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1. Full Text A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects
by Su, Ping and Li, Shupeng and Chen, Sheng and Lipina, Tatiana V and Wang, Min and Lai, Terence K.Y and Lee, Frankie H.F and Zhang, Hailong and Zhai, Dongxu and Ferguson, Stephen S.G and Nobrega, José N and Wong, Albert H.C and Roder, John C and Fletcher, Paul J and Liu, Fang
Neuron, ISSN 0896-6273, 12/2014, Volume 84, Issue 6, pp. 1302 - 1316
Current antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction with other receptors such as those for serotonin. However, these... 
ADULT BRAIN | PREPULSE INHIBITION | PROGENITOR PROLIFERATION | BEHAVIORAL PHENOTYPES | SCHIZOPHRENIA | MICE | DISC1 | NEUROSCIENCES | PREFRONTAL CORTEX | MODULATION | STRIATUM | Phosphorylation | Schizophrenia - metabolism | Humans | Receptors, Dopamine D2 - agonists | Amphetamine - pharmacology | Motor Activity - drug effects | Rats | Male | Glycogen Synthase Kinase 3 - metabolism | Receptors, Dopamine D2 - metabolism | Arrestins - metabolism | Nerve Tissue Proteins - genetics | Clathrin - metabolism | Peptides - pharmacology | Brain - metabolism | Nerve Tissue Proteins - metabolism | Animals | Prepulse Inhibition - drug effects | beta-Arrestins | Protein Binding - drug effects | Catalepsy - chemically induced | Mice | Antipsychotic Agents - pharmacology | Mutation | Glucose metabolism | Neurosciences | Antipsychotic drugs | Dopamine | Synthesis | Peptides | Animal behavior | Glycogen | Analysis | Physiological aspects | Phenols | Schizophrenia | Psychotropic drugs | Medical research | Kinases | Rodents
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2. Full Text Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
by Hiu Wing Cheung and Glenn S. Cowley and Barbara A. Weir and Jesse S. Boehm and Scott Rusin and Justine A. Scott and Alexandra East and Levi D. Ali and Patrick H. Lizotte and Terence C. Wong and Guozhi Jiang and Jessica Hsiao and Craig H. Mermel and Gad Getz and Jordi Barretina and Shuba Gopal and Pablo Tamayo and Joshua Gould and Aviad Tsherniak and Nicolas Stransky and Biao Luo and Yin Ren and Ronny Drapkin and Sangeeta N. Bhatia and Jill P. Mesirov and Levi A. Garraway and Matthew Meyerson and Eric S. Lander and David E. Root and William C. Hahn
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 30, pp. 12372 - 12377
A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts... 
Tumor cell line | Essential genes | Cell lines | Genomes | Genetic mutation | Genetic screening | Oncogenes | Ovarian cancer | Cancer | Tumors | High throughput | Lineage | RNAi | Oncogene | lineage | LUNG | GENOMIC ANALYSES | MULTIDISCIPLINARY SCIENCES | KINASE | MODEL | oncogene | high throughput | MELANOMA | PAX8 | SURVIVAL ONCOGENE | CARCINOMA | Alcohol Oxidoreductases | Paired Box Transcription Factors - genetics | RNA, Small Interfering - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Cell Proliferation | Humans | Ovarian Neoplasms - pathology | Cell Survival - genetics | Ovarian Neoplasms - genetics | Base Sequence | Cell Line, Tumor | RNA, Neoplasm - genetics | Female | PAX8 Transcription Factor | Cancer cells | Physiological aspects | Genetics | Genetic aspects | Research | Biological diversity | Biological Sciences
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3. Full Text Prognostic utility of pre- and post-treatment FDG-PET parameters in anal squamous cell carcinoma
by Duimering, Adele and Riauka, Terence and Nijjar, Tirath and Nijjar, Yugmel and Ghosh, Sunita and MacEwan, Robert and Warkentin, Heather and Schiller, Dan and Tankel, Keith and Usmani, Nawaid and Severin, Diane and Fairchild, Alysa and Mulder, Karen and Doll, Corinne and Wong, Clarence and Joseph, Kurian
Radiotherapy and Oncology, ISSN 0167-8140, 07/2019, Volume 136, pp. 21 - 28
We prospectively assessed the contributions of PET to initial staging, early detection of treatment failures, and prognostication in patients with anal... 
FDG-PET | Intensity-modulated radiation therapy | Prognosis | Anal cancer | Metabolic tumour volume | SURVIVAL | TOMOGRAPHY | CANCER | METABOLIC TUMOR VOLUME | IMPACT | THERAPY | ONCOLOGY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Pets | Glucose metabolism | CT imaging | Squamous cell carcinoma | PET imaging | Radiation | Development and progression | Radiotherapy
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4. Changing epidemiology of hand, foot, and mouth disease in Hong Kong, 2001-2009
by Ma, Edmond and Lam, Terence and Chan, K.C and Wong, Christine and Chuang, S.K
Japanese Journal of Infectious Diseases, ISSN 1344-6304, 2010, Volume 63, Issue 6, pp. 422 - 426
We report the surveillance findings of hand, foot, and mouth disease (HFMD) collected from a general practitioner-based sentinel surveillance system and... 
INFECTIOUS DISEASES | ENTEROVIRUS 71 INFECTION | TAIWAN | JAPAN | SURVEILLANCE | SINGAPORE | OUTBREAK | CHILDREN | Age Distribution | Enterovirus - classification | Humans | Child, Preschool | Hospitalization - statistics & numerical data | Infant | Male | Disease Outbreaks - statistics & numerical data | Enterovirus - isolation & purification | Young Adult | Hong Kong - epidemiology | Adolescent | Hand, Foot and Mouth Disease - pathology | General Practice - statistics & numerical data | Hand, Foot and Mouth Disease - epidemiology | Adult | Female | Seasons | Child | Hand, Foot and Mouth Disease - virology | Sentinel Surveillance
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5. Full Text Scarlet fever epidemic, Hong Kong, 2011
by Luk, Emma Y.Y and Lo, Janice Y.C and Li, Amy Z.L and Lau, Michael C.K and Cheung, Terence K.M and Wong, Alice Y.M and Wong, Monica M.H and Wong, Christine W and Chuang, Shuk-kwan and Tsang, Thomas
Emerging Infectious Diseases, ISSN 1080-6040, 10/2012, Volume 18, Issue 10, pp. 1658 - 1661
More than 900 cases of scarlet fever were recorded in Hong Kong during January July, 2011. Six cases were complicated by toxic shock syndrome, of which 2 were... 
INFECTIOUS DISEASES | IMMUNOLOGY | Scarlet Fever - epidemiology | Epidemics | Shock, Septic - etiology | Streptococcus pyogenes - drug effects | Humans | Shock, Septic - epidemiology | Scarlet Fever - complications | Electrophoresis, Gel, Pulsed-Field | Incidence | Microbial Sensitivity Tests | Streptococcus pyogenes - genetics | Hong Kong - epidemiology | Female | Scarlet Fever - microbiology | Anti-Bacterial Agents - pharmacology | Child | Scarlet fever | Septic shock | Health aspects | Index Medicus | septic | emm type | bacteria | Hong Kong | antimicrobial resistance | epidemic | shock | disease notification | Dispatch | Streptococcus pyogenes | streptococci | epidemics
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6. Full Text Abstract B33: Integration of genome-wide datasets identifies SOX10 as a lineage-specific genetic dependency in melanoma
by Wong, Terence C and Johannessen, Cory M and Garraway, Levi A
Clinical Cancer Research, ISSN 1078-0432, 02/2015, Volume 21, Issue 4 Supplement, pp. B33 - B33
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7. Full Text Activation of MAPK signaling pathway is essential for Id-1 induced serum independent prostate cancer cell growth
by Ling, Ming-Tat and Wang, Xianghong and Ouyang, Xue-Song and Lee, Terence K.W and Fan, Tian-Yong and Xu, Kexin and Tsao, Sai-Wah and Wong, Y.C
Oncogene, ISSN 0950-9232, 12/2002, Volume 21, Issue 55, pp. 8498 - 8505
The helix-loop-helix protein Id-1 has been suggested to play a positive role in cell proliferation and tumorigenesis of many types of human cancers. However,... 
Cell growth | MAPK | Id-1 | Prostate cancer | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | cell growth | HUMAN KERATINOCYTES | CELL BIOLOGY | P16/INK4A | LOOP-HELIX PROTEINS | prostate cancer | G PROGRESSION | ONCOLOGY | GENES | ID1 | GENETICS & HEREDITY | SENESCENCE | EXPRESSION | CARCINOMA | Recombinant Proteins - metabolism | Prostatic Neoplasms - pathology | MAP Kinase Signaling System - physiology | Transcription Factors - physiology | Humans | Repressor Proteins | Male | Helix-Loop-Helix Motifs | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immediate-Early Proteins | Inhibitor of Differentiation Protein 1 | Transfection | Cell Division | Early Growth Response Protein 1 | Tumor Cells, Cultured | Growth | Cancer cells | Physiological aspects | Cellular signal transduction | Research | Protein kinases | Risk factors
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8. Full Text Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer: The first experience in Hong Kong
by Wong, Matthew K.Y and Ho, James C.M and Loong, Florence and Lam, David C.L and Wong, W.M and Tam, Terence C.C and Han, L and Ip, Mary S.M
Hong Kong Medical Journal, ISSN 1024-2708, 2013, Volume 19, Issue 1, pp. 20 - 26
Objective To investigate the diagnostic performance and safety of endobronchial ultrasound-guided transbronchial needle aspiration in patients presenting with... 
Bronchoscopy | Fine-needle | Sensitivity and specificity | Neoplasm staging | Biopsy | Lung neoplasms | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | THERAPY | BRONCHOGENIC-CARCINOMA | EBUS-TBNA | GUIDELINES 2ND EDITION | fine-needle | Predictive Value of Tests | Prospective Studies | Hong Kong | Humans | Middle Aged | Bronchoscopy - methods | Hospitals, University | Lung Neoplasms - pathology | Male | Endoscopic Ultrasound-Guided Fine Needle Aspiration - adverse effects | Lymphatic Metastasis | Young Adult | Sensitivity and Specificity | Aged, 80 and over | Endoscopic Ultrasound-Guided Fine Needle Aspiration - methods | Adult | Female | Aged | Lung Neoplasms - diagnosis | Neoplasm Staging
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9. Full Text Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway
by Lo, Regina Cheuk-Lam and Leung, Carmen Oi-Ning and Chan, Kristy Kwan-Shuen and Ho, Daniel Wai-Hung and Wong, Chun-Ming and Lee, Terence Kin-Wah and Ng, Irene Oi-Lin
Cell Death and Differentiation, ISSN 1350-9047, 08/2018, Volume 25, Issue 8, pp. 1426 - 1441
Identification and characterization of functional molecular targets conferring stemness properties in hepatocellular carcinoma (HCC) offers crucial insights to... 
EPITHELIAL-MESENCHYMAL TRANSITION | PROGENITOR CELLS | BREAST-CANCER | COLORECTAL TUMORS | ELEVATED EXPRESSION | SIGNALING PATHWAY | GASTRIC-CANCER | POOR-PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGNOSTIC-SIGNIFICANCE | BETA-CATENIN | CELL BIOLOGY | Cell proliferation | Phenotypes | Wnt protein | Frizzled protein | c-Myc protein | Chemoresistance | Hepatocellular carcinoma | Tumorigenicity | Transplantation | Myc protein | Metastases | β-catenin | Liver cancer | Signal transduction | Cell lines | Xenografts | Receptor density | Cell migration | Dishevelled protein
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10. Full Text Twist Overexpression Correlates with Hepatocellular Carcinoma Metastasis through Induction of Epithelial-Mesenchymal Transition
by Terence K. Lee and Ronnie T.P. Poon and Anthony P. Yuen and Ming Tat Ling and Wei Kei Kwok and Xiang Hong Wang and Yong Chuan Wong and Xin Yuan Guan and Kwan Man and King Lok Chau and Sheung Tat Fan
Clinical Cancer Research, ISSN 1078-0432, 09/2006, Volume 12, Issue 18, pp. 5369 - 5376
Purpose: Hepatocellular carcinoma (HCC) is a rapidly growing tumor associated with a high propensity for vascular invasion and metastasis.... 
Twist | HCC | EMT | E-Cadherin | INACTIVATION | MORPHOGENESIS | SUPPRESSOR GENE | ONCOLOGY | RECURRENCE | CPG METHYLATION | ESTABLISHMENT | E-CADHERIN GENE | EXPRESSION | CANCER | DROSOPHILA | Microarray Analysis - methods | Up-Regulation | Epithelial Cells - metabolism | Cadherins - metabolism | Humans | Nuclear Proteins - metabolism | Carcinoma, Hepatocellular - secondary | Statistics as Topic | Cell Transformation, Neoplastic - metabolism | Epithelial Cells - physiology | Transfection | Carcinoma, Hepatocellular - pathology | Transcriptional Activation - physiology | Tumor Cells, Cultured | Neoplasm Invasiveness - genetics | Twist-Related Protein 1 - metabolism | Carcinoma, Hepatocellular - metabolism
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11. Full Text Response to booster doses of hepatitis B vaccine among young adults who had received neonatal vaccination
by Chan, Paul K. S and Ngai, Karry L. K and Lao, Terence T and Wong, Martin C. S and Cheung, Theresa and Yeung, Apple C. M and Chan, Martin C. W and Luk, Scotty W. C
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e107163
Background: Newborns who have received hepatitis B immunization in 1980s are now young adults joining healthcare disciplines. The need for booster, pre- and... 
MOTHERS | IMMUNITY | VIRUS-INFECTION | TAIWAN | MULTIDISCIPLINARY SCIENCES | INFANTS | HBSAG | ENDEMICITY | PROGRAM | Prospective Studies | Follow-Up Studies | Humans | Vaccination | Hepatitis B - virology | Immunization, Secondary - methods | Male | Young Adult | Hepatitis B - immunology | Hepatitis B Vaccines - therapeutic use | Adolescent | Adult | Female | Hepatitis B Vaccines - immunology | Hepatitis B - prevention & control | Hepatitis B Antibodies - immunology | Hepatitis B virus - isolation & purification | Hepatitis B virus - immunology | Immunologic Memory - immunology | Infant, Newborn | Health care | Neonates | Working groups | Infections | Vaccines | Males | Immunity | Hepatitis | Students | Newborn babies | Consent | Hepatitis B virus | Medical personnel | Antigens | Immunological memory | Immunization | Immunoglobulins | Hepatitis B surface antigen | Young adults | Gynecology | Sex differences | Obstetrics | Disease control | Disease prevention | Studies | Nursing | Workers | Adults | Females | Hepatitis B
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12. Full Text Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
by Cowley, Glenn S and Weir, Barbara A and Vazquez, Francisca and Tamayo, Pablo and Scott, Justine A and Rusin, Scott and East-Seletsky, Alexandra and Ali, Levi D and Gerath, William F.J and Pantel, Sarah E and Lizotte, Patrick H and Jiang, Guozhi and Hsiao, Jessica and Tsherniak, Aviad and Dwinell, Elizabeth and Aoyama, Simon and Okamoto, Michael and Harrington, William and Gelfand, Ellen and Green, Thomas M and Tomko, Mark J and Gopal, Shuba and Wong, Terence C and Li, Hubo and Howell, Sara and Stransky, Nicolas and Liefeld, Ted and Jang, Dongkeun and Bistline, Jonathan and Meyers, Barbara Hill and Armstrong, Scott A and Anderson, Ken C and Stegmaier, Kimberly and Reich, Michael and Pellman, David and Boehm, Jesse S and Mesirov, Jill P and Golub, Todd R and Root, David E and Hahn, William C
Scientific Data, ISSN 2052-4463, 09/2014, Volume 1, Issue 1, pp. 140035 - 140035
Using a genome-scale, lentivirally delivered shRNA library, we performed massively parallel pooled shRNA screens in 216 cancer cell lines to identify genes... 
MULTIDISCIPLINARY SCIENCES
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13. Bone metastasis to the mandible in rectal cancer and a review of the literature
by Woo, Aaron and Lechner, Breanne and Probyn, Linda and Pulenzas, Natalie and Fu, Terence and Soliman, Hany and Shum, Tracy and Chow, Edward and Wong, C Shun
Journal of Pain Management, ISSN 1939-5914, 01/2015, Volume 8, Issue 3, pp. 257 - 260
Mandible | Bone metastases | Colorectal cancer
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14. Full Text Identification and characterization of tropomyosin 3 associated with granulin-epithelin precursor in human hepatocellular carcinoma
by Lam, Ching Yan and Yip, Chi Wai and Poon, Terence C. W and Cheng, Christine K. C and Ng, Eddy W. Y and Wong, Nicholas C. L and Cheung, Phyllis F. Y and Lai, Paul B. S and Ng, Irene O. L and Fan, Sheung Tat and Cheung, Siu Tim
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40324
Background and Aim: Granulin-epithelin precursor (GEP) has previously been reported to control cancer growth, invasion, chemo-resistance, and served as novel... 
CELLS | ISOFORMS | MESSENGER-RNA | TPM3 | MUTATION | TISSUE | BIOLOGY | DIFFERENTIALLY EXPRESSED GENES | DOMINANT NEMALINE MYOPATHY | GROWTH-FACTOR | CANCER | Tropomyosin - genetics | Gene Expression | Humans | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Kaplan-Meier Estimate | Neoplasm Recurrence, Local | Cytoplasm - metabolism | RNA, Messenger - metabolism | Protein Interaction Mapping | Disease-Free Survival | Intercellular Signaling Peptides and Proteins - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Protein Precursors | Statistics, Nonparametric | Cell Line, Tumor | Protein Binding | Liver Neoplasms - pathology | Tropomyosin - metabolism | Carcinoma, Hepatocellular - metabolism | Immunohistochemistry | Liver cancer | Chemotherapy | Analysis | Liver | Monoclonal antibodies | Muscle proteins | Mass spectrometry | Cancer | Cell culture | Health sciences | Immunoprecipitation | Disease | Transcription | Laboratories | Hepatocellular carcinoma | Identification | Kinases | Proteins | Precursors | Rodents | Surgery | Medical research | Spectroscopy | Congenital diseases | Polypeptides | Tropomyosin | Therapeutic applications | Mass spectroscopy | Gene expression | Polymerase chain reaction | Granulin | Hepatocytes | Lymphomas | Mutation | Cytoplasm | Tumors
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15. Full Text Metabolic studies of 1‐testosterone in horses
by Kwok, W. H and Ho, Emmie N. M and Leung, Gary N. W and Tang, Francis P. W and Wan, Terence S. M and Wong, Henry N. C and Yeung, John H. K
Drug Testing and Analysis, ISSN 1942-7603, 02/2013, Volume 5, Issue 2, pp. 81 - 88
1‐Testosterone (17β‐hydroxy‐5α‐androst‐1‐en‐3‐one), a synthetic anabolic steroid, has been described as one of the most effective muscle‐building supplements... 
horse | 1‐testosterone | metabolism | urine | doping control | Urine | Doping control | 1-testosterone | Metabolism | Horse | CHEMISTRY, ANALYTICAL | STEROIDS | BIOCHEMICAL RESEARCH METHODS | IMPACT INDUCED FRAGMENTATIONS | STEREOCHEMICAL PROBLEMS | IDENTIFICATION | REARRANGEMENTS | CHROMATOGRAPHY-MASS-SPECTROMETRY | ESTERS | PHARMACOLOGY & PHARMACY | URINARY METABOLITES | ACETATE | Testosterone - metabolism | Animals | Gas Chromatography-Mass Spectrometry | Anabolic Agents - urine | Microsomes, Liver - metabolism | Horses - metabolism | Horses - urine | Testosterone - analogs & derivatives | Anabolic Agents - metabolism
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16. Solitary bone metastatic lesion to the cuboid in endometrial cancer and a review of the literature
by Woo, Aaron and Lechner, Breanne and Probyn, Linda and Pulenzas, Natalie and Fu, Terence and Soliman, Hany and Wong, C Shun and Shum, Tracy and Chow, Edward and Ackerman, Ida and Leung, Eric
Journal of Pain Management, ISSN 1939-5914, 01/2015, Volume 8, Issue 3, pp. 261 - 264
Endometrial cancer | Cuboid | Bone metastases
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