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1. Full Text Epistatic genetic effects among alzheimer's candidate genes
by Hohman, Timothy J and Koran, Mary Ellen and Thornton-Wells, Tricia and Alzheimer's Neuroimaging Initiativ and Alzheimer's Neuroimaging Initiative
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e80839 - e80839
Background: Novel risk variants for late-onset Alzheimer's disease (AD) have been identified and replicated in genome-wide association studies. Recent work has... 
NATIONAL INSTITUTE | RECOMMENDATIONS | MULTIDISCIPLINARY SCIENCES | QUANTITATIVE TRAIT | DISEASE | DIAGNOSTIC GUIDELINES | WHOLE-GENOME ASSOCIATION | WIDE ASSOCIATION | CR-1 | CLU | PICALM | Genetic Predisposition to Disease | Genome-Wide Association Study | Epigenesis, Genetic | Humans | Risk Factors | Databases, Genetic | Male | Genetic Markers | Amyloidogenic Proteins - metabolism | Monomeric Clathrin Assembly Proteins - genetics | Epistasis, Genetic | Apolipoproteins E - genetics | Tumor Suppressor Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Alzheimer Disease - metabolism | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Nuclear Proteins - genetics | Advertising executives | Medical research | PET imaging | Genes | Genomics | Medicine, Experimental | Genetic aspects | Single nucleotide polymorphisms | Alzheimer's disease | Index Medicus
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2. Full Text Interactions between GSK3[beta] and amyloid genes explain variance in amyloid burden
by Hohman, Timothy J and Koran, Mary Ellen I and Thornton-Wells, Tricia A
Neurobiology of Aging, ISSN 0197-4580, 03/2014, Volume 35, Issue 3, p. 460
The driving theoretical framework of Alzheimer's disease (AD) has been built around the amyloid-[beta] (A[beta]) cascade in which amyloid pathology precedes... 
Synthesis | Glycogen | Analysis | Genes | Amyloid beta-protein | Genetic research | Physiological aspects | Alzheimer's disease
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3. Full Text GSK3[beta] Interactions with Amyloid Genes: An Autopsy Verification and Extension
by Hohman, Timothy J and Chibnik, Lori and Bush, William S and Jefferson, Angela L and Jaeger, Phillip L and Thornton-Wells, Tricia A and Bennett, David A and Schneider, Julie A
Neurotoxicity Research, ISSN 1029-8428, 10/2015, Volume 28, Issue 3, p. 232
Glyocogen synthase kinase 3 (GSK3) plays an important role in the pathophysiology of Alzheimer's disease (AD) through the phosphorylation of tau. Recent work... 
Neurosciences | Genes | Single nucleotide polymorphisms | Gene expression | Alzheimer's disease
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4. Full Text Genetic resilience to amyloid-related neurodegeneration in older adulthood
by Hohman, Timothy and Koran, Mary Ellen and Thornton-Wells, Tricia
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2013, Volume 9, Issue 4, pp. P258 - P258
Neurology
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5. Full Text Age-dependent default mode network functional connectivity in individuals with Down syndrome
by Vega, Jennifer and Hohman, Timothy and Thornton-Wells, Tricia
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2013, Volume 9, Issue 4, pp. P418 - P418
Neurology | Down syndrome
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6. Full Text Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
by Lambert, Jean-Charles and Ibrahim-Verbaas, Carla A and Harold, Denise and Naj, Adam C and Sims, Rebecca and Bellenguez, Céline and Jun, Gyungah and DeStefano, Anita L and Bis, Joshua C and Beecham, Gary W and Grenier-Boley, Benjamin and Russo, Giancarlo and Thornton-Wells, Tricia A and Jones, Nicola and Smith, Albert V and Chouraki, Vincent and Thomas, Charlene and Ikram, M. Arfan and Zelenika, Diana and Vardarajan, Badri N and Kamatani, Yoichiro and Lin, Chiao-Feng and Gerrish, Amy and Schmidt, Helena and Kunkle, Brian and Fiévet, Nathalie and Amouyel, Philippe and Pasquier, Florence and Deramecourt, Vincent and De Bruijn, Renee F.A.G and Amin, Najaf and Hofman, Albert and Van Duijn, Cornelia M and Dunstan, Melanie L and Hollingworth, Paul and Owen, Michael J and O'Donovan, Michael C and Jones, Lesley and Holmans, Peter A and Moskvina, Valentina and Williams, Julie and Baldwin, Clinton and Farrer, Lindsay A and Choi, Seung-Hoan and Lunetta, Kathryn L and Fitzpatrick, Annette L and Harris, Tamara B and Psaty, Bruce M and Gilbert, John R and Hamilton-Nelson, Kara L and Martin, Eden R and Kunkle, Brian and Haines, Jonathan L and Gudnason, Vilmundur and Jonsson, Palmi V and Eiriksdottir, Gudny and Bihoreau, Marie-Thérèse and Lathrop, Mark and Valladares, Otto and Cantwell, Laura B and Wang, Li-San and Schellenberg, Gerard D and Ruiz, Agustin and Boada, Mercè and Reitz, Christiane and Mayeux, Richard and Ramirez, Alfredo and Maier, Wolfgang and Hanon, Olivier and Kukull, Walter A and Buxbaum, Joseph D and Campion, Dominique and Wallon, David and Hannequin, Didier and Crane, Paul K and Larson, Eric B and Becker, Tim and Cruchaga, Carlos and Goate, Alison M and Craig, David and Johnston, Janet A and Mc-Guinness, Bernadette and Todd, Stephen and Passmore, Peter and Berr, Claudine and Ritchie, Karen and Lopez, Oscar L and De Jager, Philip L and Evans, Denis and Lovestone, Simon and Proitsi, Petroula and Powell, John F and Letenneur, Luc and Barberger-Gateau, Pascale and Dufouil, Carole and Dartigues, Jean-François and Morón, Francisco J and Rubinsztein, David C and St. George-Hyslop, Peter and Sleegers, Kristel and ... and EADI and CHARGE and ADGC and GERAD and Cohorts for Heart and Aging Research in Genomic Epidemiology and Genetic and Environmental Risk in Alzheimer's Disease and Alzheimer's Disease Genetic Consortium and European Alzheimer's Disease Initiative (EADI) and Alzheimer's Disease Genetic Consortium (ADGC) and Genetic and Environmental Risk in Alzheimer's Disease (GERAD) and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 12/2013, Volume 45, Issue 12, pp. 1452 - 1458
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this... 
GENOTYPES | COMMON VARIANTS | IMPUTATION | GENETIC RISK | SEQUENCE | GENETICS & HEREDITY | NEURONS | RECEPTOR | MUTATIONS | CD33 | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Genetic Loci | Genome-Wide Association Study - statistics & numerical data | Case-Control Studies | Age of Onset | Aged, 80 and over | Alzheimer Disease - epidemiology | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Cohort Studies | Quantitative trait loci | Genetic aspects | Research | Genetic susceptibility | Alzheimer's disease | Identification and classification | Genealogy | Genomics | Genes | Quality control | Aging | Genomes | Alzheimers disease | Health risk assessment | Meta-analysis | Index Medicus | Genetik | Biological Sciences | Genetics | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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7. Full Text Regional brain differences in cortical thickness, surface area and subcortical volume in individuals with williams syndrome
by Meda, Shashwath A and Pryweller, Jennifer R and Thornton-Wells, Tricia A
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, pp. e31913 - e31913
Williams syndrome (WS) is a rare genetic neurodevelopmental disorder characterized by increased non-social anxiety, sensitivity to sounds and hypersociability.... 
WHITE-MATTER | ABNORMALITIES | ANXIETY | CORTEX | CONNECTIVITY | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL NEUROANATOMY | BEHAVIORAL-PHENOTYPE | GENETIC INFLUENCES | COGNITION | CHILDREN | Magnetic Resonance Imaging | Image Processing, Computer-Assisted | Humans | Cerebral Cortex - pathology | Brain Mapping | Organ Size | Adult | Female | Male | Williams Syndrome - pathology | Case-Control Studies | Brain | Anxiety | Brain research | Research | Williams syndrome | Pediatrics | Basal ganglia | Nuclear magnetic resonance--NMR | Regional development | Acoustics | Neurodevelopmental disorders | Substantia grisea | Fear & phobias | Genotype & phenotype | Cortex (frontal) | Physiology | Behavior | Cortex (temporal) | Automation | Medical imaging | Regional analysis | Cortex | Biophysics | Ganglia | Studies | Magnetic resonance imaging | Cognition & reasoning | Anxieties | Correlation analysis | Surface area | Variation | Index Medicus | Nuclear magnetic resonance | NMR
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8. Full Text Dissecting trait heterogeneity: A comparison of the clustering methods applied to genotypic data
by Thornton-Wells, Tricia A and Moore, Jason H and Haines, Jonathan L
BMC Bioinformatics, ISSN 1471-2105, 04/2006, Volume 7
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9. Full Text Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
by Sims, Rebecca and Van Der Lee, Sven J and Naj, Adam C and Bellenguez, Céline and Badarinarayan, Nandini and Jakobsdottir, Johanna and Kunkle, Brian W and Boland, Anne and Raybould, Rachel and Bis, Joshua C and Martin, Eden R and Grenier-Boley, Benjamin and Heilmann-Heimbach, Stefanie and Chouraki, Vincent and Kuzma, Amanda B and Sleegers, Kristel and Vronskaya, Maria and Ruiz, Agustin and Graham, Robert R and Olaso, Robert and Hoffmann, Per and Grove, Megan L and Vardarajan, Badri N and Hiltunen, Mikko and Nöthen, Markus M and White, Charles C and Hamilton-Nelson, Kara L and Epelbaum, Jacques and Maier, Wolfgang and Choi, Seung-Hoan and Beecham, Gary W and Dulary, Cécile and Herms, Stefan and Smith, Albert V and Funk, Cory C and Derbois, Céline and Forstner, Andreas J and Ahmad, Shahzad and Li, Hongdong and Bacq, Delphine and Harold, Denise and Satizabal, Claudia L and Valladares, Otto and Squassina, Alessio and Thomas, Rhodri and Brody, Jennifer A and Qu, Liming and Sánchez-Juan, Pascual and Morgan, Taniesha and Wolters, Frank J and Zhao, Yi and Garcia, Florentino Sanchez and Denning, Nicola and Fornage, Myriam and Malamon, John and Naranjo, Maria Candida Deniz and Majounie, Elisa and Mosley, Thomas H and Dombroski, Beth and Wallon, David and Lupton, Michelle K and Dupuis, Josée and Whitehead, Patrice and Fratiglioni, Laura and Medway, Christopher and Jian, Xueqiu and Mukherjee, Shubhabrata and Keller, Lina and Brown, Kristelle and Lin, Honghuang and Cantwell, Laura B and Panza, Francesco and McGuinness, Bernadette and Moreno-Grau, Sonia and Burgess, Jeremy D and Solfrizzi, Vincenzo and Proitsi, Petra and Adams, Hieab H and Allen, Mariet and Seripa, Davide and Pastor, Pau and Cupples, L Adrienne and Price, Nathan D and Hannequin, Didier and Frank-García, Ana and Levy, Daniel and Chakrabarty, Paramita and Caffarra, Paolo and Giegling, Ina and Beiser, Alexa S and Giedraitis, Vilmantas and Hampel, Harald and Garcia, Melissa E and Wang, Xue and Lannfelt, Lars and Mecocci, Patrizia and Eiriksdottir, Gudny and Crane, Paul K and Pasquier, Florence and Boccardi, Virginia and ... and EADI and GERAD PERADES and ARUKConsortium and CHARGE and ADGC and GERAD/PERADES, CHARGE, ADGC, EADI and ARUK Consortium and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 09/2017, Volume 49, Issue 9, pp. 1373 - 1384
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174... 
COMMON VARIANTS | IDENTIFIES VARIANTS | METAANALYSIS | GENOTYPE IMPUTATION | LOW-FREQUENCY | SUSCEPTIBILITY | GENETICS & HEREDITY | RISK | LOCI | WAVE2 COMPLEX | GENOME-WIDE ASSOCIATION | Amino Acid Sequence | Microglia - metabolism | Genetic Predisposition to Disease - genetics | Gene Frequency | Humans | Immunity, Innate - genetics | Genotype | Gene Expression Profiling | Case-Control Studies | Linkage Disequilibrium | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | Exome - genetics | Protein Interaction Maps - genetics | Adaptor Proteins, Signal Transducing - genetics | Phospholipase C gamma - genetics | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Odds Ratio | Receptors, Immunologic - genetics | Immune response | Genetic variation | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease | Neurodegenerative diseases | Genes | Genomics | Health risks | Innate immunity | Genomes | Disease control | Immunity | Microglia | Proteins | Immune systems | Studies | Consortia | DNA microarrays | Genotyping | Gene frequency | DNA methylation | Alzheimers disease | Protein interaction | Bioinformatics | Genotypes | Index Medicus | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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10. Full Text Recurrent Tissue-Specific mtDNA Mutations Are Common in Humans
by Samuels, David C and Li, Chun and Li, Bingshan and Song, Zhuo and Torstenson, Eric and Boyd Clay, Hayley and Rokas, Antonis and Thornton-Wells, Tricia A and Moore, Jason H and Hughes, Tia M and Hoffman, Robert D and Haines, Jonathan L and Murdock, Deborah G and Mortlock, Douglas P and Williams, Scott M
PLoS Genetics, ISSN 1553-7390, 11/2013, Volume 9, Issue 11, pp. e1003929 - e1003929
Mitochondrial DNA (mtDNA) variation can affect phenotypic variation; therefore, knowing its distribution within and among individuals is of importance to... 
HUMAN MITOCHONDRIAL-DNA | POINT MUTATIONS | DATA SET | REPLICATION | CONTROL REGION SEQUENCES | HEALTHY-SUBJECTS | HETEROPLASMIC MICE | GENETICS & HEREDITY | HIGH-FREQUENCY | MAJOR NONCODING REGION | AGE | DNA, Mitochondrial - genetics | Mitochondria - genetics | Polymorphism, Restriction Fragment Length - genetics | Base Sequence | Humans | DNA Replication - genetics | Muscle, Skeletal - metabolism | Genome, Mitochondrial | Mutation - genetics | Organ Specificity | Physiological aspects | Mitochondrial DNA | Research | Gene mutations | Population genetics | Index Medicus | Musculoskeletal system | Deoxyribonucleic acid | DNA | Aging | Cell division | Genomes | Mutation
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11. Full Text Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography
by Koran, Mary Ellen I and Hohman, Timothy J and Thornton-Wells, Tricia A
Human Genetics, ISSN 0340-6717, 1/2014, Volume 133, Issue 1, pp. 85 - 93
Late-onset Alzheimer’s disease (LOAD) is known to have a complex, oligogenic etiology, with considerable genetic heterogeneity. We investigated the influence... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | NATIONAL INSTITUTE | ACTIVATION | PRECURSOR | PHOSPHORYLATION | RECOMMENDATIONS | CA2+ RELEASE | DISEASE | GENETICS & HEREDITY | DIAGNOSTIC GUIDELINES | ALZHEIMERS ASSOCIATION WORKGROUPS | EPISTASIS | Reproducibility of Results | Apolipoprotein E4 - genetics | Apolipoprotein E4 - metabolism | Humans | Homeostasis | Genotype | Male | Ryanodine Receptor Calcium Release Channel - metabolism | Chromosome Mapping | Positron-Emission Tomography | Brain - metabolism | Calcium Channels, L-Type - genetics | Ryanodine Receptor Calcium Release Channel - genetics | Epistasis, Genetic | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Brain - pathology | Female | Aged | Polymorphism, Single Nucleotide | Calcium Channels, L-Type - metabolism | Alzheimer Disease - genetics | Calcium channels | PET imaging | Genes | Amyloid beta-protein | Development and progression | Amyloidosis | Alzheimer's disease | Cholesterol | Index Medicus | ADNI | calcium homeostasis | amyloid | neuroimaging genetics | Alzheimer’s disease | PET
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12. Full Text Interactions between GSK3β and amyloid genes explain variance in amyloid burden
by Hohman, Timothy J and Koran, Mary Ellen I and Thornton-Wells, Tricia A and Alzheimers Neuroimaging Initiativ and Alzheimer's Neuroimaging Initiative
Neurobiology of Aging, ISSN 0197-4580, 2014, Volume 35, Issue 3, pp. 460 - 465
Abstract The driving theoretical framework of Alzheimer's disease (AD) has been built around the amyloid-β (Aβ) cascade in which amyloid pathology precedes and... 
Neurology | Internal Medicine | ADNI | Imaging genetics | Tau | Amyloid | Alzheimer's disease | PET | PHOSPHORYLATION | ALZHEIMERS-DISEASE | QUANTITATIVE TRAIT | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | DOWN-SYNDROME | HYPOTHESIS | A-BETA | WHOLE-GENOME ASSOCIATION | PRECURSOR PROTEIN | TRANSGENIC MICE | Glycogen Synthase Kinase 3 - physiology | Plaque, Amyloid - pathology | Humans | Middle Aged | Gene Expression Regulation | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Linear Models | Male | Risk | Alzheimer Disease - pathology | Plaque, Amyloid - genetics | Glycogen Synthase Kinase 3 - genetics | Amyloid beta-Peptides - genetics | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Female | Plaque, Amyloid - metabolism | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Index Medicus | Alzheimer’s Disease | Imaging Genetics
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