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1. Present status and future perspectives of clinical management of sclerosing cholangitis
by Tazuma, Susumu
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, ISSN 0446-6586, 2019, Volume 116, Issue 8, p. 617
Journal Article
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2. Full Text Epidemiology, pathogenesis, and classification of biliary stones (common bile duct and intrahepatic)
by Tazuma, Susumu
Best Practice & Research Clinical Gastroenterology, ISSN 1521-6918, 2006, Volume 20, Issue 6, pp. 1075 - 1083
Gallstones are common in Western countries and Japan. Most gallstones are found in the gallbladder, but they sometimes pass through the cystic duct into... 
choledocholithiasis | hepatolithiasis | bile infection | bile stasis | pigment gallstone | cholesterol gallstone | POPULATION | TAIWAN | LITHIASIS | PREVALENCE | CHOLELITHIASIS | PREGNANCY | GALLBLADDER | GALLSTONE DISEASE | EXPERIENCE | GASTROENTEROLOGY & HEPATOLOGY
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3. Full Text Statins affect gallstone diseases: Underlying mechanism(s) are to be established
: Statins and gallstone diseases:A meta-analysis
by Tazuma, Susumu
Hepatology Research, ISSN 1386-6346, 09/2015, Volume 45, Issue 9, pp. 939 - 941
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4. Bile Acids in Gastroenterology
: Basic and Clinical
by Tazuma, Susumu and Takikawa, Hajime and SpringerLink (Online service)
2017, ISBN 4431560629
This book examines the biological aspects of bile acid analysis and their clinical applications, providing readers with an overview of cutting-edge discussions... 
Medicine | Hepatology | Gastroenterology | Metabolic diseases
Web Resource
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5. Full Text Statins affect gallstone diseases: Underlying mechanism(s) are to be established
by Tazuma, Susumu
Hepatology Research, ISSN 1386-6346, 09/2015, Volume 45, Issue 9, pp. 939 - 941
POPULATION | LOVASTATIN | DISSOLUTION | CHOLESTEROL GALLSTONE | REDUCTASE | RISK | PRAVASTATIN | CHOLECYSTECTOMY | INHIBITOR | GASTROENTEROLOGY & HEPATOLOGY | Gallstones | Statins
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6. Full Text Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012
by Ohara, Hirotaka and Okazaki, Kazuichi and Tsubouchi, Hirohito and Inui, Kazuo and Kawa, Shigeyuki and Kamisawa, Terumi and Tazuma, Susumu and Uchida, Kazushige and Hirano, Kenji and Yoshida, Hitoshi and Nishino, Takayoshi and Ko, Shigeru B. H and Mizuno, Nobumasa and Hamano, Hideaki and Kanno, Atsushi and Notohara, Kenji and Hasebe, Osamu and Nakazawa, Takahiro and Nakanuma, Yasuni and Takikawa, Hajime and Ministry of Health, Labor and Welfare, Japan and Japan Biliary Association and Research Committee of IgG4-related Diseases and Research Committee of Intractable Diseases of Liver and Biliary Tract
Journal of Hepato-Biliary-Pancreatic Sciences, ISSN 1868-6974, 9/2012, Volume 19, Issue 5, pp. 536 - 542
IgG4-sclerosing cholangitis (IgG4-SC) patients have an increased level of serum IgG4, dense infiltration of IgG4-positive plasma cells with extensive fibrosis... 
Pathology | Medicine & Public Health | Diagnostic Radiology | Gastroenterology | Abdominal Surgery | Internal Medicine | IgG4 | Primary sclerosing cholangitis | Sclerosing cholangitis | Surgical Oncology | Autoimmune pancreatitis | Cholangiocarcinoma | autoimmune pancreatitis | cholangiocarcinoma | primary sclerosing cholangitis | sclerosing cholangitis | LIVER-BIOPSY | BILE-DUCT | INVOLVEMENT | IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS | EXTRAPANCREATIC LESIONS | IGG4-ASSOCIATED CHOLANGITIS | CHOLANGIOGRAPHY | SPECTRUM | GASTROENTEROLOGY & HEPATOLOGY | Cholangitis, Sclerosing - pathology | Diagnosis, Differential | Immunoglobulin G - blood | Pancreatic Neoplasms - diagnosis | Humans | Cholangitis, Sclerosing - blood | Cholangitis, Sclerosing - diagnosis | Bile Ducts - pathology | Biliary Tract Neoplasms - diagnosis
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7. Full Text Nationwide survey for primary sclerosing cholangitis and IgG4‐related sclerosing cholangitis in Japan
by Tanaka, Atsushi and Tazuma, Susumu and Okazaki, Kazuichi and Tsubouchi, Hirohito and Inui, Kazuo and Takikawa, Hajime
Journal of Hepato‐Biliary‐Pancreatic Sciences, ISSN 1868-6974, 01/2014, Volume 21, Issue 1, pp. 43 - 50
Background We previously conducted nationwide surveys for primary sclerosing cholangitis (PSC) in Japan, and demonstrated several characteristic features of... 
Inflammatory bowel diseases | Nationwide survey | Autoimmune pancreatitis | Prednisolone | Ursodeoxycholic acid | SURGERY | POPULATION | PROGNOSTIC-FACTORS | CLINICAL PROFILE | RISK | PREVALENCE | NATURAL-HISTORY | SPECTRUM | OUTCOMES | GASTROENTEROLOGY & HEPATOLOGY | EPIDEMIOLOGY | Autoimmune Diseases - epidemiology | Prognosis | Humans | Japan | Middle Aged | Autoimmune Diseases - complications | Cholangitis, Sclerosing - complications | Male | Cholangitis, Sclerosing - epidemiology | Cholangitis, Sclerosing - therapy | Immunoglobulin G - immunology | Autoimmune Diseases - therapy | Adult | Female | Surveys and Questionnaires | Aged | Retrospective Studies
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8. Full Text The 2016 diagnostic criteria for primary sclerosing cholangitis
by Nakazawa, Takahiro and Nakazawa, Takahiro and Notohara, Kenji and Notohara, Kenji and Tazuma, Susumu and Tazuma, Susumu and Tanaka, Atsushi and Tanaka, Atsushi and Isayama, Hiroyuki and Isayama, Hiroyuki and Tsuyuguchi, Toshio and Tsuyuguchi, Toshio and Mori, Toshiyuki and Mori, Toshiyuki and Takikawa, Hajime and Takikawa, Hajime
Journal of Gastroenterology, ISSN 0944-1174, 7/2017, Volume 52, Issue 7, pp. 838 - 844
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown cause that is characterized pathologically by an inflammatory and... 
PSC | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Primary sclerosing cholangitis | Sclerosing cholangitis | Surgical Oncology | INFLAMMATORY-BOWEL-DISEASE | MANAGEMENT | JAPAN | GASTROENTEROLOGY & HEPATOLOGY | Liver - pathology | Cholangitis, Sclerosing - diagnostic imaging | Humans | Japan | Cholangiopancreatography, Endoscopic Retrograde | Cholangitis, Sclerosing - blood | Cholangitis, Sclerosing - complications | Cholangiopancreatography, Magnetic Resonance | Inflammatory Bowel Diseases - complications | Alkaline Phosphatase - blood | Medicine, Experimental | Medical research | Liver diseases | Phosphatases | Diagnosis | Gastrointestinal diseases | Trees | Biliary tract | Alkaline phosphatase | Inflammatory bowel diseases | Disease | Liver | Cholangitis | Stenosis | Epithelium | Bile duct | Clinical aspects | Intestine | Bile
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9. Full Text Mo1465 - Altered Bile Acid Synthesis Pathway in Hypertention-Associated Non-Alcoholic Steatohepatitis Animal Model
by Kodama, Masanobu and Tazuma, Susumu and Kanno, Keishi
Gastroenterology, ISSN 0016-5085, 04/2017, Volume 152, Issue 5, pp. S686 - S686
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10. Full Text Altered Bile Acid Synthesis Pathway in Hypertentionassociated Non-Alcoholic Steatohepatitis Animal Model
by Kodama, Masanobu and Tazuma, Susumu and Kanno, Keishi
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 5, pp. S686 - S686
Gastroenterology and Hepatology | Deoxycholic acid
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11. Full Text Altered Bile Acid Synthesis Pathway in Hypertention-Associated Non-Alcoholic Steatohepatitis Animal Model
by Kodama, Masanobu and Tazuma, Susumu and Kanno, Keishi
Gastroenterology, ISSN 0016-5085, 04/2017, Volume 152, Issue 5, p. S686
Deoxycholic acid
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12. Full Text No negative impact of serum IgG4 levels on clinical outcome in 435 patients with primary sclerosing cholangitis from Japan
by Tanaka, Atsushi and Tazuma, Susumu and Nakazawa, Takahiro and Isayama, Hiroyuki and Tsuyuguchi, Toshio and Inui, Kazuo and Takikawa, Hajime
Journal of Hepato‐Biliary‐Pancreatic Sciences, ISSN 1868-6974, 04/2017, Volume 24, Issue 4, pp. 217 - 225
Background Several studies have demonstrated that elevated serum IgG4 levels are associated with poor outcomes of primary sclerosing cholangitis (PSC), but the... 
IgG4‐related sclerosing cholangitis | IgG4‐related disease | Liver transplantation | IgG4-related sclerosing cholangitis | IgG4-related disease | STATEMENT | SURVIVAL | SURGERY | MANAGEMENT | PROGNOSTIC VARIABLES | NATURAL-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | Multivariate Analysis | Predictive Value of Tests | Prognosis | Age Factors | Immunoglobulin G - blood | Humans | Middle Aged | Male | Time Factors | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Retrospective Studies | Severity of Illness Index | Risk Assessment | Japan | Kaplan-Meier Estimate | Biomarkers - blood | Disease Progression | Disease-Free Survival | Analysis of Variance | Cholangitis, Sclerosing - physiopathology | Sex Factors | Survival Analysis | Cholangitis, Sclerosing - blood | Aged | Cholangitis, Sclerosing - mortality | Cohort Studies
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13. Full Text Classification of biliary tract cancers established by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery: 3rd English edition
by Miyazaki, Masaru and Ohtsuka, Masayuki and Miyakawa, Shuichi and Nagino, Masato and Yamamoto, Masakazu and Kokudo, Norihiro and Sano, Keiji and Endo, Itaru and Unno, Michiaki and Chijiiwa, Kazuo and Horiguchi, Akihiko and Kinoshita, Hisafumi and Oka, Masaaki and Kubota, Keiichi and Sugiyama, Masanori and Uemoto, Shinji and Shimada, Mitsuo and Suzuki, Yasuyuki and Inui, Kazuo and Tazuma, Susumu and Furuse, Junji and Yanagisawa, Akio and Nakanuma, Yasuni and Kijima, Hiroshi and Takada, Tadahiro
Journal of Hepato‐Biliary‐Pancreatic Sciences, ISSN 1868-6974, 03/2015, Volume 22, Issue 3, pp. 181 - 196
The 3rd English edition of the Japanese classification of biliary tract cancers was released approximately 10 years after the 5th Japanese edition and the 2nd... 
Internationalization | Japanese classification | UICC/AJCC staging system | Biliary tract cancers | SURGERY | GASTROENTEROLOGY & HEPATOLOGY
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14. Full Text Mo1522 An Essential Role of Hepatic Cholesterol and Bile Acid Metabolism Mediated by Nuclear Receptors FXR and LXR-a in the Development of Hepertension-Associated Non-Alcoholic Steatohepatitis
by Kodama, Masanobu and Tazuma, Susumu and Kanno, Keishi
Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 4, pp. S714 - S714
Gastroenterology and Hepatology | Physiological aspects | Cholesterol | Deoxycholic acid
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15. Full Text Aging of hospital physicians in rural Japan: A longitudinal study based on national census data
by Matsumoto, Masatoshi and Kimura, Kazuki and Inoue, Kazuo and Kashima, Saori and Koike, Soichi and Tazuma, Susumu
PLoS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6, p. e0198317
Background The disparity in the number of urban and rural physicians is a social problem in Japan. There may also be a disparity in the age of physicians. This... 
MORTALITY | IMPACT | QUALITY-OF-CARE | RETENTION | MULTIDISCIPLINARY SCIENCES | VOLUME | HEALTH-CARE | OUTCOMES | AREAS | ASSOCIATION | Japan - epidemiology | Rural Population - statistics & numerical data | Humans | Middle Aged | Rural Health Services - statistics & numerical data | Population Dynamics - statistics & numerical data | Male | Aging - physiology | Hospitals - statistics & numerical data | Censuses | Adult | Female | Aged | Longitudinal Studies | Physicians - statistics & numerical data | Practice | Health care disparities | Age distribution (Demography) | Physicians | Analysis | Medical personnel | Health sciences | Municipalities | Rural areas | Urban areas | Mortality | Workforce | Systematic review | Dentistry | Medicine | Studies | Census | Hospitals | Correlation analysis | Older people | Aging | Pharmacists | Population density | Age | Dentists | Public health | Ambulatory care
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16. Full Text Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease
by Ikegami, Tadashi and Hyogo, Hideyuki and Honda, Akira and Miyazaki, Teruo and Tokushige, Katsutoshi and Hashimoto, Etsuko and Inui, Kazuo and Matsuzaki, Yasushi and Tazuma, Susumu
Journal of Gastroenterology, ISSN 0944-1174, 11/2012, Volume 47, Issue 11, pp. 1257 - 1266
This study is a post-hoc analysis of a subset of patients who participated in our multi-institutional case-control study that evaluated the effects of... 
NAFLD | Bile acids | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Oxysterol | Abdominal Surgery | Surgical Oncology | Cholesterol metabolism | DIETARY-CHOLESTEROL | STEROL PROFILES | BILIARY CHOLESTEROL SECRETION | MASS-SPECTROMETRY | LC-ESI-MS/MS | HIGHLY SENSITIVE QUANTIFICATION | GLUCOSE-METABOLISM | INSULIN-RESISTANCE | STEATOHEPATITIS | ABSORPTION | GASTROENTEROLOGY & HEPATOLOGY | Prospective Studies | Cholesterol - blood | Fatty Liver - physiopathology | Humans | Middle Aged | Insulin Resistance | Male | Biomarkers - blood | Hypercholesterolemia - drug therapy | Case-Control Studies | Fatty Liver - drug therapy | Orphan Nuclear Receptors - blood | Young Adult | Tandem Mass Spectrometry | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Liver X Receptors | Lipid Metabolism - drug effects | Non-alcoholic Fatty Liver Disease | Chromatography, Liquid | Adult | Female | Quinolines - therapeutic use | Medical colleges | Care and treatment | Fatty liver | Hypercholesterolemia | Analysis | Physiological aspects | Insulin resistance | Insulin | Cholesterol
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17. Full Text Black Hairy Tongue Treated With Oral Antibiotics: A Case Report
by Nakajima, Masamitsu and Mizooka, Masafumi and Tazuma, Susumu
Journal of the American Geriatrics Society, ISSN 0002-8614, 02/2015, Volume 63, Issue 2, pp. 412 - 413
GERONTOLOGY | GERIATRICS & GERONTOLOGY | Cephalosporins - therapeutic use | Anti-Bacterial Agents - therapeutic use | Tongue, Hairy - pathology | Humans | Female | Tongue, Hairy - drug therapy | Tongue, Hairy - etiology | Aged | Antibiotics
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18. Full Text Bile Acids in Gastroenterology
: Basic and Clinical
by Tazuma, Susumu and Takikawa, Hajime
04/2017, 1st ed. 2017, ISBN 4431560602, 209
This book examines the biological aspects of bile acid analysis and their clinical applications, providing readers with an overview of cutting-edge discussions... 
Clinical medicine | Medicine & Public Health | Hepatology | Gastroenterology | Metabolic Diseases
eBook
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19. Full Text Wisteria floribunda agglutinin-sialylated mucin core polypeptide 1 is a sensitive biomarker for biliary tract carcinoma and intrahepatic cholangiocarcinoma: a multicenter study
by Shoda, Junichi and Shoda, Junichi and Matsuda, Atsushi and Matsuda, Atsushi and Shida, Takashi and Shida, Takashi and Yamamoto, Masakazu and Yamamoto, Masakazu and Nagino, Masato and Nagino, Masato and Tsuyuguchi, Toshio and Tsuyuguchi, Toshio and Yasaka, Takahiro and Yasaka, Takahiro and Tazuma, Susumu and Tazuma, Susumu and Uchiyama, Kazuhisa and Uchiyama, Kazuhisa and Unno, Michiaki and Unno, Michiaki and Ohkohchi, Nobuaki and Ohkohchi, Nobuaki and Nakanuma, Yasuni and Nakanuma, Yasuni and Kuno, Atsushi and Kuno, Atsushi and Narimatsu, Hisashi and Narimatsu, Hisashi
Journal of Gastroenterology, ISSN 0944-1174, 2/2017, Volume 52, Issue 2, pp. 218 - 228
Wisteria floribunda agglutinin (WFA)-sialylated mucin core polypeptide 1 (MUC1) was investigated as a new glycoprotein marker for cholangiocarcinoma (CC) using... 
Biomarker | Glycoproteomics | Medicine & Public Health | Colorectal Surgery | Hepatology | Multicenter study | Gastroenterology | Intrahepatic cholangiocarcinoma | Abdominal Surgery | Surgical Oncology | Biliary tract carcinoma | METAANALYSIS | RISK | TUMOR STAGE-2 CARCINOMA | LECTIN MICROARRAY | GALLBLADDER | HEPATOLITHIASIS | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Prospective Studies | Cholangiocarcinoma - diagnosis | Humans | Middle Aged | Male | Case-Control Studies | Young Adult | Sensitivity and Specificity | Aged, 80 and over | Adult | Female | Plant Lectins - chemistry | CA-19-9 Antigen - blood | Biliary Tract Neoplasms - pathology | Receptors, N-Acetylglucosamine - chemistry | Biliary Tract Neoplasms - diagnosis | Biomarkers, Tumor - blood | Bile Duct Neoplasms - diagnosis | Biliary Tract Diseases - diagnosis | Cholangiocarcinoma - pathology | Mucin-1 - blood | Aged | Bile Duct Neoplasms - pathology | Biliary Tract Diseases - pathology | Neoplasm Staging | Carcinoma | CEA (Oncology) | Analysis | Mucins | Cancer | Original —Liver, Pancreas, and Biliary Tract
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20. Full Text Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction
by Sugiyama, Akiko and Kanno, Keishi and Nishimichi, Norihisa and Ohta, Shoichiro and Ono, Junya and Conway, Simon J and Izuhara, Kenji and Yokosaki, Yasuyuki and Tazuma, Susumu
Journal of Gastroenterology, ISSN 0944-1174, 12/2016, Volume 51, Issue 12, pp. 1161 - 1174
Periostin is a matricellular protein that serves as a ligand for integrins and is required for tissue remodeling and fibrosis. We investigated the role of... 
Liver fibrogenesis | Medicine & Public Health | Matricellular protein | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Myofibroblasts | Cell adhesion receptor | Surgical Oncology | Cell migration | Cell Adhesion Molecules - physiology | Disease Susceptibility | Cholestasis - complications | Hepatic Stellate Cells - physiology | Cell Adhesion Molecules - deficiency | Cells, Cultured | Liver Cirrhosis, Experimental - etiology | Hepatic Stellate Cells - metabolism | Male | Cell Adhesion Molecules - metabolism | Rats, Sprague-Dawley | Cell Movement - physiology | Gene Knockdown Techniques | Mice, Knockout | Down-Regulation - physiology | Animals | Up-Regulation - physiology | Liver Cirrhosis, Experimental - pathology | Integrin alphaV - metabolism | Liver Cirrhosis, Experimental - metabolism
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