now permit the structure determination of G protein-coupled receptors (GPCRs) coupled to... 
Amino acids | G proteins | Molecular biology | Membrane proteins
Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7650, pp. 307 - 308
[...]this site is occupied by a short a-helix (H8) that is found after the final transmembrane a-helix (H7) of most GPCRs (Fig. 1). [...]the conformation of... 
Hypertension | Proteins | Ligands | Hormones | Crystal structure
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7711, pp. 620 - 5
G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to... 
G protein-coupled receptors | Serotonin | Genes | Amino acids | Genomes | Serotonin S1 receptors | Molecular chains | Proteins | Coupling (molecular) | Interfaces | Receptors | Microscopy | Ligands | Adrenergic receptors | Trends | Kinetics | Protein structure | Binding sites
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 536, Issue 7614, pp. 104 - 107
Journal Article
Annual review of pharmacology and toxicology, ISSN 0362-1642, 1/2020, Volume 60, Issue 1, pp. 51 - 71
Electron cryo-microscopy (cryo-EM) has revolutionized structure determination of membrane proteins and holds great potential for structure-based drug... 
X-ray crystallography | A | receptor | GABA | drug development | GPCR | cryo-EM | Index Medicus
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 12/2015, Volume 22, Issue 12, p. 941
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 12/2015, Volume 22, Issue 12, p. 941
Journal Article
Nature, ISSN 0028-0836, 06/2018, Volume 558, Issue 7710, p. 620
G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the human genome (around 800 genes). They transduce signals by coupling to... 
Proteins | Protein research | Research | G proteins | Serotonin | Structure | Phenols | Cells | Membrane proteins
Journal Article
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7564, p. 173
G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and trigger GDP release. Given that there are ~800 human GPCRs and 16... 
G proteins | Analysis | Allosteric proteins | Guanine | Membrane proteins | Proteins | Binding sites
Journal Article
Biophysical Journal, ISSN 0006-3495, 10/2015, Volume 109, Issue 7, p. 1307
  Membrane protein structures are being determined at an ever-accelerating rate, reflecting parallel increases in both our understanding of how to generate... 
Proteins | Membranes | Molecular structure | Fluorescence | Chromatography
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 09/2012, Volume 37, Issue 9, p. 343
  G-protein-coupled receptors (GPCRs) are medically important membrane proteins that are targeted by over 30% of small molecule drugs. At the time of writing,... 
Molecules | Mutagenesis | Systematic review | T cell receptors | Glycoproteins
Journal Article
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