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Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 105 - 109
In BRAF(V600)-mutant tumours, most mechanisms of resistance to drugs that target the BRAF and/or MEK kinases rely on reactivation of the RAS-RAF-MEK-ERK... 
MESSENGER-RNA TRANSLATION | SILVESTROL | MELANOMA | INITIATION | RAF | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | LEUKEMIA-CELLS | MODEL | FEEDBACK INHIBITION | Triterpenes - pharmacology | Humans | Eukaryotic Initiation Factor-4E - metabolism | Eukaryotic Initiation Factor-4G - metabolism | Eukaryotic Initiation Factor-4F - metabolism | Melanoma - genetics | Protein Binding - drug effects | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Phosphorylation - drug effects | Eukaryotic Initiation Factor-4F - antagonists & inhibitors | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Eukaryotic Initiation Factor-4A - antagonists & inhibitors | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Eukaryotic Initiation Factor-4F - chemistry | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Eukaryotic Initiation Factor-4A - metabolism | Drug Resistance, Neoplasm - drug effects | Thyroid Neoplasms - pathology | Antimitotic agents | Pharmaceutical research | Vemurafenib | Protein research | Research | Antineoplastic agents | Drug resistance | Phosphorylation | Biopsy | Melanoma | Mutation | Metastasis | Cancer therapies | Tumors | Cancer | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2015, Volume 54, Issue 44, pp. 12996 - 13001
Journal Article
Organic Letters, ISSN 1523-7060, 08/2016, Volume 18, Issue 15, pp. 3670 - 3673
An optimized protocol for the masking of aketoacids with acid-labile cyclic acetal protecting groups is reported. Unlike prior approaches, these new conditions... 
CHEMISTRY, ORGANIC | CHEMICAL PROTEIN-SYNTHESIS | KAHA LIGATION | Hydroxylamines - chemistry | Molecular Structure | Peptides - chemical synthesis | Peptides - chemistry | Keto Acids - chemistry | Keto Acids - chemical synthesis | Index Medicus
Journal Article
Helvetica Chimica Acta, ISSN 0018-019X, 11/2016, Volume 99, Issue 11, pp. 868 - 894
The convergent synthesis of proteins by multiple ligations requires segments protected at the N‐ and/or C‐terminus with masking groups that are orthogonal to... 
Modifier proteins | Ligation | Peptides | Protecting groups | Photochemistry | ACID | NATIVE CHEMICAL LIGATION | CARBONYL-COMPOUNDS | ALDEHYDES | PROTEIN-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | KETONES | SERINE | CRYPTO-THIOESTER | PHOTOLABILE PROTECTING GROUP
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 10/2015, Volume 54, Issue 44, pp. 12996 - 13001
The chemical synthesis of the 184-residue ferric heme-binding protein nitrophorin4 was accomplished by sequential couplings of five unprotected peptide... 
solid-phase peptide synthesis | MUTANT | heme proteins | CRYSTAL-STRUCTURE | ligation reactions | RESOLUTION | peptides | protein synthesis | COORDINATION | THIOESTER | CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE | AMINO-ACID | SERINE | NITRIC-OXIDE | N-HOMOCYSTEINYLATION | Chemical synthesis
Journal Article
Journal Article
Chemistry & Biology, ISSN 1074-5521, 09/2012, Volume 19, Issue 9, pp. 1093 - 1104
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2014, Volume 74, pp. 41 - 49
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 22, pp. 10064 - 10073
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 2531 - 2531
Journal Article
Helvetica Chimica Acta, ISSN 0018-019X, 11/2016, Volume 99, Issue 11, p. 868
  The convergent synthesis of proteins by multiple ligations requires segments protected at the N- and/or C-terminus with masking groups that are orthogonal to... 
Proteins | Protein biosynthesis | Hydroxides | Peptides
Journal Article
Microbiology and Immunology, ISSN 0385-5600, 03/2015, Volume 59, Issue 3, pp. 129 - 141
Journal Article