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1. Full Text Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
by Haeussler, Maximilian and Schönig, Kai and Eckert, Hélène and Eschstruth, Alexis and Mianné, Joffrey and Renaud, Jean-Baptiste and Schneider-Maunoury, Sylvie and Shkumatava, Alena and Teboul, Lydia and Kent, Jim and Joly, Jean-Stephane and Concordet, Jean-Paul
Genome Biology, ISSN 1474-7596, 07/2016, Volume 17, Issue 1, p. 148
Background: The success of the CRISPR/Cas9 genome editing technique depends on the choice of the guide RNA sequence, which is facilitated by various websites.... 
HUMAN GENOME | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CRISPR/CAS9 SYSTEM | HUMAN-CELLS | CRISPR-CAS9 SYSTEM | IN-VIVO | GENETICS & HEREDITY | DIGENOME-SEQ | HOMOLOGY-DIRECTED REPAIR | WEB TOOL | SGRNA DESIGN | NUCLEASES | Promoter Regions, Genetic | Algorithms | RNA, Guide - genetics | RNA, Small Nuclear - genetics | Software | Internet | Genome | CRISPR-Cas Systems - genetics | Gene Editing | Design | CRISPR | Researchers | Nucleotide sequence | Prediction models | Efficiency | Genomes | Mutation rates | Ribonucleic acid--RNA | Life Sciences | Cognitive Sciences | Neurons and Cognition | Psychology and behavior | Neurobiology
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2. Full Text Overexpression of Fto leads to increased food intake and results in obesity
by Church, Chris and Ashcroft, Frances M and Cox, Roger D and Girard, Christophe and Banks, Gareth T and Wells, Sara and Moir, Lee and McMurray, Fiona and Brüning, Jens C and Teboul, Lydia and Nolan, Patrick M
Nature Genetics, ISSN 1061-4036, 12/2010, Volume 42, Issue 12, pp. 1086 - 1092
Genome-wide association studies have identified SNPs within FTO, the human fat mass and obesity-associated gene, that are strongly associated with obesity.... 
ENERGY-EXPENDITURE | POLYMORPHISMS | VARIANTS | MOUSE | GENETICS & HEREDITY | GENE-EXPRESSION | FAT | BODY-MASS INDEX | PHYSICAL-ACTIVITY | ADULT OBESITY | CHILDREN | Area Under Curve | Motor Activity - drug effects | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | Obesity - blood | Obesity - genetics | Mixed Function Oxygenases | Dietary Fats - pharmacology | Oxo-Acid-Lyases - genetics | Dietary Fats - administration & dosage | Female | Models, Animal | Oxo-Acid-Lyases - metabolism | Energy Metabolism - genetics | Glucose Tolerance Test | Adiposity - drug effects | Circadian Rhythm - genetics | Body Temperature | Adiposity - genetics | Feeding Behavior - physiology | Feeding Behavior - drug effects | Animals | Glucose - metabolism | Mice | Circadian Rhythm - drug effects | Energy Metabolism - drug effects | Homeostasis - genetics | Obesity | Energy metabolism | Bioenergetics | Physiological aspects | Genetic aspects | Research | Single nucleotide polymorphisms | Risk factors | Studies | Body mass index | Nutrition | Diet | Rodents | Diabetes | Mutation | Regression analysis
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3. Full Text High-throughput discovery of novel developmental phenotypes
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
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4. Full Text NAADP mobilizes calcium from acidic organelles through two-pore channels
by Calcraft, Peter J and Ruas, Margarida and Pan, Zui and Cheng, Xiaotong and Arredouani, Abdelilah and Hao, Xuemei and Tang, Jisen and Rietdorf, Katja and Teboul, Lydia and Chuang, Kai-Ting and Lin, Peihui and Xiao, Rui and Wang, Chunbo and Zhu, Yingmin and Lin, Yakang and Wyatt, Christopher N and Parrington, John and Ma, Jianjie and Evans, A. Mark and Galione, Antony and Zhu, Michael X
Nature, ISSN 0028-0836, 05/2009, Volume 459, Issue 7246, pp. 596 - 600
Ca2+ mobilization from intracellular stores represents an important cell signalling process(1) that is regulated, in mammalian cells, by... 
HEART | CYCLIC ADP-RIBOSE | MECHANISM | STORES | ADENINE-DINUCLEOTIDE PHOSPHATE | CA2+ RELEASE | RYANODINE RECEPTORS | MULTIDISCIPLINARY SCIENCES | PANCREATIC BETA-CELLS | INOSITOL TRISPHOSPHATE | MESSENGER | Cell Line | Calcium Channels - metabolism | Calcium - metabolism | Humans | Molecular Sequence Data | Organelles - drug effects | NADP - pharmacology | Mice, Knockout | Insulin-Secreting Cells - metabolism | Animals | Insulin-Secreting Cells - drug effects | Calcium Signaling - drug effects | Chickens | NADP - analogs & derivatives | Protein Binding | Mice | NADP - metabolism | Calcium Channels - genetics | Organelles - metabolism | Hydrogen-Ion Concentration | Calcium, Dietary | NADP (Coenzyme) | Cellular control mechanisms | Ion channels | Cell organelles | Chemical properties | Research | Properties | Calcium | Molecular biology | Cells
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5. Full Text A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
by Bowl, Michael R and Simon, Michelle M and Ingham, Neil J and Greenaway, Simon and Santos, Luis and Cater, Heather and Taylor, Sarah and Mason, Jeremy and Kurbatova, Natalja and Pearson, Selina and Bower, Lynette R and Clary, Dave A and Meziane, Hamid and Reilly, Patrick and Minowa, Osamu and Kelsey, Lois and Allen, Sue and Clementson-Mobbs, Sharon and Codner, Gemma and Fray, Martin and Gardiner, Wendy and Joynson, Russell and Kenyon, Janet and Loeffler, Jorik and Nell, Barbara and Parker, Andrew and Quwailid, Deen and Stewart, Michelle and Walling, Alison and Zaman, Rumana and Chen, Chao-Kung and Conte, Nathalie and Matthews, Peter and Relac, Mike and Tudose, Ilinca and Warren, Jonathan and Le Marchand, Elise and El Amri, Amal and El Fertak, Leila and Ennah, Hamid and Ali-Hadji, Dalila and Ayadi, Abdel and Wattenhofer-Donze, Marie and Moulaert, David and Jacquot, Sylvie and André, Philippe and Birling, Marie-Christine and Pavlovic, Guillaume and Lalanne, Valérie and Lux, Aline and Riet, Fabrice and Mittelhaeuser, Christophe and Bour, Raphael and Guimond, Alain and Bam'Hamed, Chaouki and Leblanc, Sophie and Vasseur, Laurent and Selloum, Mohammed and Sorg, Tania and Ayabe, Shinya and Furuse, Tamio and Kaneda, Hideki and Kobayashi, Kimio and Masuya, Hiroshi and Miura, Ikuo and Obata, Yuichi and Suzuki, Tomohiro and Tamura, Masaru and Tanaka, Nobuhiko and Yamada, Ikuko and Yoshiki, Atsushi and Berberovic, Zorana and Bubshait, Mohammed and Cabezas, Jorge and Carroll, Tracy and Clark, Greg and Clarke, Shannon and Creighton, Amie and Danisment, Ozge and Eskandarian, Mohammad and Feugas, Patricia and Gertsenstein, Marina and Guo, Ruolin and Hunter, Jane and Jacob, Elsa and Lan, Qing and Laurin, Valerie and Law, Napoleon and MacMaster, Sue and Miller, David and Morikawa, Lily and Newbigging, Susan and Owen, Celeste and Penton, Patricia and Pereira, Monica and Qu, Dawei and Shang, Xueyuan and Sleep, Gillian and Sohel, Khondoker and Tondat, Sandra and ... and Int Mouse Phenotyping Consortium and International Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 886 - 11
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In... 
HAIR-CELLS | MUTAGENESIS | PROJECT | OTITIS-MEDIA | MULTIDISCIPLINARY SCIENCES | MOUSE | MUTATION | DISEASE | GENOME-WIDE | IMPAIRMENT | RESOURCE | Hearing Loss - genetics | Phenotype | Animals | Datasets as Topic | Genetic Testing | Protein Interaction Maps - genetics | Hearing Loss - epidemiology | Mice | Hearing Tests | Mice, Knockout | Consortia | Genes | Phenotyping | Auditory system | Hearing protection | Hearing impairment | Hearing loss
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6. Full Text Transgene design and delivery into the mouse genome: Keys to success
by Teboul, Lydia
Methods in Molecular Biology, ISSN 1064-3745, 2009, Volume 561, pp. 105 - 110
Mouse transgenesis by pronuclear injection generates random integration events resulting in variable overexpression efficiency. This chapter will outline... 
Design | Plasmid | Overexpression | BAC | Mouse | Delivery | Transgene | Gene Transfer Techniques | Animals | Transgenes - physiology | Chromosomes, Artificial, Yeast | Animals, Genetically Modified | Mice, Inbred C57BL | Microinjections - methods | Mice, Inbred CBA | Mice, Transgenic | Mice | Genetic Vectors | Genome
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7. Full Text Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight
by Livermore, Catherine and Warr, Nick and Chalon, Nicolas and Siggers, Pam and Mianné, Joffrey and Codner, Gemma and Teboul, Lydia and Wells, Sara and Greenfield, Andy
Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 1 - 7
Adamts16 encodes a disintegrin-like and metalloproteinase with thrombospondin motifs, 16, a member of a family of multi-domain, zinc-binding proteinases.... 
Homozygotes | CRISPR | Fetuses | Genomes | Testes | Osteoarthritis | Thrombospondin
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8. Full Text Phenotyping first-generation genome editing mutants: a new standard?
by Teboul, Lydia and Murray, Stephen A and Nolan, Patrick M
Mammalian Genome, ISSN 0938-8990, 8/2017, Volume 28, Issue 7, pp. 377 - 382
The unprecedented efficiency of the CRISPR/Cas9 system in genome engineering has opened the prospect of employing mutant founders for phenotyping cohorts, thus... 
Life Sciences | Human Genetics | Cell Biology | Animal Genetics and Genomics | DISRUPTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | GENETICS & HEREDITY | MICE | MUTATIONS | SOMATIC MOSAICISM | ONE-STEP GENERATION | NUCLEASES | Animal genetics | Genomics | CRISPR | Mosaics | Genomes | Phenotyping
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9. Full Text Introduction to Mammalian Genome Special Issue: Genome Editing
by Teboul, Lydia and Hérault, Yann and Smith, Cynthia and Whitelaw, Bruce
Mammalian Genome, ISSN 0938-8990, 8/2017, Volume 28, Issue 7, pp. 235 - 236
Life Sciences | Human Genetics | Cell Biology | Animal Genetics and Genomics | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | Mammals - genetics | Animals | Genome - genetics | Gene Editing - trends | Genomes
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10. Full Text Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse
by McMurray, Fiona and Church, Chris D and Larder, Rachel and Nicholson, George and Wells, Sara and Teboul, Lydia and Tung, Y. C. Loraine and Rimmington, Debra and Bosch, Fatima and Jimenez, Veronica and Yeo, Giles S. H and O'Rahilly, Stephen and Ashcroft, Frances M and Coll, Anthony P and Cox, Roger D
PLoS Genetics, ISSN 1553-7390, 01/2013, Volume 9, Issue 1, p. e1003166
The strongest BMI-associated GWAS locus in humans is the FTO gene. Rodent studies demonstrate a role for FTO in energy homeostasis and body composition. The... 
OBESITY-ASSOCIATED FTO | ENERGY-EXPENDITURE | VARIANTS | FOOD-INTAKE | SUBSTRATE | GENETICS & HEREDITY | MICE | CHILDHOOD | FAT MASS | GENOME-WIDE ASSOCIATION | CHILDREN | Humans | Embryonic Development - genetics | Homeostasis | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | Body Weight - genetics | Eating - genetics | Obesity - genetics | Obesity - metabolism | Animals | Gene Expression Regulation, Developmental | Oxo-Acid-Lyases - genetics | Body Composition - genetics | Mice | Germ Cells - metabolism | Energy Metabolism - genetics | Mixed Function Oxygenases - genetics | Energy metabolism | Bioenergetics | Genomics | Physiological aspects | Genetic aspects | Research | Gene expression | Health aspects | Body composition | Weight control | Mutation | Diet | Metabolism | Metabolic disorders
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11. Full Text Response to "unexpected mutations after CRISPR-Cas9 editing in vivo"
by Nutter, Lauryl M.J and Heaney, Jason D and Kent Lloyd, K.C and Murray, Stephen A and Seavitt, John R and Skarnes, William C and Teboul, Lydia and Brown, Steve D.M and Moore, Mark
Nature Methods, ISSN 1548-7091, 04/2018, Volume 15, Issue 4, pp. 235 - 236
SYSTEM | MICE | BIOCHEMICAL RESEARCH METHODS | Restriction enzymes, DNA | Gene mutations | Nucleotide sequence | Causes of | Physiological aspects | Genetic engineering | Genetic aspects | Health aspects | Methods | CRISPR | Mutation
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12. Full Text The mammalian gene function resource: The International Knockout Mouse Consortium
by Bradley, Allan and Anastassiadis, Konstantinos and Ayadi, Abdelkader and Battey, James and Bell, Cindy and Birling, Marie-Christine and Bottomley, Joanna and Brown, Steve and Bürger, Friederike and Bult, Carol and Bushell, Wendy and Collins, Francis and Desaintes, Christian and Doe, Brendan and Aris, Economides and Eppig, Janan and Finnell, Richard and Fletcher, Colin and Fray, Martin and Frendewey, David and Friedel, Roland and Grosveld, Frank and Hansen, J and Hérault, Yann and Hicks, Geoffrey and Hörlein, Aneas and Houghton, Catherine and Hrabé De Angelis, Martin and Huylebroeck, Danny and Iyer, Vivek and Jong, Pieter and Kadin, James and Kaloff, Cornelia and Kennedy, Karen and Koutsourakis, Manousos and Kent Lloyd, K.C and Marschall, Susan and Mason, Jeremy and McKerlie, Colin and McLeod, Michael and Melchner, Harald and Moore, Matt and Mujica, Alejano and Nagy, Anas and Nefedov, Mikhail and Nutter, Lauryl and Pavlovic, Guillaume and Peterson, Jane and Pollock, I and Ramirez-Solis, Ramiro and Rancourt, Derrick and Raspa, Marcello and Remacle, Jacques and Ringwald, Martin and Rosen, Barry and Rosenthal, Nadia and Rossant, Janet and Ruiz Noppinger, Patricia and Ryder, S and Schick, Joel Zupicich and Schnütgen, Frank and Schofield, Christopher and Seisenberger, Claudia and Selloum, Mohammed and Simpson, Elizabeth and Skarnes, William and Smedley, Damian and Stanford, William and Stewart, Francis and Stone, Kevin and Swan, Kate and Tadepally, Hamsa and Teboul, Jean Louis and Tocchini-Valentini, Glauco and Valenzuela, David and West, Anthony and Yamamura, Ken-Ichi and Yoshinaga, Yuko and Wurst, Martin
Mammalian Genome, ISSN 0938-8990, 10/2012, Volume 23, Issue 9-10, pp. 580 - 586
textabstractIn 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene... 
Life Sciences | Anatomy | Zoology | Cell Biology | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | Mice, Knockout - genetics | Mice | Animals | Internet | Internationality
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