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Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 49 - 53
Journal Article
Nature, ISSN 0028-0836, 03/2016, Volume 531, Issue 7596, pp. 598 - 603
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2019, Volume 15, Issue 7, pp. 666 - 668
The complement pathway is an important part of the immune system, and uncontrolled activation is implicated in many diseases. The human complement component 5... 
SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | Proteins | Complement activation | Inhibitors | Complement component C5 | Antibodies | Complement | Paroxysmal nocturnal hemoglobinuria | Optimization | Immune system
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 15, pp. 4626 - 4634
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2019, Volume 62, Issue 4, pp. 1793 - 1802
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell... 
ALLOSTERIC-INHIBITION | CHEMISTRY, MEDICINAL | PTPN11 | TYROSINE-PHOSPHATASE SHP2 | MUTATIONS | IDENTIFICATION | DISCOVERY
Journal Article
Organic Letters, ISSN 1523-7060, 11/2012, Volume 14, Issue 21, pp. 5578 - 5581
Iterative cross-coupling is a highly efficient and versatile strategy for modular construction in organic synthesis, though this has historically been... 
COST | ESTERS | CHEMISTRY, ORGANIC | ARYL | MEDICINAL CHEMISTS | GENERAL STRATEGY | TRIFLUOROMETHYLATION | Amines - chemistry | Boronic Acids - chemistry | Molecular Structure | Catalysis | Imino Acids - chemistry
Journal Article
Behavioural Pharmacology, ISSN 0955-8810, 04/2014, Volume 25, Issue 2, pp. 182 - 185
Several allosteric modulators (AMs) of the CB1 receptor have been characterized in vitro, including Org27569, which enhances CB1-specific binding of... 
mouse | CP55 | rimonabant | cannabinoid | a940 | anandamide | allosteric modulator | CP55,940 | NEUROSCIENCES | INTERNALIZATION | DISPLAY | CB1 | CANNABINOID CB1 RECEPTORS | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | Delta 9-tetrahydrocannabinol | AGONIST | Cannabinoid Receptor Modulators - pharmacology | Cannabinoid Receptor Modulators - pharmacokinetics | Catalepsy - drug therapy | Endocannabinoids - pharmacology | Allosteric Regulation | Drug Evaluation | Nociception - physiology | Catalepsy - metabolism | Male | Hypothermia - chemically induced | Cannabinoid Receptor Agonists - pharmacology | Eating - physiology | Receptor, Cannabinoid, CB1 - agonists | Piperidines - pharmacology | Hypothermia - metabolism | Nociception - drug effects | Cannabinoid Receptor Antagonists - pharmacology | Catalepsy - chemically induced | Female | Indoles - pharmacology | Piperidines - pharmacokinetics | Cyclohexanols - pharmacology | Dronabinol - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | Amidohydrolases - genetics | Mice, Inbred C57BL | Arachidonic Acids - pharmacology | Mice, Inbred ICR | Mice, Knockout | Eating - drug effects | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Hypothermia - drug therapy | Polyunsaturated Alkamides - pharmacology | Indoles - pharmacokinetics | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Index Medicus | 940 | Δ9-tetrahydrocannabinol
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2006, Volume 47, Issue 11, pp. 1861 - 1864
A novel thioacetate mediated one-step reductive acetamidation of aryl nitro compounds was developed and applied to an efficient synthesis of acetaminophen. A... 
CHEMISTRY, ORGANIC | NITROARENES | METAL | CATALYST | AMIDES
Journal Article
01/2013, ISBN 9781267833549
Plant-derived and endogenous cannabinoids (endocannabinoids) produce their cellular effects by interacting with cannabinoid receptors (CBs), which are members... 
Organic chemistry
Dissertation
Tetrahedron Letters, ISSN 0040-4039, 03/2006, Volume 47, Issue 11, p. 1861
A novel thioacetate mediated one-step reductive acetamidation of aryl nitro compounds was developed and applied to an efficient synthesis of acetaminophen. 
Hydrocarbons | Nitro compounds
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2006, Volume 47, Issue 4, pp. 565 - 567
A simple, surfactant-mediated, one-pot, solvent-free dealkylative cleavage of aryl ethers and esters followed by subsequent optional trans-alkylation under... 
CHEMISTRY, ORGANIC | DEPROTECTION | Esters
Journal Article