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gene expression (25) 25
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1. Full Text Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
by Dienstmann, Roigo and Vermeulen, Louis and Guinney, Justin and Kopetz, Scott and Tejpar, Sabine and Tabernero, Josep
Nature reviews. Cancer, ISSN 1474-175X, 2017, Volume 17, Issue 2, pp. 79 - 92
Life Sciences & Biomedicine | Oncology | Science & Technology | Epigenomics | ErbB Receptors - antagonists & inhibitors | Colorectal Neoplasms - genetics | Genomics | Humans | ErbB Receptors - genetics | Transcriptome | Consensus | Colorectal Neoplasms - etiology | Colorectal Neoplasms - immunology | Colorectal Neoplasms - drug therapy | Mutation | Precision Medicine | Care and treatment | Chemotherapy | Usage | Gene mutations | Colorectal cancer | Monoclonal antibodies | Diagnosis | Research | Vascular endothelial growth factor | Cancer | Index Medicus
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2. Full Text KRAS , BRAF , PIK3CA , and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer
by Roock, Wendy De, MD and Vriendt, Veerle De, MSc and Normanno, Nicola, MD and Ciardiello, Fortunato, Prof and Tejpar, Sabine, Prof
The lancet oncology, ISSN 1470-2045, 2011, Volume 12, Issue 6, pp. 594 - 603
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | MAP Kinase Kinase 1 - antagonists & inhibitors | PTEN Phosphohydrolase - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Drug Resistance, Neoplasm | Proto-Oncogene Proteins - genetics | Phosphatidylinositol 3-Kinases - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplasm Metastasis | Class I Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mutation | Colorectal Neoplasms - pathology | Care and treatment | Colorectal cancer | Monoclonal antibodies | Genetic aspects | Metastasis | Health aspects | Cancer | Genes | Index Medicus
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3. Full Text Association of KRAS G13D Tumor Mutations With Outcome in Patients With Metastatic Colorectal Cancer Treated With First-Line Chemotherapy With or Without Cetuximab
by Sabine Tejpar and Ilhan Celik and Michael Schlichting and Ute Sartorius and Carsten Bokemeyer and Eric Van Cutsem
Journal of clinical oncology, ISSN 0732-183X, 10/2012, Volume 30, Issue 29, pp. 3570 - 3577
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Multivariate Analysis | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Follow-Up Studies | Colorectal Neoplasms - genetics | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Antibodies, Monoclonal - therapeutic use | Male | Young Adult | Antibodies, Monoclonal, Humanized | Likelihood Functions | Neoplasm Metastasis | Neoplasm Invasiveness - pathology | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Cetuximab | Colorectal Neoplasms - mortality | Risk Assessment | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Treatment Outcome | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged | Mutation | Colorectal Neoplasms - pathology | Neoplasm Staging | Index Medicus
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4. Full Text Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes
by Stintzing, Sebastian and Tejpar, Sabine and Gibbs, Peter and Thiebach, Lars and Lenz, Heinz-Josef
European journal of cancer (1990), ISSN 0959-8049, 10/2017, Volume 84, pp. 69 - 80
Hindgut | Midgut | Colorectal carcinoma | Predictive | Metastatic | Colon | Prognostic | Life Sciences & Biomedicine | Oncology | Science & Technology | Predictive Value of Tests | Receptor, Epidermal Growth Factor - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | Molecular Diagnostic Techniques | Neoplasm Metastasis | Receptor, Epidermal Growth Factor - metabolism | Rectal Neoplasms - genetics | Colorectal Neoplasms - drug therapy | Biomarkers, Tumor - metabolism | Rectal Neoplasms - pathology | Biomarkers, Tumor - antagonists & inhibitors | Rectal Neoplasms - drug therapy | Precision Medicine | Colorectal Neoplasms - enzymology | Gastrointestinal Microbiome | Treatment Outcome | Rectal Neoplasms - enzymology | Protein Kinase Inhibitors - therapeutic use | Colonic Neoplasms - pathology | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Biomarkers, Tumor - genetics | Colonic Neoplasms - enzymology | Mutation | Colorectal Neoplasms - pathology | Medical research | Care and treatment | Colorectal cancer | Medicine, Experimental | Drug therapy | Tumors | Cancer | Epidermal growth factor | Metastasis | Spleen | Impact prediction | Microbiomes | Patients | Flexing | Molecular chains | Metastases | Rectum | Index Medicus
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5. Full Text Implications for KRAS status and EGFR-targeted therapies in metastatic CRC
by De Luca, Antonella and Van Cutsem, Eric and Normanno, Nicola and Tejpar, Sabine and Morgillo, Floriana and Ciardiello, Fortunato
Nature reviews. Clinical oncology, ISSN 1759-4774, 09/2009, Volume 6, Issue 9, pp. 519 - 527
Life Sciences & Biomedicine | Oncology | Science & Technology | ras Proteins - genetics | Exons | Colorectal Neoplasms - genetics | Humans | Molecular Sequence Data | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | Patient Selection | Antibodies, Monoclonal, Humanized | Neoplasm Metastasis | Codon | Base Sequence | Colorectal Neoplasms - drug therapy | Cetuximab | Amino Acid Sequence | Signal Transduction - genetics | Antibodies, Monoclonal - genetics | Point Mutation | Drug Resistance, Neoplasm - genetics | Valine - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aspartic Acid - metabolism | Biomarkers, Tumor - genetics | ras Proteins - therapeutic use | Colorectal Neoplasms - pathology | Genes, ras | Amino Acid Substitution | Care and treatment | Ras genes | Gene mutations | Patient outcomes | Colorectal cancer | Genetic aspects | Health aspects | Index Medicus
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6. Full Text The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis
by Houtmeyers, Rob and Souopgui, Jacob and Tejpar, Sabine and Arkell, Ruth
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 10/2013, Volume 70, Issue 20, pp. 3791 - 3811
Life Sciences | Biochemistry, general | Xenopus | Life Sciences, general | Mouse | Transcription | Zic genes | Biomedicine general | Neurological disorders | Cell Biology | Neural development | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Multigene Family | Zinc Fingers | Gastrulation | Xenopus laevis - embryology | Xenopus Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Transcription Factors - genetics | Homeodomain Proteins - genetics | Neural Crest - metabolism | Morphogenesis | Transcription Factors - metabolism | Phenotype | Animals | Gene Expression Regulation, Developmental | Neural Crest - embryology | Xenopus laevis - metabolism | Alleles | Body Patterning | Xenopus Proteins - metabolism | Mice | Xenopus laevis - genetics | Proteins | Genetic disorders | Genes | Genetic research | Development and progression | Genetic transcription | Amphibians | Index Medicus
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7. Full Text Cetuximab Plus Irinotecan, Fluorouracil, and Leucovorin As First-Line Treatment for Metastatic Colorectal Cancer: Updated Analysis of Overall Survival According to Tumor KRAS and BRAF Mutation Status
by Eric Van Cutsem and Claus-Henning Köhne and István Láng and Gunnar Folprecht and Marek P. Nowacki and Stefano Cascinu and Igor Shchepotin and Joan Maurel and David Cunningham and Sabine Tejpar and Michael Schlichting and Angela Zubel and Ilhan Celik and Philippe Rougier and Fortunato Ciardiello
Journal of clinical oncology, ISSN 0732-183X, 05/2011, Volume 29, Issue 15, pp. 2011 - 2019
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Prognosis | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Antibodies, Monoclonal, Humanized | Fluorouracil - therapeutic use | Neoplasm Metastasis | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Leucovorin - therapeutic use | Cetuximab | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Camptothecin - therapeutic use | Proto-Oncogene Proteins - genetics | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Mutation | Colorectal Neoplasms - pathology | Index Medicus
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8. Full Text Use of Early Tumor Shrinkage to Predict Long-Term Outcome in Metastatic Colorectal Cancer Treated With Cetuximab
by Hubert Piessevaux and Marc Buyse and Michael Schlichting and Eric Van Cutsem and Carsten Bokemeyer and Steffen Heeger and Sabine Tejpar
Journal of clinical oncology, ISSN 0732-183X, 10/2013, Volume 31, Issue 30, pp. 3764 - 3775
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Colorectal Neoplasms - mortality | Predictive Value of Tests | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras)