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1. Statistical genetics of infectious diseases
by Teo, Yik Ying
2017, Statistical genetics
Genetics, Population | Genome-Wide Association Study | Public Health | Communicable diseases | Statistical methods | prevention & control | Human population genetics | Biometry | Infection | Prevention | Genetics, Medical | genetics | statistics & numerical data | Medical genetics | Genetic aspects | Disease Vectors | Human genetics
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2. Full Text “Asian” Phenotype Underestimates the Genetic Diversity of Asia yet Overstates its Impact on Variability in Drug Disposition and Pharmacodynamics
by Singh, Rominder and Teo, Yik Ying
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 04/2019, Volume 105, Issue 4, pp. 802 - 805
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3. Full Text "Asian" Phenotype Underestimates the Genetic Diversity of Asia yet Overstates its Impact on Variability in Drug Disposition and Pharmacodynamics
by Singh, R and Teo, YY
CLINICAL PHARMACOLOGY & THERAPEUTICS, ISSN 0009-9236, 04/2019, Volume 105, Issue 4, pp. 802 - 805
For drug registrations, some regulatory agencies in Asia frequently require additional safety and efficacy data in Asians. Geographic location, race, and... 
PHARMACOLOGY & PHARMACY
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4. Full Text A118G single nucleotide polymorphism of human μ-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia
by Sia, Alex T and Lim, Yvonne and Lim, Eileen C. P and Goh, Rachelle W. C and Law, Hai Yang and Landau, Ruth and Teo, Yik-Ying and Tan, Ene Choo
Anesthesiology, ISSN 0003-3022, 2008, Volume 109, Issue 3, pp. 520 - 526
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5. Full Text Patterns of linkage disequilibrium atPARK16may explain variances in genetic association studies
: LINKAGE DISEQUILIBRIUM OFPARK16IN DIFFERENT RACES
by Li, Huihua and Teo, Yik-Ying and Tan, Eng-King
Movement Disorders, ISSN 0885-3185, 09/2015, Volume 30, Issue 10, pp. 1335 - 1342
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6. Full Text Genomic prediction of tuberculosis drug-resistance: Benchmarking existing databases and prediction algorithms
by Ngo, Tra-My and Teo, Yik-Ying
BMC Bioinformatics, ISSN 1471-2105, 02/2019, Volume 20, Issue 1, pp. 68 - 68
BackgroundIt is possible to predict whether a tuberculosis (TB) patient will fail to respond to specific antibiotics by sequencing the genome of the infecting... 
Genomic prediction | Drug-resistance | Tuberculosis | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFORMATION | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | CLASSIFICATION | LINEAGE | Drug resistance in microorganisms | Databases | Algorithms | Genomics | Benchmarks | Genomes | Nucleotide sequencing | Drug therapy | Rifampin | DNA sequencing | Performance evaluation | Fluoroquinolones | Phenotypes | Automation | Laboratories | Performance prediction | Identification | Drug resistance | Data bases | Computer programs | Gene sequencing | Antibiotics | Surveillance | Phenotyping | Software | Mutation | Isoniazid | Bioinformatics | Index Medicus
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7. Full Text Assessing single nucleotide variant detection and genotype calling on whole-genome sequenced individuals
by Cheng, Anthony Youzhi and Teo, Yik-Ying and Ong, Rick Twee-Hee
Bioinformatics, ISSN 1367-4803, 06/2014, Volume 30, Issue 12, pp. 1707 - 1713
Motivation: Whole-genome sequencing (WGS) is now routinely used for the detection and identification of genetic variants, particularly single nucleotide... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MAP | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Sequence Alignment | Humans | Female | Genotype | Male | High-Throughput Nucleotide Sequencing | Polymorphism, Single Nucleotide | Genome, Human | Genotyping Techniques - methods | Sequence Analysis, DNA | Index Medicus
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8. Full Text The genetic architecture of type 2 diabetes
by Fuchsberger, Christian and Flannick, Jason and Teslovich, Tanya M and Mahajan, Anubha and Agarwala, Vineeta and Gaulton, Kyle J and Ma, Clement and Fontanillas, Pierre and Moutsianas, Loukas and McCarthy, Davis J and Rivas, Manuel A and Perry, John R. B and Sim, Xueling and Blackwell, Thomas W and Robertson, Neil R and Rayner, N. William and Cingolani, Pablo and Locke, Adam E and Fernandez Tajes, Juan and Highland, Heather M and Dupuis, Josee and Chines, Peter S and Lindgren, Cecilia M and Hartl, Christopher and Jackson, Anne U and Chen, Han and Huyghe, Jeroen R and van de Bunt, Martijn and Pearson, Richard D and Kumar, Ashish and Müller-Nurasyid, Martina and Grarup, Niels and Stringham, Heather M and Gamazon, Eric R and Lee, Jaehoon and Chen, Yuhui and Scott, Robert A and Below, Jennifer E and Chen, Peng and Huang, Jinyan and Go, Min Jin and Stitzel, Michael L and Pasko, Dorota and Parker, Stephen C. J and Varga, Tibor V and Green, Todd and Beer, Nicola L and Day-Williams, Aaron G and Ferreira, Teresa and Fingerlin, Tasha and Horikoshi, Momoko and Hu, Cheng and Huh, Iksoo and Ikram, Mohammad Kamran and Kim, Bong-Jo and Kim, Yongkang and Kim, Young Jin and Kwon, Min-Seok and Lee, Juyoung and Lee, Selyeong and Lin, Keng-Han and Maxwell, Taylor J and Nagai, Yoshihiko and Wang, Xu and Welch, Ryan P and Yoon, Joon and Zhang, Weihua and Barzilai, Nir and Voight, Benjamin F and Han, Bok-Ghee and Jenkinson, Christopher P and Kuulasmaa, Teemu and Kuusisto, Johanna and Manning, Alisa and Ng, Maggie C. Y and Palmer, Nicholette D and Balkau, Beverley and Stancáková, Alena and Abboud, Hanna E and Boeing, Heiner and Gieaitis, Vilmantas and Prabhakaran, Dorairaj and Gottesman, Omri and Scott, James and Carey, Jason and Kwan, Phoenix and Grant, George and Smith, Joshua D and Neale, Benjamin M and Purcell, Shaun and Butterworth, Adam S and Howson, Joanna M. M and Lee, Heung Man and Lu, Yingchang and Kwak, Soo-Heon and Zhao, Wei and Danesh, John and Lam, Vincent K. L and Park, Kyong Soo and Saleheen, Danish and ... and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Umeå universitet and Medicin
Nature, ISSN 0028-0836, 2016, Volume 536, Issue 7614, pp. 41 - +
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been... 
Exome | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Sample Size | DNA Mutational Analysis | Diabetes Mellitus, Type 2 - genetics | Humans | Alleles | Genetic Variation - genetics | Genotyping Techniques | Europe - ethnology | Type 2 diabetes | Genomic structural variations | Nucleotide sequencing | Research | Analysis | DNA sequencing | Studies | Genetics | Genomes | Diabetes | Health risk assessment | Genes | Index Medicus | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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9. Full Text The HLA-DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations
by Kim, Kwangwoo and Bang, So-Young and Lee, Hye-Soon and Okada, Yukinori and Han, Buhm and Saw, Woei-Yuh and Teo, Yik-Ying and Bae, Sang-Cheol
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, pp. 5902 - 5902
Genetic association of the major histocompatibility complex (MHC) locus is well established in systemic lupus erythematosus (SLE), but the causal functional... 
Haplotypes | Genetic Predisposition to Disease | Genome-Wide Association Study | HLA-DRB1 Chains - genetics | Humans | Asian Continental Ancestry Group - genetics | Lupus Erythematosus, Systemic - metabolism | Male | Case-Control Studies | Amino Acid Motifs | Lupus Erythematosus, Systemic - genetics | Alleles | Protein Binding | Female | HLA-DRB1 Chains - chemistry | HLA-DRB1 Chains - metabolism | Republic of Korea | Index Medicus
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10. Full Text Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
by Flannick, Jason and Thorleifsson, Gudmar and Beer, Nicola L and Jacobs, Suzanne B.R and Grarup, Niels and Burtt, Noël P and Mahajan, Anubha and Fuchsberger, Christian and Atzmon, Gil and Benediktsson, Rafn and Blangero, John and Bowden, Don W and Brandslund, Ivan and Brosnan, Julia and Burslem, Frank and Chambers, John and Cho, Yoon Shin and Christensen, Cramer and Douglas, Desirée A and Duggirala, Ravindranath and Dymek, Zachary and Farjoun, Yossi and Fennell, Timothy and Fontanillas, Pierre and Forsén, Tom and Gabriel, Stacey and Glaser, Benjamin and Gudbjartsson, Daniel F and Hanis, Craig and Hansen, Torben and Hreidarsson, Astradur B and Hveem, Kristian and Ingelsson, Erik and Isomaa, Bo and Johansson, Stefan and Jørgensen, Torben and Jørgensen, Marit Eika and Kathiresan, Sekar and Kong, Augustine and Kooner, Jaspal and Kravic, Jasmina and Laakso, Markku and Lee, Jong-Young and Lind, Lars and Lindgren, Cecilia M and Linneberg, Allan and Masson, Gisli and Meitinger, Thomas and Mohlke, Karen L and Molven, Anders and Morris, Andrew P and Potluri, Shobha and Rauramaa, Rainer and Ribel-Madsen, Rasmus and Richard, Ann-Marie and Rolph, Tim and Salomaa, Veikko and Segrè, Ayellet V and Skärstrand, Hanna and Steinthorsdottir, Valgerdur and Stringham, Heather M and Sulem, Patrick and Tai, E Shyong and Teo, Yik Ying and Teslovich, Tanya and Thorsteinsdottir, Unnur and Trimmer, Jeff K and Tuomi, Tiinamaija and Tuomilehto, Jaakko and Vaziri-Sani, Fariba and Voight, Benjamin F and Wilson, James G and Boehnke, Michael and McCarthy, Mark I and Njølstad, Pål R and Pedersen, Oluf and Groop, Leif and Cox, David R and Stefansson, Kari and Altshuler, David and Go-T2D Consortium and T2D-Genes Consortium and T2D-GENES Consortium
Nature Genetics, ISSN 1061-4036, 2014, Volume 46, Issue 4, pp. 357 - 363
Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets1-3, but none have yet been described for type 2... 
INSULIN | COMMON VARIANTS | RESPONSES | GLUCOSE-HOMEOSTASIS | RARE | GENETICS & HEREDITY | BETA-CELL | ZINC TRANSPORTER ZNT8 | EXPRESSION | GENOME-WIDE ASSOCIATION | PATHOPHYSIOLOGY | Proinsulin - blood | Genetic Association Studies | Zinc Transporter 8 | Diabetes Mellitus, Type 2 - genetics | Humans | Molecular Sequence Data | Genotype | Sequence Analysis, DNA | Mutation, Missense - genetics | Mice, Knockout | Animals | Base Sequence | Blood Glucose - genetics | Cation Transport Proteins - genetics | Mice | Ion Transport - genetics | Type 2 diabetes | Prevention | Gene mutations | Genetic susceptibility | Genetic research | Genetic aspects | Research | Identification and classification | Proteins | Studies | Genotype & phenotype | Genetics | Genomes | Diabetes | Mutation | Index Medicus | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
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11. Full Text Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
by Mahajan, Anubha and Go, Min Jin and Zhang, Weihua and Below, Jennifer E and Gaulton, Kyle J and Ferreira, Teresa and Horikoshi, Momoko and Johnson, Anew D and Ng, Maggie C. Y and Prokopenko, Inga and Saleheen, Danish and Wang, Xu and Zeggini, Eleftheria and Abecasis, Goncalo R and Adair, Linda S and Almgren, Peter and Atalay, Mustafa and Aung, Tin and Baldassarre, Damiano and Balkau, Beverley and Bao, Yuqian and Barnett, Anthony H and Barroso, Ines and Basit, Abdul and Been, Latonya F and Beilby, John and Bell, Graeme I and Benediktsson, Rafn and Bergman, Richard N and Boehm, Bernhard O and Boerwinkle, Eric and Bonnycastle, Lori L and Burtt, Noël and Cai, Qiuyin and Campbell, Harry and Carey, Jason and Cauchi, Stephane and Caulfield, Mark and Chan, Juliana C. N and Chang, Li-Ching and Chang, Tien-Jyun and Chang, Yi-Cheng and Charpentier, Guillaume and Chen, Chien-Hsiun and Chen, Han and Chen, Yuan-Tsong and Chia, Kee-Seng and Chidambaram, Manickam and Chines, Peter S and Cho, Nam H and Cho, Young Min and Chuang, Lee-Ming and Collins, Francis S and Cornelis, Marilyn C and Couper, David J and Crenshaw, Anew T and van Dam, Rob M and Danesh, John and Das, Debashish and de Faire, Ulf and Dedoussis, George and Deloukas, Panos and Dimas, Antigone S and Dina, Christian and Doney, Alex S. F and Donnelly, Peter J and Dorkhan, Mozhgan and van Duijn, Cornelia and Dupuis, Josée and Edkins, Sarah and Elliott, Paul and Emilsson, Valur and Erbel, Raimund and Eriksson, Johan G and Escobedo, Jorge and Esko, Tonu and Eury, Elodie and Florez, Jose C and Fontanillas, Pierre and Forouhi, Nita G and Forsen, Tom and Fox, Caroline and Fraser, Ross M and Frayling, Timothy M and Froguel, Philippe and Frossard, Philippe and Gao, Yutang and Gertow, Karl and Gieger, Christian and Gigante, Bruna and Grallert, Harald and Grant, George B and Groop, Leif C and Groves, Christopher J and Grundberg, Elin and Guiducci, Candace and Hamsten, Anders and Han, Bok-Ghee and Hara, Kazuo and Hassanali, Neelam and ... and South Asian Type Diabet SAT2D Cons and DIAbet Genetics Replication & Meta and Mexican Amer Type 2 Diabet MAT2D C and Asian Genetic Epidemiology Network and Type 2 Diabet Genetic Exploration and South Asian Type 2 Diabetes (SAT2D) Consortium and Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium and Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and Mexican American Type 2 Diabetes (MAT2D) Consortium and Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
Nature genetics, ISSN 1061-4036, 2014, Volume 46, Issue 3, pp. 234 - 244
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies... 
INDIVIDUALS | GLUCOSE-HOMEOSTASIS | IMPUTATION | VARIANTS | CHROMATIN | GENETICS & HEREDITY | POPULATIONS | TRANSETHNIC METAANALYSIS | LOCI | SCALE ASSOCIATION ANALYSIS | MAP | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Hispanic Americans - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Risk Factors | Alleles | Asian Continental Ancestry Group - genetics | Polymorphism, Single Nucleotide | Case-Control Studies | Type 2 diabetes | Genetic research | Genetic aspects | Research | Genetic susceptibility | Immigration | Genomes | Genealogy | Diabetes | Architecture | Meta-analysis | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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12. Full Text Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
by Kato, Norihiro and Takeuchi, Fumihiko and Tabara, Yasuharu and Kelly, Tanika N and Go, Min Jin and Sim, Xueling and Tay, Wan Ting and Chen, Chien-Hsiun and Zhang, Yi and Yamamoto, Ken and Katsuya, Tomohiro and Yokota, Mitsuhiro and Kim, Young Jin and Ong, Rick Twee Hee and Nabika, Toru and Gu, Dongfeng and Chang, Li-Ching and Kokubo, Yoshihiro and Huang, Wei and Ohnaka, Keizo and Yamori, Yukio and Nakashima, Eitaro and Jaquish, Cashell E and Lee, Jong-Young and Seielstad, Mark and Isono, Masato and Hixson, James E and Chen, Yuan-Tsong and Miki, Tetsuro and Zhou, Xueya and Sugiyama, Takao and Jeon, Jae-Pil and Liu, Jian Jun and Takayanagi, Ryoichi and Kim, Sung Soo and Aung, Tin and Sung, Yun Ju and Zhang, Xuegong and Wong, Tien Yin and Han, Bok-Ghee and Kobayashi, Shotai and Ogihara, Toshio and Zhu, Dingliang and Iwai, Naoharu and Wu, Jer-Yuarn and Teo, Yik Ying and Tai, E Shyong and Cho, Yoon Shin and He, Jiang
Nature Genetics, ISSN 1061-4036, 06/2011, Volume 43, Issue 6, pp. 531 - 538
We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry... 
GLOBAL BURDEN | GENETIC-BASIS | RISK-FACTORS | POSITIVE SELECTION | WILL UNLOCK | JAPANESE POPULATION | DISEASE | GENETICS & HEREDITY | REGIONAL BURDEN | ESSENTIAL-HYPERTENSION | LOCI | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Blood Pressure - genetics | Gene Frequency | Humans | Asian Continental Ancestry Group - genetics | Diastole - genetics | Polymorphism, Single Nucleotide | Systole - genetics | Far East | Physiological aspects | Blood pressure | Genetic aspects | Research | Single nucleotide polymorphisms | Demographic aspects | Studies | Hypertension | Health sciences | Biomedical research | Science | Genetics | Genomes | Gene expression | Minority & ethnic groups | Epidemiology | Meta-analysis | Index Medicus
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13. Full Text Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
by Cho, Yoon Shin and Chen, Chien-Hsiun and Hu, Cheng and Long, Jirong and Hee Ong, Rick Twee and Sim, Xueling and Takeuchi, Fumihiko and Wu, Ying and Go, Min Jin and Yamauchi, Toshimasa and Chang, Yi-Cheng and Kwak, Soo Heon and Ma, Ronald C W and Yamamoto, Ken and Adair, Linda S and Aung, Tin and Cai, Qiuyin and Chang, Li-Ching and Chen, Yuan-Tsong and Gao, Yutang and Hu, Frank B and Kim, Hyung-Lae and Kim, Sangsoo and Kim, Young Jin and Lee, Jeannette Jen-Mai and Lee, Nanette R and Li, Yun and Liu, Jian Jun and Lu, Wei and Nakamura, Jiro and Nakashima, Eitaro and Ng, Daniel Peng-Keat and Tay, Wan Ting and Tsai, Fuu-Jen and Wong, Tien Yin and Yokota, Mitsuhiro and Zheng, Wei and Zhang, Rong and Wang, Congrong and So, Wing Yee and Ohnaka, Keizo and Ikegami, Hiroshi and Hara, Kazuo and Cho, Young Min and Cho, Nam H and Chang, Tien-Jyun and Bao, Yuqian and Hedman, Åsa K and Morris, Andrew P and McCarthy, Mark I and Takayanagi, Ryoichi and Park, Kyong Soo and Jia, Weiping and Chuang, Lee-Ming and Chan, Juliana C N and Maeda, Shiro and Kadowaki, Takashi and Lee, Jong-Young and Wu, Jer-Yuarn and Teo, Yik Ying and Tai, E. Shyong and Shu, Xiao Ou and Mohlke, Karen L and Kato, Norihiro and Han, Bok-Ghee and Seielstad, Mark and DIAGRAM Consortium and MuTHER Consortium
Nature Genetics, ISSN 1061-4036, 01/2012, Volume 44, Issue 1, pp. 67 - 72
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1... 
COMPLEX | VARIANTS | JAPANESE POPULATION | KCNQ1 | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | RISK | GENETIC-LOCI | MELLITUS | CHILDHOOD | Genetic Predisposition to Disease | Genome-Wide Association Study | Diabetes Mellitus, Type 2 - genetics | Humans | Asian Continental Ancestry Group - genetics | Adult | Blood Glucose | Chromosome Mapping | Polymorphism, Single Nucleotide | Far East | Case-Control Studies | Type 2 diabetes | Pancreatic beta cells | Physiological aspects | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Risk factors | Asians | Health care | Biomedical research | Pathogenesis | Genes | Principal components analysis | Genomes | Preventive medicine | Epidemiology | Meta-analysis | Studies | Councils | Genetics | Diabetes | Asian Americans | Index Medicus | Medical and Health Sciences | Medicin och hälsovetenskap
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