Autophagy, ISSN 1554-8627, 04/2012, Volume 8, Issue 4, pp. 445 - 544
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and...
stress | vacuole | autolysosome | flux | LC3 | autophagosome | lysosome | phagophore | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Stress | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | VACUOLE TARGETING PATHWAY | ENDOPLASMIC-RETICULUM STRESS | ISOLATED RAT HEPATOCYTES | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BREAST-CANCER CELLS | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | Biological Assay - methods | Animals | Autophagy - genetics | Models, Biological | Humans | Life Sciences | Cellular Biology | Review | Medical and Health Sciences | Medicin och hälsovetenskap
stress | vacuole | autolysosome | flux | LC3 | autophagosome | lysosome | phagophore | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Stress | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | VACUOLE TARGETING PATHWAY | ENDOPLASMIC-RETICULUM STRESS | ISOLATED RAT HEPATOCYTES | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BREAST-CANCER CELLS | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | Biological Assay - methods | Animals | Autophagy - genetics | Models, Biological | Humans | Life Sciences | Cellular Biology | Review | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Anesthesiology, ISSN 0003-3022, 03/2015, Volume 122, Issue 3, pp. 659 - 665
BACKGROUND:Postoperative opioid-induced respiratory depression (RD) is a significant cause of death and brain damage in the perioperative period. The authors...
SURGERY | OBSTRUCTIVE SLEEP-APNEA | EVENTS | UNIT | PATTERNS | ANESTHESIOLOGY | ACUTE PAIN MANAGEMENT | CARE | Humans | Insurance Claim Review | Middle Aged | Respiratory Insufficiency - diagnosis | Respiratory Insufficiency - epidemiology | Male | Anesthesia - adverse effects | Postoperative Complications - epidemiology | Respiratory Insufficiency - chemically induced | Postoperative Complications - diagnosis | Analgesics, Opioid - adverse effects | Adult | Female | Aged | Postoperative Complications - chemically induced | Databases, Factual
SURGERY | OBSTRUCTIVE SLEEP-APNEA | EVENTS | UNIT | PATTERNS | ANESTHESIOLOGY | ACUTE PAIN MANAGEMENT | CARE | Humans | Insurance Claim Review | Middle Aged | Respiratory Insufficiency - diagnosis | Respiratory Insufficiency - epidemiology | Male | Anesthesia - adverse effects | Postoperative Complications - epidemiology | Respiratory Insufficiency - chemically induced | Postoperative Complications - diagnosis | Analgesics, Opioid - adverse effects | Adult | Female | Aged | Postoperative Complications - chemically induced | Databases, Factual
Journal Article
Nature Reviews Neuroscience, ISSN 1471-003X, 07/2018, Volume 19, Issue 7, pp. 383 - 384
Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies...
NEUROSCIENCES | Chronic pain | Therapeutics | Homeopathy | Materia medica and therapeutics | Pain
NEUROSCIENCES | Chronic pain | Therapeutics | Homeopathy | Materia medica and therapeutics | Pain
Journal Article
Journal of Translational Medicine, ISSN 1479-5876, 01/2010, Volume 8, Issue 1, pp. 2 - 2
Background: Staphylococcal enterotoxins (SEs), SE-like (SEl) toxins, and toxic shock syndrome toxin-1 (TSST-1), produced by Staphylococcus aureus, belong to...
CHAIN | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX | STIMULATION | RECOGNITION | BOVINE | GENES | SYBR GREEN | ENTEROTOXINS | AUREUS | EXPRESSION
CHAIN | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX | STIMULATION | RECOGNITION | BOVINE | GENES | SYBR GREEN | ENTEROTOXINS | AUREUS | EXPRESSION
Journal Article
Scandinavian Journal of Pain, ISSN 1877-8860, 2016, Volume 11, Issue 1, pp. 125 - 126
Journal Article
Journal of Pain, ISSN 1526-5900, 2016, Volume 17, Issue 9, pp. T1 - T9
Abstract A variety of approaches have been used to develop diagnostic criteria for chronic pain. The published evidence of the reliability and validity of...
Anesthesia & Perioperative Care | Pain Medicine | diagnostic criteria | taxonomy | classification | Chronic pain | INTERNATIONAL CLASSIFICATION | VALIDATION | RELIABILITY | MECHANISMS | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROPATHIC PAIN | HEADACHE DISORDERS | VALIDITY | Chronic Pain - epidemiology | Pain Measurement - standards | Chronic Pain - diagnosis | Pain Measurement - methods | United States | Humans | Classification | Societies, Medical - standards | United States Food and Drug Administration | Public-Private Sector Partnerships | Medical colleges | Diagnosis | Analysis | Public-private sector cooperation
Anesthesia & Perioperative Care | Pain Medicine | diagnostic criteria | taxonomy | classification | Chronic pain | INTERNATIONAL CLASSIFICATION | VALIDATION | RELIABILITY | MECHANISMS | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROPATHIC PAIN | HEADACHE DISORDERS | VALIDITY | Chronic Pain - epidemiology | Pain Measurement - standards | Chronic Pain - diagnosis | Pain Measurement - methods | United States | Humans | Classification | Societies, Medical - standards | United States Food and Drug Administration | Public-Private Sector Partnerships | Medical colleges | Diagnosis | Analysis | Public-private sector cooperation
Journal Article
Anesthesiology, ISSN 0003-3022, 04/2016, Volume 124, Issue 4, pp. 945 - 957
BACKGROUND:Opioid-related deaths are a leading cause of accidental death, with most occurring in patients receiving chronic pain therapy. Respiratory arrest is...
RECURRENT HYPOXIA | SLEEP | INDUCED RESPIRATORY DEPRESSION | CHRONIC PAIN | OVERDOSE | ADMINISTERED MORPHINE | ANESTHESIOLOGY | POSTNATAL-DEVELOPMENT | MECHANISMS | RECEPTORS | ANALGESIA | Morphine - pharmacology | Hypercapnia - drug therapy | Drug Tolerance | Analgesics, Opioid - pharmacology | Rats | Male | Rats, Sprague-Dawley | Dose-Response Relationship, Drug | Animals | Pain - drug therapy | Respiration - drug effects | Female | Disease Models, Animal
RECURRENT HYPOXIA | SLEEP | INDUCED RESPIRATORY DEPRESSION | CHRONIC PAIN | OVERDOSE | ADMINISTERED MORPHINE | ANESTHESIOLOGY | POSTNATAL-DEVELOPMENT | MECHANISMS | RECEPTORS | ANALGESIA | Morphine - pharmacology | Hypercapnia - drug therapy | Drug Tolerance | Analgesics, Opioid - pharmacology | Rats | Male | Rats, Sprague-Dawley | Dose-Response Relationship, Drug | Animals | Pain - drug therapy | Respiration - drug effects | Female | Disease Models, Animal
Journal Article
Journal of Pain, ISSN 1526-5900, 2016, Volume 17, Issue 10, pp. 1068 - 1080
Abstract National Pain Strategy (NPS) population research objectives include: estimating chronic pain prevalence; studying pain treatment with electronic...
Anesthesia & Perioperative Care | Pain Medicine | electronic databases | epidemiology | health services research | prevalence | Chronic pain | MODERATE | ARTHRITIS | NEUROSCIENCES | CLINICAL NEUROLOGY | COMORBIDITY | MILD | CROSS-SECTIONAL SURVEY | DISABILITY | PATIENT | CHRONIC BACK-PAIN | SEVERITY | United States - epidemiology | Prevalence | Humans | Middle Aged | Male | Feasibility Studies | Young Adult | Chronic Pain - epidemiology | Psychiatric Status Rating Scales | Adult | Female | Interviews as Topic | Surveys and Questionnaires | Chronic Pain - economics | Databases, Factual | Chronic Pain - therapy | Terminology as Topic | Chronic Pain - psychology | Health Care Costs | Pilot Projects | Adolescent | Quality of Life | Aged | Pain Measurement | Electronic Health Records | Research Design | Care and treatment | Pain | Analysis | Electronic records | Medical care | Medicine, Preventive | Public health | Preventive health services | Medical care, Cost of | Quality management
Anesthesia & Perioperative Care | Pain Medicine | electronic databases | epidemiology | health services research | prevalence | Chronic pain | MODERATE | ARTHRITIS | NEUROSCIENCES | CLINICAL NEUROLOGY | COMORBIDITY | MILD | CROSS-SECTIONAL SURVEY | DISABILITY | PATIENT | CHRONIC BACK-PAIN | SEVERITY | United States - epidemiology | Prevalence | Humans | Middle Aged | Male | Feasibility Studies | Young Adult | Chronic Pain - epidemiology | Psychiatric Status Rating Scales | Adult | Female | Interviews as Topic | Surveys and Questionnaires | Chronic Pain - economics | Databases, Factual | Chronic Pain - therapy | Terminology as Topic | Chronic Pain - psychology | Health Care Costs | Pilot Projects | Adolescent | Quality of Life | Aged | Pain Measurement | Electronic Health Records | Research Design | Care and treatment | Pain | Analysis | Electronic records | Medical care | Medicine, Preventive | Public health | Preventive health services | Medical care, Cost of | Quality management
Journal Article
The journal of pain : official journal of the American Pain Society, 05/2017, Volume 18, Issue 5, p. 479
With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system that both...
Pain Measurement - standards | Pain Measurement - methods | Acute Pain - physiopathology | Humans | Public-Private Sector Partnerships - standards | Classification - methods | Acute Pain - diagnosis | Societies, Medical - standards | Acute Pain - epidemiology | Acute Pain - classification
Pain Measurement - standards | Pain Measurement - methods | Acute Pain - physiopathology | Humans | Public-Private Sector Partnerships - standards | Classification - methods | Acute Pain - diagnosis | Societies, Medical - standards | Acute Pain - epidemiology | Acute Pain - classification
Journal Article
Pain Medicine, ISSN 1526-2375, 05/2017, Volume 18, Issue 5, pp. 947 - 958
Objective. With the increasing societal awareness of the prevalence and impact of acute pain, there is a need to develop an acute pain classification system...
Acute Pain | AAPT | Taxonomy | ACTTION | AAAPT | biopsychosocial | SURVEY CRITERIA | RISK-FACTORS | MANAGEMENT | PREVALENCE | NATURAL-HISTORY | POSTOPERATIVE OPIOID CONSUMPTION | MEDICINE, GENERAL & INTERNAL | TRANSMISSION | EXPECTATION | ANESTHESIOLOGY | PHARMACOGENETICS | COHORT | Pain | Addiction | Analgesics | Standardization | Classification | Public policy | ACUTE & PERIOPERATIVE PAIN SECTION
Acute Pain | AAPT | Taxonomy | ACTTION | AAAPT | biopsychosocial | SURVEY CRITERIA | RISK-FACTORS | MANAGEMENT | PREVALENCE | NATURAL-HISTORY | POSTOPERATIVE OPIOID CONSUMPTION | MEDICINE, GENERAL & INTERNAL | TRANSMISSION | EXPECTATION | ANESTHESIOLOGY | PHARMACOGENETICS | COHORT | Pain | Addiction | Analgesics | Standardization | Classification | Public policy | ACUTE & PERIOPERATIVE PAIN SECTION
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2004, Volume 141, Issue 1, pp. 55 - 64
Tolerance to opioids frequently follows repeated drug administration and affects the clinical utility of these analgesics. Studies in simple cellular systems...
opioid receptor | GRK3 | fentanyl | withdrawal | receptor desensitization | phosphorylation | tolerance | morphine | Phosphorylation | Withdrawal | Opioid receptor | Fentanyl | Tolerance | Morphine | Receptor desensitization | KNOCK-OUT MICE | BETA-ARRESTIN-2 | DESENSITIZATION | OPIATE TOLERANCE | MECHANISMS | DEPENDENCE | MOUSE STRAINS | CURRENT VIEW | MORPHINE-TOLERANCE | PHARMACOLOGY & PHARMACY | ANTINOCICEPTIVE TOLERANCE | Fentanyl - administration & dosage | Receptors, Opioid - genetics | Analgesics, Opioid - pharmacology | Drug Implants | Fentanyl - pharmacokinetics | Evoked Potentials - physiology | Male | Hippocampus - drug effects | Fentanyl - antagonists & inhibitors | Dose-Response Relationship, Drug | Analgesics, Opioid - adverse effects | Substance Withdrawal Syndrome - metabolism | Injections, Subcutaneous | Morphine - pharmacokinetics | Reaction Time - drug effects | Substance Withdrawal Syndrome - genetics | Morphine - antagonists & inhibitors | Naloxone - pharmacokinetics | Protein-Serine-Threonine Kinases - metabolism | Receptors, Opioid - metabolism | G-Protein-Coupled Receptor Kinase 3 | Infusion Pumps, Implantable | Hot Temperature - adverse effects | Drug Tolerance | Protein-Serine-Threonine Kinases - genetics | Up-Regulation - genetics | Reaction Time - genetics | Hippocampus - cytology | Mice, Knockout | Evoked Potentials - drug effects | Up-Regulation - drug effects | Homozygote | Pain Measurement - methods | Animals | Electrophysiology - methods |
opioid receptor | GRK3 | fentanyl | withdrawal | receptor desensitization | phosphorylation | tolerance | morphine | Phosphorylation | Withdrawal | Opioid receptor | Fentanyl | Tolerance | Morphine | Receptor desensitization | KNOCK-OUT MICE | BETA-ARRESTIN-2 | DESENSITIZATION | OPIATE TOLERANCE | MECHANISMS | DEPENDENCE | MOUSE STRAINS | CURRENT VIEW | MORPHINE-TOLERANCE | PHARMACOLOGY & PHARMACY | ANTINOCICEPTIVE TOLERANCE | Fentanyl - administration & dosage | Receptors, Opioid - genetics | Analgesics, Opioid - pharmacology | Drug Implants | Fentanyl - pharmacokinetics | Evoked Potentials - physiology | Male | Hippocampus - drug effects | Fentanyl - antagonists & inhibitors | Dose-Response Relationship, Drug | Analgesics, Opioid - adverse effects | Substance Withdrawal Syndrome - metabolism | Injections, Subcutaneous | Morphine - pharmacokinetics | Reaction Time - drug effects | Substance Withdrawal Syndrome - genetics | Morphine - antagonists & inhibitors | Naloxone - pharmacokinetics | Protein-Serine-Threonine Kinases - metabolism | Receptors, Opioid - metabolism | G-Protein-Coupled Receptor Kinase 3 | Infusion Pumps, Implantable | Hot Temperature - adverse effects | Drug Tolerance | Protein-Serine-Threonine Kinases - genetics | Up-Regulation - genetics | Reaction Time - genetics | Hippocampus - cytology | Mice, Knockout | Evoked Potentials - drug effects | Up-Regulation - drug effects | Homozygote | Pain Measurement - methods | Animals | Electrophysiology - methods |