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Journal Article
Pharmaceutical Research, ISSN 0724-8741, 12/2018, Volume 35, Issue 12, pp. 1 - 9
The anti-epileptic drug pregabalin crosses the blood-brain barrier (BBB) in spite of its low lipophilicity. This study was performed to determine whether... 
Biochemistry, general | blood-brain barrier | L-type amino acid transporter | Biomedicine | Pharmacy | Medical Law | pregabalin | Pharmacology/Toxicology | Biomedical Engineering and Bioengineering | anti-epileptic drug | SYSTEM-L | ACTIVATION | INVOLVEMENT | IDENTIFICATION | GABAPENTIN | CHEMISTRY, MULTIDISCIPLINARY | LAT1 | INHIBITION | FUNCTIONAL EXPRESSION | PHARMACOLOGY & PHARMACY | BARRIER MODEL | OCTN1 | Endothelium, Vascular - cytology | Cell Line | Leucine - metabolism | RNA, Small Interfering - genetics | Anticonvulsants - pharmacokinetics | Pregabalin - pharmacokinetics | Endothelial Cells - metabolism | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Pregabalin - metabolism | Anticonvulsants - metabolism | Rats | Amino Acid Transport System y+ - genetics | Large Neutral Amino Acid-Transporter 1 - genetics | Fusion Regulatory Protein 1, Light Chains - genetics | Permeability | Blood-Brain Barrier - metabolism | Brain - blood supply | Amino Acid Transport System y+ - metabolism | Animals | Fusion Regulatory Protein 1, Light Chains - metabolism | Biological Transport | Endothelial Cells - drug effects | Brain | Amino acids | Pregabalin | RNA | Analysis | Endothelium | Heptanes | Epilepsy | mRNA | siRNA | Carboxylic acids | Gene expression | Substrates | Endothelial cells | Polymerase chain reaction | Inhibitors | Sodium | Blood-brain barrier | Inhibition | Transport | Transporter | Lipophilicity | Research Paper
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 9, pp. 1330 - 1336
Nicotine, an addictive substance, is absorbed from the lungs following inhalation of tobacco smoke, and distributed to various tissues such as liver, brain,... 
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2015, Volume 104, Issue 9, pp. 3069 - 3075
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2015, Volume 43, Issue 1, pp. 89 - 92
Nicotine is an addictive alkaloid in cigarette smoke and is responsible for tobacco dependence. It is important to consider the blood-to-liver transport of... 
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2015, Volume 104, Issue 9, pp. 3069 - 3075
The present study was carried out to investigate the blood-to-retina transport of nicotine across the inner blood-retinal barrier (BRB). Using the in vivo... 
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2015, Volume 43, Issue 1, pp. 89 - 92
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 09/2018, Volume 9, Issue 9, pp. 884 - 888
We designed and synthesized a pyrilamine derivative 1 as a selective class I HDAC inhibitor that targets pyrilamine-sensitive proton-coupled organic cation... 
blood-brain barrier | HDAC inhibitor | selective inhibitor | Histone deacetylase | pyrilamine-sensitive proton-coupled organic cation antiporter | CHEMISTRY, MEDICINAL | ACID | ALZHEIMERS-DISEASE | HUNTINGTONS-DISEASE MICE | ORGANIC CATION ANTIPORTER | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | CAPILLARY ENDOTHELIAL-CELLS | PET | TRANSGENIC MICE | HDAC
Journal Article
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