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Journal of Clinical Oncology, ISSN 0732-183X, 06/2010, Volume 28, Issue 16, pp. 2698 - 2704
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2012, Volume 30, Issue 2, pp. 184 - 189
Journal Article
Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2013, Volume 273, Issue 2, pp. 298 - 313
Journal Article
Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 6/2010, Volume 37, Issue 3, pp. 221 - 242
Journal Article
The AAPS Journal, ISSN 1550-7416, 9/2014, Volume 16, Issue 5, pp. 994 - 1008
Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate (ADC) therapeutic for treatment of human epidermal growth factor receptor 2 (HER2)-positive... 
Biochemistry, general | Biotechnology | deconjugation | trastuzumab emtansine | Biomedicine | Pharmacy | antibody–drug conjugate | population pharmacokinetic model | T-DM1 | Pharmacology/Toxicology | antibody-drug conjugate | CATABOLISM | CYTOTOXIC DRUG | CHROMATOGRAPHY-MASS-SPECTROMETRY | THERAPY | POPULATION PHARMACOKINETICS | IN-VIVO | PLASMA/SERUM | PHARMACOLOGY & PHARMACY | MICE | Injections, Intravenous | Humans | Receptor, ErbB-2 - metabolism | Macaca fascicularis | Male | Antineoplastic Agents - administration & dosage | Breast Neoplasms - metabolism | Neoplasm Metastasis | Antibodies, Monoclonal, Humanized - administration & dosage | Antibodies, Monoclonal, Humanized - pharmacokinetics | Antibodies, Monoclonal, Humanized - blood | Biotransformation | Mass Spectrometry | Chromatography, Liquid | Female | Antineoplastic Agents - pharmacokinetics | Receptor, ErbB-2 - antagonists & inhibitors | Maytansine - blood | Reproducibility of Results | Maytansine - analogs & derivatives | Drug Stability | Rats | Breast Neoplasms - drug therapy | Rats, Sprague-Dawley | Maytansine - administration & dosage | Animals | Breast Neoplasms - pathology | Models, Biological | Maytansine - pharmacokinetics | Antineoplastic Agents - blood | Breast Neoplasms - blood | Trastuzumab | Enzymes | Analysis | Breast cancer | Liquid chromatography | Metastasis | Drug therapy | Enzyme-linked immunosorbent assay | Biopharmaceutics | Index Medicus | Pharmaceutical Sciences | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Farmaceutiska vetenskaper
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2010, Volume 16, Issue 19, pp. 4769 - 4778
Journal Article