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1. Full Text The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
by Fang, Dong and Gan, Haiyun and Lee, Jeong-Heon and Han, Jing and Wang, Zhiquan and Riester, Scott M and Jin, Long and Chen, Jianji and Zhou, Hui and Wang, Jinglong and Zhang, Honglian and Yang, Na and Bradley, Elizabeth W and Ho, Thai H and Rubin, Brian P and Bridge, Julia A and Thibodeau, Stephen N and Ordog, Tamas and Chen, Yue and Van Wijnen, Andre J and Oliveira, Andre M and Xu, Rui-Ming and Westendorf, Jennifer J and Zhang, Zhiguo
Science (American Association for the Advancement of Science), ISSN 0036-8075, 06/2016, Volume 352, Issue 6291, pp. 1344 - 1348
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Epigenesis, Genetic | Genes, Neoplasm | Humans | Carcinogenesis - genetics | Lysine - genetics | Histones - genetics | Chondroblastoma - genetics | Histone-Lysine N-Methyltransferase - metabolism | Bone Neoplasms - genetics | Mutation | Methylation | Repressor Proteins - metabolism | Amino Acid Substitution | Epigenetic inheritance | Gene mutations | Histones | Physiological aspects | Genetic aspects | Observations | Cancer | Proteins | Pediatrics | Index Medicus | Residues | Mutations | Genes | Gene expression
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2. Full Text Characterization of human plasma-derived exosomal RNAs by deep sequencing
by Huang, Xiaoyi and Yuan, Tiezheng and Tschannen, Michael and Sun, Zhifu and Jacob, Howard and Du, Meijun and Liang, Meihua and Dittmar, Rachel L and Liu, Yong and Liang, Mingyu and Kohli, Manish and Thibodeau, Stephen N and Boardman, Lisa and Wang, Liang
BMC genomics, ISSN 1471-2164, 05/2013, Volume 14, Issue 1, pp. 319 - 319
Plasma | Biomarker | MicroRNA | Exosome | Next generation sequencing | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Humans | Plasma - cytology | Transcriptome | Exosomes - genetics | Extracellular Space - genetics | Chromosome Mapping | RNA Stability | Blood Donors | Sequence Analysis, RNA | Base Sequence | High-Throughput Nucleotide Sequencing | MicroRNAs - genetics | MicroRNAs - chemistry | RNA sequencing | Genomic libraries | Nucleotide sequencing | RNA | DNA | DNA sequencing | Proteins | Databases | Gene expression | Index Medicus
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3. Full Text Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states
by Sarver, Aaron L and French, Amy J and Borralho, Pedro M and Thayanithy, Venugopal and Oberg, Ann L and Silverstein, Kevin A.T and Morlan, Bruce W and Riska, Shaun M and Boardman, Lisa A and Cunningham, Julie M and Subramanian, Subbaya and Wang, Liang and Smyrk, Tom C and Rodrigues, Cecilia M.P and Thibodeau, Stephen N and Steer, Clifford J
BMC cancer, ISSN 1471-2407, 11/2009, Volume 9, Issue 1, pp. 401 - 401
Life Sciences & Biomedicine | Oncology | Science & Technology | Colonic Neoplasms - genetics | Gene Expression | Microsatellite Instability | Humans | Gene Expression Profiling | DNA Mismatch Repair - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Differentiation - genetics | DNA Methylation | Cell Transformation, Neoplastic - genetics | Colonic Neoplasms - pathology | MicroRNAs - genetics | Neoplasm Staging | Colon cancer | RNA | Physiological aspects | Causes of | Genetic aspects | Research | Genetic regulation | DNA repair | Index Medicus
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4. Full Text Whole-Genome Sequencing in Healthy People
by Lindor, Noralane M., MD and Thibodeau, Stephen N., PhD and Burke, Wylie, MD, PhD
Mayo Clinic proceedings, ISSN 0025-6196, 2016, Volume 92, Issue 1, pp. 159 - 172
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Genetic Predisposition to Disease | Pharmacogenomic Testing - standards | Precision Medicine - standards | Humans | Gene Expression Profiling - ethics | Sequence Analysis, DNA - ethics | Gene Expression Profiling - methods | Genome, Human | Pharmacogenomic Testing - methods | Sequence Analysis, DNA - methods | Precision Medicine - methods | Index Medicus | Abridged Index Medicus
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5. Full Text Pharmacogenetic Predictors of Adverse Events and Response to Chemotherapy in Metastatic Colorectal Cancer: Results From North American Gastrointestinal Intergroup Trial N9741
by Howard L. McLeod and Daniel J. Sargent and Sharon Marsh and Erin M. Green and Cristi R. King and Charles S. Fuchs and Ramesh K. Ramanathan and Stephen K. Williamson and Brian P. Findlay and Stephen N. Thibodeau and Axel Grothey and Roscoe F. Morton and Richard M. Goldberg
Journal of clinical oncology, ISSN 0732-183X, 07/2010, Volume 28, Issue 20, pp. 3227 - 3233
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Colorectal Neoplasms - mortality | Pharmacogenetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Genotype | Polymorphism, Genetic | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colorectal Neoplasms - drug therapy | Kidney Diseases - chemically induced | Aged, 80 and over | Aged | Colorectal Neoplasms - pathology | Neutropenia - genetics | Index Medicus | To15 | Original Reports | Gic5 | To2 | Faze | To9
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6. Full Text Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer
by Daniel J. Sargent and Silvia Marsoni and Genevieve Monges and Stephen N. Thibodeau and Roberto Labianca and Stanley R. Hamilton and Amy J. French and Brian Kabat and Nathan R. Foster and Valter Torri and Christine Ribic and Axel Grothey and Malcolm Moore and Alberto Zaniboni and Jean-Francois Seitz and Frank Sinicrope and Steven Gallinger
Journal of clinical oncology, ISSN 0732-183X, 07/2010, Volume 28, Issue 20, pp. 3219 - 3226
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Tumors | Colonic Neoplasms - genetics | Colonic Neoplasms - mortality | Prognosis | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Male | Combined Modality Therapy | Randomized Controlled Trials as Topic | Disease-Free Survival | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Fluorouracil - administration & dosage | Colonic Neoplasms - pathology | DNA Mismatch Repair | Biomarkers | Female | Aged | Chemotherapy, Adjuvant | Index Medicus | To15 | Original Reports | Gic5 | To2 | Gic7
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7. Full Text Prognostic Impact of Deficient DNA Mismatch Repair in Patients With Stage III Colon Cancer From a Randomized Trial of FOLFOX-Based Adjuvant Chemotherapy
by Frank A. Sinicrope and Michelle R. Mahoney and Thomas C. Smyrk and Stephen N. Thibodeau and Robert S. Warren and Monica M. Bertagnolli and Garth D. Nelson and Richard M. Goldberg and Daniel J. Sargent and Steven R. Alberts
Journal of clinical oncology, ISSN 0732-183X, 10/2013, Volume 31, Issue 29, pp. 3664 - 3672
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | ras Proteins - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - mortality | Proto-Oncogene Proteins p21(ras) | Prognosis | Colonic Neoplasms - drug therapy | Humans | Middle Aged | Male | Proto-Oncogene Proteins - genetics | Fluorouracil - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | DNA Mismatch Repair | Aged, 80 and over | Adult | Female | Leucovorin - therapeutic use | Aged | Chemotherapy, Adjuvant | Neoplasm Staging | Organoplatinum Compounds - therapeutic use | Index Medicus | To15 | Original Reports | To2 | Gic7
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8. Full Text The Mayo Clinic Biobank: A Building Block for Individualized Medicine
by Olson, Janet E., PhD and Ryu, Euijung, PhD and Johnson, Kiley J., MS, CGC and Koenig, Barbara A., PhD and Maschke, Karen J., PhD and Morrisette, Jody A., MBA and Liebow, Mark, MD and Takahashi, Paul Y., MD, MPH and Fredericksen, Zachary S., MS and Sharma, Ruchi G., BS and Anderson, Kari S., BS and Hathcock, Matthew A., MS and Carnahan, Jason A., BS and Pathak, Jyotishman, PhD and Lindor, Noralane M., MD and Beebe, Timothy J., PhD and Thibodeau, Stephen N., PhD and Cerhan, James R., MD, PhD
Mayo Clinic proceedings, ISSN 0025-6196, 2013, Volume 88, Issue 9, pp. 952 - 962
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Medical History Taking | Humans | Middle Aged | Precision Medicine - statistics & numerical data | Male | Minnesota | Advisory Committees | Patient Selection | Young Adult | Informed Consent | Blood Specimen Collection | Adolescent | Adult | Female | Aged | Medical Record Linkage | Electronic Health Records | Precision Medicine - methods | Databases, Factual | Medicine, Experimental | Health facilities | Medical research | Planning | Aims and objectives | Index Medicus | Abridged Index Medicus
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9. Full Text Biallelic BRCA2 Mutations Shape the Somatic Mutational Landscape of Aggressive Prostate Tumors
by Decker, Brennan and Karyadi, Danielle M and Davis, Brian W and Karlins, Eric and Tillmans, Lori S and Stanford, Janet L and Thibodeau, Stephen N and Ostrander, Elaine A
American journal of human genetics, ISSN 0002-9297, 05/2016, Volume 98, Issue 5, pp. 818 - 829
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Prostatic Neoplasms - secondary | Prognosis | Prostatic Neoplasms - genetics | Humans | Middle Aged | Alleles | Male | Aged | Lymphatic Metastasis | High-Throughput Nucleotide Sequencing - methods | Mutation - genetics | BRCA2 Protein - genetics | Allelomorphism | Genetic aspects | Gene mutations | Genetic variation | Health aspects | Prostate cancer | Mutation | Prostate | Genes | Tumors | Index Medicus
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10. Full Text A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer
by Timothy K. Starr and Raha Allaei and Kevin A. T. Silverstein and Rodney A. Staggs and Aaron L. Sarver and Tracy L. Bergemann and Mihir Gupta and M. Gerard O'Sullivan and Ilze Matise and Adam J. Dupuy and Lara S. Collier and Scott Powers and Ann L. Oberg and Yan W. Asmann and Stephen N. Thibodeau and Lino Tessarollo and Neal G. Copeland and Nancy A. Jenkins and Robert T. Cormier and David A. Largaespada
Science (American Association for the Advancement of Science), ISSN 0036-8075, 3/2009, Volume 323, Issue 5922, pp. 1747 - 1750
Genetic transposition | Transposons | Transgenic animals | DNA | Colorectal cancer | Reports | Mice | Genetic mutation | Genetic screening | Human genetics | Tumors | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Medical sciences | Adenocarcinoma - pathology | Genetic Testing | Oligonucleotide Array Sequence Analysis | Adenoma - genetics | Colorectal Neoplasms - genetics | Genes, Neoplasm | Humans | Gene Expression Regulation, Neoplastic | Genes, APC | Carcinoma in Situ - genetics | Smad4 Protein - genetics | Gene Deletion | Adenocarcinoma - genetics | PTEN Phosphohydrolase - genetics | Carcinoma in Situ - pathology | Mice, Transgenic | DNA Transposable Elements | Animals | Gene Amplification | Adenoma - pathology | Mutation | Colorectal Neoplasms - pathology | Monte Carlo Method | Crosses, Genetic | Genetic aspects | Research | Diagnosis | Methods | Cancer | Genetics | Gene expression | Rodents | Index Medicus
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