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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7574, pp. 525 - 530
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 10/2014, Volume 371, Issue 15, pp. 1426 - 1433
After a prolonged response, an anaplastic thyroid cancer developed resistance to mammalian target of rapamycin (mTOR) inhibition by somatic mutation of mTOR at... 
MEDICINE, GENERAL & INTERNAL | ACTIVATION | MTOR MUTATIONS | PROTEIN | LYMPHANGIOLEIOMYOMATOSIS | INHIBITION | TUBEROUS SCLEROSIS COMPLEX | ANGIOMYOLIPOMA | GENE-PRODUCTS | SENSITIVITY | SIROLIMUS | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Humans | Middle Aged | Thyroid Neoplasms - diagnostic imaging | Thyroid Carcinoma, Anaplastic | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Neoplasm Recurrence, Local - pathology | Radiography | Thyroid Neoplasms - therapy | Thyroid Neoplasms - genetics | Drug Resistance, Neoplasm - genetics | TOR Serine-Threonine Kinases - genetics | Neoplasm Recurrence, Local - diagnostic imaging | TOR Serine-Threonine Kinases - chemistry | Lymphatic Metastasis - pathology | Tumor Suppressor Proteins - genetics | Female | Protein Conformation | Mutation | Everolimus | Thyroid Neoplasms - pathology | Thyroid cancer | Research | Drug therapy | Patient outcomes | TOR protein | Tuberous sclerosis 2 protein | Nonsense mutation | Genomes | Metastasis | Drug resistance | Kinases | Cancer therapies | Metastases | Thyroid carcinoma | Proteins | Allosteric properties | Deoxyribonucleic acid--DNA | Crystal structure | Thyroid | Rapamycin | FDA approval | Radiation therapy | Patients | Studies | TSC2 protein | Chemotherapy | Womens health | Biopsy | Tumors
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2018, Volume 24, Issue 5, pp. 679 - 690
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 1047 - 1055
Journal Article
Nature Communications, ISSN 2041-1723, 05/2016, Volume 7, Issue 1, p. 11589
  Resistance to the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using... 
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7661, pp. 55 - 60
Journal Article
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 2, pp. 161 - 165
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2014, Volume 111, Issue 51, pp. E5564 - E5573
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2016, Volume 48, Issue 8, pp. 848 - 855
Journal Article