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by Franceschini, Nora and Giambartolomei, Claudia and de Vries, Paul S and Finan, Chris and Bis, Joshua C and Huntley, Rachael P and Lovering, Ruth C and Tajuddin, Salman M and Winkler, Thomas W and Graff, Misa and Kavousi, Maryam and Dale, Caroline and Smith, Albert V and Hofer, Edith and van Leeuwen, Elisabeth M and Nolte, Ilja M and Lu, Lingyi and Scholz, Markus and Sargurupremraj, Muralidharan and Pitkänen, Niina and Franzén, Oscar and Joshi, Peter K and Noordam, Raymond and Marioni, Riccardo E and Hwang, Shih-Jen and Musani, Solomon K and Schminke, Ulf and Palmas, Walter and Isaacs, Aaron and Correa, Adolfo and Zonderman, Alan B and Hofman, Albert and Teumer, Alexander and Cox, Amanda J and Uitterlinden, André G and Wong, Andrew and Smit, Andries J and Newman, Anne B and Britton, Annie and Ruusalepp, Arno and Sennblad, Bengt and Hedblad, Bo and Pasaniuc, Bogdan and Penninx, Brenda W and Langefeld, Carl D and Wassel, Christina L and Tzourio, Christophe and Fava, Cristiano and Baldassarre, Damiano and O’Leary, Daniel H and Teupser, Daniel and Kuh, Diana and Tremoli, Elena and Mannarino, Elmo and Grossi, Enzo and Boerwinkle, Eric and Schadt, Eric E and Ingelsson, Erik and Veglia, Fabrizio and Rivadeneira, Fernando and Beutner, Frank and Chauhan, Ganesh and Heiss, Gerardo and Snieder, Harold and Campbell, Harry and Völzke, Henry and Markus, Hugh S and Deary, Ian J and Jukema, J. Wouter and de Graaf, Jacqueline and Price, Jacqueline and Pott, Janne and Hopewell, Jemma C and Liang, Jingjing and Thiery, Joachim and Engmann, Jorgen and Gertow, Karl and Rice, Kenneth and Taylor, Kent D and Dhana, Klodian and Kiemeney, Lambertus A. L. M and Lind, Lars and Raffield, Laura M and Launer, Lenore J and Holdt, Lesca M and Dörr, Marcus and Dichgans, Martin and Traylor, Matthew and Sitzer, Matthias and Kumari, Meena and Kivimaki, Mika and Nalls, Mike A and Melander, Olle and Raitakari, Olli and Franco, Oscar H and Rueda-Ochoa, Oscar L and Roussos, Panos and Whincup, Peter H and Amouyel, Philippe and Giral, Philippe and ... and MEGASTROKE Consortium and Science for Life Laboratory, SciLifeLab and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Molekylär evolution and Institutionen för cell- och molekylärbiologi and Teknisk-naturvetenskapliga vetenskapsområdet and Klinisk epidemiologi and Biologiska sektionen and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 5141 - 14
Journal Article
by Sibbing, Dirk and Aradi, Dániel and Aradi, Daniel and Jacobshagen, Claudius and Gross, Lisa and Trenk, Dietmar and Geisler, Tobias and Orban, Matthias and Orban, Martin and Hadamitzky, Martin and Merkely, Béla and Kiss, Róbert Gábor and Komócsi, András and Dézsi, Csaba A and Dézsi, Csaba András and Dézsi, András Döme and Holdt, Lesca and Felix, Stephan and Felix, Stephan B and Parma, Zofia and Parma, Radoslaw and Klopotowski, Mariusz and Schwinger, Robert and Schwinger, Robert H G and Rieber, Johannes and Huber, Kurt and Neumann, Franz-Josef and Koltowski, Lukasz and Mehilli, Julinda and Huczek, Zenon and Massberg, Steffen and Lesiak, Maciej and Komosa, Anna and Kowara, Michal and Rymuza, Bartosz and Malek, Lukasz and Veress, Gábor and Lux, Árpád and Papp, Judit and Kovács, Andrea and Amer, Sayour and Ruzsa, Zoltán and Róna, Szilárd and Ili, Renáta and Ungi, Imre and Nagy, Ferenc and Zweiker, Robert and Tóth-Gayor, Gábor and Haller, Paul and von Scheidt, Wolfgang and Blüthgen, Andreas and Leggewie, Stefan and Kreider-Stempfle, Hans Ulrich and Remp, Thomas and Kara, Kaffer and Mügge, Andreas and Wutzler, Alexander and Fichtlscherer, Stephan and Zeiher, Andreas M and Seeger, Florian and Hinterseer, Martin and König, Andreas and Lederle, Susanne and Czepluch, Frauke and Maier, Lars and Schillinger, Wolfgang and Sossalla, Samuel and Hummel, Astrid and Karakas, Mahir and Sydow, Karsten and Rudolph, Tanja and Halbach, Marcel and Gori, Tommaso and Münzel, Thomas and May, Andreas and Gerstenberg, Carsten-Manuel and Pilecky, David and Deichstetter, Markus and Kääb, Stefan and Löw, Anja and Sattler, Stefan and Deuschl, Sabine and Teupser, Daniel and Mudra, Harald and Räder, Thomas and Schütz, Torsten and Vahldiek, Felix and Divchev, Dimitar and Ince, Hüseyin and Nienaber, Christoph A and Radunski, Henning and Boekstegers, Peter and Horstkotte, Jan and Mueller, Ralf and Müller, Karin and Rasp, Oliver and TROPICAL-ACS Investigators
The Lancet, ISSN 0140-6736, 10/2017, Volume 390, Issue 10104, pp. 1747 - 1757
Current guidelines recommend potent platelet inhibition with prasugrel or ticagrelor for 12 months after an acute coronary syndrome managed with percutaneous... 
ELUTING STENTS | MEDICINE, GENERAL & INTERNAL | CLOPIDOGREL | THERAPY | TICAGRELOR | TREATMENT PATTERNS | ACADEMIC RESEARCH CONSORTIUM | PRASUGREL | DIPHOSPHATE RECEPTOR INHIBITOR | MYOCARDIAL-INFARCTION PATIENTS | PLATELET REACTIVITY | Myocardial Infarction - epidemiology | Acute Coronary Syndrome - epidemiology | Drug Administration Schedule | Hemorrhage - epidemiology | Humans | Middle Aged | Europe - epidemiology | Male | Prasugrel Hydrochloride - adverse effects | Ticlopidine - analogs & derivatives | Platelet Aggregation Inhibitors - administration & dosage | Platelet Function Tests | Ticlopidine - adverse effects | Ticlopidine - administration & dosage | Acute Coronary Syndrome - therapy | Clopidogrel | Female | Stroke - epidemiology | Hemorrhage - chemically induced | Prasugrel Hydrochloride - administration & dosage | Drug Monitoring | Percutaneous Coronary Intervention | Platelet Aggregation Inhibitors - adverse effects | Transluminal angioplasty | Care and treatment | Coronary heart disease | Cardiac patients | Analysis | Anticoagulants | Heart attacks | Blood platelets | Angioplasty | Clinical trials | Acute coronary syndromes | Drug therapy | Patients | Clinical outcomes | Myocardial infarction | Intervention | Medical services | Bleeding | Consortia | Randomization | Motivation | Bioindicators | Inhibition | Cerebral infarction | Stroke | Test procedures | Health risks | Thrombosis | Coronary vessels | Biomarkers | Infarction | Cardiovascular diseases | Platelets
Journal Article
Journal Article
by Holmes, Michael V., MSc and Simon, Tabassome, MD, PhD and Exeter, Holly J., PhD and Folkersen, Lasse, PhD and Asselbergs, Folkert W., MD, PhD and Guardiola, Montse, PhD and Cooper, Jackie A., MSc and Palmen, Jutta, MSc and Hubacek, Jaroslav A., DSc, PhD and Carruthers, Kathryn F., MPhil and Horne, Benjamin D., PhD, MPH and Brunisholz, Kimberly D., MST and Mega, Jessica L., MD, MPH and van Iperen, Erik P.A., MSc and Li, Mingyao, PhD and Leusink, Maarten, MSc and Trompet, Stella, PhD and Verschuren, Jeffrey J.W., MD, MSc and Hovingh, G. Kees, MD, PhD and Dehghan, Abbas, MD, PhD and Nelson, Christopher P., PhD and Kotti, Salma, PharmD, PhD and Danchin, Nicolas, MD, PhD and Scholz, Markus, PhD and Haase, Christiane L., PhD and Rothenbacher, Dietrich, MD and Swerdlow, Daniel I., MBBS, PhD and Kuchenbaecker, Karoline B., Dipl Psych, MSc and Staines-Urias, Eleonora, MD, MSc and Goel, Anuj, MSc and van 't Hooft, Ferdinand, MD, PhD and Gertow, Karl, PhD and de Faire, Ulf, MD, PhD and Panayiotou, Andrie G., PhD and Tremoli, Elena, PhD and Baldassarre, Damiano, PhD and Veglia, Fabrizio, PhD and Holdt, Lesca M., MD, PhD and Beutner, Frank, MD, PhD and Gansevoort, Ron T., MD, PhD and Navis, Gerjan J., MD, PhD and Mateo Leach, Irene, PhD and Breitling, Lutz P., MD and Brenner, Hermann, MD, MPH and Thiery, Joachim, MD, MBA and Dallmeier, Dhayana, MD and Franco-Cereceda, Anders, MD, PhD and Boer, Jolanda M.A., PhD and Stephens, Jeffrey W., PhD and Hofker, Marten H., PhD and Tedgui, Alain, PhD and Hofman, Albert, MD, PhD and Uitterlinden, André G., PhD and Adamkova, Vera, MD, PhD and Pitha, Jan, MD, PhD and Onland-Moret, N. Charlotte, PhD and Cramer, Maarten J., MD, PhD and Nathoe, Hendrik M., MD, PhD and Spiering, Wilko, MD, PhD and Klungel, Olaf H., PharmD, PhD and Kumari, Meena, PhD and Whincup, Peter H and Morrow, David A., MD and Braund, Peter S., MSc and Hall, Alistair S., PhD and Olsson, Anders G., MD, PhD and Doevendans, Pieter A., MD, PhD and Trip, Mieke D., MD, PhD and Tobin, Martin D., PhD and Hamsten, Anders, PhD and Watkins, Hugh, PhD and Koenig, Wolfgang, MD and Nicolaides, Andrew N., PhD and Teupser, Daniel, MD, PhD and Day, Ian N.M and Carlquist, John F., PhD and Gaunt, Tom R., PhD and Ford, Ian, PhD and Sattar, Naveed and Tsimikas, Sotirios, MD and Schwartz, Gregory G., MD PhD and Lawlor, Debbie A., PhD and Morris, Richard W., PhD and Sandhu, Manjinder S., PhD and Poledne, Rudolf, PhD and Maitland-van der Zee, Anke H., PhD and Khaw, Kay-Tee, MBBChir and Keating, Brendan J., PhD and van der Harst, Pim, MD, PhD and Price, Jackie F., MD and Mehta, Shamir R., MD, MSc and Yusuf, Salim, MBBS, DPhil and Witteman, Jaqueline C.M., PhD and Franco, Oscar H., MD, PhD and Jukema, J. Wouter, MD, PhD and de Knijff, Peter, PhD and Tybjaerg-Hansen, Anne, MD, DMSc and Rader, Daniel J., MD and Farrall, Martin, MD, PhD and Samani, Nilesh J., MD and ...
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2013, Volume 62, Issue 21, pp. 1966 - 1976
Objectives This study sought to investigate the role of secretory phospholipase A2 (sPLA2 )-IIA in cardiovascular disease. Background Higher circulating levels... 
Cardiovascular | Internal Medicine | drug development | epidemiology | genetics | cardiovascular diseases | Mendelian randomization | Studies | Cardiovascular disease | Heart attacks | Drug therapy | Mortality | Cholesterol
Journal Article
Nature Communications, ISSN 2041-1723, 08/2016, Volume 7, Issue 1, p. 12429
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167888
Dysfunction of the melanocortin system can result in severe obesity accompanied with dyslipidemia and symptoms of the metabolic syndrome but the effect on... 
BRACHIOCEPHALIC ARTERY | LEPTIN | AORTIC ROOT | MULTIDISCIPLINARY SCIENCES | LIVER | HUMAN OBESITY | NONALCOHOLIC STEATOHEPATITIS | FRAMESHIFT MUTATION | KNOCKOUT MICE | E-DEFICIENT MICE | MOUSE MODELS | Receptor, Melanocortin, Type 4 - deficiency | Receptors, LDL - genetics | Bile Acids and Salts - biosynthesis | Body Size - drug effects | Atherosclerosis - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Body Weight - drug effects | Atherosclerosis - complications | Receptor, Melanocortin, Type 4 - genetics | RNA, Messenger - metabolism | Atherosclerosis - metabolism | Non-alcoholic Fatty Liver Disease - complications | Animals | Diet | Receptors, LDL - deficiency | Cholesterol - pharmacology | Hypercholesterolemia - complications | Mice | Hypercholesterolemia - genetics | Mutation | Cholesterol - biosynthesis | Hypercholesterolemia - metabolism | RNA sequencing | Genetically modified mice | Complications and side effects | Obesity | Atherosclerosis | Metabolic diseases | Research | Risk factors | Lipoproteins (low density) | Atherogenesis | Liver | Body weight | Dyslipidemia | Biosynthesis | Gene sequencing | Fatty liver | Rodents | Aorta | Lipoprotein (low density) receptors | Hyperphagia | Cardiovascular system | Melanocortin | Ribonucleic acid--RNA | Cholesterol | Lipoproteins (very low density) | Steatosis | Hypercholesterolemia | Food intake | Arteriosclerosis | Insulin resistance | Receptor density | Metabolic disorders | RNA | Ribonucleic acid | Bile
Journal Article