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Journal of Clinical Investigation, ISSN 0021-9738, 09/2016, Volume 126, Issue 9, pp. 3207 - 3218
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2018, Volume 128, Issue 5, pp. 1956 - 1970
Pulmonary arterial hypertension (PAH) is characterized by a progressive accumulation of pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterioles... 
MEDICINE, RESEARCH & EXPERIMENTAL | FIBROBLAST GROWTH FACTOR-2 | INTERLEUKIN-6 RECEPTOR | OVEREXPRESSION | SMOOTH-MUSCLE-CELLS | MICE | CYTOKINE | BMPR-II | CONTRIBUTES | IL-6 RECEPTOR | BETA | Familial Primary Pulmonary Hypertension - pathology | Up-Regulation | Vascular Remodeling | Muscle, Smooth, Vascular - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Rats | Familial Primary Pulmonary Hypertension - genetics | Mice, Transgenic | Pulmonary Artery - physiopathology | Signal Transduction - genetics | Muscle, Smooth, Vascular - physiopathology | Familial Primary Pulmonary Hypertension - metabolism | Familial Primary Pulmonary Hypertension - physiopathology | Arterioles - pathology | Muscle, Smooth, Vascular - pathology | Pulmonary Artery - metabolism | Animals | Arterioles - metabolism | Arterioles - physiopathology | Cytokine Receptor gp130 - biosynthesis | Mice | Myocytes, Smooth Muscle - metabolism | Pulmonary Artery - pathology | Care and treatment | Cytokine receptors | Physiological aspects | Development and progression | Health aspects | Pulmonary artery | Pulmonary hypertension | Interleukin-6 | Cytochrome | Hypertension | Animal models | Cytokines | Arterioles | Pathogenesis | Pulmonary arteries | Lung | Smooth muscle | Cardiovascular disease | Interleukin 6 | Proteins | Signal transduction | Interleukin 6 receptors | Rodents | Medical prognosis | Hypoxia | Heart diseases | Growth factors | Glycoprotein gp130 | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2015, Volume 192, Issue 8, pp. 983 - 997
Rationale: Inflammation and endothelial dysfunction are considered two primary instigators of pulmonary arterial hypertension (PAH). CD74 is a receptor for the... 
Macrophage migration inhibitory factor | CD74 signaling pathway | Endothelial dysfunction | Adhesion molecules | Pulmonary hypertension | CD74 | RECRUITMENT | macrophage migration inhibitory factor | pulmonary hypertension | PHENOTYPE | MIF | CELL-SURVIVAL | PREVENTS | endothelial dysfunction | FIBROBLAST GROWTH FACTOR-2 | adhesion molecules | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | MICE | CONTRIBUTES | CRITICAL CARE MEDICINE | Leukocytes, Mononuclear - metabolism | Up-Regulation | Humans | Macrophage Migration-Inhibitory Factors - immunology | Middle Aged | Macrophage Migration-Inhibitory Factors - metabolism | Male | Case-Control Studies | Familial Primary Pulmonary Hypertension - metabolism | Pulmonary Artery - metabolism | Familial Primary Pulmonary Hypertension - immunology | Leukocytes, Mononuclear - immunology | Antigens, Differentiation, B-Lymphocyte - immunology | Adult | Female | Histocompatibility Antigens Class II - metabolism | Disease Models, Animal | Endothelium, Vascular - immunology | Vascular Cell Adhesion Molecule-1 - immunology | Signal Transduction | Endothelial Cells - metabolism | Intercellular Adhesion Molecule-1 - immunology | Cells, Cultured | Endothelium, Vascular - physiopathology | Rats | E-Selectin - metabolism | E-Selectin - immunology | Inflammation | Endothelial Cells - immunology | Intercellular Adhesion Molecule-1 - metabolism | Animals | Histocompatibility Antigens Class II - immunology | Endothelium, Vascular - metabolism | Antigens, Differentiation, B-Lymphocyte - metabolism | In Vitro Techniques | Vascular Cell Adhesion Molecule-1 - metabolism | Pulmonary Artery - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 43, pp. 74917 - 74926
Pulmonary arterial hypertension (PAH) is a lethal disease that often affects the young. Although gene ( mutations are related with idiopathic and heritable... 
Genome-wide association study | Pulmonary arterial hypertension | Novel therapeutic target
Journal Article
Chest, ISSN 0012-3692, 2016, Volume 149, Issue 6, pp. 1482 - 1493
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 12/2018, Volume 19, Issue 12, p. 4105
Background: Pulmonary hypertension (PH) is a common complication of idiopathic pulmonary fibrosis (IPF) that significantly contributes to morbidity and... 
Macrophage migration inhibitory factor | Pulmonary vascular remodeling | Molecular target | Idiopathic pulmonary fibrosis associated with pulmonary hypertension (IPF-PH) | SYSTEM | TARGET | DIAGNOSIS | macrophage migration inhibitory factor | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOKINE | CHEMISTRY, MULTIDISCIPLINARY | molecular target | STRUCTURAL FEATURES | pulmonary vascular remodeling | ARTERIAL-HYPERTENSION | idiopathic pulmonary fibrosis associated with pulmonary hypertension (IPF-PH) | CONTRIBUTES | Inflammation - chemically induced | Inflammation - pathology | Idiopathic Pulmonary Fibrosis - genetics | Humans | Male | Idiopathic Pulmonary Fibrosis - chemically induced | Hypertension, Pulmonary - chemically induced | Macrophage Migration-Inhibitory Factors - genetics | Inflammation - drug therapy | Female | Receptors, CXCR4 - genetics | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Vascular Remodeling - drug effects | Bleomycin - toxicity | Disease Models, Animal | Antigens, Differentiation, B-Lymphocyte - genetics | Lung - pathology | Hypertension, Pulmonary - genetics | Isoxazoles - administration & dosage | Animals | Intramolecular Oxidoreductases - genetics | Vascular Remodeling - genetics | Lung - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Inflammation - genetics | Mice | Histocompatibility Antigens Class II - genetics | Hypertension, Pulmonary - pathology | Idiopathic Pulmonary Fibrosis - drug therapy | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 04/2014, Volume 129, Issue 15, pp. 1586 - 1597
BACKGROUND—Pericytes and their crosstalk with endothelial cells are critical for the development of a functional microvasculature and vascular remodeling. It... 
cell communication | transforming growth factor beta | fibroblast growth factor 2 | pericytes | endothelilal cells | pulmonary arterial hypertension | interleukin-6 | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOGENESIS | BONE MORPHOGENETIC PROTEIN | MICROVASCULAR PERICYTES | INHIBITION | ARTERIAL-HYPERTENSION | ADAMS-OLIVER SYNDROME | PERIPHERAL VASCULAR DISEASE | MICE | DIFFERENTIATION | CONTRIBUTES | MOLECULAR-MECHANISMS | Pericytes - drug effects | Rats, Wistar | Humans | Middle Aged | Pericytes - cytology | Fibroblast Growth Factor 2 - pharmacology | Hypertension, Pulmonary - physiopathology | Cell Communication - physiology | Male | Pericytes - physiology | Retinal Vessels - physiology | Microcirculation - physiology | Pulmonary Circulation - physiology | Interleukin-6 - physiology | Retinal Vessels - cytology | Adult | Female | Fibroblast Growth Factor 2 - physiology | Cell Differentiation - physiology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Cells, Cultured | Rats | Mice, Transgenic | Muscle, Smooth, Vascular - cytology | Neovascularization, Physiologic - physiology | Animals | Interleukin-6 - pharmacology | Cell Differentiation - drug effects | Endothelial Cells - cytology | Cell Communication - drug effects | Mice | Hypertension, Pulmonary - pathology | Endothelial Cells - drug effects | Physiological aspects | Smooth muscle | Fibroblast growth factors | Research | Pulmonary hypertension | Interleukin-6 | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 7, pp. 2725 - 2736
Macrophage migration inhibitory factor (MIF) is a key pleiotropic mediator and a promising therapeutic target in cancer as well as in several inflammatory and... 
Index Medicus
Journal Article
Cardiovascular research, ISSN 0008-6363, 06/2019
The progressive accumulation of cells in pulmonary vascular walls is a key pathological feature of pulmonary arterial hypertension (PAH) that results in... 
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 03/2019, Volume 33, Issue 3, pp. 3670 - 3679
Heightened pulmonary artery smooth muscle cell (PA-SMC) proliferation and migration and dynamic remodeling of the extracellular matrix are hallmark pathogenic... 
FIBROSIS | pulmonary vascular remodeling | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | TARGETS | SERINE ELASTASE INHIBITOR | PREVENTS | pulmonary arterial hypertension | TRANSCRIPTION FACTOR | extracellular matrix | FoxO1 | CELL BIOLOGY
Journal Article
Cardiovascular Research, ISSN 0008-6363, 2019, p. cvz153
Aims: The progressive accumulation of cells in pulmonary vascular walls is a key pathological feature of pulmonary arterial hypertension (PAH) that results in... 
Life Sciences | Human health and pathology | Pharmacology | Pharmaceutical sciences | Cardiology and cardiovascular system
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A12206 - A12206
IntroductionIn idiopathic pulmonary arterial hypertension (iPAH), pulmonary-endothelial cells (P-ECs) display phenotypic abnormalities including a greater... 
Journal Article
Circulation, ISSN 0009-7322, 11/2015, Volume 132, Issue Suppl_3 Suppl 3, pp. A12186 - A12186
BackgroundInterleukin (IL)-6 has been linked to the prognosis of pulmonary arterial hypertension (PAH). However, precise contributions of IL-6 and its... 
Journal Article
The European respiratory journal, ISSN 0903-1936, 01/2018, Volume 51, Issue 1, pp. 1701096 - 1701096
Journal Article