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Investigational new drugs, ISSN 0167-6997, 2015, Volume 33, Issue 1, pp. 201 - 214
Background This phase I/II study determined the maximal tolerable dose, dose limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics... 
NAMI-A | Ruthenium | Phase I | Medicine & Public Health | Gemcitabine | Non-small cell lung cancer | Oncology | Phase II | Pharmacology/Toxicology | Clinical study | TRANS-IMIDAZOLEDIMETHYLSULFOXIDE-TETRACHLORORUTHENATE | DNA-BINDING | METASTASIS | CHEMICAL-STABILITY | TUMORS | PLATINUM COMPLEXES | INHIBITION | LIQUID-CHROMATOGRAPHY | ONCOLOGY | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Ruthenium - administration & dosage | Deoxycytidine - pharmacokinetics | Ruthenium - adverse effects | Adult | Deoxycytidine - adverse effects | Dimethyl Sulfoxide - administration & dosage | Female | Ruthenium - blood | Dimethyl Sulfoxide - adverse effects | Organometallic Compounds - adverse effects | Deoxycytidine - administration & dosage | Carcinoma, Non-Small-Cell Lung - metabolism | Organometallic Compounds - pharmacokinetics | Treatment Outcome | Ruthenium - pharmacokinetics | Maximum Tolerated Dose | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Dimethyl Sulfoxide - analogs & derivatives | Deoxycytidine - analogs & derivatives | Dimethyl Sulfoxide - pharmacokinetics | Organometallic Compounds - administration & dosage | Complications and side effects | Dosage and administration | Research | Lung cancer, Non-small cell | Drug therapy | Studies | Clinical trials | Lung cancer | Pharmaceutical sciences | Clinical outcomes | Index Medicus
Journal Article
Analytical and Bioanalytical Chemistry, ISSN 1618-2642, 8/2019, Volume 411, Issue 20, pp. 5331 - 5345
A novel method was developed and validated for the quantification of the three approved CDK4/6 inhibitors (abemaciclib, palbociclib, and ribociclib) in both... 
Biochemistry, general | Plasma | Food Science | Palbociclib | Ribociclib | Laboratory Medicine | Tissue homogenates | Abemaciclib | LC-MS/MS | Chemistry | Analytical Chemistry | Monitoring/Environmental Analysis | Characterization and Evaluation of Materials | CHEMISTRY, ANALYTICAL | LC-MS | TISSUE | BIOCHEMICAL RESEARCH METHODS | QUANTITATIVE-ANALYSIS | PD 0332991 | CANCER | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Purines - pharmacology | Humans | Pyridines - analysis | Benzimidazoles - analysis | Piperazines - pharmacology | Animals | Piperazines - analysis | Protein Kinase Inhibitors - analysis | Aminopyridines - pharmacology | Benzimidazoles - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Purines - analysis | Pyridines - pharmacology | Chromatography, Liquid - methods | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Tandem Mass Spectrometry - methods | Aminopyridines - analysis | Ethylenediaminetetraacetic acid | Liquid chromatography | Spectrum analysis | Analysis | Liver | Methods | Brain | Matrices (mathematics) | Correlation coefficients | Tissues | Small intestine | Cyclin-dependent kinase 4 | Blood plasma | Pretreatment | Spleen | Correlation coefficient | Spectroscopy | Elution | Kidneys | Ions | Mass spectroscopy | Stability analysis | Calibration | Chromatography | Dilution | Inhibitors | Human performance | Storage conditions | Acetonitrile | Scientific imaging | Mass spectrometry | Research Paper
Journal Article
International journal of cancer, ISSN 0020-7136, 07/2019
Galunisertib (LY2157299), a promising small-molecule inhibitor of the transforming growth factor-beta (TGF-β) receptor, is currently in mono- and combination... 
Index Medicus
Journal Article
Journal Article
MOLECULAR PHARMACEUTICS, ISSN 1543-8384, 09/2019, Volume 16, Issue 9, pp. 3842 - 3852
Ribociclib is a CDK4/6 inhibitor recently approved for the treatment of some types of breast cancer in combination with an aromatase inhibitor. It is currently... 
BCRP | DRUG | MEDICINE, RESEARCH & EXPERIMENTAL | P-gp | PERMEABILITY | brain penetration | METASTASES | PENETRATION | CYP3A4 | BLOOD-TUMOR BARRIER | CDK4/6 inhibitor | PHARMACOLOGY & PHARMACY | KNOCKOUT | ABC TRANSPORTERS | INHIBITOR | PHASE-I | ribociclib | CANCER RESISTANCE PROTEIN | Index Medicus
Journal Article
Cancer research, ISSN 0008-5472, 2004, Volume 64, Issue 16, pp. 5804 - 5811
Journal Article
Investigational New Drugs, ISSN 0167-6997, 02/2015, Volume 33, Issue 1, p. 201
Background This phase I/II study determined the maximal tolerable dose, dose limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics... 
NAMI-A | Ruthenium | Phase I | Gemcitabine | Non-small cell lung cancer | Phase II | Clinical study
Journal Article
Journal Article
Journal Article
Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 07/2004, Volume 18, Issue 13, pp. 1465 - 1471
The development of a liquid chromatography/tandem mass spectrometric assay for the quantitative analysis of the novel tubulin inhibitor D‐24851 in human plasma... 
SPECTROSCOPY | CHEMISTRY, ANALYTICAL | Reference Standards | Reproducibility of Results | Antineoplastic Agents - urine | Acetamides - urine | Humans | Mass Spectrometry | Indoles - blood | Antineoplastic Agents - blood | Molecular Structure | Chromatography, High Pressure Liquid | Acetamides - blood | Indoles - urine
Journal Article