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Cancer Cell, ISSN 1535-6108, 08/2019, Volume 36, Issue 2, pp. 156 - 167.e7
We report that mouse LSL ; (KP)-mediated lung adenocarcinoma (LADC) tumorigenesis can proceed through both PKCι-dependent and PKCι-independent pathways. The... 
lung cancer | Wnt signaling | bronchoalveolar stem cells | protein kinase Cι signaling | therapeutic vulnerability | alveolar type 2 cells | Kras/Trp53 transformation | lung adenocarcinoma molecular subtypes
Journal Article
Oncotarget, ISSN 1949-2553, 11/2018, Volume 9, Issue 91, pp. 36358 - 36370
Phosphatidylinositol-4-phosphate 5-kinase type-1C (PIP5K1C) is a lipid kinase that regulates focal adhesion dynamics and cell attachment through site-specific... 
Phosphorylation | Breast cancer | PIP5K1C | Invasive phenotype
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 139 - 151
We report that two oncogenes coamplified on chromosome 3q26, and , cooperate to drive a stem-like phenotype in lung squamous cell carcinoma (LSCC). Protein... 
INITIATING CELLS | DETECTS FREQUENT | STEM-CELLS | PROTEIN | CANCER CELLS | EPITHELIUM | ONCOLOGY | TRANSFORMED GROWTH | PKC-IOTA | KINASE-C-IOTA | BASAL-CELLS | CELL BIOLOGY | Acyltransferases - antagonists & inhibitors | Protein Kinase C - genetics | RNA, Small Interfering - genetics | Cell Proliferation | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | SOXB1 Transcription Factors - antagonists & inhibitors | Lung Neoplasms - pathology | Acyltransferases - metabolism | Acyltransferases - genetics | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | SOXB1 Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | Cell Transformation, Neoplastic - genetics | Isoenzymes - metabolism | Protein Kinase C - metabolism | Neoplastic Stem Cells - pathology | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Isoenzymes - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Protein Kinase C - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | High-Throughput Nucleotide Sequencing | Mice | Cell Transformation, Neoplastic - pathology | Isoenzymes - antagonists & inhibitors | Apoptosis | Squamous cell carcinoma | Genetic aspects | Cancer
Journal Article
Cancer Research, ISSN 0008-5472, 05/2015, Volume 75, Issue 9 Supplement, pp. PD6-4 - PD6-4
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 6, pp. 3473 - 3474
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 2, p. e17490
Journal Article
Cancer Research, ISSN 0008-5472, 07/2008, Volume 68, Issue 14, pp. 5888 - 5895
The anti-rheumatoid agent aurothiomalate (ATM) is a potent inhibitor of oncogenic PKCι ATM inhibits non-small lung cancer (NSCLC) growth by binding PKCι and... 
non-small cell lung cancer | tumorigenicity | small cell lung cancer | anchorage-independent growth | mechanism-based therapy
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 10/2017, Volume 216, Issue 10, pp. 3073 - 3085
Journal Article
Journal Article