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by Ridker, Paul M and MacFadyen, Jean G and Thuren, Tom and Everett, Brendan M and Libby, Peter and Glynn, Robert J and Ridker, Paul and Lorenzatti, Alberto and Krum, Henry and Varigos, John and Siostrzonek, Peter and Sinnaeve, Peter and Fonseca, Francisco and Nicolau, Jose and Gotcheva, Nina and Genest, Jacques and Yong, Huo and Urina-Triana, Miguel and Milicic, Davor and Cifkova, Renata and Vettus, Riina and Koenig, Wolfgang and Anker, Stephan D and Manolis, Athanasios J and Wyss, Fernando and Forster, Tamas and Sigurdsson, Axel and Pais, Prem and Fucili, Alessandro and Ogawa, Hisao and Shimokawa, Hiroaki and Veze, Irina and Petrauskiene, Birute and Salvador, Leon and Kastelein, John and Cornel, Jan Hein and Klemsdal, Tor Ole and Medina, Felix and Budaj, Andrzej and Vida-Simiti, Luminita and Kobalava, Zhanna and Otasevic, Petar and Pella, Daniel and Lainscak, Mitja and Seung, Ki-Bae and Commerford, Patrick and Dellborg, Mikael and Donath, Marc and Hwang, Juey-Jen and Kultursay, Hakan and Flather, Marcus and Ballantyne, Christie and Bilazarian, Seth and Chang, William and East, Cara and Everett, Brendan and Forgosh, Les and Glynn, Robert and Harris, Barry and Ligueros, Monica and Bohula, Erin and Charmarthi, Bindu and Cheng, Susan and Chou, Sherry and Danik, Jacqueline and McMahon, Graham and Maron, Bradley and Ning, MingMing and Olenchock, Benjamin and Pande, Reena and Perlstein, Todd and Pradhan, Aruna and Rost, Natalia and Singhal, Aneesh and Taqueti, Viviany and Wei, Nancy and Burris, Howard and Cioffi, Angela and Dalseg, Anne Marie and Ghosh, Nilanjan and Gralow, Julie and Mayer, Tina and Rugo, Hope and Fowler, Vance and Limaye, Ajit P and Cosgrove, Sara and Levine, Donald and Lopes, Renato and Scott, John and Hilkert, Robert and Tamesby, Georgia and Mickel, Carolyn and Manning, Brian and Woelcke, Julian and Tan, Monique and Manfreda, Sheryl and Ponce, Tom and Kam, Jane and Saini, Ravinder and Banker, Kehur and ... and CANTOS Trial Group and CANTOS Trial Grp
The Lancet (British edition), ISSN 0140-6736, 2017, Volume 390, Issue 10105, pp. 1833 - 1842
Journal Article
Clinical therapeutics, ISSN 0149-2918, 2014, Volume 36, Issue 11, pp. 1625 - 1637
Abstract Purpose Interleukin (IL)-1β, an inflammatory molecule, contributes to the development of atherothrombosis and worsening of islet β-cell function.... 
Internal Medicine | Medical Education | pharmacokinetics | type 2 diabetes mellitus | high-sensitivity C-reactive protein | canakinumab | pharmacodynamics | interleukin-1β | High-sensitivity C-reactive protein | Pharmacodynamics | Type 2 diabetes mellitus | Canakinumab | Pharmacokinetics | Interleukin-1β | C-REACTIVE PROTEIN | PERIODIC SYNDROME | TREAT GOUTY-ARTHRITIS | ACUTE FLARES | PREVENTION | interleukin-1 beta | STATIN THERAPY | DISEASE | ACZ885 | PHARMACOLOGY & PHARMACY | IL-1-BETA | OUTCOMES | Hypoglycemic Agents - pharmacokinetics | Double-Blind Method | Antibodies, Monoclonal - pharmacology | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Antibodies, Monoclonal - pharmacokinetics | Half-Life | Male | Biomarkers - blood | Diabetes Mellitus, Type 2 - metabolism | Hypoglycemic Agents - pharmacology | Young Adult | C-Reactive Protein - metabolism | Hypoglycemic Agents - administration & dosage | Antibodies, Monoclonal - administration & dosage | Adolescent | Adult | Female | Aged | Metformin - administration & dosage | Diabetes Mellitus, Type 2 - drug therapy | Interleukin-1beta - antagonists & inhibitors | Type 2 diabetes | Monoclonal antibodies | Care and treatment | Pancreatic beta cells | Dosage and administration | Heart attacks | Laboratories | Mortality | Biomarkers | Cardiovascular disease | Arthritis | Diabetes | Drug dosages | Cholesterol
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2018, Volume 391, Issue 10118, pp. 319 - 328
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2018, Volume 71, Issue 21, pp. 2392 - 2401
Subclinical inflammation mediated in part by interleukin (IL)-1β participates in peripheral insulin resistance and impaired pancreatic insulin secretion. The... 
cardiovascular disease | inflammation | diabetes | randomized trial | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | ANTAGONIST | CARDIOVASCULAR OUTCOMES | NECROSIS-FACTOR-ALPHA | INTERLEUKIN-6 | TARGETING INFLAMMATION | GLUCOSE | IL-1-BETA | ETANERCEPT | TYPE-2 | Prediabetic State - blood | Double-Blind Method | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | Humans | Middle Aged | Antibodies, Monoclonal - therapeutic use | Male | Prediabetic State - drug therapy | Blood Glucose - drug effects | Dose-Response Relationship, Drug | Prediabetic State - diagnosis | Antibodies, Monoclonal, Humanized | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Anti-Inflammatory Agents - therapeutic use | Female | Aged | Disease Management | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Interleukin-1beta - antagonists & inhibitors | Type 2 diabetes | Prevention | Interleukins | Anti-inflammatory drugs | Analysis | Insulin resistance | Prediabetic state | Diabetes therapy | Myocardial infarction | Fasting | C-reactive protein | Heart attacks | Diabetes mellitus | Interleukin | Health risks | Risk reduction | Inflammation | Glucose | Insulin | Patients | Thrombosis | Incidence | Interleukin 6 | Proteins | Confidence intervals | Hemoglobin | Infarction | Diabetes | Thromboembolism | Pancreas | Diabetes mellitus (non-insulin dependent) | Drug dosages
Journal Article
Circulation (New York, N.Y.), ISSN 0009-7322, 12/2012, Volume 126, Issue 23, pp. 2739 - 2748
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 59, Issue 13, pp. E1539 - E1539
Journal Article
Journal Article
Journal of clinical lipidology, ISSN 1933-2874, 2014, Volume 8, Issue 3, pp. 301 - 302
Journal Article
European heart journal, ISSN 1522-9645, 2019, Volume 41, Issue 23, pp. 2153 - 2163
Abstract Aims The Canakinumab Antiinflammatory Thrombosis Outcomes Study (CANTOS) established that targeting inflammation with interleukin-1β (IL-1β)... 
C-REACTIVE PROTEIN | PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | ATHEROSCLEROSIS | Cardiovascular disease | RECEPTOR | Inflammation | Interleukin-6 | Clinical trial | (IL)-18 | Interleukin-18 | CORONARY-HEART-DISEASE | EXPRESSION
Journal Article