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index medicus (30) 30
animals (21) 21
cardiomyocytes (16) 16
cardiac & cardiovascular systems (15) 15
humans (15) 15
tissue engineering (13) 13
myocytes, cardiac - metabolism (12) 12
maturation (11) 11
stem cells (11) 11
analysis (9) 9
cell biology (9) 9
heart (9) 9
rats (9) 9
tissue engineering - methods (9) 9
tissue (8) 8
mice (7) 7
myocardium - pathology (7) 7
myocytes, cardiac - pathology (7) 7
physiology (7) 7
article (6) 6
cells, cultured (6) 6
engineered heart muscle (6) 6
fibroblasts (6) 6
heart cells (6) 6
male (6) 6
muscle (6) 6
research article (6) 6
calcium (5) 5
cell differentiation (5) 5
differentiation (5) 5
disease (5) 5
expression (5) 5
growth (5) 5
hematology (5) 5
hypertrophy (5) 5
myocardial contraction (5) 5
myocytes (5) 5
peripheral vascular disease (5) 5
proteins (5) 5
regeneration (5) 5
activation (4) 4
apoptosis (4) 4
biophysics (4) 4
calcium - metabolism (4) 4
cardiomyopathy (4) 4
cells (4) 4
collagen (4) 4
embryonic stem-cells (4) 4
female (4) 4
heart diseases (4) 4
heart-failure (4) 4
multidisciplinary sciences (4) 4
muscles (4) 4
mutation (4) 4
myocardium (4) 4
myocardium - cytology (4) 4
myocardium - metabolism (4) 4
myocytes, cardiac - transplantation (4) 4
pluripotency (4) 4
rat (4) 4
rats, wistar (4) 4
repair (4) 4
signal transduction (4) 4
ventricle (4) 4
animals, newborn (3) 3
arrhythmia (3) 3
biochemistry & molecular biology (3) 3
calcium channels (3) 3
cardiac muscle (3) 3
cardiology (3) 3
cardiomegaly - pathology (3) 3
cardiovascular (3) 3
cell & tissue engineering (3) 3
cell line (3) 3
cell proliferation (3) 3
disease models, animal (3) 3
electrical-stimulation (3) 3
gene expression (3) 3
gene-expression (3) 3
generation (3) 3
heart failure (3) 3
induced pluripotent stem cells - metabolism (3) 3
ion channels (3) 3
medical research (3) 3
medicine (3) 3
models (3) 3
mouse model (3) 3
muscle contraction (3) 3
myocardial infarction - pathology (3) 3
myocardial infarction - physiopathology (3) 3
phosphorylation (3) 3
physiological aspects (3) 3
pluripotent stem-cells (3) 3
protein binding (3) 3
rats, nude (3) 3
stem-cells (3) 3
stimulation (3) 3
abridged index medicus (2) 2
actin (2) 2
adrenergic receptors (2) 2
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1. Full Text Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue
by Tiburcy, M and Didie, M and Boy, O and Christalla, P and Doker, S and Naito, H and Karikkineth, B.C and El-Armouche, A and Grimm, M and Nose, M and Eschenhagen, T and Zieseniss, A and Katschinksi, D.M and Hamdani, N and Linke, W.A and Yin, X.K and Mayr, M and Zimmermann, W.H
Circulation Research, ISSN 0009-7330, 2011, Volume 109, Issue 10, pp. 1105 - 1114
RATIONALE:Cardiac tissue engineering should provide “realistic” in vitro heart muscle models and surrogate tissue for myocardial repair. For either... 
cardiac myocytes | maturation | tissue engineering | hypertrophy | caspase activation | extracellular matrix | sarcomere | CARDIAC & CARDIOVASCULAR SYSTEMS | ADULT-RAT CARDIOMYOCYTES | MYOCYTES | MUSCLE | BIOENGINEERED CARDIAC GRAFTS | HYPERPLASIA | MYOSIN HEAVY-CHAIN | RIGHT VENTRICULAR MYOCARDIUM | EARLY POSTNATAL-DEVELOPMENT | BINUCLEATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Cell Proliferation | Age Factors | Rats, Wistar | Extracellular Matrix - metabolism | Cardiomegaly - pathology | Sarcomeres - pathology | Cell Differentiation - genetics | Gene Expression Regulation, Developmental | Regeneration - genetics | Myocardium - metabolism | Aging | Cell Culture Techniques | Proteomics - methods | Tissue Engineering | Animals, Newborn | Myocardial Contraction | Sarcomeres - metabolism | Cells, Cultured | Cardiomegaly - physiopathology | Rats | Myocardium - pathology | Organogenesis | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - metabolism | Cardiomegaly - genetics | Apoptosis | Cardiomegaly - metabolism
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2. Full Text RhoA ambivalently controls prominent myofibroblast characteritics by involving distinct signaling routes
by Jatho, Aline and Hartmann, Svenja and Kittana, Naim and Mügge, Felicitas and Wuertz, Christina M and Tiburcy, Malte and Zimmermann, Wolfram-Hubertus and Katschinski, Dörthe M and Lutz, Susanne
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0137519
Introduction RhoA has been shown to be beneficial in cardiac disease models when overexpressed in cardiomyocytes, whereas its role in cardiac fibroblasts (CF)... 
CARDIAC FIBROBLASTS | CELLS | ACTIVATION | PROTEIN | INHIBITION | ACETYLATION | MULTIDISCIPLINARY SCIENCES | GROWTH | TISSUE | GENE-EXPRESSION | ALPHA-TUBULIN | Myofibroblasts - metabolism | Animals | Polymerase Chain Reaction | Cell Survival - genetics | Cells, Cultured - physiology | Rats | Signal Transduction - physiology | rhoA GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - genetics | Cell Movement - genetics | Cell Movement - physiology | Cell Survival - physiology | Physiological aspects | Bone morphogenetic proteins | Muscle proteins | Transforming growth factors | Analysis | Viscoelasticity | Heart | Migration | Smooth muscle | Cardiovascular disease | Remodeling | Kinases | Cell adhesion & migration | Proteins | Cell growth | Tubulin | Actin | Cascades | Fibroblasts | Physiology | Acetylation | Heart diseases | Growth factors | Phenotypes | Immunoglobulins | Contractility | Connective tissue growth factor | RhoA protein | Cardiomyocytes | Pharmacology | Gene expression | Muscle contraction | Coronary artery disease | Rho-associated kinase | Environmental conditions | Signaling | Collagen | Fibrosis | Cytoskeleton | Three dimensional models | Cancer
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3. Full Text Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling
by Abilez, Oscar J and Tzatzalos, Evangeline and Yang, Huaxiao and Zhao, Ming‐Tao and Jung, Gwanghyun and Zöllner, Alexander M and Tiburcy, Malte and Riegler, Johannes and Matsa, Elena and Shukla, Praveen and Zhuge, Yan and Chour, Tony and Chen, Vincent C and Burridge, Paul W and Karakikes, Ioannis and Kuhl, Ellen and Bernstein, Daniel and Couture, Larry A and Gold, Joseph D and Zimmermann, Wolfram H and Wu, Joseph C
STEM CELLS, ISSN 1066-5099, 02/2018, Volume 36, Issue 2, pp. 265 - 277
The ability to differentiate human pluripotent stem cells (hPSCs) into cardiomyocytes (CMs) makes them an attractive source for repairing injured myocardium,... 
Bioengineering | Heart | Computational modeling | Tissue engineering | Cardiac | Engineered heart muscle | Cardiomyocyte | Calcium handling | Tissue regeneration | Pluripotent stem cells | RAT | CARDIAC-MUSCLE | CELL BIOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | HEMATOLOGY | MYOCARDIUM | TISSUE | FAILURE | CELL & TISSUE ENGINEERING | STIFFNESS | ONCOLOGY | DISEASE | CARDIOMYOCYTE DIFFERENTIATION | PLURIPOTENT STEM-CELL | Pluripotent Stem Cells - metabolism | Cell Line | Computational Biology - methods | Flow Cytometry | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Myocytes, Cardiac - cytology | Humans | Myocardium - metabolism | Myocytes, Cardiac - metabolism | Myocardium - cytology | Computer-generated environments | Computer simulation | Embryonic stem cells | Immunohistochemistry | Neonates | Flow cytometry | Calcium | Embryo cells | Stem cell transplantation | Polydimethyl siloxanes | Calcium signalling | Receptors | Alignment | Calcium-binding protein | Fibroblasts | Ion channels | Stiffness | Mathematical models | Polydimethylsiloxane | Stress concentration | Calcium channels | Stress analysis | Maturation | Cardiac muscle | Caveolin | Muscles | Calcium imaging | Cardiomyocytes | Maintenance | Potassium channels | Gene expression | Cytometry | Troponin | Stress distribution | Computation | Human performance | Collagen | Stem cells | Computer applications | Myocardium | Adrenergic receptors | Potassium | Receptors (physiology) | Pluripotency | Structure-function relationships | Index Medicus
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4. Full Text Hyperthermia influences the effects of sodium channel blocking drugs in human-induced pluripotent stem cell-derived cardiomyocytes
by El-Battrawy, Ibrahim and Lang, Siegfried and Zhao, Zhihan and Akin, Ibrahim and Yücel, Gökhan and Meister, Sophie and Patocskai, Bence and Behnes, Michael and Rudic, Boris and Tülümen, Erol and Liebe, Volker and Tiburcy, Malte and Dworacek, Jennifer and Zimmermann, Wolfram-Hubertus and Utikal, Jochen and Wieland, Thomas and Borggrefe, Martin and Zhou, Xiao-Bo
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0166143 - e0166143
Introduction Fever can increase the susceptibility to supraventricular and ventricular arrhythmias, in which sodium channel dysfunction has been implicated.... 
MOLECULAR CHARACTERIZATION | BRUGADA-SYNDROME | TEMPERATURE | LIDOCAINE | MULTIDISCIPLINARY SCIENCES | RANOLAZINE | MUTATION | CURRENTS | ATRIAL-FIBRILLATION | FEVER | DEPENDENCE | Lidocaine - pharmacology | Hot Temperature - adverse effects | Humans | Sodium Channel Blockers - pharmacology | Flecainide - pharmacology | Sodium Channels - drug effects | Sodium Channels - physiology | Patch-Clamp Techniques | Myocytes, Cardiac - drug effects | Pluripotent Stem Cells - drug effects | Polymerase Chain Reaction | Ranolazine - pharmacology | Ajmaline - pharmacology | Drugs | Arrhythmia | Flecainide | Analysis | Stem cells | Heart cells | Cardiac arrhythmia | Temperature | Physiological effects | Human influences | Inactivation | Recovery | Temperature effects | Electrocardiography | Fibroblasts | Inhibition | Temperature dependence | Deactivation | Cardiomyocytes | Steady state | Fever | Sodium | Skin | Mutation | Ventricle | Lidocaine | Sodium currents | Hyperthermia | Pluripotency | Index Medicus
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5. Full Text Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult
by Vogler, Melanie and Zieseniss, Anke and Hesse, Amke R and Levent, Elif and Tiburcy, Malte and Heinze, Eva and Burzlaff, Nicolai and Schley, Gunnar and Eckardt, Kai Uwe and Willam, Carsten and Katschinski, Dörthe M
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 10/2015, Volume 467, Issue 10, pp. 2141 - 2149
Several genetically modified mouse models implicated that prolyl-4-hydroxylase domain (PHD) enzymes are critical mediators for protecting tissues from an... 
Hypoxia | Biomedicine | Human Physiology | Ischemia | HIF | Prolyl-hydroxylase inhibitor | HYPOXIA-INDUCIBLE FACTOR | ACTIVATION | PHYSIOLOGY | HIF PROLYL HYDROXYLASES | MYOCARDIAL-INFARCTION | REPERFUSION INJURY | FACTOR-I | HIF-1-ALPHA | CARDIOPROTECTION | CEREBRAL-ISCHEMIA | 4-HYDROXYLASE | Glycine - analogs & derivatives | Glycine - therapeutic use | Mice, Inbred C57BL | Male | Myocardial Infarction - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Prolyl-Hydroxylase Inhibitors - therapeutic use | Cardiotonic Agents - therapeutic use | Transcription Factors - metabolism | Animals | Isoquinolines - pharmacology | Myocardial Infarction - drug therapy | Glycine - pharmacology | Ischemic Preconditioning, Myocardial | Ischemic Postconditioning | Isoquinolines - therapeutic use | Mice | Analysis | Heme | Genetically modified organisms | Physiological aspects | Hydroxylases | Heart attack
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6. Full Text Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts
by Streckfuss-Bömeke, Katrin and Wolf, Frieder and Azizian, Azadeh and Stauske, Michael and Tiburcy, Malte and Wagner, Stefan and Hübscher, Daniela and Dressel, Ralf and Chen, Simin and Jende, Jörg and Wulf, Gerald and Lorenz, Verena and Schön, Michael P and Maier, Lars S and Zimmermann, Wolfram H and Hasenfuss, Gerd and Guan, Kaomei
European Heart Journal, ISSN 0195-668X, 09/2013, Volume 34, Issue 33, pp. 2618 - 2629
Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening,... 
Cardiomyocytes | Hair keratinocytes | Skin fibroblasts | Human-induced pluripotent stem cells | Mesenchymal stem cells | DEFINED FACTORS | CARDIAC & CARDIOVASCULAR SYSTEMS | CASSETTE | TISSUE | MATURATION | FUNCTIONAL CARDIOMYOCYTES | GENERATION | HUMAN SOMATIC-CELLS | EFFICIENT | Biomarkers - metabolism | Skin - cytology | Nanog Homeobox Protein | Bone Marrow Cells - cytology | Calcium - metabolism | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | Cells, Cultured | Keratinocytes - cytology | SOXB1 Transcription Factors - metabolism | Action Potentials - physiology | Mesenchymal Stromal Cells - cytology | Octamer Transcription Factor-3 - metabolism | Fibroblasts - cytology | Hair - cytology | DNA Methylation - physiology | Induced Pluripotent Stem Cells - cytology | Cell Differentiation - physiology | Cellular Reprogramming - physiology | Tissue Engineering
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7. Full Text Sunday, 26 August 2012
by Kobayashi, J and Yoshida, M and Tarui, S and Hirata, M and Takahashi, K and Naruse, K and Kasahara, S and Sano, S and Oh, H and Halbach, M and Peinkofer, G and Baumgartner, S and Krausgrill, B and Fatima, A and Hescheler, J and Saric, T and Mueller-Ehmsen, J and Kamakura, T and Makiyama, T and Sasaki, K and Hattori, T and Ohno, S and Yoshida, Y and Horie, M and Kimura, T and Guan, K and Streckfuss-Boemeke, K and Wolf, F and Azizian, A and Stauske, M and Tiburcy, M and Wagner, S and Maier, L. S and Zimmermann, W. H and Hasenfuss, G and Mehta, A and Sequiera, G. L and Sudibyo, Y and Jun, L and Wong, P and Liew, R and Shim, W and Dambrot, C and Braam, S. R and Freund, C. M. A. H and Van De Pas, S and Ward-Van Oostwaard, D and Atsma, D. E and Mummery, C. L and Shigeta, T and Kureishi Bando, Y and Aoyama, M and Monji, A and Mitsui, T and Cheng, X. W and Murohara, T and Saikawa, T and Nishio, S and Takahashi, N and Thuc, L. C and Saito, S and Fukui, A and Kume, O and Hara, M and Nakagawa, M and Teshima, Y and Radovits, T and Olah, A and Nemeth, B and Hidi, L and Birtalan, E and Kokeny, G and Szabo, G and Merkely, B and Rottlaender, D and Wolny, M and Motloch, L. J and Gebing, T and Reda, S and Hoppe, U. C and Feijoo-Bandin, S and Rodriguez-Penas, D and Garcia-Rua, V and Otero, M. F and Mosquera-Leal, A and Gonzalez-Juanatey, J. R and Lago, M. F and Dimitriadis, K and Tsioufis, C and Tsiachris, D and Kasiakogias, A and Psaltopoulou, T and Tzamou, V and Mazaraki, A and Andrikou, I and Pitsavos, C and Stefanadis, C and Mill, J. G and Rodrigues, S. L and Baldo, M. P and ... and on behalf of IRTG - 1566 PROMISE and on behalf of The SAVIOR investigators and on behalf of On behalf of the PLATelet inhibition and patient Outcomes (PLATO) investigators and on behalf of EPES Acute Cardiac Care group and on behalf of WHICH? Trial Investigators and on behalf of Prof. Geibel. PD Dr. Harloff, Dr. Guenther and on behalf of Italian ClinicalService Project and on behalf of PL-ACS Invaestigators and on behalf of EmbraceAC Study Group and on behalf of CHFN and on behalf of The interventional working group of the lebanese society of cardiology and on behalf of SAFETY Investigators and on behalf of grant of IGA Ministry of health of the Czech Republic no. NS9824-4/2008 and on behalf of the Korean Hypertension Research Network and on behalf of Jian-Jun Li and on behalf of the FRANCE2 steering Committee and on behalf of Cardiology&Development and on behalf of St. Antonius center for platelet function research and on behalf of the MANTRA Study investigators and on behalf of ROCKET AF Executive Committee and on behalf of Tako tsubo Italian Network and on behalf of the AF meta-analysis team and on behalf of Ibaraki Coronary Artery Disease Study (ICAS) registry and on behalf of ICALOR and on behalf of MANTRA Study Investigators and on behalf of Competence Network Heart Failure Germany and on behalf of APPRAISE-2 Study Group and on behalf of Sapaldia Study Group and on behalf of CHF-HOT Study and on behalf of CAPIRE Investigators and on behalf of Francesco Barilla, et al and on behalf of VIDA-IC investigators and on behalf of The BETTER-CARE Study Investigators and on behalf of BMIR and on behalf of The International Registry of Acute Aortic Dissection (IRAD) and on behalf of Francesca Frexia and on behalf of VIDA IC investigators and on behalf of FAST-MI 2010 and on behalf of Hypersleep and on behalf of ACTION and on behalf of SHIFT echostudy and on behalf of Korea Acute Myocardial Infarction Registry and on behalf of Barbanza investigators and on behalf of The GARFIELD Investigators and on behalf of the CHOICE trial investigators and on behalf of NIPPON DATA80/90 Research Group and on behalf of MINAP Steering Group and on behalf of PROTECT investigators and on behalf of TuePic and on behalf of Center for Clinical Heart Research, Oslo University Hospital, Ullevaal and on behalf of PROTECTION IV investigators and on behalf of ASAP Investigators and on behalf of FP7 project and on behalf of GARFIELD Investigators and on behalf of LIPID study investigators and on behalf of NIPPON DATA 80 Research Group and on behalf of COACH and on behalf of INH and on behalf of CARDIO-ARSIF registry and on behalf of Hopital Cardiologique, CIC a thematique cardiovasculaire CIC-005 INSERM, Universite Victor Segalen, CHU de Bordeaux, Bordeaux, France and on behalf of Registry of Cardiovascular Interventions, Czech Republic and on behalf of INPETU and on behalf of The International Registry of Acute Aortic Dissection and on behalf of the FAST-MI 2010 investigators and on behalf of PL-ACS Invastigators and on behalf of The Austrian Acute PCI Investigators and on behalf of Competence Network Heart Failure and on behalf of Thyroid Studies Collaboration and on behalf of University Centre for Cardiovascular Science and on behalf of SCAAR-registry and on behalf of BASKET/BASKET-PROVE Investigators and on behalf of Cardiac and on behalf of on behalf of the German Competence Network Heart Failure and the German Competence Network for HIV/AIDS and on behalf of Northern Iwate Heart Disease Registry Consortium and on behalf of J-MELODIC Investigators and on behalf of nil and on behalf of German Competence Network Heart Failure and on behalf of ARISTOTLE Investigators and on behalf of NA and on behalf of Popovici M
European Heart Journal, ISSN 0195-668X, 08/2012, Volume 33, Issue suppl 1, pp. 19 - 338
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8. Full Text 5044Heat shock protein 47 knockout in fibroblasts causes contractile dysfunction in engineered human myocardium
by Sur, S and Noack, C and Christalla, P and Tiburcy, M and Nagata, K and Mayr, M and Zimmermann, W.-H
European Heart Journal, ISSN 0195-668X, 08/2017, Volume 38, Issue suppl_1
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9. Full Text P2545Inducible paracrine release of IGF-1 improves heart muscle thickness and function
by Soong, P.L and Sur, S and Fujita, B and Grishina, E and Kuzyakova, M and Tiburcy, M and Zimmermann, W.H
European Heart Journal, ISSN 0195-668X, 08/2017, Volume 38, Issue suppl_1
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10. Full Text Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair
by Tiburcy, Malte and Hudson, James E and Balfanz, Paul and Schlick, Susanne and Meyer, Tim and Chang Liao, Mei-Ling and Levent, Elif and Raad, Farah and Zeidler, Sebastian and Wingender, Edgar and Riegler, Johannes and Wang, Mouer and Gold, Joseph D and Kehat, Izhak and Wettwer, Erich and Ravens, Ursula and Dierickx, Pieterjan and van Laake, Linda W and Goumans, Marie Jose and Khadjeh, Sara and Toischer, Karl and Hasenfuss, Gerd and Couture, Larry A and Unger, Andreas and Linke, Wolfgang A and Araki, Toshiyuki and Neel, Benjamin and Keller, Gordon and Gepstein, Lior and Wu, Joseph C and Zimmermann, Wolfram-Hubertus
Circulation, ISSN 0009-7322, 05/2017, Volume 135, Issue 19, pp. 1832 - 1847
BACKGROUND:Advancing structural and functional maturation of stem cell–derived cardiomyocytes remains a key challenge for applications in disease modeling,... 
heart failure | stem cells | tissue engineering | models, cardiovascular | regeneration | Tissue Engineering - methods | Induced Pluripotent Stem Cells - physiology | Humans | Induced Pluripotent Stem Cells - transplantation | Rats | Myocardium - pathology | Heart Failure - pathology | Ventricular Remodeling - physiology | Rats, Nude | Embryonic Stem Cells - physiology | Myocardium - cytology | Heart Failure - therapy | Myocytes, Cardiac - transplantation | Animals | Myocytes, Cardiac - physiology | Embryonic Stem Cells - transplantation | Printing, Three-Dimensional | Cell Differentiation - physiology | LONG-TERM | CARDIAC & CARDIOVASCULAR SYSTEMS | STIMULATION | FUNCTIONAL MATURATION | CARDIAC MYOCYTES | TISSUE | CARDIOMYOCYTES | HYPERTROPHY | INFARCTED RAT HEARTS | EMBRYONIC STEM-CELLS | PERIPHERAL VASCULAR DISEASE | DIFFERENTIATION | Heart failure | Care and treatment | Research | Tissue engineering | Stem cells | Index Medicus | Abridged Index Medicus | Stem Cells | Translational Studies | Contractile Function | Regeneration | Myocardial Regeneration | Heart Failure | Biomarkers | Cell Therapy | Tissue Engineering | Disease Modelling
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11. Full Text Extracellular Signal-Regulated Kinases 1 and 2 Regulate the Balance Between Eccentric and Concentric Cardiac Growth
by Kehat, Izhak and Davis, Jennifer and Tiburcy, Malte and Accornero, Federica and Saba-El-Leil, Marc K and Maillet, Marjorie and York, Allen J and Lorenz, John N and Zimmermann, Wolfram H and Meloche, Sylvain and Molkentin, Jeffery D
Circulation Research, ISSN 0009-7330, 01/2011, Volume 108, Issue 2, pp. 176 - 183
RATIONALE:An increase in cardiac afterload typically produces concentric hypertrophy characterized by an increase in cardiomyocyte width, whereas volume... 
ventricular remodeling | signaling | MAPK | hypertrophy | heart | genetically altered mice | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTES | CA2+ RELEASE | HEART-FAILURE | CARDIOMYOPATHY | MECHANISMS | KNOCKOUT MICE | ERK1/2 | DISEASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | TRANSGENIC MICE | Phosphorylation | Mitogen-Activated Protein Kinase 3 - genetics | Cells, Cultured | MAP Kinase Kinase 1 - metabolism | Mice, Transgenic | Mice, Knockout | Myocytes, Cardiac - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Myocytes, Cardiac - metabolism | Models, Animal | Signal Transduction - physiology | Mice | Hypertrophy | Mitogen-Activated Protein Kinase 1 - metabolism
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12. Full Text Cardiac macrotissues-on-a-plate models for phenotypic drug screens
by Meyer, Tim and Tiburcy, Malte and Zimmermann, Wolfram-Hubertus
Advanced Drug Delivery Reviews, ISSN 0169-409X, 02/2019, Volume 140, pp. 93 - 100
Facilitated by the introduction of human induced pluripotent stem cells and protocols for their efficient directed differentiation at high quantity and... 
IN-VITRO | FUNCTIONAL MATURATION | HEART-FAILURE | TISSUE | MUSCLE | PHARMACOLOGY & PHARMACY | ENGINEERED HUMAN MYOCARDIUM | MICROPHYSIOLOGICAL DEVICES | CARDIOMYOCYTES | DIFFERENTIATION | PLURIPOTENT STEM-CELL | Models | Anisotropy | Analysis | Stem cells
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13. Full Text Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy
by Borchert, Thomas and Hübscher, Daniela and Guessoum, Celina I and Lam, Tuan-Dinh D and Ghadri, Jelena R and Schellinger, Isabel N and Tiburcy, Malte and Liaw, Norman Y and Li, Yun and Haas, Jan and Sossalla, Samuel and Huber, Mia A and Cyganek, Lukas and Jacobshagen, Claudius and Dressel, Ralf and Raaz, Uwe and Nikolaev, Viacheslav O and Guan, Kaomei and Thiele, Holger and Meder, Benjamin and Wollnik, Bernd and Zimmermann, Wolfram-Hubertus and Lüscher, Thomas F and Hasenfuss, Gerd and Templin, Christian and Streckfuss-Bömeke, Katrin
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2017, Volume 70, Issue 8, pp. 975 - 991
Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The... 
electrical activity | broken heart syndrome | catecholamine | iPSC cardiomyocytes | lipotoxicity | TTS pathogenesis | CARDIAC & CARDIOVASCULAR SYSTEMS | TAKO-TSUBO | CARDIOMYOCYTES | ISOPROTERENOL | DEFICIENCY | PATHOGENESIS | STRESS CARDIOMYOPATHY | PATHWAY | MOUSE MODEL | ACUTE MYOCARDIAL-INFARCTION | Induced Pluripotent Stem Cells - pathology | Signal Transduction | Humans | Middle Aged | Cells, Cultured | Myocytes, Cardiac - pathology | Myocytes, Cardiac - metabolism | Adult | Female | Cell Differentiation | Receptors, Adrenergic, beta - metabolism | Takotsubo Cardiomyopathy - pathology | Catecholamines - pharmacology | Takotsubo Cardiomyopathy - metabolism | Induced Pluripotent Stem Cells - metabolism | Protein kinase A | Heart | Cardiac arrhythmia | Regulators | Phosphorylation | Heart attacks | Calcium | Toxicity | Cardiomyopathy | Pathogenesis | Ryanodine receptors | Lipids | Stimulation | Kinases | Contraction | Rodents | DNA methylation | Fibroblasts | Heart diseases | Adenosine monophosphate | Computer simulation | Cardiac muscle | Complications | Calcium channels (voltage-gated) | Muscles | Cyclic AMP | Cardiomyocytes | Metabolism | Catecholamine | Patients | Muscle contraction | Studies | Sensitivity | Adenosine kinase | Somatic cells | Stem cells | Phase (cyclic) | Adrenergic receptors | Ventricle | In vitro methods and tests | Pluripotency | Inhibitory postsynaptic potentials | Index Medicus | Abridged Index Medicus
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14. Full Text Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model
by Riegler, Johannes and Tiburcy, Malte and Ebert, Antje and Tzatzalos, Evangeline and Raaz, Uwe and Abilez, Oscar J and Shen, Qi and Kooreman, Nigel G and Neofytou, Evgenios and Chen, Vincent C and Wang, Mouer and Meyer, Tim and Tsao, Philip S and Connolly, Andrew J and Couture, Larry A and Gold, Joseph D and Zimmermann, Wolfram H and Wu, Joseph C
Circulation Research, ISSN 0009-7330, 09/2015, Volume 117, Issue 8, pp. 720 - 730
RATIONALE:Tissue engineering approaches may improve survival and functional benefits from human embryonic stem cell–derived cardiomyocyte transplantation,... 
Myocardial infarction | Cell survival | Cardiac function tests | Tissue engineering | Myocardial ischemia | Transplantation | Cardiac MRI | tissue engineering | cell survival | cardiac MRI | myocardial infarction | transplantation | myocardial ischemia | cardiac function tests | CARDIAC & CARDIOVASCULAR SYSTEMS | TISSUE | CARDIOMYOPATHY | CELL-DERIVED CARDIOMYOCYTES | COCULTURE | SHEETS | CARDIAC RHABDOMYOMA | RAT HEARTS</