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Records of Natural Products, 01/2017, Volume 11, Issue 1, p. 77
A new phloroglucinol derivative, identified as 3-benzoyl-3-hydroxy-5-(3-methylbut-2-en-1-yl)cyclopentane-1,2,4-trione (1 ), together with eight previously... 
Journal Article
Current Drug Targets, ISSN 1389-4501, 11/2008, Volume 9, Issue 11, pp. 921 - 921
Despite of breakthroughs in medical sciences the parasitic diseases have still remained to be the major global health problem, affecting billions and killing... 
Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 12/2017, Volume 14, Issue 12, pp. e1700324 - n/a
Journal Article
Current Drug Metabolism, ISSN 1389-2002, 03/2017, Volume 18, Issue 3, p. 173
Journal Article
Records of Natural Products, ISSN 1307-6167, 2017, Volume 11, Issue 1, pp. 77 - 81
A new phloroglucinol derivative, identified as 3-benzoyl-3-hydroxy-5-(3-methylbut-2-en-1yl) cyclopentane-1,2,4-trione (1), together with eight previously... 
MAO-A and MAO-B | Phloroglucinol derivatives | Spectroscopic analyses | Hypericum | CHEMISTRY, MEDICINAL | spectroscopic analyses | CHEMISTRY, APPLIED | phloroglucinol derivatives | PLANT SCIENCES
Journal Article
Current Drug Targets, ISSN 1389-4501, 2008, Volume 9, Issue 11, p. 921
Journal Article
Journal Article
MOLECULES, ISSN 1420-3049, 02/2019, Volume 24, Issue 4, p. 810
The investigation of the constituents that were isolated from Turnera diffusa (damiana) for their inhibitory activities against recombinant human monoamine... 
molecular docking | Turnera diffusa | PROTEIN | acacetin 7-methyl ether | BIOCHEMISTRY & MOLECULAR BIOLOGY | monoamine oxidase-B | FLAVONOIDS | acacetin | monoamine oxidase-A | molecular dynamics | CHEMISTRY, MULTIDISCIPLINARY | neurological disorder
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2018, Volume 155, pp. 82 - 91
The endocannabinoid system plays an important role in the pathophysiology of various neurological disorders, such as anxiety, depression, neurodegenerative... 
Virodhamine | Docking | MAO-B | Enzyme kinetics | Endocannabinoids | Kynuramine dihydrobromide (PubChem CID: 16219543) | Phenelzine sulfate (PubChem CID: 61100) | (R)-(+)-Methanandamide (PubChem CID: 6321351) | 2-Arachidonoylglycerol (PubChem CID: 5282280) | Dimethyl sulfoxide (PubChem CID: 679) | R-(−)-Deprenyl hydrochloride (PubChem CID: 5195) | Noladin ether (PubChem CID: 6483057) | Potassium phosphate (PubChem CID: 516951) | Clorgyline (PubChem CID: 28767) | Anandamide (PubChem CID: 5281969) | Oleylethanolamide (PubChem CID: 5283454) | 4-Hydroxyquinoline (PubChem CID: 69141) | Safinamide (PubChem CID: 131682) | Virodhamine trifluoroacetate (PubChem CID: 91691131) | NEUROTRANSMISSION | RESOLUTION | CRYSTAL-STRUCTURES | ANTIDEPRESSANTS | PHARMACOLOGY & PHARMACY | MAO INHIBITORS | RAT-BRAIN | BINDING | CANNABINOIDS | PARKINSONS-DISEASE | CB1 RECEPTORS | Cannabinoid Receptor Modulators - metabolism | Cannabinoid Receptor Modulators - pharmacology | Endocannabinoids - metabolism | Monoamine Oxidase Inhibitors - pharmacology | Molecular Docking Simulation - methods | Endocannabinoids - pharmacology | Humans | Cannabinoids - chemistry | Rats | PC12 Cells | Cannabinoids - pharmacology | Animals | Cannabinoid Receptor Modulators - chemistry | Monoamine Oxidase Inhibitors - metabolism | Monoamine Oxidase Inhibitors - chemistry | Cannabinoids - metabolism | Endocannabinoids - chemistry | Monoamine Oxidase - metabolism | Enzymes | Evaluation | Nervous system diseases | Monoamine oxidase | Analysis | Pharmacy | Index Medicus | docking | endocannabinoids | virodhamine | enzyme kinetics
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2009, Volume 241, Issue 1, pp. 14 - 22
Primaquine, an 8-aminoquinoline, is the drug of choice for radical cure of relapsing malaria. Use of primaquine is limited due to its hemotoxicity,... 
Methemoglobin | Hemotoxicity | Cytochrome P | Primaquine | Erythrocytes
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17486 - 17491
Individuals with glucose 6-phosphate dehydrogenase (G6PD) deficiency are at risk for the development of hemolytic anemia when given 8-aminoquinolines (8-AQs),... 
Hemolysis | Dehydrogenases | Malaria | Erythrocytes | Antimalarials | Mice | Drug design | Reticulocytes | Dosage | Blood | IMMUNOCOMPROMISED MICE | IMMUNODEFICIENT MICE | DRUG | TRANSMISSION | HUMAN MALARIA | SCID MICE | PLASMODIUM-FALCIPARUM | HUMAN ERYTHROCYTES | MULTIDISCIPLINARY SCIENCES | RED-BLOOD-CELLS | PRIMAQUINE | Dapsone - adverse effects | Humans | Transplantation, Heterologous | Dapsone - therapeutic use | Erythrocyte Transfusion - methods | Dose-Response Relationship, Drug | Mefloquine - therapeutic use | Sensitivity and Specificity | Female | Doxycycline - adverse effects | Pyrimethamine - therapeutic use | Antimalarials - adverse effects | Drug Evaluation, Preclinical - methods | Reproducibility of Results | Glucosephosphate Dehydrogenase Deficiency - blood | Pyrimethamine - adverse effects | Doxycycline - therapeutic use | Glucosephosphate Dehydrogenase Deficiency - therapy | Chloroquine - therapeutic use | Antimalarials - therapeutic use | Combined Modality Therapy | Chloroquine - adverse effects | Mice, SCID | Mefloquine - adverse effects | Animals | Primaquine - therapeutic use | Anemia, Hemolytic - diagnosis | Anemia, Hemolytic - chemically induced | Mice, Inbred NOD | Primaquine - adverse effects | Anemia, Hemolytic - blood | Aminoquinolines - therapeutic use | Erythrocyte Count | Aminoquinolines - adverse effects | Phosphates | Physiological aspects | Oxidoreductases | Anemia | Health aspects | Risk factors | Glucose | Toxicity | Risk assessment | Rodents | Index Medicus | Biological Sciences
Journal Article
Journal of Natural Products, ISSN 0163-3864, 10/2017, Volume 80, Issue 10, pp. 2795 - 2798
The first synthesis of 2-methyl-6-pentadecyl-Δ1,6-piperideine (1), a major alkaloid of the piperideine chemotype in fire ant venoms, and its analogues,... 
Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2009, Volume 241, Issue 1, p. 14
Primaquine, an 8-aminoquinoline, is the drug of choice for radical cure of relapsing malaria. Use of primaquine is limited due to its hemotoxicity,... 
Phosphates | Dehydrogenases | Thiols | Metabolites | Primaquine | Fluoxetine | Analysis | Pharmacy | Cytochrome P-450 | Glucose | Dextrose | Glutathione
Journal Article
Molecules, ISSN 1420-3049, 02/2019, Volume 24, Issue 4, p. 777
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 10/2019, Volume 91, pp. 103094 - 103094
Guanylthiourea (GTU) has been identified as an important antifolate antimalarial pharmacophore unit, whereas, 4-amino quinolones are already known for... 
Molecular dynamics | 4-Aminoquinoline | In vitro studies | Guanylthiourea | Molecular docking | PfDHFR | Index Medicus
Journal Article
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