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1. Tacrolimus once-daily formulation in the prophylaxis of transplant rejection in renal or liver allograft recipients: A viewpoint by Helio Tedesco Silva Jr
by Silva Jr, Helio Tedesco
Drugs (New York, N.Y.), ISSN 0012-6667, 2007, Volume 67, Issue 13, pp. 1944 - 1945
Tacrolimus - therapeutic use | Liver Transplantation | Graft Rejection - prevention & control | Humans | Immunosuppressive Agents - therapeutic use | Immunosuppressive Agents - adverse effects | Kidney Transplantation | Patient Compliance | Tacrolimus - adverse effects | Delayed-Action Preparations | Immunosuppressive Agents - administration & dosage | Tacrolimus - administration & dosage | Index Medicus
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2. Full Text The Long Journey of mTOR Inhibitors and the Long Path That Is Still Ahead
by Tedesco Silva, Helio
Transplantation, ISSN 0041-1337, 02/2018, Volume 102, Issue 2S Suppl 1, pp. S1 - S2
Transplantation | Immunology | Life Sciences & Biomedicine | Surgery | Science & Technology | Index Medicus
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3. Full Text Can Mammalian Target of Rapamycin Inhibitors Replace Mycophenolate in Hypersensitized Kidney Transplant Recipients?
by Tedesco-Silva, Helio
Transplantation, ISSN 0041-1337, 08/2020, Volume 104, Issue 8, pp. 1535 - 1536
Transplantation | Immunology | Life Sciences & Biomedicine | Surgery | Science & Technology | Index Medicus
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4. Full Text Early conversion of pediatric kidney transplant patients to everolimus with reduced tacrolimus and steroid elimination: Results of a randomized trial
by Tönshoff, Burkhard and Ettenger, Robert and Dello Strologo, Luca and Marks, Stephen D and Pape, Lars and Tedesco‐Silva, Helio and Bjerre, Anna and Christian, Martin and Meier, Matthias and Martzloff, El‐Djouher and Rauer, Barbara and Ng, Jennifer and Lopez, Patricia
American journal of transplantation, ISSN 1600-6135, 03/2019, Volume 19, Issue 3, pp. 811 - 822
immunosuppressant—mechanistic target of rapamycin: everolimus | immunosuppressant—calcineurin inhibitor: tacrolimus | clinical research/practice | immunosuppressive regimens—minimization/withdrawal | kidney transplantation/nephrology | pediatrics | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Pediatrics | Kidneys | Tacrolimus | Mycophenolic acid | Renal function | Transplants & implants | Immunoproliferative diseases | Patients | Evidence-based medicine | Glomerular filtration rate | Graft rejection | Biopsy | Lymphocytes | Mycophenolate mofetil | Steroid hormones | Kidney transplantation | Index Medicus
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5. Full Text Wound Healing Complications in Kidney Transplant Recipients Receiving Everolimus
by Ueno, Priscilla and Felipe, Claudia and Ferreira, Alexandra and Cristelli, Marina and Viana, Laila and Mansur, Juliana and Basso, Geovana and Hannun, Pedro and Aguiar, Wilson and Tedesco Silva, Helio and Medina-Pestana, Jose
Transplantation, ISSN 0041-1337, 04/2017, Volume 101, Issue 4, pp. 844 - 850
Transplantation | Immunology | Life Sciences & Biomedicine | Surgery | Science & Technology | Prednisone - adverse effects | Prospective Studies | Recombinant Fusion Proteins - adverse effects | Humans | Middle Aged | Risk Factors | Antibodies, Monoclonal - adverse effects | Male | Treatment Outcome | Tacrolimus - adverse effects | Mycophenolic Acid - adverse effects | Time Factors | Everolimus - adverse effects | Ultrasonography | Brazil | Adult | Female | Immunosuppressive Agents - adverse effects | Drug Therapy, Combination | Wound Healing - drug effects | Antilymphocyte Serum - adverse effects | Kidney Transplantation - adverse effects | Index Medicus | Original Clinical Science—General
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6. Full Text Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial
by Rostaing, Lionel, MD, PhD and Bunnapradist, Suphamai, MD and Grinyó, Josep M., MD and Ciechanowski, Kazimierz, MD, PhD and Denny, Jason E., MD and Silva, Helio Tedesco, MD and Budde, Klemens, MD and Envarsus Study Group and Envarsus Study Grp
American journal of kidney diseases, ISSN 0272-6386, 2015, Volume 67, Issue 4, pp. 648 - 659
Nephrology | tacrolimus | pill burden | transplant recipient | randomized controlled trial (RCT) | kidney transplantation | efficacy | Immunosuppression | bioavailability | treatment failure | Envarsus | safety | end-stage renal disease (ESRD) | formulation | biopsy-proven acute rejection | extended-release | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Prospective Studies | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Male | Kidney Transplantation | Time Factors | Adult | Female | Aged | Immunosuppressive Agents - administration & dosage | Tacrolimus - administration & dosage | Index Medicus
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7. Full Text The Challenges Associated With a Calcineurin Inhibitor-free Regimen After Heart Transplantation
by Silva, Helio Tedesco
Transplantation, ISSN 0041-1337, 04/2019, Volume 103, Issue 4, pp. 664 - 665
Transplantation | Immunology | Life Sciences & Biomedicine | Surgery | Science & Technology
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8. Full Text Targeting JAK/STAT Signaling to Prevent Rejection After Kidney Transplantation: A Reappraisal
by Baan, Carla C and Kannegieter, Nynke M and Felipe, Claudia Rosso and Tedesco Silva, Helio
Transplantation, ISSN 0041-1337, 09/2016, Volume 100, Issue 9, pp. 1833 - 1839
Phosphorylation | Humans | Immunosuppressive Agents - pharmacokinetics | Kidney - enzymology | Kidney - immunology | STAT Transcription Factors - metabolism | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Janus Kinase 3 - antagonists & inhibitors | Drug Dosage Calculations | Janus Kinase 3 - metabolism | Immunosuppressive Agents - administration & dosage | Graft Rejection - enzymology | Kidney - surgery | Protein Kinase Inhibitors - pharmacokinetics | Kidney - drug effects | Graft Rejection - prevention & control | Risk Factors | Treatment Outcome | Protein Kinase Inhibitors - administration & dosage | Animals | Signal Transduction - drug effects | Immunosuppressive Agents - adverse effects | Graft Rejection - immunology | Drug Monitoring | Graft Survival - drug effects | Kidney Transplantation - adverse effects | Index Medicus
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9. Full Text Everolimus plus early tacrolimus minimization: a phase III, randomized, open‐label, multicentre trial in renal transplantation
by Langer, Robert M and Hené, Ronald and Vitko, Stefan and Christiaans, Maarten and Tedesco‐Silva, Helio and Ciechanowski, Kazimierz and Cassuto, Elisabeth and Rostaing, Lionel and Vilatoba, Mario and Machein, Uwe and Ulbricht, Bettina and Junge, Guido and Dong, Gaohong and Pascual, Julio
Transplant international, ISSN 0934-0874, 05/2012, Volume 25, Issue 5, pp. 592 - 602
everolimus | calcineurin inhibitor minimization | tacrolimus | mammalian target of rapamycin inhibitor | proliferation signal inhibitors | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Sirolimus - analogs & derivatives | Glomerular Filtration Rate | Graft Rejection - prevention & control | Humans | Middle Aged | Graft Rejection - etiology | Male | Treatment Outcome | Tacrolimus - adverse effects | Kidney Transplantation - methods | Calcineurin Inhibitors | Sirolimus - administration & dosage | Kidney Transplantation - physiology | Time Factors | Adult | Female | Immunosuppressive Agents - adverse effects | Kidney Transplantation - immunology | Everolimus | Immunosuppressive Agents - administration & dosage | Kidney Transplantation - adverse effects | Tacrolimus - administration & dosage | Clinical trials | Kidneys | Angiogenesis inhibitors | Tacrolimus | Index Medicus
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10. Full Text Clinicopathological Characteristics and Effect of Late Acute Rejection on Renal Transplant Outcomes
by Rodrigues, Carolina A and Franco, Marcello F and Cristelli, Marina P and Pestana, Jose O.M and Tedesco-Silva, Helio
Transplantation, ISSN 0041-1337, 10/2014, Volume 98, Issue 8, pp. 885 - 892
Chronic rejection | Acute rejection | Graft loss | Late rejection | Kidney transplant | Transplantation | Immunology | Life Sciences & Biomedicine | Surgery | Science & Technology | Acute Disease | Glomerular Filtration Rate | Kidney - pathology | Humans | Middle Aged | Proportional Hazards Models | Male | Treatment Outcome | Adult | Female | Retrospective Studies | Graft Rejection - pathology | Kidney Transplantation - adverse effects | Index Medicus
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11. Full Text Randomized trial of everolimus-facilitated calcineurin inhibitor minimization over 24 months in renal transplantation
by Cibrik, Diane and Silva Jr, Helio Tedesco and Vathsala, Anantharaman and Lackova, Eva and Cornu-Artis, Catherine and Walker, Rowan G and Wang, Zailong and Zibari, Gazi B and Shihab, Fuad and Kim, Yu S
Transplantation, ISSN 0041-1337, 04/2013, Volume 95, Issue 7, pp. 933 - 942
Renal transplantation | Renal function | Cyclosporine | Everolimus | Calcineurin inhibitor toxicity | Transplantation | Immunology | Life Sciences & Biomedicine | Surgery | Science & Technology | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Adrenal Cortex Hormones - therapeutic use | Cyclosporine - blood | Calcineurin Inhibitors | Glomerular Filtration Rate - drug effects | Immunosuppressive Agents - blood | Time Factors | Graft Rejection - mortality | Adult | Female | Drug Therapy, Combination | Sirolimus - adverse effects | Sirolimus - analogs & derivatives | Sirolimus - therapeutic use | Graft Rejection - physiopathology | Graft Rejection - prevention & control | Kaplan-Meier Estimate | Treatment Outcome | Sirolimus - blood | Cyclosporine - therapeutic use | Mycophenolic Acid - analogs & derivatives | Mycophenolic Acid - therapeutic use | Cyclosporine - adverse effects | Immunosuppressive Agents - adverse effects | Kidney Transplantation - mortality | Graft Rejection - immunology | Drug Monitoring | Graft Survival - drug effects | Kidney Transplantation - immunology | Kidney Transplantation - adverse effects | Index Medicus
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12. Full Text Three‐year outcomes from the CRADLE study in de novo pediatric kidney transplant recipients receiving everolimus with reduced tacrolimus and early steroid withdrawal
by Tönshoff, Burkhard and Tedesco‐Silva, Helio and Ettenger, Robert and Christian, Martin and Bjerre, Anna and Dello Strologo, Luca and Marks, Stephen D and Pape, Lars and Veldandi, Udaykiran and Lopez, Patricia and Cousin, Marc and Pandey, Priti and Meier, Matthias
American journal of transplantation, ISSN 1600-6135, 01/2021, Volume 21, Issue 1, pp. 123 - 137
immunosuppressant—mechanistic target of rapamycin: everolimus | patient safety | clinical research/practice | immunosuppressive regimens—minimization/withdrawal | kidney transplantation/nephrology | graft survival | glomerular filtration rate (GFR) | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Medical research | Pediatrics | Kidneys | Corticosteroids | Tacrolimus | Medicine, Experimental | Organ transplant recipients | Mycophenolate mofetil | Corticoids | Mycophenolic acid | Drug withdrawal | Glomerular filtration rate | Graft rejection | Kidney transplants | Biopsy | Steroid hormones | Kidney transplantation | Index Medicus
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13. CYP3A53 and CYP2C83 variants influence exposure and clinical outcomes of tacrolimus-based therapy
by Genvigir, Fabiana Dalla Vecchia and Brayan Campos-Salazar, Antony and Felipe, Claudia Rosso and Tedesco-Silva Jr, Helio and Medina-Pestana, Jose Osmar and Doi, Sonia de Quateli and Cerda, Alvaro and Hirata, Mario Hiroyuki and Herrero, Maria Jose and Alino, Salvador Francisco and Crespo Hirata, Rosario Dominguez
Pharmacogenomics, ISSN 1462-2416, 01/2020, Volume 21, Issue 1, pp. 7 - 21
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Index Medicus
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14. Full Text The challenges associated with a calcineurin inhibitor free regimen after heart transplantation
by Silva, Helio Tedesco
Transplantation, ISSN 0041-1337, 09/2018, p. 1
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15. Full Text ATHENA: wisdom and warfare in defining the role of de novo mTOR inhibition in kidney transplantation
by Chadban, Steve and Tedesco-Silva, Helio
Kidney international, ISSN 0085-2538, 07/2019, Volume 96, Issue 1, pp. 27 - 30
Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | Index Medicus
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