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science & technology (46) 46
animals (43) 43
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1. Full Text Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
by Haeussler, Maximilian and Schönig, Kai and Eckert, Hélène and Eschstruth, Alexis and Mianné, Joffrey and Renaud, Jean-Baptiste and Schneider-Maunoury, Sylvie and Shkumatava, Alena and Teboul, Lydia and Kent, Jim and Joly, Jean-Stephane and Concordet, Jean-Paul
Genome Biology, ISSN 1474-7596, 07/2016, Volume 17, Issue 1, pp. 148 - 148
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Promoter Regions, Genetic | Algorithms | RNA, Guide - genetics | RNA, Small Nuclear - genetics | Software | Internet | Genome | CRISPR-Cas Systems - genetics | Gene Editing | Design | CRISPR | Researchers | Nucleotide sequence | Prediction models | Efficiency | Genomes | Mutation rates | Ribonucleic acid--RNA | Index Medicus | Life Sciences | Cognitive Sciences | Neurons and Cognition | Psychology and behavior | Neurobiology | Research
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2. Full Text Anticipating and Identifying Collateral Damage in Genome Editing
by Burgio, Gaëtan and Teboul, Lydia
Trends in genetics, ISSN 0168-9525, 12/2020, Volume 36, Issue 12, pp. 905 - 914
genome editing | ectopic insertions | on-target activity | off-target activity | validation | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Nucleases | Crop yields | Medical research | Civilian casualties | Usage | Genomics | Health care reform | Medicine, Experimental | Genetic research | Genomes | Livestock | DNA binding proteins | Index Medicus
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3. Full Text Overexpression of Fto leads to increased food intake and results in obesity
by Church, Chris and Ashcroft, Frances M and Cox, Roger D and Girard, Christophe and Banks, Gareth T and Wells, Sara and Moir, Lee and McMurray, Fiona and Brüning, Jens C and Teboul, Lydia and Nolan, Patrick M
Nature genetics, ISSN 1061-4036, 12/2010, Volume 42, Issue 12, pp. 1086 - 1092
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Obesity | Biological and medical sciences | Metabolic diseases | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Area Under Curve | Motor Activity - drug effects | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | Obesity - blood | Obesity - genetics | Mixed Function Oxygenases | Dietary Fats - pharmacology | Oxo-Acid-Lyases - genetics | Dietary Fats - administration & dosage | Female | Models, Animal | Oxo-Acid-Lyases - metabolism | Energy Metabolism - genetics | Glucose Tolerance Test | Adiposity - drug effects | Circadian Rhythm - genetics | Body Temperature | Adiposity - genetics | Feeding Behavior - physiology | Feeding Behavior - drug effects | Animals | Glucose - metabolism | Mice | Circadian Rhythm - drug effects | Energy Metabolism - drug effects | Homeostasis - genetics | Energy metabolism | Bioenergetics | Physiological aspects | Genetic aspects | Research | Single nucleotide polymorphisms | Risk factors | Studies | Body mass index | Nutrition | Diet | Rodents | Diabetes | Mutation | Regression analysis | Index Medicus | Life Sciences | Human health and pathology | Endocrinology and metabolism
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4. Full Text Phenotyping first-generation genome editing mutants: a new standard?
by Teboul, Lydia and Murray, Stephen A and Nolan, Patrick M
Mammalian genome, ISSN 0938-8990, 8/2017, Volume 28, Issue 7, pp. 377 - 382
Life Sciences | Human Genetics | Cell Biology | Animal Genetics and Genomics | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Genetic Association Studies - standards | Genetic Engineering - methods | Gene Editing - standards | Genetic Association Studies - methods | Phenotype | Animals | CRISPR-Cas Systems | Genetic Engineering - standards | Mosaicism | Gene Editing - methods | Chimerism | Mutation | Genome | Animal genetics | Genomics | CRISPR | Mosaics | Genomes | Phenotyping | Index Medicus
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5. Full Text NAADP mobilizes calcium from acidic organelles through two-pore channels
by Calcraft, Peter J and Ruas, Margarida and Pan, Zui and Cheng, Xiaotong and Arredouani, Abdelilah and Hao, Xuemei and Tang, Jisen and Rietdorf, Katja and Teboul, Lydia and Chuang, Kai-Ting and Lin, Peihui and Xiao, Rui and Wang, Chunbo and Zhu, Yingmin and Lin, Yakang and Wyatt, Christopher N and Parrington, John and Ma, Jianjie and Evans, A. Mark and Galione, Antony and Zhu, Michael X
Nature (London), ISSN 0028-0836, 05/2009, Volume 459, Issue 7246, pp. 596 - 600
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Cell structures and functions | Cell membranes. Ionic channels. Membrane pores | Cell Line | Calcium Channels - metabolism | Calcium - metabolism | Humans | Molecular Sequence Data | Organelles - drug effects | NADP - pharmacology | Mice, Knockout | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Calcium Signaling - drug effects | Chickens | NADP - analogs & derivatives | Protein Binding | Mice | NADP - metabolism | Calcium Channels - genetics | Organelles - metabolism | Hydrogen-Ion Concentration | Calcium, Dietary | NADP (Coenzyme) | Cellular control mechanisms | Ion channels | Cell organelles | Chemical properties | Research | Properties | Calcium | Molecular biology | Cells | Index Medicus
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6. Full Text Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical Safety
by Teboul, Lydia and Herault, Yann and Wells, Sara and Qasim, Waseem and Pavlovic, Guillaume
Molecular therapy, ISSN 1525-0016, 06/2020, Volume 28, Issue 6, pp. 1422 - 1431
gene delivery | research reproducibility | CRISPR/Cas9 | clinical safety | gene therapy | functional genomics | medical research | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Index Medicus | Life Sciences
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7. Full Text Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis
by Fratta, Pietro and Sivakumar, Prasanth and Humphrey, Jack and Lo, Kitty and Ricketts, Thomas and Oliveira, Hugo and Brito‐Armas, Jose M and Kalmar, Bernadett and Ule, Agnieszka and Yu, Yichao and Birsa, Nicol and Bodo, Cristian and Collins, Toby and Conicella, Alexander E and Mejia Maza, Alan and Marrero‐Gagliardi, Alessandro and Stewart, Michelle and Mianne, Joffrey and Corrochano, Silvia and Emmett, Warren and Codner, Gemma and Groves, Michael and Fukumura, Ryutaro and Gondo, Yoichi and Lythgoe, Mark and Pauws, Erwin and Peskett, Emma and Stanier, Philip and Teboul, Lydia and Hallegger, Martina and Calvo, Andrea and Chiò, Adriano and Isaacs, Adrian M and Fawzi, Nicolas L and Wang, Eric and Housman, David E and Baralle, Francisco and Greensmith, Linda and Buratti, Emanuele and Plagnol, Vincent and Fisher, Elizabeth MC and Acevedo‐Arozena, Abraham
The EMBO journal, ISSN 0261-4189, 06/2018, Volume 37, Issue 11, p. n/a
cryptic exon | ALS | splicing | TDP‐43 | skiptic exon | TDP-43 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA-Binding Proteins - genetics | Gene Expression Regulation - genetics | Alternative Splicing - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Exons - genetics | DNA-Binding Proteins - genetics | Motor Neurons - pathology | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | RNA Splicing - genetics | Mice | Mutation | Phenotypes | Splicing | Pathogenesis | Exons | Amyotrophic lateral sclerosis | Gene expression | Ribonucleic acid--RNA | Molecular chains | Mutants | Complexity | Proteins | RNA-binding protein | Motor neuron diseases | Neurodegeneration | Degeneration | RNA processing | Index Medicus | Neuroscience | RNA Biology | Molecular Biology of Disease
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8. Full Text Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight
by Livermore, Catherine and Warr, Nick and Chalon, Nicolas and Siggers, Pam and Mianne, Joffrey and Codner, Gemma and Teboul, Lydia and Wells, Sara and Greenfield, Andy
Scientific reports, ISSN 2045-2322, 11/2019, Volume 9, Issue 1, pp. 17195 - 7
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Homozygotes | CRISPR | Fertility | Fetuses | Genomes | Testes | Osteoarthritis | Thrombospondin | Index Medicus
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