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Diabetes, ISSN 0012-1797, 02/2009, Volume 58, Issue 2, pp. 422 - 432
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2006, Volume 103, Issue 51, pp. 19575 - 19580
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8452 - 8457
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to... 
Obesity | Gels | Nonesterified fatty acids | Palmitates | Type 2 diabetes mellitus | Diabetes | Islets of Langerhans | Insulin | Fatty acids | Apoptosis | Type 2 diabetes | 2D difference gel electrophoresis proteomics | Hyperproinsulinemia | Mechanisms of β-cell lipotoxicity | Free fatty acids | LEVELS PREDICT | HUMAN PANCREATIC-ISLETS | ENZYME-ACTIVITY | MULTIDISCIPLINARY SCIENCES | mechanisms of beta-cell lipotoxicity | INSULIN-SECRETION | free fatty acids | ENDOPLASMIC-RETICULUM STRESS | type 2 diabetes | PYRUVATE-DEHYDROGENASE ACTIVITY | PROHORMONE CONVERTASES | FREE FATTY-ACIDS | LINE INS-1 | TRIGLYCERIDE ACCUMULATION | hyperproinsulinemia | Endoplasmic Reticulum - enzymology | Golgi Apparatus - enzymology | Cell Survival | Diabetes Mellitus, Type 2 - genetics | Humans | Cells, Cultured | Diabetes Mellitus, Type 2 - enzymology | Apoptosis - genetics | Proteome | Hyperglycemia - genetics | Insulin-Secreting Cells - ultrastructure | Animals | Insulin-Secreting Cells - drug effects | Mice, Mutant Strains | Palmitates - pharmacology | Carboxypeptidase H - metabolism | Hyperglycemia - enzymology | Hyperinsulinism - enzymology | Hyperinsulinism - genetics | Mice | Palmitates - metabolism | Carboxypeptidase H - genetics | Insulin-Secreting Cells - enzymology | Biological Sciences | mechanisms of β-cell lipotoxicity
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, p. e12958
Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing... 
GLUCAGON-LIKE PEPTIDE-1 | ISLETS | SMALL-MOLECULE | GLUCOSE | MULTIDISCIPLINARY SCIENCES | BETA-CELL APOPTOSIS | CHANNELS | IDENTIFICATION | PALMITATE | STRESS | Cell Line | Cell Survival - drug effects | Drug Evaluation, Preclinical - methods | Islets of Langerhans - drug effects | High-Throughput Screening Assays - instrumentation | Homeodomain Proteins - metabolism | Humans | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Invertebrates - chemistry | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Islets of Langerhans - metabolism | Drug Evaluation, Preclinical - instrumentation | Trans-Activators - genetics | Trans-Activators - metabolism | Insulin-Secreting Cells - cytology | Mice | Insulin - genetics | Biological Factors - pharmacology | High-Throughput Screening Assays - methods | Cell differentiation | Gene expression | Insulin | Genes | Diabetes therapy | Bioengineering | Drugs | Regulators | Transformation | High-throughput screening | Identification | Statistical methods | Drug development | Kinases | Cell growth | Surgery | Penicillin | Physiology | Pancreas | Content analysis | Data analysis | Cell survival | Secretion | Diabetes mellitus | Lead compounds | Medical screening | Survival | Beta cells | Screening | Morphology | Stem cells | Diabetes | Cancer | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2008, Volume 105, Issue 24, p. 8452
  Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used... 
Proteins | Obesity | Peptides | Diabetes | Cells | Apoptosis
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 15, p. 9909
Pancreatic β-cell death is a critical event in type 1 diabetes, type 2 diabetes, and clinical islet transplantation. We have previously shown that prolonged... 
Journal Article
Diabetes, ISSN 0012-1797, 02/2009, Volume 58, Issue 2, p. 422
  Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER Ca(2+) release channels in the ER... 
Journal Article
Diabetes, ISSN 0012-1797, 02/2009, Volume 58, Issue 2, p. 422
OBJECTIVE--Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER [Ca.sup.2+] release channels in... 
Calcium channels | Pancreatic beta cells | Cell death | Physiological aspects | Genetic aspects | Research | Diabetes | Risk factors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 15, pp. 9909 - 9916
Pancreatic beta-cell death is a critical event in type 1 diabetes, type 2 diabetes, and clinical islet transplantation. We have previously shown that prolonged... 
INTRACELLULAR CA2 | LOCALIZATION | ISLETS | ALZHEIMERS-DISEASE | RYANODINE RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | MEDIATED APOPTOSIS | RELEASE | HYPOXIA
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 06/2008, Volume 105, Issue 24, pp. 8452 - 8457
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce beta -cell function and survival. An unbiased proteomic screen was used... 
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 15, p. 9909
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 15, pp. 9909 - 9916
Pancreatic beta -cell death is a critical event in type 1 diabetes, type 2 diabetes, and clinical islet transplantation. We have previously shown that... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2006, Volume 103, Issue 51, pp. 19575 - 19580
Insulin is both a hormone regulating energy metabolism and a growth factor. We and others have shown that physiological doses of insulin initiate complex... 
Receptors | Phosphorylation | Gels | Proteomics | Islet cells | Type 2 diabetes mellitus | Diabetes | Insulin | Apoptosis | Type 1 diabetes mellitus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2008, Volume 105, Issue 24, pp. 8452 - 8457
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce [beta]-cell function and survival. An unbiased proteomic screen was... 
Physiological aspects | Proteases | Hyperlipidemia | Health aspects | Risk factors | Apoptosis
Journal Article
Journal Article
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