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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12564 - 12569
Here we show that the functional human ortholog of Greatwall protein kinase (Gwl) is the microtubule-associated serine/threonine kinase-like protein, MAST-L.... 
Phosphorylation | Phenotypes | Phosphatases | Mitosis | Metaphase | HeLa cells | Small interfering RNA | Cell separation | Cyclins | Daughter cells | Slippage | Phosphatase | Kinase | Spindle assembly checkpoint | Cell cycle | XENOPUS EGG EXTRACTS | ACTIVATION | cell cycle | spindle assembly checkpoint | MULTIDISCIPLINARY SCIENCES | MITOSIS | kinase | PATHWAY | THROMBOCYTOPENIA | phosphatase | CHECKPOINT | slippage | EXIT | PROGRESSION | Cell Cycle - genetics | Okadaic Acid - pharmacology | RNA, Small Interfering - genetics | Phosphoric Monoester Hydrolases - genetics | Humans | Okadaic Acid - metabolism | Protein-Serine-Threonine Kinases - genetics | Cyclin B1 | Proteins - genetics | Mitosis - drug effects | Proteins - metabolism | Protein Phosphatase 2 - metabolism | Cell Cycle - physiology | Cyclin B - metabolism | Cell Cycle - drug effects | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | RNA, Small Interfering - metabolism | Spindle (Cell division) | Genetic aspects | Properties | Protein kinases | Cell division | Enzymes | Cytokines | Kinases | Enzyme kinetics | Cells | Index Medicus | Protein-Serine-Threonine Kinases | Biochemistry, Molecular Biology | Okadaic Acid | Proteins | Life Sciences | Phosphoric Monoester Hydrolases | Cell Cycle | Cyclin B | RNA, Small Interfering | Protein Phosphatase 2 | Biological Sciences
Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6011, pp. 1673 - 1677
Journal Article
Cell Cycle, ISSN 1538-4101, 05/2014, Volume 13, Issue 9, pp. 1400 - 1412
Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low... 
Cdk1 | cyclin B1 | PP2A | SAC | mitosis | RO3306 | Mitosis | Cyclin | B1 | Report
Journal Article
The Journal of cell biology, ISSN 0021-9525, 02/2019, Volume 218, Issue 2, pp. 541 - 558
Greatwall (GWL) is an essential kinase that indirectly controls PP2A-B55, the phosphatase counterbalancing cyclin B/CDK1 activity during mitosis. In Xenopus... 
MITOSIS | ENDOSULFINE | PHOSPHORYLATION | PATHWAY | SUBSTRATE | CHROMOSOME CONDENSATION | PROTEIN PHOSPHATASE 2A | GREATWALL KINASE | INHIBITOR | SUBUNIT | CELL BIOLOGY | Phosphorylation | Animal models | Mitosis | Cell division | Embryo fibroblasts | Dephosphorylation | Ablation | Proteins | Embryonic growth stage | DNA biosynthesis | Embryogenesis | Cyclin B | S phase | Cell cycle | Viability | Deoxyribonucleic acid--DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17374 - 17379
Greatwall is a protein kinase involved in the inhibition of protein phosphatase 2 (PP2A)-B55 complexes to maintain the mitotic state. Although its biochemical... 
Phosphorylation | Phosphatases | Mitosis | Cell cycle | Cultured cells | Chromosomes | Embryos | Cyclins | Cytoplasm | Cells | Cell division | Mitotic kinases | Cell cycle regulation | Mitotic phosphatases | Nuclear export | LOCALIZATION | ENTRY | MULTIDISCIPLINARY SCIENCES | KINASE | cell division | PROTEIN PHOSPHATASE 2A | MASTL | mitotic kinases | DROSOPHILA | MITOSIS | CHROMOSOME | mitotic phosphatases | nuclear export | cell cycle regulation | PROGRESSION | Mammals - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Male | Embryo, Mammalian - metabolism | Protein Subunits - metabolism | RNA Interference | Time Factors | Mammals - embryology | Female | Active Transport, Cell Nucleus | Protein-Serine-Threonine Kinases - metabolism | Protein Subunits - genetics | Amino Acid Sequence | Mammals - metabolism | Cells, Cultured | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Mice, Knockout | Sequence Homology, Amino Acid | Nuclear Envelope - metabolism | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Luminescent Proteins - genetics | Mice | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | Research | Phosphotransferases | Kinases | Rodents | Index Medicus | Biological Sciences
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 02/2019, Volume 9, Issue 1, pp. 2861 - 12
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, pp. 44001 - 44001
In human eggs, aneuploidy increases with age and can result in infertility and genetic diseases. Studies in mouse oocytes suggest that reduced centromere... 
MATERNAL AGE | CHROMOSOME BIORIENTATION | MICROTUBULE INTERFACE | TRISOMY FORMATION | IMMATURE OOCYTES | MULTIDISCIPLINARY SCIENCES | MOUSE OOCYTES | MOLECULAR ARCHITECTURE | SPINDLE ASSEMBLY CHECKPOINT | CELL-CYCLE | MEIOSIS-I | Signal transduction | BUBR1 protein | Infertility | Metaphase | Chromatids | Aneuploidy | Localization | Eggs | Age | Oocytes | Index Medicus | Life Sciences | Cellular Biology
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